pDuet TDP43 WT Citations (6)
Originally described in: TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity.Johnson BS, Snead D, Lee JJ, McCaffery JM, Shorter J, Gitler AD J Biol Chem. 2009 Jul 24. 284(30):20329-39. PubMed Journal
Articles Citing pDuet TDP43 WT
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In Vivo Formation of Vacuolated Multi-phase Compartments Lacking Membranes.
Schmidt HB, Rohatgi R.
Cell Rep. 2016 Aug 2;16(5):1228-36. doi: 10.1016/j.celrep.2016.06.088. Epub 2016 Jul 21.
PubMed
Associated Plasmids |
A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.
Wang A, Conicella AE, Schmidt HB, Martin EW, Rhoads SN, Reeb AN, Nourse A, Ramirez Montero D, Ryan VH, Rohatgi R, Shewmaker F, Naik MT, Mittag T, Ayala YM, Fawzi NL.
EMBO J. 2018 Mar 1;37(5). pii: embj.201797452. doi: 10.15252/embj.201797452. Epub 2018 Feb 9.
PubMed
Associated Plasmids |
| The role of liquid-liquid phase separation in aggregation of the TDP-43 low-complexity domain. Babinchak WM, Haider R, Dumm BK, Sarkar P, Surewicz K, Choi JK, Surewicz WK. J Biol Chem. 2019 Apr 19;294(16):6306-6317. doi: 10.1074/jbc.RA118.007222. Epub 2019 Feb 27. PubMed |
| The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis. Nguyen TM, Kabotyanski EB, Reineke LC, Shao J, Xiong F, Lee JH, Dubrulle J, Johnson H, Stossi F, Tsoi PS, Choi KJ, Ellis AG, Zhao N, Cao J, Adewunmi O, Ferreon JC, Ferreon ACM, Neilson JR, Mancini MA, Chen X, Kim J, Ma L, Li W, Rosen JM. Nucleic Acids Res. 2020 Mar 18;48(5):2621-2642. doi: 10.1093/nar/gkz1176. PubMed |
| In vivo anti-tumor effect of PARP inhibition in IDH1/2 mutant MDS/AML resistant to targeted inhibitors of mutant IDH1/2. Gbyli R, Song Y, Liu W, Gao Y, Biancon G, Chandhok NS, Wang X, Fu X, Patel A, Sundaram R, Tebaldi T, Mamillapalli P, Zeidan AM, Flavell RA, Prebet T, Bindra RS, Halene S. Leukemia. 2022 May;36(5):1313-1323. doi: 10.1038/s41375-022-01536-x. Epub 2022 Mar 10. PubMed |
| Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology. Francois-Moutal L, Scott DD, Ambrose AJ, Zerio CJ, Rodriguez-Sanchez M, Dissanayake K, May DG, Carlson JM, Barbieri E, Moutal A, Roux KJ, Shorter J, Khanna R, Barmada SJ, McGurk L, Khanna M. Sci Rep. 2022 May 17;12(1):8140. doi: 10.1038/s41598-022-12191-8. PubMed |
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