pcDNA3-HA-PHLPP1 N-terminal truncation Citations (10)

Originally described in: PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.
Gao T, Furnari F, Newton AC Mol Cell. 2005 Apr 1. 18(1):13-24. PubMed Journal

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Articles Citing pcDNA3-HA-PHLPP1 N-terminal truncation

Articles
USP1 regulates AKT phosphorylation by modulating the stability of PHLPP1 in lung cancer cells. Zhiqiang Z, Qinghui Y, Yongqiang Z, Jian Z, Xin Z, Haiying M, Yuepeng G. J Cancer Res Clin Oncol. 2012 Jul;138(7):1231-8. doi: 10.1007/s00432-012-1193-3. Epub 2012 Mar 20. PubMed
InterAKTions with FKBPs--mutational and pharmacological exploration. Fabian AK, Marz A, Neimanis S, Biondi RM, Kozany C, Hausch F. PLoS One. 2013;8(2):e57508. doi: 10.1371/journal.pone.0057508. Epub 2013 Feb 28. PubMed
A novel immunomodulatory function of PHLPP1: inhibition of iNOS via attenuation of STAT1 ser727 phosphorylation in mouse macrophages. Alamuru NP, Behera S, Butchar JP, Tridandapani S, Kaimal Suraj S, Babu PP, Hasnain SE, Ehtesham NZ, Parsa KV. J Leukoc Biol. 2014 Jan 17. PubMed
Interactome of the negative regulator of nuclear import BRCA1-binding protein 2. Fatima S, Wagstaff KM, Loveland KL, Jans DA. Sci Rep. 2015 Mar 30;5:9459. doi: 10.1038/srep09459. PubMed
Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation. Bradley EW, Carpio LR, Newton AC, Westendorf JJ. J Biol Chem. 2015 Jun 26;290(26):16272-80. doi: 10.1074/jbc.M114.612937. Epub 2015 May 7. PubMed
Oncogenic Ras differentially regulates metabolism and anoikis in extracellular matrix-detached cells. Mason JA, Davison-Versagli CA, Leliaert AK, Pape DJ, McCallister C, Zuo J, Durbin SM, Buchheit CL, Zhang S, Schafer ZT. Cell Death Differ. 2016 Aug;23(8):1271-82. doi: 10.1038/cdd.2016.15. Epub 2016 Feb 26. PubMed
ERK1/2 activated PHLPP1 induces skeletal muscle ER stress through the inhibition of a novel substrate AMPK. Behera S, Kapadia B, Kain V, Alamuru-Yellapragada NP, Murunikkara V, Kumar ST, Babu PP, Seshadri S, Shivarudraiah P, Hiriyan J, Gangula NR, Maddika S, Misra P, Parsa KVL. Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1702-1716. doi: 10.1016/j.bbadis.2018.02.019. Epub 2018 Feb 27. PubMed
Pink1 regulates FKBP5 interaction with AKT/PHLPP and protects neurons from neurotoxin stress induced by MPP(). Boonying W, Joselin A, Huang E, Qu D, Safarpour F, Iyirhiaro GO, Gonzalez YR, Callaghan SM, Slack RS, Figeys D, Chung YH, Park DS. J Neurochem. 2019 Aug;150(3):312-329. doi: 10.1111/jnc.14683. Epub 2019 Apr 2. PubMed
PHLPP1 counter-regulates STAT1-mediated inflammatory signaling. Cohen Katsenelson K, Stender JD, Kawashima AT, Lorden G, Uchiyama S, Nizet V, Glass CK, Newton AC. Elife. 2019 Aug 13;8. pii: 48609. doi: 10.7554/eLife.48609. PubMed
PHLPP1 promotes neutral lipid accumulation through AMPK/ChREBP-dependent lipid uptake and fatty acid synthesis pathways. Balamurugan K, Medishetti R, Kotha J, Behera P, Chandra K, Mavuduru VA, Joshi MB, Samineni R, Katika MR, Ball WB, Thondamal M, Challa A, Chatti K, Parsa KVL. iScience. 2022 Jan 12;25(2):103766. doi: 10.1016/j.isci.2022.103766. eCollection 2022 Feb 18. PubMed

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