VCP(wt)-EGFP Citations (24)
Originally described in: VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD.Tresse E, Salomons FA, Vesa J, Bott LC, Kimonis V, Yao TP, Dantuma NP, Taylor JP Autophagy. 2010 Feb 22. 6(2):. PubMed Journal
Articles Citing VCP(wt)-EGFP
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| The ubiquitin regulatory X (UBX) domain-containing protein TUG regulates the p97 ATPase and resides at the endoplasmic reticulum-golgi intermediate compartment. Orme CM, Bogan JS. J Biol Chem. 2012 Feb 24;287(9):6679-92. doi: 10.1074/jbc.M111.284232. Epub 2011 Dec 29. PubMed |
| Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associated degradation. Blount JR, Burr AA, Denuc A, Marfany G, Todi SV. PLoS One. 2012;7(5):e36542. doi: 10.1371/journal.pone.0036542. Epub 2012 May 9. PubMed |
| Methylation of the PTPRO gene in human hepatocellular carcinoma and identification of VCP as its substrate. Hsu SH, Motiwala T, Roy S, Claus R, Mustafa M, Plass C, Freitas MA, Ghoshal K, Jacob ST. J Cell Biochem. 2013 Aug;114(8):1810-8. doi: 10.1002/jcb.24525. PubMed |
| Identification of epithelial stromal interaction 1 as a novel effector downstream of Kruppel-like factor 8 in breast cancer invasion and metastasis. Li T, Lu H, Shen C, Lahiri SK, Wason MS, Mukherjee D, Yu L, Zhao J. Oncogene. 2014 Sep 25;33(39):4746-55. doi: 10.1038/onc.2013.415. Epub 2013 Oct 7. PubMed |
| Endoplasmic reticulum-associated degradation controls cell surface expression of gamma-aminobutyric acid, type B receptors. Zemoura K, Schenkel M, Acuna MA, Yevenes GE, Zeilhofer HU, Benke D. J Biol Chem. 2013 Nov 29;288(48):34897-905. doi: 10.1074/jbc.M113.514745. Epub 2013 Oct 10. PubMed |
| The type II deiodinase is retrotranslocated to the cytoplasm and proteasomes via p97/Atx3 complex. Arrojo E Drigo R, Egri P, Jo S, Gereben B, Bianco AC. Mol Endocrinol. 2013 Dec;27(12):2105-15. doi: 10.1210/me.2013-1281. Epub 2013 Nov 6. PubMed |
| ERAD-dependent control of the Wnt secretory factor Evi. Glaeser K, Urban M, Fenech E, Voloshanenko O, Kranz D, Lari F, Christianson JC, Boutros M. EMBO J. 2018 Feb 15;37(4). pii: embj.201797311. doi: 10.15252/embj.201797311. Epub 2018 Jan 29. PubMed |
| Trafficking of the human ether-a-go-go-related gene (hERG) potassium channel is regulated by the ubiquitin ligase rififylin (RFFL). Roder K, Kabakov A, Moshal KS, Murphy KR, Xie A, Dudley S, Turan NN, Lu Y, MacRae CA, Koren G. J Biol Chem. 2019 Jan 4;294(1):351-360. doi: 10.1074/jbc.RA118.003852. Epub 2018 Nov 6. PubMed |
| VCP/p97 controls signals of the ERK1/2 pathway transmitted via the Shoc2 scaffolding complex: novel insights into IBMPFD pathology. Jang H, Jang ER, Wilson PG, Anderson D, Galperin E. Mol Biol Cell. 2019 Jul 1;30(14):1655-1663. doi: 10.1091/mbc.E19-03-0144. Epub 2019 May 15. PubMed |
| Heterozygous mutations in valosin-containing protein (VCP) and resistance to VCP inhibitors. Bastola P, Bilkis R, De Souza C, Minn K, Chien J. Sci Rep. 2019 Jul 29;9(1):11002. doi: 10.1038/s41598-019-47085-9. PubMed |
| Kushenol E inhibits autophagy and impairs lysosomal positioning via VCP/p97 inhibition. Kwon M, Jang M, Kim GH, Oh T, Ryoo IJ, Ryu HW, Oh SR, Kim BY, Jang JH, Ko SK, Ahn JS. Biochem Pharmacol. 2020 May;175:113861. doi: 10.1016/j.bcp.2020.113861. Epub 2020 Feb 17. PubMed |
| Coupling of translation quality control and mRNA targeting to stress granules. Moon SL, Morisaki T, Stasevich TJ, Parker R. J Cell Biol. 2020 Aug 3;219(8). pii: 151851. doi: 10.1083/jcb.202004120. PubMed |
| Phospho-Ser(784)-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer. Zhu C, Rogers A, Asleh K, Won J, Gao D, Leung S, Li S, Vij KR, Zhu J, Held JM, You Z, Nielsen TO, Shao J. Cell Rep. 2020 Jun 9;31(10):107745. doi: 10.1016/j.celrep.2020.107745. PubMed |
| The Impact of ALS-Associated Genes hnRNPA1, MATR3, VCP and UBQLN2 on the Severity of TDP-43 Aggregation. Bajc Cesnik A, Motaln H, Rogelj B. Cells. 2020 Jul 28;9(8). pii: cells9081791. doi: 10.3390/cells9081791. PubMed |
| The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, Goldfarb D, Ho CT, Cloer EW, Boyer NP, Hardie C, Bock AJ, Johnson EC, Anil J, Major MB, Gupton SL. Mol Biol Cell. 2021 Feb 15;32(4):314-330. doi: 10.1091/mbc.E20-10-0622. Epub 2020 Dec 30. PubMed |
| VPS13D interacts with VCP/p97 and negatively regulates endoplasmic reticulum-mitochondria interactions. Du Y, Wang J, Xiong J, Fang N, Ji WK. Mol Biol Cell. 2021 Aug 1;32(16):1474-1486. doi: 10.1091/mbc.E21-03-0097. Epub 2021 Jun 16. PubMed |
| Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular chaperones as modifiers of poly-GA aggregation. Liu F, Morderer D, Wren MC, Vettleson-Trutza SA, Wang Y, Rabichow BE, Salemi MR, Phinney BS, Oskarsson B, Dickson DW, Rossoll W. Acta Neuropathol Commun. 2022 Feb 14;10(1):22. doi: 10.1186/s40478-022-01322-x. PubMed |
| Cryo-EM structure of dodecamer human p97 in complex with NMS-873 reveals S765-G779 peptide plays critical role for D2 ring oligomerization. Liu S, Ye X, Liu W, Liu L, Li D, Lin Q, Wang T. Biochem Biophys Res Commun. 2022 Apr 23;601:146-152. doi: 10.1016/j.bbrc.2022.02.056. Epub 2022 Feb 24. PubMed |
| WIPI2 positively regulates mitophagy by promoting mitochondrial recruitment of VCP. Lu G, Tan HWS, Schmauck-Medina T, Wang L, Chen J, Cho YL, Chen K, Zhang JZ, He W, Wu Y, Xia D, Zhou J, Fang EF, Fang L, Liu W, Shen HM. Autophagy. 2022 Dec;18(12):2865-2879. doi: 10.1080/15548627.2022.2052461. Epub 2022 Apr 7. PubMed |
| Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance. Wrobel L, Hill SM, Djajadikerta A, Fernandez-Estevez M, Karabiyik C, Ashkenazi A, Barratt VJ, Stamatakou E, Gunnarsson A, Rasmusson T, Miele EW, Beaton N, Bruderer R, Feng Y, Reiter L, Castaldi MP, Jarvis R, Tan K, Burli RW, Rubinsztein DC. Nat Commun. 2022 Jul 16;13(1):4146. doi: 10.1038/s41467-022-31905-0. PubMed |
| EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly. Tang X, Wei W, Snowball JM, Nakayasu ES, Bell SM, Ansong C, Lin X, Whitsett JA. iScience. 2022 Nov 24;26(1):105667. doi: 10.1016/j.isci.2022.105667. eCollection 2023 Jan 20. PubMed |
| DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin. Sepulveda GP, Gushchanskaia ES, Mora-Martin A, Esse R, Nikorich I, Ceballos A, Kwan J, Blum BC, Dholiya P, Emili A, Perissi V, Cardamone MD, Grishok A. bioRxiv [Preprint]. 2024 Feb 7:2024.02.06.579191. doi: 10.1101/2024.02.06.579191. PubMed |
p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol.
Wrobel L, Hoffmann JL, Li X, Rubinsztein DC.
Sci Adv. 2024 May 3;10(18):eadl6082. doi: 10.1126/sciadv.adl6082. Epub 2024 May 3.
PubMed
Associated Plasmids |
| TurboID-Based IRE1 Interactome Reveals Participants of the Endoplasmic Reticulum-Associated Protein Degradation Machinery in the Human Mast Cell Leukemia Cell Line HMC-1.2. Ahmed N, Preisinger C, Wilhelm T, Huber M. Cells. 2024 Apr 25;13(9):747. doi: 10.3390/cells13090747. PubMed |
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