Flag-Keap1 Citations (10)

Originally described in: Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy.
Fan W, Tang Z, Chen D, Moughon D, Ding X, Chen S, Zhu M, Zhong Q Autophagy. 2010 Jul 22. 6(5):. PubMed Journal

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Articles Citing Flag-Keap1

Articles
TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy. Jena KK, Kolapalli SP, Mehto S, Nath P, Das B, Sahoo PK, Ahad A, Syed GH, Raghav SK, Senapati S, Chauhan S, Chauhan S. EMBO J. 2018 Sep 14;37(18). pii: embj.201798358. doi: 10.15252/embj.201798358. Epub 2018 Aug 24. PubMed
A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Bollong MJ, Lee G, Coukos JS, Yun H, Zambaldo C, Chang JW, Chin EN, Ahmad I, Chatterjee AK, Lairson LL, Schultz PG, Moellering RE. Nature. 2018 Oct;562(7728):600-604. doi: 10.1038/s41586-018-0622-0. Epub 2018 Oct 15. PubMed
HDAC5 catalytic activity suppresses cardiomyocyte oxidative stress and NRF2 target gene expression. Hu T, Schreiter FC, Bagchi RA, Tatman PD, Hannink M, McKinsey TA. J Biol Chem. 2019 May 24;294(21):8640-8652. doi: 10.1074/jbc.RA118.007006. Epub 2019 Apr 8. PubMed
PIDD interaction with KEAP1 as a new mutation-independent mechanism to promote NRF2 stabilization and chemoresistance in NSCLC. Ji L, Zhang R, Chen J, Xue Q, Moghal N, Tsao MS. Sci Rep. 2019 Aug 27;9(1):12437. doi: 10.1038/s41598-019-48763-4. PubMed
Label-Free Interactome Analysis Revealed an Essential Role of CUL3-KEAP1 Complex in Mediating the Ubiquitination and Degradation of PHD2. Luo A, Chen Y. J Proteome Res. 2020 Jan 3;19(1):260-268. doi: 10.1021/acs.jproteome.9b00513. Epub 2019 Dec 6. PubMed
Helicobacter pylori infection induces STAT3 phosphorylation on Ser727 and autophagy in human gastric epithelial cells and mouse stomach. Piao JY, Kim SJ, Kim DH, Park JH, Park SA, Han HJ, Na HK, Yoon K, Lee HN, Kim N, Hahm KB, Surh YJ. Sci Rep. 2020 Sep 24;10(1):15711. doi: 10.1038/s41598-020-72594-3. PubMed
Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain. Vasavda C, Xu R, Liew J, Kothari R, Dhindsa RS, Semenza ER, Paul BD, Green DP, Sabbagh MF, Shin JY, Yang W, Snowman AM, Albacarys LK, Moghekar A, Pardo-Villamizar CA, Luciano M, Huang J, Bettegowda C, Kwatra SG, Dong X, Lim M, Snyder SH. Sci Adv. 2022 Aug 5;8(31):eabo5633. doi: 10.1126/sciadv.abo5633. Epub 2022 Aug 3. PubMed
Succinylation of a KEAP1 sensor lysine promotes NRF2 activation. Ibrahim L, Stanton C, Nutsch K, Nguyen T, Li-Ma C, Ko Y, Lander GC, Wiseman RL, Bollong MJ. bioRxiv. 2023 May 9:2023.05.08.539908. doi: 10.1101/2023.05.08.539908. Preprint. PubMed
SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway. Dong L, Xu M, Li Y, Xu W, Wu C, Zheng H, Xiao Z, Sun G, Ding L, Li X, Li W, Zhou L, Xia Q. Cell Death Dis. 2023 Jun 14;14(6):361. doi: 10.1038/s41419-023-05873-2. PubMed
A NRF2 inhibitor selectively sensitizes KEAP1 mutant tumor cells to cisplatin and gefitinib by restoring NRF2-inhibitory function of KEAP1 mutants. Aboulkassim T, Tian X, Liu Q, Qiu D, Hancock M, Wu JH, Batist G. Cell Rep. 2023 Sep 26;42(9):113104. doi: 10.1016/j.celrep.2023.113104. Epub 2023 Sep 12. PubMed

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