Tet-pLKO-neo Citations (37)
Originally described in: Single-vector inducible lentiviral RNAi system for oncology target validation.Wiederschain D, Wee S, Chen L, Loo A, Yang G, Huang A, Chen Y, Caponigro G, Yao YM, Lengauer C, Sellers WR, Benson JD Cell Cycle. 2009 Feb 1. 8(3):498-504. PubMed Journal
Articles Citing Tet-pLKO-neo
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Cancer vulnerabilities unveiled by genomic loss. Nijhawan D, Zack TI, Ren Y, Strickland MR, Lamothe R, Schumacher SE, Tsherniak A, Besche HC, Rosenbluh J, Shehata S, Cowley GS, Weir BA, Goldberg AL, Mesirov JP, Root DE, Bhatia SN, Beroukhim R, Hahn WC. Cell. 2012 Aug 17;150(4):842-54. doi: 10.1016/j.cell.2012.07.023. PubMed |
Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1-Positive Alveolar Rhabdomyosarcoma. Kephart JJ, Tiller RG, Crose LE, Slemmons KK, Chen PH, Hinson AR, Bentley RC, Chi JT, Linardic CM. Clin Cancer Res. 2015 Nov 1;21(21):4868-80. doi: 10.1158/1078-0432.CCR-14-1797. Epub 2015 Jun 12. PubMed |
Heat shock factor 1 induces cancer stem cell phenotype in breast cancer cell lines. Wang B, Lee CW, Witt A, Thakkar A, Ince TA. Breast Cancer Res Treat. 2015 Aug;153(1):57-66. doi: 10.1007/s10549-015-3521-1. Epub 2015 Jul 30. PubMed |
SOX11 and HIG-2 are cross-regulated and affect growth in mantle cell lymphoma. Kuci V, Nordstrom L, Conrotto P, Ek S. Leuk Lymphoma. 2016 Jan 12:1-10. PubMed |
An integrin beta4-EGFR unit promotes hepatocellular carcinoma lung metastases by enhancing anchorage independence through activation of FAK-AKT pathway. Leng C, Zhang ZG, Chen WX, Luo HP, Song J, Dong W, Zhu XR, Chen XP, Liang HF, Zhang BX. Cancer Lett. 2016 Jun 28;376(1):188-96. doi: 10.1016/j.canlet.2016.03.023. Epub 2016 Mar 17. PubMed |
KLF4 transcriptionally activates non-canonical WNT5A to control epithelial stratification. Tetreault MP, Weinblatt D, Shaverdashvili K, Yang Y, Katz JP. Sci Rep. 2016 May 17;6:26130. doi: 10.1038/srep26130. PubMed |
Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth. McIntyre A, Hulikova A, Ledaki I, Snell C, Singleton D, Steers G, Seden P, Jones D, Bridges E, Wigfield S, Li JL, Russell A, Swietach P, Harris AL. Cancer Res. 2016 Jul 1;76(13):3744-55. doi: 10.1158/0008-5472.CAN-15-1862. Epub 2016 May 17. PubMed |
Targeting endogenous DLK1 exerts antitumor effect on hepatocellular carcinoma through initiating cell differentiation. Cai CM, Xiao X, Wu BH, Wei BF, Han ZG. Oncotarget. 2016 Nov 1;7(44):71466-71476. doi: 10.18632/oncotarget.12214. PubMed |
Targeted depletion of PIK3R2 induces regression of lung squamous cell carcinoma. Vallejo-Diaz J, Olazabal-Moran M, Cariaga-Martinez AE, Pajares MJ, Flores JM, Pio R, Montuenga LM, Carrera AC. Oncotarget. 2016 Dec 20;7(51):85063-85078. doi: 10.18632/oncotarget.13195. PubMed |
TCF7L1 promotes skin tumorigenesis independently of beta-catenin through induction of LCN2. Ku AT, Shaver TM, Rao AS, Howard JM, Rodriguez CN, Miao Q, Garcia G, Le D, Yang D, Borowiak M, Cohen DN, Chitsazzadeh V, Diwan AH, Tsai KY, Nguyen H. Elife. 2017 May 3;6. pii: e23242. doi: 10.7554/eLife.23242. PubMed |
ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis. Bose R, Karthaus WR, Armenia J, Abida W, Iaquinta PJ, Zhang Z, Wongvipat J, Wasmuth EV, Shah N, Sullivan PS, Doran MG, Wang P, Patruno A, Zhao Y, Zheng D, Schultz N, Sawyers CL. Nature. 2017 Jun 29;546(7660):671-675. doi: 10.1038/nature22820. Epub 2017 Jun 14. PubMed |
A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma. Slemmons KK, Crose LES, Riedel S, Sushnitha M, Belyea B, Linardic CM. Mol Cancer Res. 2017 Dec;15(12):1777-1791. doi: 10.1158/1541-7786.MCR-17-0004. Epub 2017 Sep 18. PubMed |
PAX2 maintains the differentiation of mouse oviductal epithelium and inhibits the transition to a stem cell-like state. Alwosaibai K, Abedini A, Al-Hujaily EM, Tang Y, Garson K, Collins O, Vanderhyden BC. Oncotarget. 2017 Aug 10;8(44):76881-76897. doi: 10.18632/oncotarget.20173. eCollection 2017 Sep 29. PubMed |
Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts. Oda T, Sekimoto T, Kurashima K, Fujimoto M, Nakai A, Yamashita T. J Cell Sci. 2018 May 8;131(9). pii: jcs.210724. doi: 10.1242/jcs.210724. PubMed |
Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation. Ackerman D, Tumanov S, Qiu B, Michalopoulou E, Spata M, Azzam A, Xie H, Simon MC, Kamphorst JJ. Cell Rep. 2018 Sep 4;24(10):2596-2605.e5. doi: 10.1016/j.celrep.2018.08.015. PubMed |
Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy. Bertero T, Oldham WM, Grasset EM, Bourget I, Boulter E, Pisano S, Hofman P, Bellvert F, Meneguzzi G, Bulavin DV, Estrach S, Feral CC, Chan SY, Bozec A, Gaggioli C. Cell Metab. 2019 Jan 8;29(1):124-140.e10. doi: 10.1016/j.cmet.2018.09.012. Epub 2018 Oct 4. PubMed |
MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis.
Tu WB, Shiah YJ, Lourenco C, Mullen PJ, Dingar D, Redel C, Tamachi A, Ba-Alawi W, Aman A, Al-Awar R, Cescon DW, Haibe-Kains B, Arrowsmith CH, Raught B, Boutros PC, Penn LZ.
Cancer Cell. 2018 Oct 8;34(4):579-595.e8. doi: 10.1016/j.ccell.2018.09.001.
PubMed
Associated Plasmids |
Growth Factor Independence 1B-Mediated Transcriptional Repression and Lineage Allocation Require Lysine-Specific Demethylase 1-Dependent Recruitment of the BHC Complex. McClellan D, Casey MJ, Bareyan D, Lucente H, Ours C, Velinder M, Singer J, Lone MD, Sun W, Coria Y, Mason CC, Engel ME. Mol Cell Biol. 2019 Jun 13;39(13). pii: MCB.00020-19. doi: 10.1128/MCB.00020-19. Print 2019 Jul 1. PubMed |
How to Choose the Right Inducible Gene Expression System for Mammalian Studies? Kallunki T, Barisic M, Jaattela M, Liu B. Cells. 2019 Jul 30;8(8). pii: cells8080796. doi: 10.3390/cells8080796. PubMed |
Epidermal growth factor (EGF) triggers nuclear calcium signaling through the intranuclear phospholipase Cdelta-4 (PLCdelta4). de Miranda MC, Rodrigues MA, de Angelis Campos AC, Faria JAQA, Kunrath-Lima M, Mignery GA, Schechtman D, Goes AM, Nathanson MH, Gomes DA. J Biol Chem. 2019 Nov 8;294(45):16650-16662. doi: 10.1074/jbc.RA118.006961. Epub 2019 Sep 19. PubMed |
The spectraplakin Dystonin antagonizes YAP activity and suppresses tumourigenesis. Jain PB, Guerreiro PS, Canato S, Janody F. Sci Rep. 2019 Dec 27;9(1):19843. doi: 10.1038/s41598-019-56296-z. PubMed |
Heat-Triggered Remote Control of CRISPR-dCas9 for Tunable Transcriptional Modulation. Gamboa L, Phung EV, Li H, Meyers JP, Hart AC, Miller IC, Kwong GA. ACS Chem Biol. 2020 Feb 21;15(2):533-542. doi: 10.1021/acschembio.9b01005. Epub 2020 Jan 13. PubMed |
PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models. Hernandez AL, Young CD, Bian L, Weigel K, Nolan K, Frederick B, Han G, He G, Devon Trahan G, Rudolph MC, Jones KL, Oweida AJ, Karam SD, Raben D, Wang XJ. Clin Cancer Res. 2020 Jun 15;26(12):3058-3070. doi: 10.1158/1078-0432.CCR-19-0514. Epub 2020 Mar 5. PubMed |
Wnt signaling and Loxl2 promote aggressive osteosarcoma. Matsuoka K, Bakiri L, Wolff LI, Linder M, Mikels-Vigdal A, Patino-Garcia A, Lecanda F, Hartmann C, Sibilia M, Wagner EF. Cell Res. 2020 Jul 20. pii: 10.1038/s41422-020-0370-1. doi: 10.1038/s41422-020-0370-1. PubMed |
Loss of BRMS2 induces cell growth inhibition and translation capacity reduction in colorectal cancer cells. Liu Y, Xu W, Xu X, Tan Z, Xu J, Ma L, Du P, Yang Y. Am J Cancer Res. 2021 Mar 1;11(3):930-944. eCollection 2021. PubMed |
RNA sensing via the RIG-I-like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency. Stok JE, Oosenbrug T, Ter Haar LR, Gravekamp D, Bromley CP, Zelenay S, Reis E Sousa C, van der Veen AG. EMBO J. 2022 Mar 15;41(6):e109760. doi: 10.15252/embj.2021109760. Epub 2022 Feb 14. PubMed |
Integrative genome-wide analysis reveals EIF3A as a key downstream regulator of translational repressor protein Musashi 2 (MSI2). Karmakar S, Ramirez O, Paul KV, Gupta AK, Kumari V, Botti V, de Los Mozos IR, Neuenkirchen N, Ross RJ, Karanicolas J, Neugebauer KM, Pillai MM. NAR Cancer. 2022 May 2;4(2):zcac015. doi: 10.1093/narcan/zcac015. eCollection 2022 Jun. PubMed |
SETD4-mediated KU70 methylation suppresses apoptosis. Wang Y, Liu B, Lu H, Liu J, Romanienko PJ, Montelione GT, Shen Z. Cell Rep. 2022 May 10;39(6):110794. doi: 10.1016/j.celrep.2022.110794. PubMed |
TGFBR3 supports anoikis through suppressing ATF4 signaling. Hsu YJ, Yin YJ, Tsai KF, Jian CC, Liang ZW, Hsu CY, Wang CC. J Cell Sci. 2022 Sep 1;135(17):jcs258396. doi: 10.1242/jcs.258396. Epub 2022 Aug 30. PubMed |
Nuclear FGFR1 promotes pancreatic stellate cell-driven invasion through up-regulation of Neuregulin 1. Coetzee AS, Carter EP, Rodriguez-Fernandez L, Heward J, Wang Q, Karim SA, Boughetane L, Milton C, Uyulur F, Morton JP, Kocher HM, Grose RP. Oncogene. 2023 Feb;42(7):491-500. doi: 10.1038/s41388-022-02513-5. Epub 2022 Nov 10. PubMed |
Profilin 1 deficiency drives mitotic defects and reduces genome stability. Scotto di Carlo F, Russo S, Muyas F, Mangini M, Garribba L, Pazzaglia L, Genesio R, Biamonte F, De Luca AC, Santaguida S, Scotlandi K, Cortes-Ciriano I, Gianfrancesco F. Commun Biol. 2023 Jan 4;6(1):9. doi: 10.1038/s42003-022-04392-8. PubMed |
DNA damage-induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation. Oda T, Gotoh N, Kasamatsu T, Handa H, Saitoh T, Sasaki N. Cell Prolif. 2023 Jun;56(6):e13398. doi: 10.1111/cpr.13398. Epub 2023 Jan 15. PubMed |
Executioner caspases restrict mitochondrial RNA-driven Type I IFN induction during chemotherapy-induced apoptosis. Killarney ST, Washart R, Soderquist RS, Hoj JP, Lebhar J, Lin KH, Wood KC. Nat Commun. 2023 Mar 14;14(1):1399. doi: 10.1038/s41467-023-37146-z. PubMed |
Functional classification of DDOST variants of uncertain clinical significance in congenital disorders of glycosylation. Kas SM, Mundra PA, Smith DL, Marais R. Sci Rep. 2023 Oct 17;13(1):17648. doi: 10.1038/s41598-023-42178-y. PubMed |
Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing CDC73 and p53 mediated apoptosis. Yu Z, Dong X, Song M, Xu A, He Q, Li H, Ouyang W, Chouchane L, Ma X. Int J Cancer. 2024 Feb 15;154(4):723-737. doi: 10.1002/ijc.34769. Epub 2023 Oct 19. PubMed |
Heat shock factor 1 directly regulates transsulfuration pathway to promote prostate cancer proliferation and survival. Hauck JS, Moon D, Jiang X, Wang ME, Zhao Y, Xu L, Quang H, Butler W, Chen M, Macias E, Gao X, He Y, Huang J. Commun Biol. 2024 Jan 3;7(1):9. doi: 10.1038/s42003-023-05727-9. PubMed |
Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction. Kalkan BM, Ozcan SC, Cicek E, Gonen M, Acilan C. Cell Death Dis. 2024 Mar 16;15(3):222. doi: 10.1038/s41419-024-06601-0. PubMed |
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