pT3-myr-AKT-HA Citations (23)

Originally described in: Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma.
Calvisi DF, Wang C, Ho C, Ladu S, Lee SA, Mattu S, Destefanis G, Delogu S, Zimmermann A, Ericsson J, Brozzetti S, Staniscia T, Chen X, Dombrowski F, Evert M Gastroenterology. 2011 Mar;140(3):1071-83. Epub 2010 Dec 11. PubMed Journal

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Articles Citing pT3-myr-AKT-HA

Articles
Adjuvant gemcitabine therapy improves survival in a locally induced, R0-resectable model of metastatic intrahepatic cholangiocarcinoma. Gurlevik E, Fleischmann-Mundt B, Armbrecht N, Longerich T, Woller N, Kloos A, Hoffmann D, Schambach A, Wirth TC, Manns MP, Zender L, Kubicka S, Kuhnel F. Hepatology. 2013 Sep;58(3):1031-41. doi: 10.1002/hep.26468. Epub 2013 Jul 29. PubMed
Microsphere priming facilitates induction of potent therapeutic T-cell immune responses against autochthonous liver cancers. Brinkhoff B, Ostroumov D, Heemcke J, Woller N, Gurlevik E, Manns MP, Longerich T, Zender L, Harty JT, Kubicka S, Kuhnel F, Wirth TC. Eur J Immunol. 2014 Apr;44(4):1213-24. doi: 10.1002/eji.201343794. Epub 2014 Jan 16. PubMed
CXCL5/CXCR2 axis promotes bladder cancer cell migration and invasion by activating PI3K/AKT-induced upregulation of MMP2/MMP9. Gao Y, Guan Z, Chen J, Xie H, Yang Z, Fan J, Wang X, Li L. Int J Oncol. 2015 Jun 9. doi: 10.3892/ijo.2015.3041. PubMed
Viral Infection of Tumors Overcomes Resistance to PD-1-immunotherapy by Broadening Neoantigenome-directed T-cell Responses. Woller N, Gurlevik E, Fleischmann-Mundt B, Schumacher A, Knocke S, Kloos AM, Saborowski M, Geffers R, Manns MP, Wirth TC, Kubicka S, Kuhnel F. Mol Ther. 2015 Oct;23(10):1630-40. doi: 10.1038/mt.2015.115. Epub 2015 Jun 26. PubMed
Administration of Gemcitabine After Pancreatic Tumor Resection in Mice Induces an Antitumor Immune Response Mediated by Natural Killer Cells. Gurlevik E, Fleischmann-Mundt B, Brooks J, Demir IE, Steiger K, Ribback S, Yevsa T, Woller N, Kloos A, Ostroumov D, Armbrecht N, Manns MP, Dombrowski F, Saborowski M, Kleine M, Wirth TC, Oettle H, Ceyhan GO, Esposito I, Calvisi DF, Kubicka S, Kuhnel F. Gastroenterology. 2016 Aug;151(2):338-350.e7. doi: 10.1053/j.gastro.2016.05.004. Epub 2016 May 20. PubMed
Tailored Tumor Immunogenicity Reveals Regulation of CD4 and CD8 T Cell Responses against Cancer. Knocke S, Fleischmann-Mundt B, Saborowski M, Manns MP, Kuhnel F, Wirth TC, Woller N. Cell Rep. 2016 Nov 22;17(9):2234-2246. doi: 10.1016/j.celrep.2016.10.086. PubMed
Critical role of Myc activation in mouse hepatocarcinogenesis induced by the activation of AKT and RAS pathways. Xin B, Yamamoto M, Fujii K, Ooshio T, Chen X, Okada Y, Watanabe K, Miyokawa N, Furukawa H, Nishikawa Y. Oncogene. 2017 Sep 7;36(36):5087-5097. doi: 10.1038/onc.2017.114. Epub 2017 May 8. PubMed
Oncogenic Determination of a Broad Spectrum of Phenotypes of Hepatocyte-Derived Mouse Liver Tumors. Yamamoto M, Xin B, Watanabe K, Ooshio T, Fujii K, Chen X, Okada Y, Abe H, Taguchi Y, Miyokawa N, Furukawa H, Nishikawa Y. Am J Pathol. 2017 Dec;187(12):2711-2725. doi: 10.1016/j.ajpath.2017.07.022. Epub 2017 Sep 28. PubMed
Perioperative, Spatiotemporally Coordinated Activation of T and NK Cells Prevents Recurrence of Pancreatic Cancer. Brooks J, Fleischmann-Mundt B, Woller N, Niemann J, Ribback S, Peters K, Demir IE, Armbrecht N, Ceyhan GO, Manns MP, Wirth TC, Kubicka S, Bernhardt G, Smyth MJ, Calvisi DF, Gurlevik E, Kuhnel F. Cancer Res. 2018 Jan 15;78(2):475-488. doi: 10.1158/0008-5472.CAN-17-2415. Epub 2017 Nov 27. PubMed
Mouse Model for Hepatocellular Carcinoma and Cholangiocarcinoma Originated from Mature Hepatocytes. Yamamoto M, Xin B, Nishikawa Y. Methods Mol Biol. 2019;1905:221-236. doi: 10.1007/978-1-4939-8961-4_20. PubMed
Targeting Jak/Stat pathway as a therapeutic strategy against SP/CD44+ tumorigenic cells in Akt/beta-catenin-driven hepatocellular carcinoma. Toh TB, Lim JJ, Hooi L, Rashid MBMA, Chow EK. J Hepatol. 2020 Jan;72(1):104-118. doi: 10.1016/j.jhep.2019.08.035. Epub 2019 Sep 18. PubMed
Generation of combined hepatocellular-cholangiocarcinoma through transdifferentiation and dedifferentiation in p53-knockout mice. Liu Y, Xin B, Yamamoto M, Goto M, Ooshio T, Kamikokura Y, Tanaka H, Meng L, Okada Y, Mizukami Y, Nishikawa Y. Cancer Sci. 2021 Aug;112(8):3111-3124. doi: 10.1111/cas.14996. Epub 2021 Jun 27. PubMed
WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression. Wu M, Xia X, Hu J, Fowlkes NW, Li S. Nat Commun. 2021 Jun 9;12(1):3500. doi: 10.1038/s41467-021-23864-9. PubMed
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade. Yang Z, Xu G, Wang B, Liu Y, Zhang L, Jing T, Tang M, Xu X, Jiao K, Xiang L, Fu Y, Tang D, Zhang X, Jin W, Zhuang G, Zhao X, Liu Y. Nat Commun. 2021 Aug 11;12(1):4852. doi: 10.1038/s41467-021-25032-5. PubMed
Discovery of bletillain, an unusual benzyl polymer with significant autophagy-inducing effects in A549 lung cancer cells through the Akt/GSK-3beta/beta-catenin signaling pathway. Zhu H, Dai O, Zhou F, Yang L, Liu F, Liu Y, He YL, Bu L, Guo L, Peng C, Xiong L. Bioorg Chem. 2021 Dec;117:105449. doi: 10.1016/j.bioorg.2021.105449. Epub 2021 Oct 23. PubMed
METTL1 promotes hepatocarcinogenesis via m(7) G tRNA modification-dependent translation control. Chen Z, Zhu W, Zhu S, Sun K, Liao J, Liu H, Dai Z, Han H, Ren X, Yang Q, Zheng S, Peng B, Peng S, Kuang M, Lin S. Clin Transl Med. 2021 Dec;11(12):e661. doi: 10.1002/ctm2.661. PubMed
Molecular Subgroups of Intrahepatic Cholangiocarcinoma Discovered by Single-Cell RNA Sequencing-Assisted Multiomics Analysis. Bao X, Li Q, Chen J, Chen D, Ye C, Dai X, Wang Y, Li X, Rong X, Cheng F, Jiang M, Zhu Z, Ding Y, Sun R, Liu C, Huang L, Jin Y, Li B, Lu J, Wu W, Guo Y, Fu W, Langley SR, Tano V, Fang W, Guo T, Sheng J, Zhao P, Ruan J. Cancer Immunol Res. 2022 Jul 1;10(7):811-828. doi: 10.1158/2326-6066.CIR-21-1101. PubMed
Geospatial Immune Heterogeneity Reflects the Diverse Tumor-Immune Interactions in Intrahepatic Cholangiocarcinoma. Lin Y, Peng L, Dong L, Liu D, Ma J, Lin J, Chen X, Lin P, Song G, Zhang M, Liu Y, Rao J, Wei C, Lu Y, Zhang S, Ding G, Peng Z, Lu H, Wang X, Zhou J, Fan J, Wu K, Gao Q. Cancer Discov. 2022 Oct 5;12(10):2350-2371. doi: 10.1158/2159-8290.CD-21-1640. PubMed
DKK1 drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with anti-DKK1 therapeutic DKN-01. Jarman EJ, Horcas-Lopez M, Waddell SH, MacMaster S, Gournopanos K, Soong DYH, Musialik KI, Tsokkou P, Ng ME, Cambridge WA, Wilson DH, Kagey MH, Newman W, Pollard JW, Boulter L. Liver Int. 2023 Jan;43(1):208-220. doi: 10.1111/liv.15383. Epub 2022 Sep 15. PubMed
Intravital electrochemical nanosensor as a tool for the measurement of reactive oxygen/nitrogen species in liver diseases. Abakumova T, Vaneev A, Naumenko V, Shokhina A, Belousov V, Mikaelyan A, Balysheva K, Gorelkin P, Erofeev A, Zatsepin T. J Nanobiotechnology. 2022 Nov 24;20(1):497. doi: 10.1186/s12951-022-01688-z. PubMed
SRSF3 and HNRNPH1 Regulate Radiation-Induced Alternative Splicing of Protein Arginine Methyltransferase 5 in Hepatocellular Carcinoma. Wen C, Tian Z, Li L, Chen T, Chen H, Dai J, Liang Z, Ma S, Liu X. Int J Mol Sci. 2022 Nov 27;23(23):14832. doi: 10.3390/ijms232314832. PubMed
Multimodal label-free imaging of murine hepatocellular carcinoma with a subcellular resolution. Chebotarev AS, Ledyaeva VS, Patsap OI, Ivanov AA, Fedotov AB, Belousov VV, Shokhina AG, Lanin AA. J Biophotonics. 2023 Dec;16(12):e202300228. doi: 10.1002/jbio.202300228. Epub 2023 Sep 13. PubMed
A DNA/RNA heteroduplex oligonucleotide coupling asparagine depletion restricts FGFR2 fusion-driven intrahepatic cholangiocarcinoma. Chu Z, Zhang B, Zhou X, Yuan H, Gao C, Liu L, Xiao Y, Zhang J, Hong J, Liang J, Chen D, Yao N. Mol Ther Nucleic Acids. 2023 Oct 5;34:102047. doi: 10.1016/j.omtn.2023.102047. eCollection 2023 Dec 12. PubMed

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