pCDNA3-Myc3-Nrf2 Citations (33)
Originally described in: BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.Furukawa M, Xiong Y Mol Cell Biol. 2005 Jan . 25(1):162-71. PubMed Journal
Articles Citing pCDNA3-Myc3-Nrf2
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| Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation. Kim M, Kim S, Lim JH, Lee C, Choi HC, Woo CH. J Biol Chem. 2012 Nov 23;287(48):40722-31. doi: 10.1074/jbc.M112.381509. Epub 2012 Oct 5. PubMed |
| Bisphenol A activates the Nrf1/2-antioxidant response element pathway in HEK 293 cells. Chepelev NL, Enikanolaiye MI, Chepelev LL, Almohaisen A, Chen Q, Scoggan KA, Coughlan MC, Cao XL, Jin X, Willmore WG. Chem Res Toxicol. 2013 Mar 18;26(3):498-506. doi: 10.1021/tx400036v. Epub 2013 Feb 13. PubMed |
| Membrane-bound CYB5R3 is a common effector of nutritional and oxidative stress response through FOXO3a and Nrf2. Siendones E, SantaCruz-Calvo S, Martin-Montalvo A, Cascajo MV, Ariza J, Lopez-Lluch G, Villalba JM, Acquaviva-Bourdain C, Roze E, Bernier M, de Cabo R, Navas P. Antioxid Redox Signal. 2014 Oct 20;21(12):1708-25. doi: 10.1089/ars.2013.5479. Epub 2014 Feb 28. PubMed |
| RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1. Bakkar N, Kousari A, Kovalik T, Li Y, Bowser R. Mol Cell Biol. 2015 Jul 15;35(14):2385-99. doi: 10.1128/MCB.00087-15. Epub 2015 May 4. PubMed |
| Role of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram Syndrome. Cagalinec M, Liiv M, Hodurova Z, Hickey MA, Vaarmann A, Mandel M, Zeb A, Choubey V, Kuum M, Safiulina D, Vasar E, Veksler V, Kaasik A. PLoS Biol. 2016 Jul 19;14(7):e1002511. doi: 10.1371/journal.pbio.1002511. eCollection 2016 Jul. PubMed |
T-REX on-demand redox targeting in live cells.
Parvez S, Long MJ, Lin HY, Zhao Y, Haegele JA, Pham VN, Lee DK, Aye Y.
Nat Protoc. 2016 Dec;11(12):2328-2356. doi: 10.1038/nprot.2016.114. Epub 2016 Oct 27.
PubMed
Associated Plasmids |
| The Keap1-Nrf2 Stress Response Pathway Promotes Mitochondrial Hyperfusion Through Degradation of the Mitochondrial Fission Protein Drp1. Sabouny R, Fraunberger E, Geoffrion M, Ng AC, Baird SD, Screaton RA, Milne R, McBride HM, Shutt TE. Antioxid Redox Signal. 2017 Dec 20;27(18):1447-1459. doi: 10.1089/ars.2016.6855. Epub 2017 Jul 7. PubMed |
| beta-TrCP1 Is a Vacillatory Regulator of Wnt Signaling. Long MJ, Lin HY, Parvez S, Zhao Y, Poganik JR, Huang P, Aye Y. Cell Chem Biol. 2017 Aug 17;24(8):944-957.e7. doi: 10.1016/j.chembiol.2017.06.009. Epub 2017 Jul 20. PubMed |
| iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding. Ge W, Zhao K, Wang X, Li H, Yu M, He M, Xue X, Zhu Y, Zhang C, Cheng Y, Jiang S, Hu Y. Cancer Cell. 2017 Nov 13;32(5):561-573.e6. doi: 10.1016/j.ccell.2017.09.008. Epub 2017 Oct 12. PubMed |
| A hypermorphic antioxidant response element is associated with increased MS4A6A expression and Alzheimer's disease. Lacher SE, Alazizi A, Wang X, Bell DA, Pique-Regi R, Luca F, Slattery M. Redox Biol. 2018 Apr;14:686-693. doi: 10.1016/j.redox.2017.10.018. Epub 2017 Oct 27. PubMed |
| A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib. Ebelt ND, Kaoud TS, Edupuganti R, Van Ravenstein S, Dalby KN, Van Den Berg CL. Oncotarget. 2017 Aug 24;8(62):104894-104912. doi: 10.18632/oncotarget.20581. eCollection 2017 Dec 1. PubMed |
| Targeting the upstream transcriptional activator of PD-L1 as an alternative strategy in melanoma therapy. Zhu B, Tang L, Chen S, Yin C, Peng S, Li X, Liu T, Liu W, Han C, Stawski L, Xu ZX, Zhou G, Chen X, Gao X, Goding CR, Xu N, Cui R, Cao P. Oncogene. 2018 Sep;37(36):4941-4954. doi: 10.1038/s41388-018-0314-0. Epub 2018 May 22. PubMed |
| TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy. Jena KK, Kolapalli SP, Mehto S, Nath P, Das B, Sahoo PK, Ahad A, Syed GH, Raghav SK, Senapati S, Chauhan S, Chauhan S. EMBO J. 2018 Sep 14;37(18). pii: embj.201798358. doi: 10.15252/embj.201798358. Epub 2018 Aug 24. PubMed |
| Nuclear RNR-alpha antagonizes cell proliferation by directly inhibiting ZRANB3. Fu Y, Long MJC, Wisitpitthaya S, Inayat H, Pierpont TM, Elsaid IM, Bloom JC, Ortega J, Weiss RS, Aye Y. Nat Chem Biol. 2018 Oct;14(10):943-954. doi: 10.1038/s41589-018-0113-5. Epub 2018 Aug 27. PubMed |
| A catalogue of somatic NRF2 gain-of-function mutations in cancer. Kerins MJ, Ooi A. Sci Rep. 2018 Aug 27;8(1):12846. doi: 10.1038/s41598-018-31281-0. PubMed |
| Andalucin from Artemisia lannta suppresses the neuroinflammation via the promotion of Nrf2-mediated HO-1 levels by blocking the p65-p300 interaction in LPS-activated BV2 microglia. Wang X, Gai YN, Li BB, Huang LL. Phytomedicine. 2018 Dec 1;51:226-232. doi: 10.1016/j.phymed.2018.06.014. Epub 2018 Jun 23. PubMed |
| Diosmetin induces apoptosis and enhances the chemotherapeutic efficacy of paclitaxel in non-small cell lung cancer cells via Nrf2 inhibition. Chen X, Wu Q, Chen Y, Zhang J, Li H, Yang Z, Yang Y, Deng Y, Zhang L, Liu B. Br J Pharmacol. 2019 Jun;176(12):2079-2094. doi: 10.1111/bph.14652. Epub 2019 May 11. PubMed |
| Axonal pathology in hPSC-based models of Parkinson's disease results from loss of Nrf2 transcriptional activity at the Map1b gene locus. Czaniecki C, Ryan T, Stykel MG, Drolet J, Heide J, Hallam R, Wood S, Coackley C, Sherriff K, Bailey CDC, Ryan SD. Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14280-14289. doi: 10.1073/pnas.1900576116. Epub 2019 Jun 24. PubMed |
| HTLV-1 basic leucine zipper factor protects cells from oxidative stress by upregulating expression of Heme Oxygenase I. Rushing AW, Rushing B, Hoang K, Sanders SV, Peloponese JM Jr, Polakowski N, Lemasson I. PLoS Pathog. 2019 Jun 28;15(6):e1007922. doi: 10.1371/journal.ppat.1007922. eCollection 2019 Jun. PubMed |
| NRF2 SUMOylation promotes de novo serine synthesis and maintains HCC tumorigenesis. Guo H, Xu J, Zheng Q, He J, Zhou W, Wang K, Huang X, Fan Q, Ma J, Cheng J, Mei W, Xing R, Cai R. Cancer Lett. 2019 Dec 1;466:39-48. doi: 10.1016/j.canlet.2019.09.010. Epub 2019 Sep 20. PubMed |
| Decoupling of Nrf2 Expression Promotes Mesenchymal State Maintenance in Non-Small Cell Lung Cancer. Haley JA, Ruiz CF, Montal ED, Wang D, Haley JD, Girnun GD. Cancers (Basel). 2019 Oct 2;11(10). pii: cancers11101488. doi: 10.3390/cancers11101488. PubMed |
| Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance. Liu N, Lin X, Huang C. Br J Cancer. 2020 Jan;122(2):279-292. doi: 10.1038/s41416-019-0660-x. Epub 2019 Dec 10. PubMed |
| Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. Shin JW, Chun KS, Kim DH, Kim SJ, Kim SH, Cho NC, Na HK, Surh YJ. Biochem Pharmacol. 2020 Mar;173:113820. doi: 10.1016/j.bcp.2020.113820. Epub 2020 Jan 20. PubMed |
| The positive feedback loop between Nrf2 and phosphogluconate dehydrogenase stimulates proliferation and clonogenicity of human hepatoma cells. Ong AJ, Saeidi S, Chi NHK, Kim SJ, Kim DH, Kim SH, Park SA, Cha YN, Na HK, Surh YJ. Free Radic Res. 2020 May 27:1-12. doi: 10.1080/10715762.2020.1761547. PubMed |
| Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds. Castiglione GM, Xu Z, Zhou L, Duh EJ. Nat Commun. 2020 May 18;11(1):2476. doi: 10.1038/s41467-020-16129-4. PubMed |
| SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1. Zhang S, Wang J, Wang L, Aliyari S, Cheng G. Cell Mol Immunol. 2022 Aug;19(8):872-882. doi: 10.1038/s41423-022-00887-w. Epub 2022 Jun 23. PubMed |
| Z-REX uncovers a bifurcation in function of Keap1 paralogs. Van Hall-Beauvais A, Poganik JR, Huang KT, Parvez S, Zhao Y, Lin HY, Liu X, Long MJC, Aye Y. Elife. 2022 Oct 27;11:e83373. doi: 10.7554/eLife.83373. PubMed |
| ARD1 stabilizes NRF2 through direct interaction and promotes colon cancer progression. Fang X, Lee YH, Jang JH, Kim SJ, Kim SH, Kim DH, Na HK, Kim KO, Baek JH, Surh YJ. Life Sci. 2023 Jan 15;313:121217. doi: 10.1016/j.lfs.2022.121217. Epub 2022 Nov 25. PubMed |
| USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction. Hertel A, Alves LM, Dutz H, Tascher G, Bonn F, Kaulich M, Dikic I, Eimer S, Steinberg F, Bremm A. Cell Rep. 2022 Dec 6;41(10):111653. doi: 10.1016/j.celrep.2022.111653. PubMed |
| Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy. Xia Q, Li Y, Xu W, Wu C, Zheng H, Liu L, Dong L. Cell Biosci. 2023 Feb 21;13(1):37. doi: 10.1186/s13578-023-00978-9. PubMed |
| SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway. Dong L, Xu M, Li Y, Xu W, Wu C, Zheng H, Xiao Z, Sun G, Ding L, Li X, Li W, Zhou L, Xia Q. Cell Death Dis. 2023 Jun 14;14(6):361. doi: 10.1038/s41419-023-05873-2. PubMed |
| A NRF2 inhibitor selectively sensitizes KEAP1 mutant tumor cells to cisplatin and gefitinib by restoring NRF2-inhibitory function of KEAP1 mutants. Aboulkassim T, Tian X, Liu Q, Qiu D, Hancock M, Wu JH, Batist G. Cell Rep. 2023 Sep 26;42(9):113104. doi: 10.1016/j.celrep.2023.113104. Epub 2023 Sep 12. PubMed |
| Live-cell imaging Unveils stimulus-specific dynamics of Nrf2 activation in UV-exposed melanoma cells: Implications for antioxidant compound screening. Htut NW, Onkoksoong T, Saelim M, Kueanjinda P, Sampattavanich S, Panich U. Free Radic Biol Med. 2024 Feb 1;211:1-11. doi: 10.1016/j.freeradbiomed.2023.12.007. Epub 2023 Dec 11. PubMed |
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