pcDNA3-Flag mTOR wt Citations (31)
Originally described in: The FKBP12-rapamycin-binding domain is required for FKBP12-rapamycin-associated protein kinase activity and G1 progression.Vilella-Bach M, Nuzzi P, Fang Y, Chen J J Biol Chem. 1999 Feb 12. 274(7):4266-72. PubMed Journal
Articles Citing pcDNA3-Flag mTOR wt
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| Coordinated targeting of the EGFR signaling axis by microRNA-27a*. Wu X, Bhayani MK, Dodge CT, Nicoloso MS, Chen Y, Yan X, Adachi M, Thomas L, Galer CE, Jiffar T, Pickering CR, Kupferman ME, Myers JN, Calin GA, Lai SY. Oncotarget. 2013 Sep;4(9):1388-98. PubMed |
| Convergent regulation of the lysosomal two-pore channel-2 by Mg(2)(+), NAADP, PI(3,5)P(2) and multiple protein kinases. Jha A, Ahuja M, Patel S, Brailoiu E, Muallem S. EMBO J. 2014 Mar 3;33(5):501-11. doi: 10.1002/embj.201387035. Epub 2014 Feb 5. PubMed |
A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.
Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan A, Beck AH, Sabatini DM.
Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14.
PubMed
Associated Plasmids |
| ATG4B promotes colorectal cancer growth independent of autophagic flux. Liu PF, Leung CM, Chang YH, Cheng JS, Chen JJ, Weng CJ, Tsai KW, Hsu CJ, Liu YC, Hsu PC, Pan HW, Shu CW. Autophagy. 2014 Aug;10(8):1454-65. doi: 10.4161/auto.29556. Epub 2014 Jun 12. PubMed |
| Molecular switch role of Akt in Polygonatum odoratum lectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cells. Li C, Chen J, Lu B, Shi Z, Wang H, Zhang B, Zhao K, Qi W, Bao J, Wang Y. PLoS One. 2014 Jul 3;9(7):e101526. doi: 10.1371/journal.pone.0101526. eCollection 2014. PubMed |
| Annexin A1 Preferentially Predicts Poor Prognosis of Basal-Like Breast Cancer Patients by Activating mTOR-S6 Signaling. Bhardwaj A, Ganesan N, Tachibana K, Rajapakshe K, Albarracin CT, Gunaratne PH, Coarfa C, Bedrosian I. PLoS One. 2015 May 22;10(5):e0127678. doi: 10.1371/journal.pone.0127678. eCollection 2015. PubMed |
| HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth. Su KH, Cao J, Tang Z, Dai S, He Y, Sampson SB, Benjamin IJ, Dai C. Nat Cell Biol. 2016 May;18(5):527-39. doi: 10.1038/ncb3335. Epub 2016 Apr 4. PubMed |
| Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets. Chen YB, Xu J, Skanderup AJ, Dong Y, Brannon AR, Wang L, Won HH, Wang PI, Nanjangud GJ, Jungbluth AA, Li W, Ojeda V, Hakimi AA, Voss MH, Schultz N, Motzer RJ, Russo P, Cheng EH, Giancotti FG, Lee W, Berger MF, Tickoo SK, Reuter VE, Hsieh JJ. Nat Commun. 2016 Oct 7;7:13131. doi: 10.1038/ncomms13131. PubMed |
| Diminished DYRK2 sensitizes hormone receptor-positive breast cancer to everolimus by the escape from degrading mTOR. Mimoto R, Nihira NT, Hirooka S, Takeyama H, Yoshida K. Cancer Lett. 2017 Jan 1;384:27-38. doi: 10.1016/j.canlet.2016.10.015. Epub 2016 Oct 13. PubMed |
| MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1. Brown MC, Gromeier M. Cell Rep. 2017 Feb 7;18(6):1444-1457. doi: 10.1016/j.celrep.2017.01.023. PubMed |
| mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan KL, Mischel PS. Mol Cell. 2017 Jul 6;67(1):128-138.e7. doi: 10.1016/j.molcel.2017.05.030. Epub 2017 Jun 22. PubMed |
| Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation. Bruning U, Morales-Rodriguez F, Kalucka J, Goveia J, Taverna F, Queiroz KCS, Dubois C, Cantelmo AR, Chen R, Loroch S, Timmerman E, Caixeta V, Bloch K, Conradi LC, Treps L, Staes A, Gevaert K, Tee A, Dewerchin M, Semenkovich CF, Impens F, Schilling B, Verdin E, Swinnen JV, Meier JL, Kulkarni RA, Sickmann A, Ghesquiere B, Schoonjans L, Li X, Mazzone M, Carmeliet P. Cell Metab. 2018 Dec 4;28(6):866-880.e15. doi: 10.1016/j.cmet.2018.07.019. Epub 2018 Aug 23. PubMed |
| mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53. Jung SH, Hwang HJ, Kang D, Park HA, Lee HC, Jeong D, Lee K, Park HJ, Ko YG, Lee JS. Oncogene. 2019 Mar;38(10):1639-1650. doi: 10.1038/s41388-018-0521-8. Epub 2018 Oct 18. PubMed |
| Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells. Li X, Zhu G, Yao X, Wang N, Hu R, Kong Q, Zhou D, Long L, Cai J, Zhou W. Onco Targets Ther. 2018 Dec 11;11:8977-8985. doi: 10.2147/OTT.S187315. eCollection 2018. PubMed |
The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.
Kovalski JR, Bhaduri A, Zehnder AM, Neela PH, Che Y, Wozniak GG, Khavari PA.
Mol Cell. 2019 Jan 4. pii: S1097-2765(18)31031-1. doi: 10.1016/j.molcel.2018.12.001.
PubMed
Associated Plasmids |
| Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR. Zhang X, Chen W, Gao Q, Yang J, Yan X, Zhao H, Su L, Yang M, Gao C, Yao Y, Inoki K, Li D, Shao R, Wang S, Sahoo N, Kudo F, Eguchi T, Ruan B, Xu H. PLoS Biol. 2019 May 21;17(5):e3000252. doi: 10.1371/journal.pbio.3000252. eCollection 2019 May. PubMed |
| Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway. Lin J, Jiao A, Lv W, Zhang C, Shi Y, Yang Z, Sun N, Li X, Zhang J. Front Pharmacol. 2019 Aug 9;10:896. doi: 10.3389/fphar.2019.00896. eCollection 2019. PubMed |
| Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR. Xiao B, Zuo D, Hirukawa A, Cardiff RD, Lamb R, Sonenberg N, Muller WJ. Cell Rep. 2020 Apr 28;31(4):107571. doi: 10.1016/j.celrep.2020.107571. PubMed |
| Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease. Kim D, Park G, Huuhtanen J, Lundgren S, Khajuria RK, Hurtado AM, Munoz-Calleja C, Cardenoso L, Gomez-Garcia de Soria V, Chen-Liang TH, Eldfors S, Ellonen P, Hannula S, Kankainen M, Bruck O, Kreutzman A, Salmenniemi U, Lonnberg T, Jerez A, Itala-Remes M, Myllymaki M, Keranen MAI, Mustjoki S. Nat Commun. 2020 May 7;11(1):2246. doi: 10.1038/s41467-020-16115-w. PubMed |
| Loss of FBXW7-mediated degradation of BRAF elicits resistance to BET inhibitors in adult T cell leukemia cells. Yeh CH, Bellon M, Wang F, Zhang H, Fu L, Nicot C. Mol Cancer. 2020 Sep 9;19(1):139. doi: 10.1186/s12943-020-01254-x. PubMed |
| Rhein Suppresses Colorectal Cancer Cell Growth by Inhibiting the mTOR Pathway In Vitro and In Vivo. Zhang H, Yi JK, Huang H, Park S, Park S, Kwon W, Kim E, Jang S, Kim SY, Choi SK, Kim SH, Liu K, Dong Z, Ryoo ZY, Kim MO. Cancers (Basel). 2021 Apr 30;13(9). pii: cancers13092176. doi: 10.3390/cancers13092176. PubMed |
| Functional and structural analyses of novel Smith-Kingsmore Syndrome-Associated MTOR variants reveal potential new mechanisms and predictors of pathogenicity. Besterman AD, Althoff T, Elfferich P, Gutierrez-Mejia I, Sadik J, Bernstein JA, van Ierland Y, Kattentidt-Mouravieva AA, Nellist M, Abramson J, Martinez-Agosto JA. PLoS Genet. 2021 Jul 1;17(7):e1009651. doi: 10.1371/journal.pgen.1009651. eCollection 2021 Jul. PubMed |
| An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress. Nuchel J, Tauber M, Nolte JL, Morgelin M, Turk C, Eckes B, Demetriades C, Plomann M. Mol Cell. 2021 Aug 19;81(16):3275-3293.e12. doi: 10.1016/j.molcel.2021.06.017. Epub 2021 Jul 9. PubMed |
| VHL suppresses RAPTOR and inhibits mTORC1 signaling in clear cell renal cell carcinoma. Ganner A, Gehrke C, Klein M, Thegtmeier L, Matulenski T, Wingendorf L, Wang L, Pilz F, Greidl L, Meid L, Kotsis F, Walz G, Frew IJ, Neumann-Haefelin E. Sci Rep. 2021 Jul 21;11(1):14827. doi: 10.1038/s41598-021-94132-5. PubMed |
| Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt. Yu Z, Chen J, Takagi E, Wang F, Saha B, Liu X, Joubert LM, Gleason CE, Jin M, Li C, Nowotny C, Agard D, Cheng Y, Pearce D. J Biol Chem. 2022 Sep;298(9):102288. doi: 10.1016/j.jbc.2022.102288. Epub 2022 Aug 1. PubMed |
| Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling integrity is required for mammary tumorigenesis. Zhang S, Lee SH, Nie L, Huang Y, Zou G, Jung YS, Jun S, Zhang J, Lien EM, Chen J, Park JI. Cancer Commun (Lond). 2023 Jan;43(1):159-163. doi: 10.1002/cac2.12382. Epub 2022 Nov 6. PubMed |
| An integrated genetic analysis of epileptogenic brain malformed lesions. Fujita A, Kato M, Sugano H, Iimura Y, Suzuki H, Tohyama J, Fukuda M, Ito Y, Baba S, Okanishi T, Enoki H, Fujimoto A, Yamamoto A, Kawamura K, Kato S, Honda R, Ono T, Shiraishi H, Egawa K, Shirai K, Yamamoto S, Hayakawa I, Kawawaki H, Saida K, Tsuchida N, Uchiyama Y, Hamanaka K, Miyatake S, Mizuguchi T, Nakashima M, Saitsu H, Miyake N, Kakita A, Matsumoto N. Acta Neuropathol Commun. 2023 Mar 2;11(1):33. doi: 10.1186/s40478-023-01532-x. PubMed |
| mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion. Liu HJ, Du H, Khabibullin D, Zarei M, Wei K, Freeman GJ, Kwiatkowski DJ, Henske EP. Nat Commun. 2023 Mar 3;14(1):1214. doi: 10.1038/s41467-023-36881-7. PubMed |
| Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor. Nicastro R, Brohee L, Alba J, Nuchel J, Figlia G, Kipschull S, Gollwitzer P, Romero-Pozuelo J, Fernandes SA, Lamprakis A, Vanni S, Teleman AA, De Virgilio C, Demetriades C. Nat Cell Biol. 2023 Sep;25(9):1303-1318. doi: 10.1038/s41556-023-01198-6. Epub 2023 Aug 10. PubMed |
| Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation. Li TY, Wang Q, Gao AW, Li X, Sun Y, Mottis A, Shong M, Auwerx J. Cell Discov. 2023 Sep 7;9(1):92. doi: 10.1038/s41421-023-00589-1. PubMed |
| mTOR Pathway Somatic Pathogenic Variants in Focal Malformations of Cortical Development: Novel Variants, Topographic Mapping, and Clinical Outcomes. Krochmalnek E, Accogli A, St-Onge J, Addour-Boudrahem N, Prakash G, Kim SH, Brunette-Clement T, Alhajaj G, Mougharbel L, Bruneau E, Myers KA, Dubeau F, Karamchandani J, Farmer JP, Atkinson J, Hall J, Chantal Poulin C, Rosenblatt B, Lafond-Lapalme J, Weil A, Fallet-Bianco C, Albrecht S, Sonenberg N, Riviere JB, Dudley RW, Srour M. Neurol Genet. 2023 Oct 26;9(6):e200103. doi: 10.1212/NXG.0000000000200103. eCollection 2023 Dec. PubMed |
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