pcDNA3-HA-PHLPP2 Citations (10)

Originally described in: PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.
Brognard J, Sierecki E, Gao T, Newton AC Mol Cell. 2007 Mar 23. 25(6):917-31. PubMed Journal

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Articles Citing pcDNA3-HA-PHLPP2

Articles
Diacylglycerol kinase delta modulates Akt phosphorylation through pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2). Crotty TM, Nakano T, Stafforini DM, Topham MK. J Biol Chem. 2013 Jan 18;288(3):1439-47. doi: 10.1074/jbc.M112.407379. Epub 2012 Nov 26. PubMed
InterAKTions with FKBPs--mutational and pharmacological exploration. Fabian AK, Marz A, Neimanis S, Biondi RM, Kozany C, Hausch F. PLoS One. 2013;8(2):e57508. doi: 10.1371/journal.pone.0057508. Epub 2013 Feb 28. PubMed
mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2. Kim K, Qiang L, Hayden MS, Sparling DP, Purcell NH, Pajvani UB. Nat Commun. 2016 Jan 8;7:10255. doi: 10.1038/ncomms10255. PubMed
Transmembrane and Coiled-Coil Domain 1 Impairs the AKT Signaling Pathway in Urinary Bladder Urothelial Carcinoma: A Characterization of a Tumor Suppressor. Li CF, Wu WR, Chan TC, Wang YH, Chen LR, Wu WJ, Yeh BW, Liang SS, Shiue YL. Clin Cancer Res. 2017 Dec 15;23(24):7650-7663. doi: 10.1158/1078-0432.CCR-17-0002. Epub 2017 Sep 29. PubMed
ERK1/2 activated PHLPP1 induces skeletal muscle ER stress through the inhibition of a novel substrate AMPK. Behera S, Kapadia B, Kain V, Alamuru-Yellapragada NP, Murunikkara V, Kumar ST, Babu PP, Seshadri S, Shivarudraiah P, Hiriyan J, Gangula NR, Maddika S, Misra P, Parsa KVL. Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1702-1716. doi: 10.1016/j.bbadis.2018.02.019. Epub 2018 Feb 27. PubMed
The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding. Madigan JP, Hou F, Ye L, Hu J, Dong A, Tempel W, Yohe ME, Randazzo PA, Jenkins LMM, Gottesman MM, Tong Y. J Biol Chem. 2018 Oct 19;293(42):16142-16159. doi: 10.1074/jbc.RA118.003525. Epub 2018 Aug 24. PubMed
m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Liu J, Eckert MA, Harada BT, Liu SM, Lu Z, Yu K, Tienda SM, Chryplewicz A, Zhu AC, Yang Y, Huang JT, Chen SM, Xu ZG, Leng XH, Yu XC, Cao J, Zhang Z, Liu J, Lengyel E, He C. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27. PubMed
Inhibition of PHLPP1/2 phosphatases rescues pancreatic beta-cells in diabetes. Lupse B, Annamalai K, Ibrahim H, Kaur S, Geravandi S, Sarma B, Pal A, Awal S, Joshi A, Rafizadeh S, Madduri MK, Khazaei M, Liu H, Yuan T, He W, Gorrepati KDD, Azizi Z, Qi Q, Ye K, Oberholzer J, Maedler K, Ardestani A. Cell Rep. 2021 Aug 3;36(5):109490. doi: 10.1016/j.celrep.2021.109490. PubMed
PHLPP1 promotes neutral lipid accumulation through AMPK/ChREBP-dependent lipid uptake and fatty acid synthesis pathways. Balamurugan K, Medishetti R, Kotha J, Behera P, Chandra K, Mavuduru VA, Joshi MB, Samineni R, Katika MR, Ball WB, Thondamal M, Challa A, Chatti K, Parsa KVL. iScience. 2022 Jan 12;25(2):103766. doi: 10.1016/j.isci.2022.103766. eCollection 2022 Feb 18. PubMed
PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble. Sharma M, Dey CS. Cell Commun Signal. 2022 Nov 14;20(1):179. doi: 10.1186/s12964-022-00987-0. PubMed

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