HA-TAZ Citations (21)
Originally described in: TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway.Lei QY, Zhang H, Zhao B, Zha ZY, Bai F, Pei XH, Zhao S, Xiong Y, Guan KL Mol Cell Biol. 2008 Apr;28(7):2426-36. Epub 2008 Jan 28. PubMed Journal
Articles Citing HA-TAZ
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| Differential topical susceptibility to TGFbeta in intact and injured regions of the epithelium: key role in myofibroblast transition. Speight P, Nakano H, Kelley TJ, Hinz B, Kapus A. Mol Biol Cell. 2013 Nov;24(21):3326-36. doi: 10.1091/mbc.E13-04-0220. Epub 2013 Sep 4. PubMed |
| CDK1 phosphorylation of TAZ in mitosis inhibits its oncogenic activity. Zhang L, Chen X, Stauffer S, Yang S, Chen Y, Dong J. Oncotarget. 2015 Oct 13;6(31):31399-412. doi: 10.18632/oncotarget.5189. PubMed |
| Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFbeta-regulated Smad3. Speight P, Kofler M, Szaszi K, Kapus A. Nat Commun. 2016 May 18;7:11642. doi: 10.1038/ncomms11642. PubMed |
| Transformation by Polyomavirus Middle T Antigen Involves A Unique Bimodal Interaction with the Hippo Effector YAP. Rouleau C, Pores Fernando AT, Hwang JH, Faure N, Jiang T, White EA, Roberts TM, Schaffhausen BS. J Virol. 2016 May 18. pii: JVI.00417-16. PubMed |
| Hippo signaling interactions with Wnt/beta-catenin and Notch signaling repress liver tumorigenesis. Kim W, Khan SK, Gvozdenovic-Jeremic J, Kim Y, Dahlman J, Kim H, Park O, Ishitani T, Jho EH, Gao B, Yang Y. J Clin Invest. 2017 Jan 3;127(1):137-152. doi: 10.1172/JCI88486. Epub 2016 Nov 21. PubMed |
| Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells. Feng J, Yang H, Zhang Y, Wei H, Zhu Z, Zhu B, Yang M, Cao W, Wang L, Wu Z. Oncogene. 2017 Oct 19;36(42):5829-5839. doi: 10.1038/onc.2017.188. Epub 2017 Jun 12. PubMed |
| TGF-beta1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism. Miranda MZ, Bialik JF, Speight P, Dan Q, Yeung T, Szaszi K, Pedersen SF, Kapus A. J Biol Chem. 2017 Sep 8;292(36):14902-14920. doi: 10.1074/jbc.M117.780502. Epub 2017 Jul 24. PubMed |
| YAP and TAZ mediate steroid-induced alterations in the trabecular meshwork cytoskeleton in human trabecular meshwork cells. Peng J, Wang H, Wang X, Sun M, Deng S, Wang Y. Int J Mol Med. 2018 Jan;41(1):164-172. doi: 10.3892/ijmm.2017.3207. Epub 2017 Oct 23. PubMed |
| A tightly controlled Src-YAP signaling axis determines therapeutic response to dasatinib in renal cell carcinoma. Sun J, Wang X, Tang B, Liu H, Zhang M, Wang Y, Ping F, Ding J, Shen A, Geng M. Theranostics. 2018 May 11;8(12):3256-3267. doi: 10.7150/thno.23964. eCollection 2018. PubMed |
| OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ. Zhang Z, Du J, Wang S, Shao L, Jin K, Li F, Wei B, Ding W, Fu P, van Dam H, Wang A, Jin J, Ding C, Yang B, Zheng M, Feng XH, Guan KL, Zhang L. Mol Cell. 2019 Jan 3;73(1):7-21.e7. doi: 10.1016/j.molcel.2018.10.030. Epub 2018 Nov 21. PubMed |
| ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail. Bertran MT, Mouilleron S, Zhou Y, Bajaj R, Uliana F, Kumar GS, van Drogen A, Lee R, Banerjee JJ, Hauri S, O'Reilly N, Gstaiger M, Page R, Peti W, Tapon N. Nat Commun. 2019 Feb 15;10(1):771. doi: 10.1038/s41467-019-08686-0. PubMed |
| Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis. Wang X, Cai B, Yang X, Sonubi OO, Zheng Z, Ramakrishnan R, Shi H, Valenti L, Pajvani UB, Sandhu J, Infante RE, Radhakrishnan A, Covey DF, Guan KL, Buck J, Levin LR, Tontonoz P, Schwabe RF, Tabas I. Cell Metab. 2020 May 5;31(5):969-986.e7. doi: 10.1016/j.cmet.2020.03.010. Epub 2020 Apr 6. PubMed |
| Lactate-induced MRP1 expression contributes to metabolism-based etoposide resistance in non-small cell lung cancer cells. Dong Q, Zhou C, Ren H, Zhang Z, Cheng F, Xiong Z, Chen C, Yang J, Gao J, Zhang Y, Xu L, Fang J, Cao Y, Wei H, Wu Z. Cell Commun Signal. 2020 Oct 23;18(1):167. doi: 10.1186/s12964-020-00653-3. PubMed |
| Activation of Hepatic Stellate Cells Requires Dissociation of E-Cadherin-Containing Adherens Junctions with Hepatocytes. Urushima H, Yuasa H, Matsubara T, Kuroda N, Hara Y, Inoue K, Wake K, Sato T, Friedman SL, Ikeda K. Am J Pathol. 2021 Mar;191(3):438-453. doi: 10.1016/j.ajpath.2020.12.007. Epub 2020 Dec 18. PubMed |
| WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma. Driskill JH, Zheng Y, Wu BK, Wang L, Cai J, Rakheja D, Dellinger M, Pan D. Genes Dev. 2021 Apr 1;35(7-8):495-511. doi: 10.1101/gad.348221.120. Epub 2021 Mar 25. PubMed |
| EGFR Activates a TAZ-Driven Oncogenic Program in Glioblastoma. Gao M, Fu Y, Zhou W, Gui G, Lal B, Li Y, Xia S, Ji H, Eberhart CG, Laterra J, Ying M. Cancer Res. 2021 Jul 1;81(13):3580-3592. doi: 10.1158/0008-5472.CAN-20-2773. Epub 2021 Apr 28. PubMed |
| RhoA-ROCK competes with YAP to regulate amoeboid breast cancer cell migration in response to lymphatic-like flow. Mohammadalipour A, Diaz MF, Livingston M, Ewere A, Zhou A, Horton PD, Olamigoke LT, Lamar JM, Hagan JP, Lee HJ, Wenzel PL. FASEB Bioadv. 2022 Feb 14;4(5):342-361. doi: 10.1096/fba.2021-00055. eCollection 2022 May. PubMed |
| Structure-based discovery of a novel small-molecule inhibitor of TEAD palmitoylation with anticancer activity. Gridnev A, Maity S, Misra JR. Front Oncol. 2022 Nov 29;12:1021823. doi: 10.3389/fonc.2022.1021823. eCollection 2022. PubMed |
| Skeletal diseases caused by mutations in PTH1R show aberrant differentiation of skeletal progenitors due to dysregulation of DEPTOR. Csukasi F, Bosakova M, Barta T, Martin JH, Arcedo J, Barad M, Rico-Llanos GA, Zieba J, Becerra J, Krejci P, Duran I, Krakow D. Front Cell Dev Biol. 2023 Jan 16;10:963389. doi: 10.3389/fcell.2022.963389. eCollection 2022. PubMed |
TEAD Inhibition Overcomes YAP1/TAZ-driven Primary and Acquired Resistance to KRASG12C Inhibitors.
Edwards AC, Stalnecker CA, Jean Morales A, Taylor KE, Klomp JE, Klomp JA, Waters AM, Sudhakar N, Hallin J, Tang TT, Olson P, Post L, Christensen JG, Cox AD, Der CJ.
Cancer Res. 2023 Nov 7. doi: 10.1158/0008-5472.CAN-23-2994.
PubMed
Associated Plasmids |
| Lactate drives CD38 signaling to promote Epithelial-Mesenchymal Transition through Snail induction in non-small cell lung cancer cells. Lu Y, Yang Y, Chang T, Jiang Q, Yang C, Fu C, Wei H, He Y, Wu Z. J Cell Commun Signal. 2024 Feb 14;18(1):e12018. doi: 10.1002/ccs3.12018. eCollection 2024 Mar. PubMed |
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