pLKO mouse shRNA 1 raptor Citations (19)
Originally described in: An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, Gray NS J Biol Chem. 2009 Mar 20. 284(12):8023-32. PubMed Journal
Articles Citing pLKO mouse shRNA 1 raptor
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| Deficiency in mTORC1-controlled C/EBPbeta-mRNA translation improves metabolic health in mice. Zidek LM, Ackermann T, Hartleben G, Eichwald S, Kortman G, Kiehntopf M, Leutz A, Sonenberg N, Wang ZQ, von Maltzahn J, Muller C, Calkhoven CF. EMBO Rep. 2015 Aug;16(8):1022-36. doi: 10.15252/embr.201439837. Epub 2015 Jun 25. PubMed |
| DEPTOR promotes survival of cervical squamous cell carcinoma cells and its silencing induces apoptosis through downregulating PI3K/AKT and by up-regulating p38 MAP kinase. Srinivas KP, Viji R, Dan VM, Sajitha IS, Prakash R, Rahul PV, Santhoshkumar TR, Lakshmi S, Pillai MR. Oncotarget. 2016 Apr 26;7(17):24154-71. doi: 10.18632/oncotarget.8131. PubMed |
| mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease. Norambuena A, Wallrabe H, McMahon L, Silva A, Swanson E, Khan SS, Baerthlein D, Kodis E, Oddo S, Mandell JW, Bloom GS. Alzheimers Dement. 2016 Sep 29. pii: S1552-5260(16)32895-3. doi: 10.1016/j.jalz.2016.08.015. PubMed |
| NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres. Rai R, Hu C, Broton C, Chen Y, Lei M, Chang S. Mol Cell. 2017 Mar 2;65(5):801-817.e4. doi: 10.1016/j.molcel.2017.01.016. Epub 2017 Feb 16. PubMed |
| CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development. Dillon GM, Tyler WA, Omuro KC, Kambouris J, Tyminski C, Henry S, Haydar TF, Beffert U, Ho A. Neuron. 2017 Mar 22;93(6):1344-1358.e5. doi: 10.1016/j.neuron.2017.02.039. Epub 2017 Mar 9. PubMed |
| Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival. Pan Y, Smithson LJ, Ma Y, Hambardzumyan D, Gutmann DH. Oncotarget. 2017 May 16;8(20):32977-32989. doi: 10.18632/oncotarget.16516. PubMed |
| Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability. Johnson B, VanBlargan LA, Xu W, White JP, Shan C, Shi PY, Zhang R, Adhikari J, Gross ML, Leung DW, Diamond MS, Amarasinghe GK. Immunity. 2018 Mar 20;48(3):487-499.e5. doi: 10.1016/j.immuni.2018.01.014. Epub 2018 Mar 8. PubMed |
| Four Key Steps Control Glycolytic Flux in Mammalian Cells. Tanner LB, Goglia AG, Wei MH, Sehgal T, Parsons LR, Park JO, White E, Toettcher JE, Rabinowitz JD. Cell Syst. 2018 Jul 25;7(1):49-62.e8. doi: 10.1016/j.cels.2018.06.003. Epub 2018 Jun 27. PubMed |
| ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer. Harwood FC, Klein Geltink RI, O'Hara BP, Cardone M, Janke L, Finkelstein D, Entin I, Paul L, Houghton PJ, Grosveld GC. Sci Adv. 2018 Sep 12;4(9):eaar3938. doi: 10.1126/sciadv.aar3938. eCollection 2018 Sep. PubMed |
| A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-beta oligomers. Norambuena A, Wallrabe H, Cao R, Wang DB, Silva A, Svindrych Z, Periasamy A, Hu S, Tanzi RE, Kim DY, Bloom GS. EMBO J. 2018 Nov 15;37(22):e100241. doi: 10.15252/embj.2018100241. Epub 2018 Oct 22. PubMed |
| Mechanism of Regulation of Big-Conductance Ca(2+)-Activated K(+) Channels by mTOR Complex 2 in Podocytes. Wang Y, Tao J, Wang M, Yang L, Ning F, Xin H, Xu X, Cai H, Zhang W, Yu K, Zhang X. Front Physiol. 2019 Feb 28;10:167. doi: 10.3389/fphys.2019.00167. eCollection 2019. PubMed |
| A Strategic Approach for Fluorescence Imaging of Membrane Proteins in a Native-like Environment. Swiecicki JM, Santana JT, Imperiali B. Cell Chem Biol. 2019 Dec 3. pii: S2451-9456(19)30390-3. doi: 10.1016/j.chembiol.2019.11.008. PubMed |
| Targeted therapy for mTORC1-driven tumours through HDAC inhibition by exploiting innate vulnerability of mTORC1 hyper-activation. Yang F, Sun S, Wang C, Haas M, Yeo S, Guan JL. Br J Cancer. 2020 Jun;122(12):1791-1802. doi: 10.1038/s41416-020-0839-1. Epub 2020 Apr 27. PubMed |
Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus.
Zhou X, Zhong Y, Molinar-Inglis O, Kunkel MT, Chen M, Sun T, Zhang J, Shyy JY, Trejo J, Newton AC, Zhang J.
Nat Commun. 2020 Nov 30;11(1):6088. doi: 10.1038/s41467-020-19937-w.
PubMed
Associated Plasmids |
Rheb regulates nuclear mTORC1 activity independent of farnesylation.
Zhong Y, Zhou X, Guan KL, Zhang J.
Cell Chem Biol. 2022 Jun 16;29(6):1037-1045.e4. doi: 10.1016/j.chembiol.2022.02.006. Epub 2022 Mar 15.
PubMed
Associated Plasmids |
| mTORC2 suppresses cell death induced by hypo-osmotic stress by promoting sphingomyelin transport. Ono Y, Matsuzawa K, Ikenouchi J. J Cell Biol. 2022 Apr 4;221(4):e202106160. doi: 10.1083/jcb.202106160. Epub 2022 Mar 23. PubMed |
| Sequence and chromatin features guide DNA double-strand break resection initiation. Gnugge R, Reginato G, Cejka P, Symington LS. Mol Cell. 2023 Apr 20;83(8):1237-1250.e15. doi: 10.1016/j.molcel.2023.02.010. Epub 2023 Mar 13. PubMed |
| YOLOX-DG robotic detection systems for large-scale underwater concrete structures. Zhang C, Ma H, Chen Z, Li S, Ma Z, Huang H, Zhu R, Jiao P. iScience. 2024 Feb 28;27(4):109337. doi: 10.1016/j.isci.2024.109337. eCollection 2024 Apr 19. PubMed |
| Transcriptome regulation by PARP13 in basal and antiviral states in human cells. Busa VF, Ando Y, Aigner S, Yee BA, Yeo GW, Leung AKL. iScience. 2024 Feb 16;27(4):109251. doi: 10.1016/j.isci.2024.109251. eCollection 2024 Apr 19. PubMed |
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