pDEST26-hOPTN-D474N Citations (1)
Originally described in: Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP.Zhu G, Wu CJ, Zhao Y, Ashwell JD Curr Biol. 2007 Aug 21. 17(16):1438-43. PubMed Journal
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Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism. Shen WC, Li HY, Chen GC, Chern Y, Tu PH. Autophagy. 2015 Apr 3;11(4):685-700. doi: 10.4161/auto.36098. PubMed |
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