pEGFP-C1-Ataxin3Q84 Citations (21)
Originally described in: Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis.Chai Y, Shao J, Miller VM, Williams A, Paulson HL Proc Natl Acad Sci U S A. 2002 Jul 9. 99(14):9310-5. PubMed Journal
Articles Citing pEGFP-C1-Ataxin3Q84
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| Insulin/IGF-1 signaling regulates proteasome activity through the deubiquitinating enzyme UBH-4. Matilainen O, Arpalahti L, Rantanen V, Hautaniemi S, Holmberg CI. Cell Rep. 2013 Jun 27;3(6):1980-95. doi: 10.1016/j.celrep.2013.05.012. Epub 2013 Jun 13. PubMed |
| Mahogunin ring finger 1 suppresses misfolded polyglutamine aggregation and cytotoxicity. Chhangani D, Nukina N, Kurosawa M, Amanullah A, Joshi V, Upadhyay A, Mishra A. Biochim Biophys Acta. 2014 Sep;1842(9):1472-84. doi: 10.1016/j.bbadis.2014.04.014. Epub 2014 Apr 24. PubMed |
| Ubiquitin ligase ITCH recruitment suppresses the aggregation and cellular toxicity of cytoplasmic misfolded proteins. Chhangani D, Upadhyay A, Amanullah A, Joshi V, Mishra A. Sci Rep. 2014 May 28;4:5077. doi: 10.1038/srep05077. PubMed |
| Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3. Gao R, Liu Y, Silva-Fernandes A, Fang X, Paulucci-Holthauzen A, Chatterjee A, Zhang HL, Matsuura T, Choudhary S, Ashizawa T, Koeppen AH, Maciel P, Hazra TK, Sarkar PS. PLoS Genet. 2015 Jan 15;11(1):e1004834. doi: 10.1371/journal.pgen.1004834. eCollection 2015 Jan. PubMed |
| CCT complex restricts neuropathogenic protein aggregation via autophagy. Pavel M, Imarisio S, Menzies FM, Jimenez-Sanchez M, Siddiqi FH, Wu X, Renna M, O'Kane CJ, Crowther DC, Rubinsztein DC. Nat Commun. 2016 Dec 8;7:13821. doi: 10.1038/ncomms13821. PubMed |
| Loss of laforin or malin results in increased Drp1 level and concomitant mitochondrial fragmentation in Lafora disease mouse models. Upadhyay M, Agarwal S, Bhadauriya P, Ganesh S. Neurobiol Dis. 2017 Jan 4;100:39-51. doi: 10.1016/j.nbd.2017.01.002. PubMed |
| Lanosterol Suppresses the Aggregation and Cytotoxicity of Misfolded Proteins Linked with Neurodegenerative Diseases. Upadhyay A, Amanullah A, Mishra R, Kumar A, Mishra A. Mol Neurobiol. 2017 Jan 19. doi: 10.1007/s12035-016-0377-2. PubMed |
| Polyglutamine tracts regulate beclin 1-dependent autophagy. Ashkenazi A, Bento CF, Ricketts T, Vicinanza M, Siddiqi F, Pavel M, Squitieri F, Hardenberg MC, Imarisio S, Menzies FM, Rubinsztein DC. Nature. 2017 May 4;545(7652):108-111. doi: 10.1038/nature22078. Epub 2017 Apr 26. PubMed |
| Calpain inhibition is protective in Machado-Joseph disease zebrafish due to induction of autophagy. Watchon M, Yuan KC, Mackovski N, Svahn AJ, Cole NJ, Goldsbury C, Rinkwitz S, Becker TS, Nicholson GA, Laird AS. J Neurosci. 2017 Jul 7. pii: 1142-17. doi: 10.1523/JNEUROSCI.1142-17.2017. PubMed |
| A protein quality control pathway regulated by linear ubiquitination. van Well EM, Bader V, Patra M, Sanchez-Vicente A, Meschede J, Furthmann N, Schnack C, Blusch A, Longworth J, Petrasch-Parwez E, Mori K, Arzberger T, Trumbach D, Angersbach L, Showkat C, Sehr DA, Berlemann LA, Goldmann P, Clement AM, Behl C, Woerner AC, Saft C, Wurst W, Haass C, Ellrichmann G, Gold R, Dittmar G, Hipp MS, Hartl FU, Tatzelt J, Winklhofer KF. EMBO J. 2019 May 2;38(9). pii: embj.2018100730. doi: 10.15252/embj.2018100730. Epub 2019 Mar 18. PubMed |
| Polyphenolic flavonoid (Myricetin) upregulated proteasomal degradation mechanisms: Eliminates neurodegenerative proteins aggregation. Joshi V, Mishra R, Upadhyay A, Amanullah A, Poluri KM, Singh S, Kumar A, Mishra A. J Cell Physiol. 2019 Nov;234(11):20900-20914. doi: 10.1002/jcp.28695. Epub 2019 Apr 19. PubMed |
| Rationally designed small molecules targeting toxic CAG repeat RNA that causes Huntington's disease (HD) and spinocerebellar ataxia (SCAs). Khan E, Biswas S, Mishra SK, Mishra R, Samanta S, Mishra A, Tawani A, Kumar A. Biochimie. 2019 Aug;163:21-32. doi: 10.1016/j.biochi.2019.05.001. Epub 2019 May 8. PubMed |
| Rhes travels from cell to cell and transports Huntington disease protein via TNT-like protrusion. Sharma M, Subramaniam S. J Cell Biol. 2019 Jun 3;218(6):1972-1993. doi: 10.1083/jcb.201807068. Epub 2019 May 10. PubMed |
| Discovery of a potent small molecule inhibiting Huntington's disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein. Khan E, Mishra SK, Mishra R, Mishra A, Kumar A. Sci Rep. 2019 Nov 14;9(1):16872. doi: 10.1038/s41598-019-53410-z. PubMed |
| DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases. Zhang N, Bewick B, Schultz J, Tiwari A, Krencik R, Zhang A, Adachi K, Xia G, Yun K, Sarkar P, Ashizawa T. Neurotherapeutics. 2021 Jun 23. pii: 10.1007/s13311-021-01075-w. doi: 10.1007/s13311-021-01075-w. PubMed |
| A Novel Calpain Inhibitor Compound Has Protective Effects on a Zebrafish Model of Spinocerebellar Ataxia Type 3. Robinson KJ, Yuan K, Plenderleith SK, Watchon M, Laird AS. Cells. 2021 Sep 29;10(10). pii: cells10102592. doi: 10.3390/cells10102592. PubMed |
| The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated deficits. Koppenol R, Conceicao A, Afonso IT, Afonso-Reis R, Costa RG, Tome S, Teixeira D, da Silva JP, Codesso JM, Brito DVC, Mendonca L, Marcelo A, Pereira de Almeida L, Matos CA, Nobrega C. Brain. 2022 Dec 13:awac473. doi: 10.1093/brain/awac473. PubMed |
| Itraconazole Confers Cytoprotection Against Neurodegenerative Disease-Associated Abnormal Protein Aggregation. Dubey AR, Mishra R, Jagtap YA, Kinger S, Kumar P, Dhiman R, Ghosh S, Singh S, Prasad A, Jana NR, Mishra A. Mol Neurobiol. 2023 May;60(5):2397-2412. doi: 10.1007/s12035-023-03230-0. Epub 2023 Jan 19. PubMed |
| A multi-layered network model identifies Akt1 as a common modulator of neurodegeneration. Na D, Lim DH, Hong JS, Lee HM, Cho D, Yu MS, Shaker B, Ren J, Lee B, Song JG, Oh Y, Lee K, Oh KS, Lee MY, Choi MS, Choi HS, Kim YH, Bui JM, Lee K, Kim HW, Lee YS, Gsponer J. Mol Syst Biol. 2023 Dec 6;19(12):e11801. doi: 10.15252/msb.202311801. Epub 2023 Nov 20. PubMed |
| Trehalose Promotes Clearance of Proteotoxic Aggregation of Neurodegenerative Disease-Associated Aberrant Proteins. Kumar P, Kinger S, Dubey AR, Jagtap YA, Choudhary A, Prasad A, Jha HC, Dhiman R, Gutti RK, Mishra A. Mol Neurobiol. 2023 Dec 7. doi: 10.1007/s12035-023-03824-8. PubMed |
| Detecting material state changes in the nucleolus by label-free digital holographic microscopy. Zorbas C, Soenmez A, Leger J, De Vleeschouwer C, Lafontaine DL. EMBO Rep. 2024 Jun;25(6):2786-2811. doi: 10.1038/s44319-024-00134-5. Epub 2024 Apr 23. PubMed |
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