pcDNA3.1(+)Flag-His-ATM wt Citations (34)
Originally described in: Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD Science. 1998 Sep 11;281(5383):1677-9. PubMed Journal
Articles Citing pcDNA3.1(+)Flag-His-ATM wt
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| Identification of lethal microRNAs specific for head and neck cancer. Lindenbergh-van der Plas M, Martens-de Kemp SR, de Maaker M, van Wieringen WN, Ylstra B, Agami R, Cerisoli F, Leemans CR, Braakhuis BJ, Brakenhoff RH. Clin Cancer Res. 2013 Oct 15;19(20):5647-57. doi: 10.1158/1078-0432.CCR-12-2295. Epub 2013 Aug 13. PubMed |
| The tumor suppressor, TAX1BP2, is a novel substrate of ATM kinase. Lai WL, Hung WY, Ching YP. Oncogene. 2014 Nov 6;33(45):5303-9. doi: 10.1038/onc.2013.481. Epub 2013 Nov 18. PubMed |
| Dinaciclib (SCH727965) inhibits the unfolded protein response through a CDK1- and 5-dependent mechanism. Nguyen TK, Grant S. Mol Cancer Ther. 2014 Mar;13(3):662-74. doi: 10.1158/1535-7163.MCT-13-0714. Epub 2013 Dec 20. PubMed |
| Integrative radiation systems biology. Unger K. Radiat Oncol. 2014 Jan 11;9:21. doi: 10.1186/1748-717X-9-21. PubMed |
| Activation of the prereplication complex is blocked by mimosine through reactive oxygen species-activated ataxia telangiectasia mutated (ATM) protein without DNA damage. Kubota S, Fukumoto Y, Ishibashi K, Soeda S, Kubota S, Yuki R, Nakayama Y, Aoyama K, Yamaguchi N, Yamaguchi N. J Biol Chem. 2014 Feb 28;289(9):5730-46. doi: 10.1074/jbc.M113.546655. Epub 2014 Jan 13. PubMed |
| ROS-PIASgamma cross talk channelizes ATM signaling from resistance to apoptosis during chemosensitization of resistant tumors. Mohanty S, Saha S, Md S Hossain D, Adhikary A, Mukherjee S, Manna A, Chakraborty S, Mazumdar M, Ray P, Das K, Chakraborty J, Sa G, Das T. Cell Death Dis. 2014 Jan 23;5:e1021. doi: 10.1038/cddis.2013.534. PubMed |
| ATM functions at the peroxisome to induce pexophagy in response to ROS. Zhang J, Tripathi DN, Jing J, Alexander A, Kim J, Powell RT, Dere R, Tait-Mulder J, Lee JH, Paull TT, Pandita RK, Charaka VK, Pandita TK, Kastan MB, Walker CL. Nat Cell Biol. 2015 Oct;17(10):1259-69. doi: 10.1038/ncb3230. Epub 2015 Sep 7. PubMed |
| Phosphorylation-Dependent Regulation of the DNA Damage Response of Adaptor Protein KIBRA in Cancer Cells. Mavuluri J, Beesetti S, Surabhi R, Kremerskothen J, Venkatraman G, Rayala SK. Mol Cell Biol. 2016 Apr 15;36(9):1354-65. doi: 10.1128/MCB.01004-15. Print 2016 May 1. PubMed |
miR-34 activity is modulated through 5'-end phosphorylation in response to DNA damage.
Salzman DW, Nakamura K, Nallur S, Dookwah MT, Metheetrairut C, Slack FJ, Weidhaas JB.
Nat Commun. 2016 Mar 21;7:10954. doi: 10.1038/ncomms10954.
PubMed
Associated Plasmids |
| Regulation of human pollambda by ATM-mediated phosphorylation during non-homologous end joining. Sastre-Moreno G, Pryor JM, Moreno-Onate M, Herrero-Ruiz AM, Cortes-Ledesma F, Blanco L, Ramsden DA, Ruiz JF. DNA Repair (Amst). 2017 Mar;51:31-45. doi: 10.1016/j.dnarep.2017.01.004. Epub 2017 Jan 17. PubMed |
| Nuclear Gene 33/Mig6 regulates the DNA damage response through an ATM serine/threonine kinase-dependent mechanism. Li C, Park S, Zhang X, Eisenberg LM, Zhao H, Darzynkiewicz Z, Xu D. J Biol Chem. 2017 Oct 6;292(40):16746-16759. doi: 10.1074/jbc.M117.803338. Epub 2017 Aug 25. PubMed |
| LRRK2 interacts with ATM and regulates Mdm2-p53 cell proliferation axis in response to genotoxic stress. Chen Z, Cao Z, Zhang W, Gu M, Zhou ZD, Li B, Li J, Tan EK, Zeng L. Hum Mol Genet. 2017 Nov 15;26(22):4494-4505. doi: 10.1093/hmg/ddx337. PubMed |
| EBV-encoded miRNAs target ATM-mediated response in nasopharyngeal carcinoma. Lung RW, Hau PM, Yu KH, Yip KY, Tong JH, Chak WP, Chan AW, Lam KH, Lo AK, Tin EK, Chau SL, Pang JC, Kwan JS, Busson P, Young LS, Yap LF, Tsao SW, To KF, Lo KW. J Pathol. 2018 Apr;244(4):394-407. doi: 10.1002/path.5018. Epub 2018 Feb 16. PubMed |
| Triptolide sensitizes breast cancer cells to Doxorubicin through the DNA damage response inhibition. Deng Y, Li F, He P, Yang Y, Yang J, Zhang Y, Liu J, Tong Y, Li Q, Mei X, Shu Z, Zhao Q. Mol Carcinog. 2018 Jun;57(6):807-814. doi: 10.1002/mc.22795. Epub 2018 Mar 25. PubMed |
| Insufficiency of DNA repair enzyme ATM promotes naive CD4 T-cell loss in chronic hepatitis C virus infection. Zhao J, Dang X, Zhang P, Nguyen LN, Cao D, Wang L, Wu X, Morrison ZD, Zhang Y, Jia Z, Xie Q, Wang L, Ning S, El Gazzar M, Moorman JP, Yao ZQ. Cell Discov. 2018 Apr 10;4:16. doi: 10.1038/s41421-018-0015-4. eCollection 2018. PubMed |
| Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria. Qian M, Liu Z, Peng L, Tang X, Meng F, Ao Y, Zhou M, Wang M, Cao X, Qin B, Wang Z, Zhou Z, Wang G, Gao Z, Xu J, Liu B. Elife. 2018 May 2;7. pii: 34836. doi: 10.7554/eLife.34836. PubMed |
| Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr. Cell. 2018 Sep 20;175(1):101-116.e25. doi: 10.1016/j.cell.2018.08.038. Epub 2018 Sep 13. PubMed |
| Acute and rapid degradation of endogenous proteins by Trim-Away. Clift D, So C, McEwan WA, James LC, Schuh M. Nat Protoc. 2018 Oct;13(10):2149-2175. doi: 10.1038/s41596-018-0028-3. PubMed |
| Regulation of ATM and ATR by SMARCAL1 and BRG1. Sethy R, Rakesh R, Patne K, Arya V, Sharma T, Haokip DT, Kumari R, Muthuswami R. Biochim Biophys Acta Gene Regul Mech. 2018 Dec;1861(12):1076-1092. doi: 10.1016/j.bbagrm.2018.10.004. Epub 2018 Oct 11. PubMed |
| Reconstitution of the Ataxia-Telangiectasia Cellular Phenotype With Lentiviral Vectors. Carranza D, Torres-Rusillo S, Ceballos-Perez G, Blanco-Jimenez E, Munoz-Lopez M, Garcia-Perez JL, Molina IJ. Front Immunol. 2018 Nov 20;9:2703. doi: 10.3389/fimmu.2018.02703. eCollection 2018. PubMed |
| ATM is activated by ATP depletion and modulates mitochondrial function through NRF1. Chow HM, Cheng A, Song X, Swerdel MR, Hart RP, Herrup K. J Cell Biol. 2019 Mar 4;218(3):909-928. doi: 10.1083/jcb.201806197. Epub 2019 Jan 14. PubMed |
| ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans. Kreis P, Gallrein C, Rojas-Puente E, Mack TGA, Kroon C, Dinkel V, Willmes C, Murk K, Tom-Dieck S, Schuman EM, Kirstein J, Eickholt BJ. Nat Commun. 2019 Jan 30;10(1):486. doi: 10.1038/s41467-019-08420-w. PubMed |
| ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy. Zhao J, Nguyen LNT, Nguyen LN, Dang X, Cao D, Khanal S, Schank M, Thakuri BKC, Ogbu SC, Morrison ZD, Wu XY, Li Z, Zou Y, El Gazzar M, Ning S, Wang L, Moorman JP, Yao ZQ. Front Immunol. 2019 Nov 5;10:2531. doi: 10.3389/fimmu.2019.02531. eCollection 2019. PubMed |
| Ataxia telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma. Sarkar A, Stellrecht CM, Vangapandu HV, Ayres M, Kaipparettu BA, Park JH, Balakrishnan K, Burks JK, Pandita TK, Hittelman WN, Neelapu SS, Gandhi V. Haematologica. 2020 Feb 6. pii: haematol.2019.234385. doi: 10.3324/haematol.2019.234385. PubMed |
| Activation of ATM kinase by ROS generated during ionophore-induced mitophagy in human T and B cell malignancies. Sarkar A, Gandhi V. Mol Cell Biochem. 2021 Jan;476(1):417-423. doi: 10.1007/s11010-020-03917-1. Epub 2020 Sep 29. PubMed |
| Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m(6)A Methylation. Sun HL, Zhu AC, Gao Y, Terajima H, Fei Q, Liu S, Zhang L, Zhang Z, Harada BT, He YY, Bissonnette MB, Hung MC, He C. Mol Cell. 2020 Nov 19;80(4):633-647.e7. doi: 10.1016/j.molcel.2020.10.026. PubMed |
| An ATM-Chk2-INCENP pathway activates the abscission checkpoint. Petsalaki E, Zachos G. J Cell Biol. 2021 Feb 1;220(2). pii: 211635. doi: 10.1083/jcb.202008029. PubMed |
| SERPINE2/PN-1 regulates the DNA damage response and radioresistance by activating ATM in lung cancer. Zhang J, Wu Q, Zhu L, Xie S, Tu L, Yang Y, Wu K, Zhao Y, Wang Y, Xu Y, Chen X, Ma S, Zhang S. Cancer Lett. 2022 Jan 1;524:268-283. doi: 10.1016/j.canlet.2021.10.001. Epub 2021 Oct 11. PubMed |
| A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling. Banerjee D, Langberg K, Abbas S, Odermatt E, Yerramothu P, Volaric M, Reidenbach MA, Krentz KJ, Rubinstein CD, Brautigan DL, Abbas T, Gelfand BD, Ambati J, Kerur N. Nat Commun. 2021 Oct 27;12(1):6207. doi: 10.1038/s41467-021-26240-9. PubMed |
| Prediction of breast cancer risk based on flow variant analysis of circulating peripheral blood mononuclear cells. Loke J, Alim I, Yam S, Klugman S, Xia LC, Gruber D, Tegay D, LaBella A, Onel K, Ostrer H. HGG Adv. 2022 Jan 8;3(2):100085. doi: 10.1016/j.xhgg.2022.100085. eCollection 2022 Apr 14. PubMed |
| Persistent DNA damage associated with ATM kinase deficiency promotes microglial dysfunction. Bourseguin J, Cheng W, Talbot E, Hardy L, Lai J, Jeffries AM, Lodato MA, Lee EA, Khoronenkova SV. Nucleic Acids Res. 2022 Mar 21;50(5):2700-2718. doi: 10.1093/nar/gkac104. PubMed |
| Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress. Bodnar-Wachtel M, Huber AL, Gorry J, Hacot S, Burlet D, Gerossier L, Guey B, Goutagny N, Bartosch B, Ballot E, Lecuelle J, Truntzer C, Ghiringhelli F, Py BF, Coute Y, Ballesta A, Lantuejoul S, Hall J, Tissier A, Petrilli V. Life Sci Alliance. 2023 Feb 6;6(4):e202201494. doi: 10.26508/lsa.202201494. Print 2023 Apr. PubMed |
| Kaposi's sarcoma herpesvirus exploits the DNA damage response to circularize its genome. Li S, Liu B, Tan M, Juillard F, Szymula A, Alvarez AL, Van Sciver N, George A, Ramachandran A, Raina K, Tumuluri VS, Costa CN, Simas JP, Kaye KM. Nucleic Acids Res. 2024 Feb 28;52(4):1814-1829. doi: 10.1093/nar/gkad1224. PubMed |
| The DNA damage-independent ATM signalling maintains CBP/DOT1L axis in MLL rearranged acute myeloid leukaemia. Wang G, Zhang W, Ren J, Zeng Y, Dang X, Tian X, Yu W, Li Z, Ma Y, Yang P, Lu J, Zheng J, Lu B, Xu J, Liang A. Oncogene. 2024 Jun;43(25):1900-1916. doi: 10.1038/s41388-024-02998-2. Epub 2024 Apr 26. PubMed |
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