pCI HA NEDD4 Citations (19)
Originally described in: Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling.Gao S, Alarcon C, Sapkota G, Rahman S, Chen PY, Goerner N, Macias MJ, Erdjument-Bromage H, Tempst P, Massague J Mol Cell. 2009 Nov 13. 36(3):457-68. PubMed Journal
Articles Citing pCI HA NEDD4
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| NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway. Eide PW, Cekaite L, Danielsen SA, Eilertsen IA, Kjenseth A, Fykerud TA, Agesen TH, Bruun J, Rivedal E, Lothe RA, Leithe E. Cell Signal. 2013 Jan;25(1):12-8. doi: 10.1016/j.cellsig.2012.08.012. Epub 2012 Sep 5. PubMed |
| SCF(beta-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway. Liu J, Wan L, Liu P, Inuzuka H, Liu J, Wang Z, Wei W. Oncotarget. 2014 Feb 28;5(4):1026-37. PubMed |
E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3.
Chesarino NM, McMichael TM, Yount JS.
PLoS Pathog. 2015 Aug 11;11(8):e1005095. doi: 10.1371/journal.ppat.1005095. eCollection 2015 Aug.
PubMed
Associated Plasmids |
| The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters. Aleidi SM, Howe V, Sharpe LJ, Yang A, Rao G, Brown AJ, Gelissen IC. J Biol Chem. 2015 Oct 2;290(40):24604-13. doi: 10.1074/jbc.M115.675579. Epub 2015 Aug 20. PubMed |
| Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3. Noyes NC, Hampton B, Migliorini M, Strickland DK. Biochemistry. 2016 Mar 1;55(8):1204-13. doi: 10.1021/acs.biochem.5b01218. Epub 2016 Feb 17. PubMed |
| Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner. Liu J, Wan L, Liu J, Yuan Z, Zhang J, Guo J, Malumbres M, Liu J, Zou W, Wei W. Cell Discov. 2016 Feb 2;2:15044. doi: 10.1038/celldisc.2015.44. eCollection 2016. PubMed |
| The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions. Totland MZ, Bergsland CH, Fykerud TA, Knudsen LM, Rasmussen NL, Eide PW, Yohannes Z, Sorensen V, Brech A, Lothe RA, Leithe E. J Cell Sci. 2017 Sep 1;130(17):2867-2882. doi: 10.1242/jcs.202408. Epub 2017 Jul 21. PubMed |
| The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome. Park HJ, Ryu D, Parmar M, Giasson BI, McFarland NR. PLoS One. 2017 Sep 6;12(9):e0184262. doi: 10.1371/journal.pone.0184262. eCollection 2017. PubMed |
| Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells. Suen KM, Lin CC, Seiler C, George R, Poncet-Montange G, Biter AB, Ahmed Z, Arold ST, Ladbury JE. Int J Biochem Cell Biol. 2018 Jan;94:89-97. doi: 10.1016/j.biocel.2017.11.014. Epub 2017 Dec 5. PubMed |
| The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy. Pei G, Buijze H, Liu H, Moura-Alves P, Goosmann C, Brinkmann V, Kawabe H, Dorhoi A, Kaufmann SHE. Autophagy. 2017;13(12):2041-2055. doi: 10.1080/15548627.2017.1376160. Epub 2017 Dec 17. PubMed |
| NEDD4-induced degradative ubiquitination of phosphatidylinositol 4-phosphate 5-kinase alpha and its implication in breast cancer cell proliferation. Tran MH, Seo E, Min S, Nguyen QT, Choi J, Lee UJ, Hong SS, Kang H, Mansukhani A, Jou I, Lee SY. J Cell Mol Med. 2018 Sep;22(9):4117-4129. doi: 10.1111/jcmm.13689. Epub 2018 May 30. PubMed |
Encoding human serine phosphopeptides in bacteria for proteome-wide identification of phosphorylation-dependent interactions.
Barber KW, Muir P, Szeligowski RV, Rogulina S, Gerstein M, Sampson JR, Isaacs FJ, Rinehart J.
Nat Biotechnol. 2018 Aug;36(7):638-644. doi: 10.1038/nbt.4150. Epub 2018 Jun 11.
PubMed
Associated Plasmids |
| Protein kinase CK2 activation is required for transforming growth factor beta-induced epithelial-mesenchymal transition. Kim S, Ham S, Yang K, Kim K. Mol Oncol. 2018 Oct;12(10):1811-1826. doi: 10.1002/1878-0261.12378. Epub 2018 Sep 21. PubMed |
| Nedd4 E3 ligase and beta-arrestins regulate ubiquitination, trafficking, and stability of the mGlu7 receptor. Lee S, Park S, Lee H, Han S, Song JM, Han D, Suh YH. Elife. 2019 Aug 2;8. pii: 44502. doi: 10.7554/eLife.44502. PubMed |
| PPARgamma induces NEDD4 gene expression to promote autophagy and insulin action. Liu J, Yao Q, Xiao L, Ma W, Li F, Lai B, Wang N. FEBS J. 2020 Feb;287(3):529-545. doi: 10.1111/febs.15042. Epub 2019 Aug 24. PubMed |
| Characterization of Small-Molecule-Induced Changes in Parkinson's-Related Trafficking via the Nedd4 Ubiquitin Signaling Cascade. Hatstat AK, Ahrendt HD, Foster MW, Mayne L, Moseley MA, Englander SW, McCafferty DG. Cell Chem Biol. 2021 Jan 21;28(1):14-25.e9. doi: 10.1016/j.chembiol.2020.10.008. Epub 2020 Nov 10. PubMed |
| Control of ribosomal protein synthesis by the Microprocessor complex. Jiang X, Prabhakar A, Van der Voorn SM, Ghatpande P, Celona B, Venkataramanan S, Calviello L, Lin C, Wang W, Black BL, Floor SN, Lagna G, Hata A. Sci Signal. 2021 Feb 23;14(671). pii: 14/671/eabd2639. doi: 10.1126/scisignal.abd2639. PubMed |
| A Proteomics-Based Approach Identifies the NEDD4 Adaptor NDFIP2 as an Important Regulator of Ifitm3 Levels. Marziali F, Song Y, Nguyen XN, Belmudes L, Burlaud-Gaillard J, Roingeard P, Coute Y, Cimarelli A. Viruses. 2023 Sep 26;15(10):1993. doi: 10.3390/v15101993. PubMed |
| PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer. Xu L, Xiang W, Yang J, Gao J, Wang X, Meng L, Ye K, Zhao XH, Zhang XD, Jin L, Ye Y. J Exp Clin Cancer Res. 2024 Jan 11;43(1):17. doi: 10.1186/s13046-023-02937-1. PubMed |
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