pLKO.1 GFP shRNA Citations (84)
Originally described in: The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM Science. 2008 Jun 13. 320(5882):1496-501. PubMed Journal
Articles Citing pLKO.1 GFP shRNA
| Articles |
|---|
| p53-mediated heterochromatin reorganization regulates its cell fate decisions. Mungamuri SK, Benson EK, Wang S, Gu W, Lee SW, Aaronson SA. Nat Struct Mol Biol. 2012 Apr 1;19(5):478-84, S1. doi: 10.1038/nsmb.2271. PubMed |
| MicroRNA-34b inhibits pancreatic cancer metastasis through repressing Smad3. Liu C, Cheng H, Shi S, Cui X, Yang J, Chen L, Cen P, Cai X, Lu Y, Wu C, Yao W, Qin Y, Liu L, Long J, Xu J, Li M, Yu X. Curr Mol Med. 2013 May;13(4):467-78. PubMed |
| Proteome identification of proteins interacting with histone methyltransferase SET8. Qin Y, Ouyang H, Liu J, Xie Y. Acta Biochim Biophys Sin (Shanghai). 2013 Apr;45(4):303-8. doi: 10.1093/abbs/gmt011. Epub 2013 Feb 17. PubMed |
| Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells. Wang C, Yi T, Qin L, Maldonado RA, von Andrian UH, Kulkarni S, Tellides G, Pober JS. J Clin Invest. 2013 Apr;123(4):1677-93. doi: 10.1172/JCI66204. Epub 2013 Mar 8. PubMed |
| Calretinin is essential for mesothelioma cell growth/survival in vitro: a potential new target for malignant mesothelioma therapy? Blum W, Schwaller B. Int J Cancer. 2013 Nov;133(9):2077-88. doi: 10.1002/ijc.28218. Epub 2013 Jul 9. PubMed |
| Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2. Wang C, Qin L, Manes TD, Kirkiles-Smith NC, Tellides G, Pober JS. J Exp Med. 2014 Mar 10;211(3):395-404. doi: 10.1084/jem.20131125. Epub 2014 Feb 10. PubMed |
| Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC. Nature. 2014 May 1;509(7498):105-9. doi: 10.1038/nature13148. Epub 2014 Mar 30. PubMed |
| MicroRNA-26a promotes anoikis in human hepatocellular carcinoma cells by targeting alpha5 integrin. Zhang X, Cheng SL, Bian K, Wang L, Zhang X, Yan B, Jia LT, Zhao J, Gammoh N, Yang AG, Zhang R. Oncotarget. 2015 Feb 10;6(4):2277-89. PubMed |
| Polarity Protein Scrib Facilitates Endothelial Inflammatory Signaling. Kruse C, Kurz AR, Palfi K, Humbert PO, Sperandio M, Brandes RP, Fork C, Michaelis UR. Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1954-62. doi: 10.1161/ATVBAHA.115.305678. Epub 2015 Jul 23. PubMed |
| The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes. Langsfeld ES, Bodily JM, Laimins LA. PLoS Pathog. 2015 Sep 25;11(9):e1005181. doi: 10.1371/journal.ppat.1005181. eCollection 2015 Sep. PubMed |
| Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis. Mancias JD, Pontano Vaites L, Nissim S, Biancur DE, Kim AJ, Wang X, Liu Y, Goessling W, Kimmelman AC, Harper JW. Elife. 2015 Oct 5;4. doi: 10.7554/eLife.10308. PubMed |
| Integrated genomics approach to identify biologically relevant alterations in fewer samples. Chandrani P, Upadhyay P, Iyer P, Tanna M, Shetty M, Raghuram GV, Oak N, Singh A, Chaubal R, Ramteke M, Gupta S, Dutt A. BMC Genomics. 2015 Nov 14;16(1):936. doi: 10.1186/s12864-015-2138-4. PubMed |
| NIPBL Controls RNA Biogenesis to Prevent Activation of the Stress Kinase PKR. Yuen KC, Xu B, Krantz ID, Gerton JL. Cell Rep. 2016 Jan 5;14(1):93-102. doi: 10.1016/j.celrep.2015.12.012. Epub 2015 Dec 24. PubMed |
| The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein. Prior KK, Wittig I, Leisegang MS, Groenendyk J, Weissmann N, Michalak M, Jansen-Durr P, Shah AM, Brandes RP. J Biol Chem. 2016 Mar 25;291(13):7045-59. doi: 10.1074/jbc.M115.710772. Epub 2016 Feb 9. PubMed |
| Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes. Hecht VC, Sullivan LB, Kimmerling RJ, Kim DH, Hosios AM, Stockslager MA, Stevens MM, Kang JH, Wirtz D, Vander Heiden MG, Manalis SR. J Cell Biol. 2016 Feb 15;212(4):439-47. doi: 10.1083/jcb.201506118. PubMed |
| Oncogenic function of the homeobox A13-long noncoding RNA HOTTIP-insulin growth factor-binding protein 3 axis in human gastric cancer. Wang SS, Wuputra K, Liu CJ, Lin YC, Chen YT, Chai CY, Lin CS, Kuo KK, Tsai MH, Wang SW, Chen KK, Miyoshi H, Nakamura Y, Saito S, Hanafusa T, Wu DC, Lin CS, Yokoyama KK. Oncotarget. 2016 Jun 14;7(24):36049-36064. doi: 10.18632/oncotarget.9102. PubMed |
| EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis. Liu H, Li W, Yu X, Gao F, Duan Z, Ma X, Tan S, Yuan Y, Liu L, Wang J, Zhou X, Yang Y. Oncotarget. 2016 Aug 30;7(35):56338-56354. doi: 10.18632/oncotarget.10841. PubMed |
| Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC. Nature. 2016 Aug 25;536(7617):479-83. PubMed |
| AEG-1 promotes mesenchymal transition through the activation of Rho GTPases in human glioblastoma cells. Park SY, Choi M, Park D, Jeong M, Ahn KS, Lee J, Fisher PB, Yun M, Lee SG. Oncol Rep. 2016 Nov;36(5):2641-2646. doi: 10.3892/or.2016.5106. Epub 2016 Sep 19. PubMed |
| Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer. Ni T, Li XY, Lu N, An T, Liu ZP, Fu R, Lv WC, Zhang YW, Xu XJ, Grant Rowe R, Lin YS, Scherer A, Feinberg T, Zheng XQ, Chen BA, Liu XS, Guo QL, Wu ZQ, Weiss SJ. Nat Cell Biol. 2016 Nov;18(11):1221-1232. doi: 10.1038/ncb3425. Epub 2016 Oct 17. PubMed |
| Targeting MCL-1 sensitizes human esophageal squamous cell carcinoma cells to cisplatin-induced apoptosis. Yu X, Li W, Xia Z, Xie L, Ma X, Liang Q, Liu L, Wang J, Zhou X, Yang Y, Liu H. BMC Cancer. 2017 Jun 28;17(1):449. doi: 10.1186/s12885-017-3442-y. PubMed |
| Condensin II is anchored by TFIIIC and H3K4me3 in the mammalian genome and supports the expression of active dense gene clusters. Yuen KC, Slaughter BD, Gerton JL. Sci Adv. 2017 Jun 21;3(6):e1700191. doi: 10.1126/sciadv.1700191. eCollection 2017 Jun. PubMed |
| Reprogramming Antagonizes the Oncogenicity of HOXA13-Long Noncoding RNA HOTTIP Axis in Gastric Cancer Cells. Wu DC, Wang SSW, Liu CJ, Wuputra K, Kato K, Lee YL, Lin YC, Tsai MH, Ku CC, Lin WH, Wang SW, Kishikawa S, Noguchi M, Wu CC, Chen YT, Chai CY, Lin CS, Kuo KK, Yang YH, Miyoshi H, Nakamura Y, Saito S, Nagata K, Lin CS, Yokoyama KK. Stem Cells. 2017 Oct;35(10):2115-2128. doi: 10.1002/stem.2674. Epub 2017 Aug 23. PubMed |
| MicroRNA miR-128 represses LINE-1 (L1) retrotransposition by down-regulating the nuclear import factor TNPO1. Idica A, Sevrioukov EA, Zisoulis DG, Hamdorf M, Daugaard I, Kadandale P, Pedersen IM. J Biol Chem. 2017 Dec 15;292(50):20494-20508. doi: 10.1074/jbc.M117.807677. Epub 2017 Oct 3. PubMed |
| Deguelin, an Aurora B Kinase Inhibitor, Exhibits Potent Anti-Tumor Effect in Human Esophageal Squamous Cell Carcinoma. Yu X, Liang Q, Liu W, Zhou L, Li W, Liu H. EBioMedicine. 2017 Dec;26:100-111. doi: 10.1016/j.ebiom.2017.10.030. Epub 2017 Nov 3. PubMed |
| HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target. Fok JHL, Hedayat S, Zhang L, Aronson LI, Mirabella F, Pawlyn C, Bright MD, Wardell CP, Keats JJ, De Billy E, Rye CS, Chessum NEA, Jones K, Morgan GJ, Eccles SA, Workman P, Davies FE. Clin Cancer Res. 2018 May 15;24(10):2395-2407. doi: 10.1158/1078-0432.CCR-17-1594. Epub 2018 Feb 1. PubMed |
| Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway. Li M, Yu X, Li W, Liu T, Deng G, Liu W, Liu H, Gao F. Oncotarget. 2017 Oct 26;9(1):152-166. doi: 10.18632/oncotarget.22077. eCollection 2018 Jan 2. PubMed |
| Capsaicin inhibits glycolysis in esophageal squamous cell carcinoma by regulating hexokinase2 expression. Mao X, Zhu H, Luo D, Ye L, Yin H, Zhang J, Zhang Y, Zhang Y. Mol Med Rep. 2018 Apr;17(4):6116-6121. doi: 10.3892/mmr.2018.8574. Epub 2018 Feb 8. PubMed |
| De novo mutations in MED13, a component of the Mediator complex, are associated with a novel neurodevelopmental disorder. Snijders Blok L, Hiatt SM, Bowling KM, Prokop JW, Engel KL, Cochran JN, Bebin EM, Bijlsma EK, Ruivenkamp CAL, Terhal P, Simon MEH, Smith R, Hurst JA, McLaughlin H, Person R, Crunk A, Wangler MF, Streff H, Symonds JD, Zuberi SM, Elliott KS, Sanders VR, Masunga A, Hopkin RJ, Dubbs HA, Ortiz-Gonzalez XR, Pfundt R, Brunner HG, Fisher SE, Kleefstra T, Cooper GM. Hum Genet. 2018 May;137(5):375-388. doi: 10.1007/s00439-018-1887-y. Epub 2018 May 8. PubMed |
| Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size. Yosefzon Y, Soteriou D, Feldman A, Kostic L, Koren E, Brown S, Ankawa R, Sedov E, Glaser F, Fuchs Y. Mol Cell. 2018 May 17;70(4):573-587.e4. doi: 10.1016/j.molcel.2018.04.019. PubMed |
| Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance. Takahashi N, Chen HY, Harris IS, Stover DG, Selfors LM, Bronson RT, Deraedt T, Cichowski K, Welm AL, Mori Y, Mills GB, Brugge JS. Cancer Cell. 2018 Jun 11;33(6):985-1003.e7. doi: 10.1016/j.ccell.2018.05.001. Epub 2018 May 24. PubMed |
Aspartate is an endogenous metabolic limitation for tumour growth.
Sullivan LB, Luengo A, Danai LV, Bush LN, Diehl FF, Hosios AM, Lau AN, Elmiligy S, Malstrom S, Lewis CA, Vander Heiden MG.
Nat Cell Biol. 2018 Jul;20(7):782-788. doi: 10.1038/s41556-018-0125-0. Epub 2018 Jun 25.
PubMed
Associated Plasmids |
| Deguelin attenuates non-small cell lung cancer cell metastasis through inhibiting the CtsZ/FAK signaling pathway. Li W, Yu X, Ma X, Xie L, Xia Z, Liu L, Yu X, Wang J, Zhou H, Zhou X, Yang Y, Liu H. Cell Signal. 2018 Oct;50:131-141. doi: 10.1016/j.cellsig.2018.07.001. Epub 2018 Jul 7. PubMed |
| Repression of Noxa by Bmi1 contributes to deguelin-induced apoptosis in non-small cell lung cancer cells. Li W, Yu X, Xia Z, Yu X, Xie L, Ma X, Zhou H, Liu L, Wang J, Yang Y, Liu H. J Cell Mol Med. 2018 Dec;22(12):6213-6227. doi: 10.1111/jcmm.13908. Epub 2018 Sep 25. PubMed |
| Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis. Santana-Codina N, Roeth AA, Zhang Y, Yang A, Mashadova O, Asara JM, Wang X, Bronson RT, Lyssiotis CA, Ying H, Kimmelman AC. Nat Commun. 2018 Nov 23;9(1):4945. doi: 10.1038/s41467-018-07472-8. PubMed |
| Calretinin Functions in Malignant Mesothelioma Cells Cannot Be Replaced by the Closely Related Ca(2+)-Binding Proteins Calbindin-D28k and Parvalbumin. Worthmuller J, Oberson A, Salicio V, Blum W, Schwaller B. Int J Mol Sci. 2018 Dec 12;19(12). pii: ijms19124015. doi: 10.3390/ijms19124015. PubMed |
| Calretinin promotes invasiveness and EMT in malignant mesothelioma cells involving the activation of the FAK signaling pathway. Worthmuller J, Blum W, Pecze L, Salicio V, Schwaller B. Oncotarget. 2018 Nov 20;9(91):36256-36272. doi: 10.18632/oncotarget.26332. eCollection 2018 Nov 20. PubMed |
| NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms. Santana-Codina N, Gableske S, Quiles Del Rey M, Malachowska B, Jedrychowski MP, Biancur DE, Schmidt PJ, Fleming MD, Fendler W, Harper JW, Kimmelman AC, Mancias JD. Haematologica. 2019 Jan 10. pii: haematol.2018.204123. doi: 10.3324/haematol.2018.204123. PubMed |
| Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon. Li X, Deng M, Petrucelli AS, Zhu C, Mo J, Zhang L, Tam JW, Ariel P, Zhao B, Zhang S, Ke H, Li P, Dokholyan NV, Duncan JA, Ting JP. Immunity. 2019 Mar 19;50(3):591-599.e6. doi: 10.1016/j.immuni.2019.02.009. PubMed |
| miR-128 Restriction of LINE-1 (L1) Retrotransposition Is Dependent on Targeting hnRNPA1 mRNA. Fung L, Guzman H, Sevrioukov E, Idica A, Park E, Bochnakian A, Daugaard I, Jury D, Mortazavi A, Zisoulis DG, Pedersen IM. Int J Mol Sci. 2019 Apr 21;20(8). pii: ijms20081955. doi: 10.3390/ijms20081955. PubMed |
| TDP-43 is Required for Mammary Gland Repopulation and Proliferation of Mammary Epithelial Cells. Zhao L, Li L, Xu H, Ke H, Zou L, Yang Q, Shen CJ, Nie J, Jiao B. Stem Cells Dev. 2019 Jul 15;28(14):944-953. doi: 10.1089/scd.2019.0011. Epub 2019 Jun 11. PubMed |
| Interferon-Inducible MicroRNA miR-128 Modulates HIV-1 Replication by Targeting TNPO3 mRNA. Bochnakian A, Zhen A, Zisoulis DG, Idica A, KewalRamani VN, Neel N, Daugaard I, Hamdorf M, Kitchen S, Lee K, Pedersen IM. J Virol. 2019 Sep 30;93(20). pii: JVI.00364-19. doi: 10.1128/JVI.00364-19. Print 2019 Oct 15. PubMed |
| NPM-ALK Is a Key Regulator of the Oncoprotein FOXM1 in ALK-Positive Anaplastic Large Cell Lymphoma. Haque M, Li J, Huang YH, Almowaled M, Barger CJ, Karpf AR, Wang P, Chen W, Turner SD, Lai R. Cancers (Basel). 2019 Aug 6;11(8). pii: cancers11081119. doi: 10.3390/cancers11081119. PubMed |
| BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells. Debruyne DN, Dries R, Sengupta S, Seruggia D, Gao Y, Sharma B, Huang H, Moreau L, McLane M, Day DS, Marco E, Chen T, Gray NS, Wong KK, Orkin SH, Yuan GC, Young RA, George RE. Nature. 2019 Aug;572(7771):676-680. doi: 10.1038/s41586-019-1472-0. Epub 2019 Aug 7. PubMed |
| Downregulation of transgelin 2 promotes breast cancer metastasis by activating the reactive oxygen species/nuclear factorkappaB signaling pathway. Yang L, Hong Q, Xu SG, Kuang XY, Di GH, Liu GY, Wu J, Shao ZM, Yu SJ. Mol Med Rep. 2019 Nov;20(5):4045-4258. doi: 10.3892/mmr.2019.10643. Epub 2019 Sep 3. PubMed |
| Beclin 1 Promotes Endosome Recruitment of Hepatocyte Growth Factor Tyrosine Kinase Substrate to Suppress Tumor Proliferation. Matthew-Onabanjo AN, Janusis J, Mercado-Matos J, Carlisle AE, Kim D, Levine F, Cruz-Gordillo P, Richards R, Lee MJ, Shaw LM. Cancer Res. 2020 Jan 15;80(2):249-262. doi: 10.1158/0008-5472.CAN-19-1555. Epub 2019 Nov 19. PubMed |
| TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh. Zhao L, Ke H, Xu H, Wang GD, Zhang H, Zou L, Xiang S, Li M, Peng L, Zhou M, Li L, Ao L, Yang Q, Shen CJ, Yi P, Wang L, Jiao B. Nat Commun. 2020 Jan 17;11(1):341. doi: 10.1038/s41467-019-14183-1. PubMed |
| TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination. Deng M, Tam JW, Wang L, Liang K, Li S, Zhang L, Guo H, Luo X, Zhang Y, Petrucelli A, Davis BK, Conti BJ, June Brickey W, Ko CC, Lei YL, Sun S, Ting JP. Nat Commun. 2020 May 4;11(1):2193. doi: 10.1038/s41467-020-16014-0. PubMed |
| Targeting RET Kinase in Neuroendocrine Prostate Cancer. VanDeusen HR, Ramroop JR, Morel KL, Bae SY, Sheahan AV, Sychev Z, Lau NA, Cheng LC, Tan VM, Li Z, Petersen A, Lee JK, Park JW, Yang R, Hwang JH, Coleman I, Witte ON, Morrissey C, Corey E, Nelson PS, Ellis L, Drake JM. Mol Cancer Res. 2020 Aug;18(8):1176-1188. doi: 10.1158/1541-7786.MCR-19-1245. Epub 2020 May 27. PubMed |
| The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis. Zeng J, Dong S, Luo Z, Xie X, Fu B, Li P, Liu C, Yang X, Chen Y, Wang X, Liu Z, Wu J, Yan Y, Wang F, Chen JF, Zhang J, Long G, Goldman SA, Li S, Zhao Z, Liang Q. Cell Stem Cell. 2020 Oct 1;27(4):618-632.e9. doi: 10.1016/j.stem.2020.07.012. Epub 2020 Aug 6. PubMed |
| Transient commensal clonal interactions can drive tumor metastasis. Naffar-Abu Amara S, Kuiken HJ, Selfors LM, Butler T, Leung ML, Leung CT, Kuhn EP, Kolarova T, Hage C, Ganesh K, Panayiotou R, Foster R, Rueda BR, Aktipis A, Spellman P, Ince TA, Xiu J, Oberley M, Gatalica Z, Navin N, Mills GB, Bronson RT, Brugge JS. Nat Commun. 2020 Nov 16;11(1):5799. doi: 10.1038/s41467-020-19584-1. PubMed |
| Suppression of p16 alleviates the senescence-associated secretory phenotype. Buj R, Leon KE, Anguelov MA, Aird KM. Aging (Albany NY). 2021 Feb 6;13(3):3290-3312. doi: 10.18632/aging.202640. Epub 2021 Feb 6. PubMed |
| Promotive Role of CircATRNL1 on Chondrogenic Differentiation of BMSCs Mediated by miR-338-3p. Zheng J, Lin Y, Tang F, Guo H, Yan L, Hu S, Wu H. Arch Med Res. 2021 Jul;52(5):514-522. doi: 10.1016/j.arcmed.2021.02.003. Epub 2021 Feb 18. PubMed |
| Glucocorticoid counteracts cellular mechanoresponses by LINC01569-dependent glucocorticoid receptor-mediated mRNA decay. Zhu H, Li J, Li Y, Zheng Z, Guan H, Wang H, Tao K, Liu J, Wang Y, Zhang W, Li C, Li J, Jia L, Bai W, Hu D. Sci Adv. 2021 Feb 24;7(9). pii: 7/9/eabd9923. doi: 10.1126/sciadv.abd9923. Print 2021 Feb. PubMed |
| Pannexin 1 binds beta-catenin to modulate melanoma cell growth and metabolism. Sayedyahossein S, Huang K, Li Z, Zhang C, Kozlov AM, Johnston D, Nouri-Nejad D, Dagnino L, Betts DH, Sacks DB, Penuela S. J Biol Chem. 2021 Jan-Jun;296:100478. doi: 10.1016/j.jbc.2021.100478. Epub 2021 Feb 26. PubMed |
| Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia. Goldfarb AN, Freeman KC, Sahu RK, Elagib KE, Holy M, Arneja A, Polanowska-Grabowska R, Gru AA, White Z 3rd, Khalil S, Kerins MJ, Ooi A, Leitinger N, Luckey CJ, Delehanty LL. Nat Commun. 2021 Mar 12;12(1):1645. doi: 10.1038/s41467-021-21938-2. PubMed |
| Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly. Yang CS, Jividen K, Kamata T, Dworak N, Oostdyk L, Remlein B, Pourfarjam Y, Kim IK, Du KP, Abbas T, Sherman NE, Wotton D, Paschal BM. Nat Commun. 2021 May 11;12(1):2705. doi: 10.1038/s41467-021-23055-6. PubMed |
| Therapeutic Silencing of BCL-2 Using NK Cell-Derived Exosomes as a Novel Therapeutic Approach in Breast Cancer. Kaban K, Hinterleitner C, Zhou Y, Salva E, Kantarci AG, Salih HR, Marklin M. Cancers (Basel). 2021 May 15;13(10). pii: cancers13102397. doi: 10.3390/cancers13102397. PubMed |
| Overexpression of Replication-Dependent Histone Signifies a Subset of Dedifferentiated Liposarcoma with Increased Aggressiveness. Yoo Y, Park SY, Jo EB, Choi M, Lee KW, Hong D, Lee S, Lee CR, Lee Y, Um JY, Park JB, Seo SW, Choi YL, Kim S, Lee SG, Choi M. Cancers (Basel). 2021 Jun 22;13(13). pii: cancers13133122. doi: 10.3390/cancers13133122. PubMed |
| Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration. Huang H, Gont A, Kee L, Dries R, Pfeifer K, Sharma B, Debruyne DN, Harlow M, Sengupta S, Guan J, Yeung CM, Wang W, Hallberg B, Palmer RH, Irwin MS, George RE. Cell Rep. 2021 Jul 13;36(2):109363. doi: 10.1016/j.celrep.2021.109363. PubMed |
| TRAF6 Promoted Tumor Glycolysis in Non-Small-Cell Lung Cancer by Activating the Akt-HIFalpha Pathway. Feng L, Feng S, Nie Z, Deng Y, Xuan Y, Chen X, Lu Y, Liang L, Chen Y. Biomed Res Int. 2021 Aug 6;2021:3431245. doi: 10.1155/2021/3431245. eCollection 2021. PubMed |
| Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway. Kawabata H, Ono Y, Tamamura N, Oyama K, Ueda J, Sato H, Takahashi K, Taniue K, Okada T, Fujibayashi S, Hayashi A, Goto T, Enomoto K, Konishi H, Fujiya M, Miyakawa K, Tanino M, Nishikawa Y, Koga D, Watanabe T, Maeda C, Karasaki H, Liss AS, Mizukami Y, Okumura T. J Gastroenterol. 2022 Mar;57(3):208-220. doi: 10.1007/s00535-021-01846-4. Epub 2022 Jan 11. PubMed |
| Identification of Ferroptosis-Related Gene Prognostic Signature and HSF1 for Reversing Doxorubicin and Gemcitabine Resistance in Uterine Carcinosarcoma. Han S, Liu Q, Yang Z, Ma J, Liu D, Yan C, Liang D. Dis Markers. 2022 Jan 12;2022:6400227. doi: 10.1155/2022/6400227. eCollection 2022. PubMed |
| MST4 negatively regulates type I interferons production via targeting MAVS-mediated pathway. Liu W, Ma Z, Wu Y, Yuan C, Zhang Y, Liang Z, Yang Y, Zhang W, Jiao P. Cell Commun Signal. 2022 Jul 12;20(1):103. doi: 10.1186/s12964-022-00922-3. PubMed |
| ARID1A-deficient bladder cancer is dependent on PI3K signaling and sensitive to EZH2 and PI3K inhibitors. Rehman H, Chandrashekar DS, Balabhadrapatruni C, Nepal S, Balasubramanya SAH, Shelton AK, Skinner KR, Ma AH, Rao T, Agarwal S, Eich ML, Robinson AD, Naik G, Manne U, Netto GJ, Miller CR, Pan CX, Sonpavde G, Varambally S, Ferguson JE 3rd. JCI Insight. 2022 Aug 22;7(16):e155899. doi: 10.1172/jci.insight.155899. PubMed |
| TGFBR3 supports anoikis through suppressing ATF4 signaling. Hsu YJ, Yin YJ, Tsai KF, Jian CC, Liang ZW, Hsu CY, Wang CC. J Cell Sci. 2022 Sep 1;135(17):jcs258396. doi: 10.1242/jcs.258396. Epub 2022 Aug 30. PubMed |
| Epithelial-mesenchymal reprogramming by KLF4-regulated Rictor expression contributes to metastasis of non-small cell lung cancer cells. Zhou H, Guan Q, Hou X, Liu L, Zhou L, Li W, Liu H. Int J Biol Sci. 2022 Jul 18;18(13):4869-4883. doi: 10.7150/ijbs.73548. eCollection 2022. PubMed |
| A-Kinase Anchoring Protein 9 Promotes Gastric Cancer Progression as a Downstream Effector of Cadherin 1. Yan Q, Wu Y, Li D, Li Y. J Oncol. 2022 Oct 22;2022:2830634. doi: 10.1155/2022/2830634. eCollection 2022. PubMed |
| The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models. Hebron KE, Wan X, Roth JS, Liewehr DJ, Sealover NE, Frye WJE, Kim A, Stauffer S, Perkins OL, Sun W, Isanogle KA, Robinson CM, James A, Awasthi P, Shankarappa P, Luo X, Lei H, Butcher D, Smith R, Edmondson EF, Chen JQ, Kedei N, Peer CJ, Shern JF, Figg WD, Chen L, Hall MD, Difilippantonio S, Barr FG, Kortum RL, Robey RW, Vaseva AV, Khan J, Yohe ME. Clin Cancer Res. 2023 Jan 17;29(2):472-487. doi: 10.1158/1078-0432.CCR-22-1646. PubMed |
| Ras-mediated activation of mTORC2 promotes breast epithelial cell migration and invasion. Collins SE, Wiegand ME, Werner AN, Brown IN, Mundo MI, Swango DJ, Mouneimne G, Charest PG. Mol Biol Cell. 2023 Feb 1;34(2):ar9. doi: 10.1091/mbc.E22-06-0236. Epub 2022 Dec 21. PubMed |
| Suppression of fatty acid oxidation supports pancreatic cancer growth and survival under hypoxic conditions through autophagy induction. Kim B, Gwak J, Kim M, Yang S, Hwang S, Shin S, Kim JH, Son J, Jeong SM. Cancer Gene Ther. 2023 Jun;30(6):878-889. doi: 10.1038/s41417-023-00598-y. Epub 2023 Feb 17. PubMed |
| Tcf21 marks visceral adipose mesenchymal progenitors and functions as a rate-limiting factor during visceral adipose tissue development. Liu Q, Li C, Deng B, Gao P, Wang L, Li Y, Shiri M, Alkaifi F, Zhao J, Stephens JM, Simintiras CA, Francis J, Sun J, Fu X. Cell Rep. 2023 Mar 28;42(3):112166. doi: 10.1016/j.celrep.2023.112166. Epub 2023 Feb 28. PubMed |
| A single-cell atlas of bovine skeletal muscle reveals mechanisms regulating intramuscular adipogenesis and fibrogenesis. Wang L, Gao P, Li C, Liu Q, Yao Z, Li Y, Zhang X, Sun J, Simintiras C, Welborn M, McMillin K, Oprescu S, Kuang S, Fu X. J Cachexia Sarcopenia Muscle. 2023 Jul 12. doi: 10.1002/jcsm.13292. PubMed |
| De novo purine metabolism is a metabolic vulnerability of cancers with low p16 expression. Tangudu NK, Buj R, Wang J, Cole AR, Uboveja A, Fang R, Amalric A, Lyons MA, Chandran UR, Aird KM. bioRxiv. 2023 Jul 15:2023.07.15.549149. doi: 10.1101/2023.07.15.549149. Preprint. PubMed |
| Skp2-mediated MLKL degradation confers cisplatin-resistant in non-small cell lung cancer cells. Zhou H, Zhou L, Guan Q, Hou X, Wang C, Liu L, Wang J, Yu X, Li W, Liu H. Commun Biol. 2023 Aug 2;6(1):805. doi: 10.1038/s42003-023-05166-6. PubMed |
| Oligomerisation mediated by the D2 domain of DTX3L is critical for DTX3L-PARP9 reading function of mono-ADP-ribosylated androgen receptor. Vela-Rodriguez C, Yang C, Alanen HI, Eki R, Abbas TA, Maksimainen MM, Glumoff T, Duman R, Wagner A, Paschal BM, Lehtio L. bioRxiv [Preprint]. 2023 Nov 29:2023.11.29.569193. doi: 10.1101/2023.11.29.569193. PubMed |
| HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance. Ling H, Li Y, Peng C, Yang S, Seto E. bioRxiv [Preprint]. 2023 Dec 7:2023.12.05.570182. doi: 10.1101/2023.12.05.570182. PubMed |
| Inhibiting the m(6)A Reader IGF2BP3 Suppresses Ovarian Cancer Cell Growth via Regulating PLAGL2 mRNA Stabilization. Dai TT, Li YZ, Hu HT, Zhao YM, Peng HY, Bai WD, Wang JW. World J Oncol. 2024 Feb;15(1):100-113. doi: 10.14740/wjon1747. Epub 2024 Jan 10. PubMed |
| alphaKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation. Uboveja A, Huang Z, Buj R, Amalric A, Wang H, Tangudu NK, Cole AR, Megill E, Kantner D, Chatoff A, Ahmad H, Marcinkiewicz MM, Disharoon JA, Graff S, Dahl ES, Hempel N, Stallaert W, Sidoli S, Bitler BG, Long DT, Snyder NW, Aird KM. bioRxiv [Preprint]. 2024 Feb 11:2024.02.06.578742. doi: 10.1101/2024.02.06.578742. PubMed |
| A common cellular response to broad splicing perturbations is characterized by metabolic transcript downregulation driven by the Mdm2-p53 axis. Varineau JE, Calo E. Dis Model Mech. 2024 Feb 1;17(2):dmm050356. doi: 10.1242/dmm.050356. Epub 2024 Mar 1. PubMed |
| Oligomerization mediated by the D2 domain of DTX3L is critical for DTX3L-PARP9 reading function of mono-ADP-ribosylated androgen receptor. Vela-Rodriguez C, Yang C, Alanen HI, Eki R, Abbas TA, Maksimainen MM, Glumoff T, Duman R, Wagner A, Paschal BM, Lehtio L. Protein Sci. 2024 Apr;33(4):e4945. doi: 10.1002/pro.4945. PubMed |
| De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression. Tangudu NK, Buj R, Wang H, Wang J, Cole AR, Uboveja A, Fang R, Amalric A, Yang B, Chatoff A, Crispim CV, Sajjakulnukit P, Lyons MA, Cooper K, Hempel N, Lyssiotis CA, Chandran UR, Snyder NW, Aird KM. Cancer Res Commun. 2024 May 2;4(5):1174-1188. doi: 10.1158/2767-9764.CRC-23-0450. PubMed |
| HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression. Ling H, Li Y, Peng C, Yang S, Seto E. NAR Cancer. 2024 Apr 22;6(2):zcae018. doi: 10.1093/narcan/zcae018. eCollection 2024 Jun. PubMed |
| Cadherin-11 contributes to the heterogenous and dynamic Wnt-Wnt-beta-catenin pathway activation in Ewing sarcoma. Shirai R, Biebighauser T, Walker D, Oviedo J, Nelson-Taylor S, Bodlak A, Porfilio T, Oike N, Goodspeed A, Hayashi M. PLoS One. 2024 Jun 14;19(6):e0305490. doi: 10.1371/journal.pone.0305490. eCollection 2024. PubMed |
If you have published an article using this material, please email us at [email protected] to have your article added to this page.