pCMV4 p65 Citations (37)
Originally described in: The 65-kDa subunit of human NF-kappa B functions as a potent transcriptional activator and a target for v-Rel-mediated repression.Ballard DW, Dixon EP, Peffer NJ, Bogerd H, Doerre S, Stein B, Greene WC Proc Natl Acad Sci U S A. 1992 Mar 1. 89(5):1875-9. PubMed Journal
Articles Citing pCMV4 p65
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| The measles virus V protein binds to p65 (RelA) to suppress NF-kappaB activity. Schuhmann KM, Pfaller CK, Conzelmann KK. J Virol. 2011 Apr;85(7):3162-71. doi: 10.1128/JVI.02342-10. Epub 2011 Jan 26. PubMed |
| Expression of human carbonyl reductase 3 (CBR3; SDR21C2) is inducible by pro-inflammatory stimuli. Malatkova P, Ebert B, Wsol V, Maser E. Biochem Biophys Res Commun. 2012 Apr 6;420(2):368-73. doi: 10.1016/j.bbrc.2012.03.002. Epub 2012 Mar 8. PubMed |
| Loss of methylation in CpG sites in the NF-kappaB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes. de Andres MC, Imagawa K, Hashimoto K, Gonzalez A, Roach HI, Goldring MB, Oreffo RO. Arthritis Rheum. 2013 Mar;65(3):732-42. doi: 10.1002/art.37806. PubMed |
| Nuclear Factor-κB (NF-κB) Regulates the Expression of Human Testis-Enriched Leucine-Rich Repeats and WD Repeat Domain Containing 1 (LRWD1) Gene. Teng YN, Chuang PJ, Liu YW. Int J Mol Sci. 2012 Dec 28;14(1):625-39. doi: 10.3390/ijms14010625. PubMed |
| Enhanced NF-kappaB activity impairs vascular function through PARP-1-, SP-1-, and COX-2-dependent mechanisms in type 2 diabetes. Kassan M, Choi SK, Galan M, Bishop A, Umezawa K, Trebak M, Belmadani S, Matrougui K. Diabetes. 2013 Jun;62(6):2078-87. doi: 10.2337/db12-1374. Epub 2013 Jan 24. PubMed |
| ELF4 is critical for induction of type I interferon and the host antiviral response. You F, Wang P, Yang L, Yang G, Zhao YO, Qian F, Walker W, Sutton R, Montgomery R, Lin R, Iwasaki A, Fikrig E. Nat Immunol. 2013 Dec;14(12):1237-46. doi: 10.1038/ni.2756. Epub 2013 Nov 3. PubMed |
| The cytokine and endocannabinoid systems are co-regulated by NF-kappaB p65/RelA in cell culture and transgenic mouse models of Huntington's disease and in striatal tissue from Huntington's disease patients. Laprairie RB, Warford JR, Hutchings S, Robertson GS, Kelly ME, Denovan-Wright EM. J Neuroimmunol. 2014 Feb 15;267(1-2):61-72. doi: 10.1016/j.jneuroim.2013.12.008. Epub 2013 Dec 12. PubMed |
| Dicoumarol sensitizes renal cell carcinoma Caki cells to TRAIL-induced apoptosis through down-regulation of Bcl-2, Mcl-1 and c-FLIP in a NQO1-independent manner. Park EJ, Min KJ, Choi KS, Kwon TK. Exp Cell Res. 2014 Apr 15;323(1):144-54. doi: 10.1016/j.yexcr.2014.01.009. Epub 2014 Jan 22. PubMed |
| Tumor necrosis factor (TNF)-alpha induction of CXCL10 in endothelial cells requires protein arginine methyltransferase 5 (PRMT5)-mediated nuclear factor (NF)-kappaB p65 methylation. Harris DP, Bandyopadhyay S, Maxwell TJ, Willard B, DiCorleto PE. J Biol Chem. 2014 May 30;289(22):15328-39. doi: 10.1074/jbc.M114.547349. Epub 2014 Apr 21. PubMed |
| Identification of TNF-alpha-responsive promoters and enhancers in the intestinal epithelial cell model Caco-2. Boyd M, Coskun M, Lilje B, Andersson R, Hoof I, Bornholdt J, Dahlgaard K, Olsen J, Vitezic M, Bjerrum JT, Seidelin JB, Nielsen OH, Troelsen JT, Sandelin A. DNA Res. 2014 Dec;21(6):569-83. doi: 10.1093/dnares/dsu022. Epub 2014 Jul 2. PubMed |
| Extracellular signal-regulated kinase activation during cardiac hypertrophy reduces sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) transcription. Huang H, Joseph LC, Gurin MI, Thorp EB, Morrow JP. J Mol Cell Cardiol. 2014 Oct;75:58-63. doi: 10.1016/j.yjmcc.2014.06.018. Epub 2014 Jul 6. PubMed |
| A nucleolin-DNMT1 regulatory axis in acute myeloid leukemogenesis. Shen N, Yan F, Pang J, Wu LC, Al-Kali A, Litzow MR, Liu S. Oncotarget. 2014 Jul 30;5(14):5494-509. PubMed |
| CD133 and DNA-PK regulate MDR1 via the PI3K- or Akt-NF-kappaB pathway in multidrug-resistant glioblastoma cells in vitro. Xi G, Hayes E, Lewis R, Ichi S, Mania-Farnell B, Shim K, Takao T, Allender E, Mayanil CS, Tomita T. Oncogene. 2015 Mar 30. doi: 10.1038/onc.2015.78. PubMed |
| Inhibition of NF-kappaB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocelular apoptosis. M Rodrigues P, B Afonso M, L Simao A, M Borralho P, M P Rodrigues C, E Castro R. Sci Rep. 2015 Dec 1;5:17528. doi: 10.1038/srep17528. PubMed |
| Inactivation of PI3-K/Akt and reduction of SP1 and p65 expression increase the effect of solamargine on suppressing EP4 expression in human lung cancer cells. Chen Y, Tang Q, Wu J, Zheng F, Yang L, Hann SS. J Exp Clin Cancer Res. 2015 Dec 21;34:154. doi: 10.1186/s13046-015-0272-0. PubMed |
| Nuclear factor-kappaB regulates the expression of multiple genes encoding liver transport proteins. Balasubramaniyan N, Ananthanarayanan M, Suchy FJ. Am J Physiol Gastrointest Liver Physiol. 2016 Apr 15;310(8):G618-28. doi: 10.1152/ajpgi.00363.2015. Epub 2016 Feb 11. PubMed |
| PRMT5-Mediated Methylation of NF-kappaB p65 at Arg174 Is Required for Endothelial CXCL11 Gene Induction in Response to TNF-alpha and IFN-gamma Costimulation. Harris DP, Chandrasekharan UM, Bandyopadhyay S, Willard B, DiCorleto PE. PLoS One. 2016 Feb 22;11(2):e0148905. doi: 10.1371/journal.pone.0148905. eCollection 2016. PubMed |
| Demethylation of an NF-kappaB enhancer element orchestrates iNOS induction in osteoarthritis and is associated with altered chondrocyte cell cycle. de Andres MC, Takahashi A, Oreffo RO. Osteoarthritis Cartilage. 2016 Nov;24(11):1951-1960. doi: 10.1016/j.joca.2016.06.002. Epub 2016 Jun 13. PubMed |
| miR-130b, an onco-miRNA in bladder cancer, is directly regulated by NF-kappaB and sustains NF-kappaB activation by decreasing Cylindromatosis expression. Cui X, Kong C, Zhu Y, Zeng Y, Zhang Z, Liu X, Zhan B, Piao C, Jiang Z. Oncotarget. 2016 Jul 26;7(30):48547-48561. doi: 10.18632/oncotarget.10423. PubMed |
| CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Kojima Y, Volkmer JP, McKenna K, Civelek M, Lusis AJ, Miller CL, Direnzo D, Nanda V, Ye J, Connolly AJ, Schadt EE, Quertermous T, Betancur P, Maegdefessel L, Matic LP, Hedin U, Weissman IL, Leeper NJ. Nature. 2016 Aug 4;536(7614):86-90. PubMed |
| Nuclear factor-kappaB regulates expression of platelet phospholipase C-beta2 (PLCB2). Mao G, Jin J, Kunapuli SP, Rao AK. Thromb Haemost. 2016 Oct 28;116(5):931-940. doi: 10.1160/TH15-09-0749. Epub 2016 Jul 28. PubMed |
| Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice. Wang X, Buechler NL, Martin A, Wells J, Yoza B, McCall CE, Vachharajani V. PLoS One. 2016 Aug 8;11(8):e0160431. doi: 10.1371/journal.pone.0160431. eCollection 2016. PubMed |
| Activation of AMPKalpha mediates additive effects of solamargine and metformin on suppressing MUC1 expression in castration-resistant prostate cancer cells. Xiang S, Zhang Q, Tang Q, Zheng F, Wu J, Yang L, Hann SS. Sci Rep. 2016 Nov 10;6:36721. doi: 10.1038/srep36721. PubMed |
| Induction of Apoptosis by Berberine in Hepatocellular Carcinoma HepG2 Cells via Downregulation of NF-kappaB. Li M, Zhang M, Zhang ZL, Liu N, Han XY, Liu QC, Deng WJ, Liao CX. Oncol Res. 2017 Jan 26;25(2):233-239. doi: 10.3727/096504016X14742891049073. PubMed |
| Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP. Shen Y, Kapfhamer D, Minnella AM, Kim JE, Won SJ, Chen Y, Huang Y, Low LH, Massa SM, Swanson RA. Nat Commun. 2017 Sep 22;8(1):624. doi: 10.1038/s41467-017-00707-0. PubMed |
| Anthocyanin complex exerts anti-cholangiocarcinoma activities and improves the efficacy of drug treatment in a gemcitabine-resistant cell line. Intuyod K, Priprem A, Pairojkul C, Hahnvajanawong C, Vaeteewoottacharn K, Pinlaor P, Pinlaor S. Int J Oncol. 2018 Mar 7. doi: 10.3892/ijo.2018.4306. PubMed |
| Crosstalk of NF-kappaB/P65 and LncRNA HOTAIR-Mediated Repression of MUC1 Expression Contribute to Synergistic Inhibition of Castration-Resistant Prostate Cancer by Polyphyllin 1-Enzalutamide Combination Treatment. Xiang S, Zou P, Wu J, Zheng F, Tang Q, Zhou J, Hann SS. Cell Physiol Biochem. 2018;47(2):759-773. doi: 10.1159/000490028. Epub 2018 May 22. PubMed |
| Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis. Wang X, Buechler NL, Long DL, Furdui CM, Yoza BK, McCall CE, Vachharajani V. Inflammation. 2019 Feb;42(1):156-169. doi: 10.1007/s10753-018-0881-9. PubMed |
| Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-kappaB Activation and PD-L1 Expression. Jin X, Ding D, Yan Y, Li H, Wang B, Ma L, Ye Z, Ma T, Wu Q, Rodrigues DN, Kohli M, Jimenez R, Wang L, Goodrich DW, de Bono J, Dong H, Wu H, Zhu R, Huang H. Mol Cell. 2019 Jan 3;73(1):22-35.e6. doi: 10.1016/j.molcel.2018.10.034. Epub 2018 Dec 6. PubMed |
| MEK5/ERK5 activation regulates colon cancer stem-like cell properties. Pereira DM, Gomes SE, Borralho PM, Rodrigues CMP. Cell Death Discov. 2019 Feb 11;5:68. doi: 10.1038/s41420-019-0150-1. eCollection 2019. PubMed |
| High glucose induces apoptosis of HUVECs in a mitochondria-dependent manner by suppressing hexokinase 2 expression. Zhang J, Guo Y, Ge W, Zhou X, Pan M. Exp Ther Med. 2019 Jul;18(1):621-629. doi: 10.3892/etm.2019.7609. Epub 2019 May 24. PubMed |
| Regulation of PLPP3 gene expression by NF-kappaB family transcription factors. Mao G, Smyth SS, Morris AJ. J Biol Chem. 2019 Sep 20;294(38):14009-14019. doi: 10.1074/jbc.RA119.009002. Epub 2019 Jul 30. PubMed |
| Functional genetic variants can mediate their regulatory effects through alteration of transcription factor binding. Johnston AD, Simoes-Pires CA, Thompson TV, Suzuki M, Greally JM. Nat Commun. 2019 Aug 2;10(1):3472. doi: 10.1038/s41467-019-11412-5. PubMed |
| NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor. Bury M, Le Calve B, Lessard F, Dal Maso T, Saliba J, Michiels C, Ferbeyre G, Blank V. Cell Rep. 2019 Nov 5;29(6):1469-1481.e9. doi: 10.1016/j.celrep.2019.09.087. PubMed |
| DEPTOR is a microRNA-155 target regulating migration and cytokine production in diffuse large B-cell lymphoma cells. Jablonska E, Bialopiotrowicz E, Szydlowski M, Prochorec-Sobieszek M, Juszczynski P, Szumera-Cieckiewicz A. Exp Hematol. 2020 Aug;88:56-67.e2. doi: 10.1016/j.exphem.2020.07.005. Epub 2020 Jul 20. PubMed |
| NF-kappaB Blockade with Oral Administration of Dimethylaminoparthenolide (DMAPT), Delays Prostate Cancer Resistance to Androgen Receptor (AR) Inhibition and Inhibits AR Variants. Morel KL, Hamid AA, Clohessy JG, Pandell N, Ellis L, Sweeney CJ. Mol Cancer Res. 2021 Jul;19(7):1137-1145. doi: 10.1158/1541-7786.MCR-21-0099. Epub 2021 Apr 16. PubMed |
| Novel POLE mutations identified in patients with IMAGE-I syndrome cause aberrant subcellular localisation and protein degradation in the nucleus. Nakano T, Sasahara Y, Kikuchi A, Moriya K, Niizuma H, Niihori T, Shirota M, Funayama R, Nakayama K, Aoki Y, Kure S. J Med Genet. 2022 May 9. pii: jmedgenet-2021-108300. doi: 10.1136/jmedgenet-2021-108300. PubMed |
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