HRE-luciferase Citations (80)
Originally described in: PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a).Emerling BM, Weinberg F, Liu JL, Mak TW, Chandel NS Proc Natl Acad Sci U S A. 2008 Feb 19. 105(7):2622-7. PubMed Journal
Articles Citing HRE-luciferase
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| Ethanol extract of Portulaca oleracea L. protects against hypoxia-induced neuro damage through modulating endogenous erythropoietin expression. Wanyin W, Liwei D, Lin J, Hailiang X, Changquan L, Min L. J Nutr Biochem. 2012 Apr;23(4):385-91. doi: 10.1016/j.jnutbio.2010.12.015. Epub 2011 May 2. PubMed |
| Induction and testing of hypoxia in cell culture. Wu D, Yotnda P. J Vis Exp. 2011 Aug 12;(54). pii: 2899. doi: 10.3791/2899. PubMed |
| Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1alpha activity in hypoxia. Fujita N, Markova D, Anderson DG, Chiba K, Toyama Y, Shapiro IM, Risbud MV. J Biol Chem. 2012 May 11;287(20):16975-86. doi: 10.1074/jbc.M111.334466. Epub 2012 Mar 26. PubMed |
| Hydrogen sulfide inhibits the translational expression of hypoxia-inducible factor-1alpha. Wu B, Teng H, Yang G, Wu L, Wang R. Br J Pharmacol. 2012 Dec;167(7):1492-505. doi: 10.1111/j.1476-5381.2012.02113.x. PubMed |
| Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-alpha (TNF-alpha) on cells of the nucleus pulposus through co-activation of nuclear factor kappaB (NF-kappaB)/p65 signaling. Fujita N, Gogate SS, Chiba K, Toyama Y, Shapiro IM, Risbud MV. J Biol Chem. 2012 Nov 16;287(47):39942-53. doi: 10.1074/jbc.M112.375964. Epub 2012 Sep 4. PubMed |
| Wnt/beta-catenin signaling enhances hypoxia-induced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1alpha signaling. Zhang Q, Bai X, Chen W, Ma T, Hu Q, Liang C, Xie S, Chen C, Hu L, Xu S, Liang T. Carcinogenesis. 2013 May;34(5):962-73. doi: 10.1093/carcin/bgt027. Epub 2013 Jan 27. PubMed |
| Hypoxia-inducible factor (HIF)-1alpha and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1alpha level and transcriptional activity. Tran CM, Fujita N, Huang BL, Ong JR, Lyons KM, Shapiro IM, Risbud MV. J Biol Chem. 2013 May 3;288(18):12654-66. doi: 10.1074/jbc.M112.448860. Epub 2013 Mar 24. PubMed |
| Sphingosine-1-Phosphate as a Regulator of Hypoxia-Induced Factor-1alpha in Thyroid Follicular Carcinoma Cells. Kalhori V, Kemppainen K, Asghar MY, Bergelin N, Jaakkola P, Tornquist K. PLoS One. 2013 Jun 18;8(6):e66189. Print 2013. PubMed |
| DeltaNp63 promotes pediatric neuroblastoma and osteosarcoma by regulating tumor angiogenesis. Bid HK, Roberts RD, Cam M, Audino A, Kurmasheva RT, Lin J, Houghton PJ, Cam H. Cancer Res. 2014 Jan 1;74(1):320-9. doi: 10.1158/0008-5472.CAN-13-0894. Epub 2013 Oct 23. PubMed |
| The interplay between epigenetic silencing, oncogenic KRas and HIF-1 regulatory pathways in control of BNIP3 expression in human colorectal cancer cells. Swiderek E, Kalas W, Wysokinska E, Pawlak A, Rak J, Strzadala L. Biochem Biophys Res Commun. 2013 Nov 29;441(4):707-12. doi: 10.1016/j.bbrc.2013.10.098. Epub 2013 Nov 5. PubMed |
| Gramicidin A blocks tumor growth and angiogenesis through inhibition of hypoxia-inducible factor in renal cell carcinoma. David JM, Owens TA, Inge LJ, Bremner RM, Rajasekaran AK. Mol Cancer Ther. 2014 Apr;13(4):788-99. doi: 10.1158/1535-7163.MCT-13-0891. Epub 2014 Feb 3. PubMed |
| HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells. Fujita N, Hirose Y, Tran CM, Chiba K, Miyamoto T, Toyama Y, Shapiro IM, Risbud MV. FASEB J. 2014 Jun;28(6):2455-65. doi: 10.1096/fj.13-243741. Epub 2014 Feb 20. PubMed |
| Exosomal HIF1alpha supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes. Aga M, Bentz GL, Raffa S, Torrisi MR, Kondo S, Wakisaka N, Yoshizaki T, Pagano JS, Shackelford J. Oncogene. 2014 Sep 11;33(37):4613-22. doi: 10.1038/onc.2014.66. Epub 2014 Mar 24. PubMed |
| FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. Hirose Y, Johnson ZI, Schoepflin ZR, Markova DZ, Chiba K, Toyama Y, Shapiro IM, Risbud MV. J Biol Chem. 2014 Jul 25;289(30):20594-605. PubMed |
| The neurotensin-HIF-1alpha-VEGFalpha axis orchestrates hypoxia, colonic inflammation, and intestinal angiogenesis. Bakirtzi K, West G, Fiocchi C, Law IK, Iliopoulos D, Pothoulakis C. Am J Pathol. 2014 Dec;184(12):3405-14. doi: 10.1016/j.ajpath.2014.08.015. Epub 2014 Oct 7. PubMed |
| Hypoxia-inducible factors modulate the stemness and malignancy of colon cancer cells by playing opposite roles in canonical Wnt signaling. Santoyo-Ramos P, Likhatcheva M, Garcia-Zepeda EA, Castaneda-Patlan MC, Robles-Flores M. PLoS One. 2014 Nov 14;9(11):e112580. doi: 10.1371/journal.pone.0112580. eCollection 2014. PubMed |
| MiR-338-3p inhibits hepatocarcinoma cells and sensitizes these cells to sorafenib by targeting hypoxia-induced factor 1alpha. Xu H, Zhao L, Fang Q, Sun J, Zhang S, Zhan C, Liu S, Zhang Y. PLoS One. 2014 Dec 22;9(12):e115565. doi: 10.1371/journal.pone.0115565. eCollection 2014. PubMed |
| Prolyl-4-hydroxylase domain protein 2 controls NF-kappaB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus. Li J, Yuan W, Jiang S, Ye W, Yang H, Shapiro IM, Risbud MV. J Biol Chem. 2015 Mar 13;290(11):7195-207. doi: 10.1074/jbc.M114.611483. Epub 2015 Jan 29. PubMed |
| Mammalian Ste20-like kinase 4 promotes pituitary cell proliferation and survival under hypoxia. Xiong W, Knox AJ, Xu M, Kiseljak-Vassiliades K, Colgan SP, Brodsky KS, Kleinschmidt-Demasters BK, Lillehei KO, Wierman ME. Mol Endocrinol. 2015 Mar;29(3):460-72. doi: 10.1210/me.2014-1332. Epub 2015 Feb 4. PubMed |
| Acetylation site specificities of lysine deacetylase inhibitors in human cells. Scholz C, Weinert BT, Wagner SA, Beli P, Miyake Y, Qi J, Jensen LJ, Streicher W, McCarthy AR, Westwood NJ, Lain S, Cox J, Matthias P, Mann M, Bradner JE, Choudhary C. Nat Biotechnol. 2015 Apr;33(4):415-23. doi: 10.1038/nbt.3130. Epub 2015 Mar 9. PubMed |
| Parathyroid hormone regulation of hypoxia-inducible factor signaling in osteoblastic cells. Wong A, Loots GG, Yellowley CE, Dose AC, Genetos DC. Bone. 2015 Jul 4;81:97-103. doi: 10.1016/j.bone.2015.07.002. PubMed |
| High Glucose Upregulates ADAM17 through HIF-1alpha in Mesangial Cells. Li R, Uttarwar L, Gao B, Charbonneau M, Shi Y, Chan JS, Dubois CM, Krepinsky JC. J Biol Chem. 2015 Jul 14. pii: jbc.M115.651604. PubMed |
| Hypoxia-inducible factor-1a contributes to dendritic overgrowth in tuberous sclerosis. Zhang L, Feliciano DM, Huang T, Zhang S, Bordey A. Neurosci Lett. 2016 Jan 26;612:43-7. doi: 10.1016/j.neulet.2015.11.038. Epub 2015 Dec 2. PubMed |
| Class I and IIa HDACs Mediate HIF-1alpha Stability Through PHD2-Dependent Mechanism, While HDAC6, a Class IIb Member, Promotes HIF-1alpha Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc. Schoepflin ZR, Shapiro IM, Risbud MV. J Bone Miner Res. 2016 Jun;31(6):1287-99. doi: 10.1002/jbmr.2787. Epub 2016 Mar 15. PubMed |
| AK-1, a SIRT2 inhibitor, destabilizes HIF-1alpha and diminishes its transcriptional activity during hypoxia. Lee SD, Kim W, Jeong JW, Park JW, Kim JE. Cancer Lett. 2016 Jan 22. pii: S0304-3835(16)30001-5. doi: 10.1016/j.canlet.2016.01.031. PubMed |
| ALDOA functions as an oncogene in the highly metastatic pancreatic cancer. Ji S, Zhang B, Liu J, Qin Y, Liang C, Shi S, Jin K, Liang D, Xu W, Xu H, Wang W, Wu C, Liu L, Liu C, Xu J, Ni Q, Yu X. Cancer Lett. 2016 Apr 28;374(1):127-35. doi: 10.1016/j.canlet.2016.01.054. Epub 2016 Feb 12. PubMed |
| Expression, clinical significance and mechanism of Slit2 in papillary thyroid cancer. Shi RL, Qu N, Liao T, Wang YL, Wang Y, Sun GH, Ji QH. Int J Oncol. 2016 May;48(5):2055-62. doi: 10.3892/ijo.2016.3412. Epub 2016 Mar 2. PubMed |
| VEGF Promotes Glycolysis in Pancreatic Cancer via HIF1alpha Up-Regulation. Shi S, Xu J, Zhang B, Ji S, Xu W, Liu J, Jin K, Liang D, Liang C, Liu L, Liu C, Qin Y, Yu X. Curr Mol Med. 2016;16(4):394-403. PubMed |
| Circadian factors BMAL1 and RORalpha control HIF-1alpha transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health. Suyama K, Silagi ES, Choi H, Sakabe K, Mochida J, Shapiro IM, Risbud MV. Oncotarget. 2016 Mar 31. doi: 10.18632/oncotarget.8521. PubMed |
| Insulin Downregulates the Transcriptional Coregulator CITED2, an Inhibitor of Proangiogenic Function in Endothelial Cells. Wang X, Lockhart SM, Rathjen T, Albadawi H, Sorensen D, O'Neill BT, Dwivedi N, Preil SR, Beck HC, Dunwoodie SL, Watkins MT, Rasmussen LM, Rask-Madsen C. Diabetes. 2016 Dec;65(12):3680-3690. Epub 2016 Aug 25. PubMed |
| Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism. Cacace A, Sboarina M, Vazeille T, Sonveaux P. Oncogene. 2016 Oct 17. doi: 10.1038/onc.2016.364. PubMed |
| FGF11 induced by hypoxia interacts with HIF-1alpha and enhances its stability. Lee KW, Yim HS, Shin J, Lee C, Lee JH, Jeong JY. FEBS Lett. 2016 Dec 27. doi: 10.1002/1873-3468.12547. PubMed |
| alpha-Tocopheryl Phosphate Induces VEGF Expression via CD36/PI3Kgamma in THP-1 Monocytes. Zingg JM, Azzi A, Meydani M. J Cell Biochem. 2017 Jan 6. doi: 10.1002/jcb.25871. PubMed |
| Expression of HMGB2 indicates worse survival of patients and is required for the maintenance of Warburg effect in pancreatic cancer. Cai X, Ding H, Liu Y, Pan G, Li Q, Yang Z, Liu W. Acta Biochim Biophys Sin (Shanghai). 2017 Feb 6;49(2):119-127. doi: 10.1093/abbs/gmw124. PubMed |
| Monomethyltransferase SETD8 regulates breast cancer metabolism via stabilizing hypoxia-inducible factor 1alpha. Huang R, Yu Y, Zong X, Li X, Ma L, Zheng Q. Cancer Lett. 2017 Apr 1;390:1-10. doi: 10.1016/j.canlet.2016.12.038. Epub 2017 Jan 13. PubMed |
| Requirement of Hsp105 in CoCl2-induced HIF-1alpha accumulation and transcriptional activation. Mikami H, Saito Y, Okamoto N, Kakihana A, Kuga T, Nakayama Y. Exp Cell Res. 2017 Mar 15;352(2):225-233. doi: 10.1016/j.yexcr.2017.02.004. Epub 2017 Feb 6. PubMed |
| Mitochondrial complex II regulates a distinct oxygen sensing mechanism in monocytes. Sharma S, Wang J, Cortes Gomez E, Taggart RT, Baysal BE. Hum Mol Genet. 2017 Apr 1;26(7):1328-1339. doi: 10.1093/hmg/ddx041. PubMed |
| Vanillin Suppresses Cell Motility by Inhibiting STAT3-Mediated HIF-1alpha mRNA Expression in Malignant Melanoma Cells. Park EJ, Lee YM, Oh TI, Kim BM, Lim BO, Lim JH. Int J Mol Sci. 2017 Mar 1;18(3). pii: ijms18030532. doi: 10.3390/ijms18030532. PubMed |
| Retinoic acid receptor-related orphan receptor RORalpha regulates differentiation and survival of keratinocytes during hypoxia. Li H, Zhou L, Dai J. J Cell Physiol. 2017 Mar 23. doi: 10.1002/jcp.25924. PubMed |
| A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism. Liu W, Zhang B, Hu Q, Qin Y, Xu W, Shi S, Liang C, Meng Q, Xiang J, Liang D, Ji S, Liu J, Hu P, Liu L, Liu C, Long J, Ni Q, Yu X, Xu J. Int J Oncol. 2017 May;50(5):1792-1800. doi: 10.3892/ijo.2017.3938. Epub 2017 Mar 28. PubMed |
| Hypoxia-inducible factor-2alpha promotes tumor progression and has crosstalk with Wnt/beta-catenin signaling in pancreatic cancer. Zhang Q, Lou Y, Zhang J, Fu Q, Wei T, Sun X, Chen Q, Yang J, Bai X, Liang T. Mol Cancer. 2017 Jul 14;16(1):119. doi: 10.1186/s12943-017-0689-5. PubMed |
| Bicarbonate Recycling by HIF-1-Dependent Carbonic Anhydrase Isoforms 9 and 12 Is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells. Silagi ES, Schoepflin ZR, Seifert EL, Merceron C, Schipani E, Shapiro IM, Risbud MV. J Bone Miner Res. 2018 Feb;33(2):338-355. doi: 10.1002/jbmr.3293. Epub 2017 Oct 9. PubMed |
| Hypoxia-inducible factor-1alpha/interleukin-1beta signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment. Zhang J, Zhang Q, Lou Y, Fu Q, Chen Q, Wei T, Yang J, Tang J, Wang J, Chen Y, Zhang X, Zhang J, Bai X, Liang T. Hepatology. 2018 May;67(5):1872-1889. doi: 10.1002/hep.29681. Epub 2018 Mar 26. PubMed |
| Factor inhibiting HIF1-A novel target of SUMOylation in the human placenta. Sallais J, Alahari S, Tagliaferro A, Bhattacharjee J, Post M, Caniggia I. Oncotarget. 2017 Dec 7;8(69):114002-114018. doi: 10.18632/oncotarget.23113. eCollection 2017 Dec 26. PubMed |
| TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1alpha axis and indicates prognosis in pancreatic cancer. Xiang J, Hu Q, Qin Y, Ji S, Xu W, Liu W, Shi S, Liang C, Liu J, Meng Q, Liang D, Ni Q, Xu J, Zhang B, Yu X. Cell Death Dis. 2018 Feb 23;9(3):321. doi: 10.1038/s41419-018-0367-6. PubMed |
| Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1alpha axis. Li Q, Li Y, Liang L, Li J, Luo D, Liu Q, Cai S, Li X. Cell Commun Signal. 2018 Jun 8;16(1):26. doi: 10.1186/s12964-018-0241-2. PubMed |
| AAED1 modulates proliferation and glycolysis in gastric cancer. Zhang B, Wu J, Cai Y, Luo M, Wang B, Gu Y. Oncol Rep. 2018 Aug;40(2):1156-1164. doi: 10.3892/or.2018.6478. Epub 2018 Jun 7. PubMed |
| The Protein Phosphatase PPM1G Destabilizes HIF-1alpha Expression. Pyo J, Ryu J, Kim W, Choi JS, Jeong JW, Kim JE. Int J Mol Sci. 2018 Aug 5;19(8). pii: ijms19082297. doi: 10.3390/ijms19082297. PubMed |
| The p75 neurotrophin receptor enhances HIF-dependent signaling in glioma. Tong B, Pantazopoulou V, Johansson E, Pietras A. Exp Cell Res. 2018 Oct 1;371(1):122-129. doi: 10.1016/j.yexcr.2018.08.002. Epub 2018 Aug 6. PubMed |
| CRISPR/Cas9-mediated knockout of HIF-1alpha gene in epithelioma papulosum cyprini (EPC) cells inhibited apoptosis and viral hemorrhagic septicemia virus (VHSV) growth. Kim MS, Kim KH. Arch Virol. 2018 Dec;163(12):3395-3402. doi: 10.1007/s00705-018-4018-0. Epub 2018 Sep 15. PubMed |
| Collagen prolyl 4-hydroxylase 1 is essential for HIF-1alpha stabilization and TNBC chemoresistance. Xiong G, Stewart RL, Chen J, Gao T, Scott TL, Samayoa LM, O'Connor K, Lane AN, Xu R. Nat Commun. 2018 Oct 26;9(1):4456. doi: 10.1038/s41467-018-06893-9. PubMed |
| UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer. Hu Q, Qin Y, Ji S, Xu W, Liu W, Sun Q, Zhang Z, Liu M, Ni Q, Yu X, Xu X. Cancer Lett. 2019 Jun 28;452:226-236. doi: 10.1016/j.canlet.2019.03.024. Epub 2019 Mar 22. PubMed |
| MiR-200c downregulates HIF-1alpha and inhibits migration of lung cancer cells. Byun Y, Choi YC, Jeong Y, Lee G, Yoon S, Jeong Y, Yoon J, Baek K. Cell Mol Biol Lett. 2019 Apr 27;24:28. doi: 10.1186/s11658-019-0152-2. eCollection 2019. PubMed |
| P4HA1/HIF1alpha feedback loop drives the glycolytic and malignant phenotypes of pancreatic cancer. Cao XP, Cao Y, Li WJ, Zhang HH, Zhu ZM. Biochem Biophys Res Commun. 2019 Aug 27;516(3):606-612. doi: 10.1016/j.bbrc.2019.06.096. Epub 2019 Jun 22. PubMed |
| Cardamonin inhibits breast cancer growth by repressing HIF-1alpha-dependent metabolic reprogramming. Jin J, Qiu S, Wang P, Liang X, Huang F, Wu H, Zhang B, Zhang W, Tian X, Xu R, Shi H, Wu X. J Exp Clin Cancer Res. 2019 Aug 27;38(1):377. doi: 10.1186/s13046-019-1351-4. PubMed |
| Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma. Jung J, Zhang Y, Celiku O, Zhang W, Song H, Williams BJ, Giles AJ, Rich JN, Abounader R, Gilbert MR, Park DM. Cancer Res. 2019 Oct 15;79(20):5218-5232. doi: 10.1158/0008-5472.CAN-19-0198. Epub 2019 Sep 5. PubMed |
| Quantitative Proteomics Reveal Peroxiredoxin Perturbation Upon Persistent Lymphocytic Choriomeningitis Virus Infection in Human Cells. Benej M, Danchenko M, Oveckova I, Cervenak F, Tomaska L, Grossmannova K, Polcicova K, Golias T, Tomaskova J. Front Microbiol. 2019 Oct 25;10:2438. doi: 10.3389/fmicb.2019.02438. eCollection 2019. PubMed |
| A role of hypoxia-inducible factor 1 alpha in Murine Gammaherpesvirus 68 (MHV68) lytic replication and reactivation from latency. Lopez-Rodriguez DM, Kirillov V, Krug LT, Mesri EA, Andreansky S. PLoS Pathog. 2019 Dec 6;15(12):e1008192. doi: 10.1371/journal.ppat.1008192. eCollection 2019 Dec. PubMed |
| ARNT-dependent HIF-2 transcriptional activity is not sufficient to regulate downstream target genes in neuroblastoma. Persson CU, von Stedingk K, Fredlund E, Bexell D, Pahlman S, Wigerup C, Mohlin S. Exp Cell Res. 2020 Mar 15;388(2):111845. doi: 10.1016/j.yexcr.2020.111845. Epub 2020 Jan 13. PubMed |
| Hypoxia and the hypoxia inducible factor 1alpha activate protein kinase A by repressing RII beta subunit transcription. Lucia K, Wu Y, Garcia JM, Barlier A, Buchfelder M, Saeger W, Renner U, Stalla GK, Theodoropoulou M. Oncogene. 2020 Apr;39(16):3367-3380. doi: 10.1038/s41388-020-1223-6. Epub 2020 Feb 28. PubMed |
| Activated HIF1alpha of tumor cells promotes chemoresistance development via recruiting GDF15-producing tumor-associated macrophages in gastric cancer. Yu S, Li Q, Yu Y, Cui Y, Li W, Liu T, Liu F. Cancer Immunol Immunother. 2020 May 9. pii: 10.1007/s00262-020-02598-5. doi: 10.1007/s00262-020-02598-5. PubMed |
| Evidence of mesenchymal stromal cell adaptation to local microenvironment following subcutaneous transplantation. Preda MB, Lupan AM, Neculachi CA, Leti LI, Fenyo IM, Popescu S, Rusu EG, Marinescu CI, Simionescu M, Burlacu A. J Cell Mol Med. 2020 Sep;24(18):10889-10897. doi: 10.1111/jcmm.15717. Epub 2020 Aug 12. PubMed |
| Targeting Hypoxia Sensitizes TNBC to Cisplatin and Promotes Inhibition of Both Bulk and Cancer Stem Cells. Sulaiman A, McGarry S, Chambers J, Al-Kadi E, Phan A, Li L, Mediratta K, Dimitroulakos J, Addison C, Li X, Wang L. Int J Mol Sci. 2020 Aug 12;21(16). pii: ijms21165788. doi: 10.3390/ijms21165788. PubMed |
| Conditional ablation of MAPK7 expression in chondrocytes impairs endochondral bone formation in limbs and adaptation of chondrocytes to hypoxia. Yang X, Zhong D, Gao W, Liao Z, Chen Y, Zhang S, Zhou H, Su P, Xu C. Cell Biosci. 2020 Sep 10;10:103. doi: 10.1186/s13578-020-00462-8. eCollection 2020. PubMed |
| Macrophage-Hypoxia-Inducible Factor-1alpha Signaling in Carotid Artery Stenosis. Kim GD, Ng HP, Chan ER, Mahabeleshwar GH. Am J Pathol. 2021 Jun;191(6):1118-1134. doi: 10.1016/j.ajpath.2021.03.008. Epub 2021 Mar 19. PubMed |
| Short lifespan of syngeneic transplanted MSC is a consequence of in vivo apoptosis and immune cell recruitment in mice. Preda MB, Neculachi CA, Fenyo IM, Vacaru AM, Publik MA, Simionescu M, Burlacu A. Cell Death Dis. 2021 Jun 2;12(6):566. doi: 10.1038/s41419-021-03839-w. PubMed |
| DYRK3 contributes to differentiation and hypoxic control in neuroblastoma. Ivanova E, Sharma SD, Brichkina A, Pfefferle P, Keber U, Pagenstecher A, Lauth M. Biochem Biophys Res Commun. 2021 Aug 27;567:215-221. doi: 10.1016/j.bbrc.2021.06.053. Epub 2021 Jun 22. PubMed |
| Low-Density Lipoprotein Receptor-Related Protein 6 Cell Surface Availability Regulates Fuel Metabolism in Astrocytes. Chow HM, Sun JK, Hart RP, Cheng KK, Hung CHL, Lau TM, Kwan KM. Adv Sci (Weinh). 2021 Aug;8(16):e2004993. doi: 10.1002/advs.202004993. Epub 2021 Jun 27. PubMed |
| LRP5 Regulates HIF-1alpha Stability via Interaction with PHD2 in Ischemic Myocardium. Ju S, Lim L, Wi K, Park C, Ki YJ, Choi DH, Song H. Int J Mol Sci. 2021 Jun 19;22(12). pii: ijms22126581. doi: 10.3390/ijms22126581. PubMed |
| USP14 maintains HIF1-alpha stabilization via its deubiquitination activity in hepatocellular carcinoma. Lv C, Wang S, Lin L, Wang C, Zeng K, Meng Y, Sun G, Wei S, Liu Y, Zhao Y. Cell Death Dis. 2021 Aug 21;12(9):803. doi: 10.1038/s41419-021-04089-6. PubMed |
| Reprogramming of glucocorticoid receptor function by hypoxia. Vanderhaeghen T, Timmermans S, Watts D, Paakinaho V, Eggermont M, Vandewalle J, Wallaeys C, Van Wyngene L, Van Looveren K, Nuyttens L, Dewaele S, Vanden Berghe J, Lemeire K, De Backer J, Dirkx L, Vanden Berghe W, Caljon G, Ghesquiere B, De Bosscher K, Wielockx B, Palvimo JJ, Beyaert R, Libert C. EMBO Rep. 2022 Jan 5;23(1):e53083. doi: 10.15252/embr.202153083. Epub 2021 Oct 26. PubMed |
| Mitochondrial DHODH regulates hypoxia-inducible factor 1 expression in OTSCC. Gao W, Hu L, Zhang M, Liu S, Xu S, Chow VL, Chan JY, Wong TS. Am J Cancer Res. 2022 Jan 15;12(1):48-67. eCollection 2022. PubMed |
| Endothelial PPARdelta facilitates the post-ischemic vascular repair through interaction with HIF1alpha. Wu Y, Tang X, Lee S, Hong H, Cao X, Lau CW, Liu B, Chawla A, Ma RCW, Huang Y, Lui KO, Tian XY. Theranostics. 2022 Jan 24;12(4):1855-1869. doi: 10.7150/thno.69017. eCollection 2022. PubMed |
| Hypoxia-inducible lentiviral gene expression in engineered human macrophages. Chinn HK, Gardell JL, Matsumoto LR, Labadie KP, Mihailovic TN, Lieberman NAP, Davis A, Pillarisetty VG, Crane CA. J Immunother Cancer. 2022 Jun;10(6). pii: jitc-2021-003770. doi: 10.1136/jitc-2021-003770. PubMed |
| Synergistic activation of genes promoting invasiveness by dual deprivation in oxygen and nutrients. Jehanno C, Le Page Y, Flouriot G, Le Goff P, Michel D. Int J Exp Pathol. 2023 Apr;104(2):64-75. doi: 10.1111/iep.12464. Epub 2023 Jan 24. PubMed |
| Extracellular vesicles from neural progenitor cells promote functional recovery after stroke in mice with pharmacological inhibition of neurogenesis. Campero-Romero AN, Real FH, Santana-Martinez RA, Molina-Villa T, Aranda C, Rios-Castro E, Tovar-Y-Romo LB. Cell Death Discov. 2023 Jul 28;9(1):272. doi: 10.1038/s41420-023-01561-4. PubMed |
| m(6)A demethylase FTO stabilizes LINK-A to exert oncogenic roles via MCM3-mediated cell-cycle progression and HIF-1alpha activation. Nan Y, Liu S, Luo Q, Wu X, Zhao P, Chang W, Zhang R, Li Y, Liu Z. Cell Rep. 2023 Oct 31;42(10):113273. doi: 10.1016/j.celrep.2023.113273. Epub 2023 Oct 19. PubMed |
| The E3 ubiquitin ligase RBCK1: Implications in the tumor immune microenvironment and antiangiogenic therapy of glioma. Guo J, Sun D, Zhang J, Guo J, Wu Z, Chen Y, Xu Y, Zhou D, Cui Y, Mo Q, Li Y, Zhao T, You Q. Comput Struct Biotechnol J. 2023 Oct 13;21:5212-5227. doi: 10.1016/j.csbj.2023.10.020. eCollection 2023. PubMed |
| Evolution of a novel regulatory mechanism of hypoxia inducible factor in hypoxia-tolerant electric fishes. Elbassiouny AA, Buck LT, Abatti LE, Mitchell JA, Crampton WGR, Lovejoy NR, Chang BSW. J Biol Chem. 2024 Mar;300(3):105727. doi: 10.1016/j.jbc.2024.105727. Epub 2024 Feb 5. PubMed |
| Cholesterol accumulation impairs HIF-1alpha-dependent immunometabolic reprogramming of LPS-stimulated macrophages by upregulating the NRF2 pathway. Ting KKY, Yu P, Dow R, Ibrahim H, Karim S, Polenz CK, Winer DA, Woo M, Jongstra-Bilen J, Cybulsky MI. Sci Rep. 2024 May 15;14(1):11162. doi: 10.1038/s41598-024-61493-6. PubMed |
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