pRK5 FLAG human DEPTOR Citations (15)

Originally described in: DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival.
Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, Gray NS, Sabatini DM Cell. 2009 May 13. ():. PubMed Journal

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Articles Citing pRK5 FLAG human DEPTOR

Articles
The endosomal sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of rapamycin antagonist DEPTOR. Verma R, Marchese A. J Biol Chem. 2015 Mar 13;290(11):6810-24. doi: 10.1074/jbc.M114.606699. Epub 2015 Jan 20. PubMed
Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy. Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, Sorino C, Ponzoni M, Bossi G, Federico V, La Rosa F, Ricciardi MR, Lesma E, De Meo PD, Castrignano T, Petrucci MT, Pisani F, Chesi M, Bergsagel PL, Floridi A, Tonon G, Passananti C, Blandino G, Fanciulli M. EMBO J. 2015 May 5;34(9):1214-30. doi: 10.15252/embj.201489920. Epub 2015 Mar 14. PubMed
p38gamma and delta promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation. Gonzalez-Teran B, Lopez JA, Rodriguez E, Leiva L, Martinez-Martinez S, Bernal JA, Jimenez-Borreguero LJ, Redondo JM, Vazquez J, Sabio G. Nat Commun. 2016 Jan 22;7:10477. doi: 10.1038/ncomms10477. PubMed
DEPTOR promotes survival of cervical squamous cell carcinoma cells and its silencing induces apoptosis through downregulating PI3K/AKT and by up-regulating p38 MAP kinase. Srinivas KP, Viji R, Dan VM, Sajitha IS, Prakash R, Rahul PV, Santhoshkumar TR, Lakshmi S, Pillai MR. Oncotarget. 2016 Apr 26;7(17):24154-71. doi: 10.18632/oncotarget.8131. PubMed
The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Carbonneau M, M Gagne L, Lalonde ME, Germain MA, Motorina A, Guiot MC, Secco B, Vincent EE, Tumber A, Hulea L, Bergeman J, Oppermann U, Jones RG, Laplante M, Topisirovic I, Petrecca K, Huot ME, Mallette FA. Nat Commun. 2016 Sep 14;7:12700. doi: 10.1038/ncomms12700. PubMed
Deptor transcriptionally regulates endoplasmic reticulum homeostasis in multiple myeloma cells. Catena V, Bruno T, De Nicola F, Goeman F, Pallocca M, Iezzi S, Sorino C, Cigliana G, Floridi A, Blandino G, Fanciulli M. Oncotarget. 2016 Oct 25;7(43):70546-70558. doi: 10.18632/oncotarget.12060. PubMed
MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1. Brown MC, Gromeier M. Cell Rep. 2017 Feb 7;18(6):1444-1457. doi: 10.1016/j.celrep.2017.01.023. PubMed
DEPTOR Deficiency-Mediated mTORc1 Hyperactivation in Vascular Endothelial Cells Promotes Angiogenesis. Ding Y, Shan L, Nai W, Lin X, Zhou L, Dong X, Wu H, Xiao M, Zhou X, Wang L, Li T, Fu Y, Lin Y, Jia C, Dai M, Bai X. Cell Physiol Biochem. 2018;46(2):520-531. doi: 10.1159/000488619. Epub 2018 Mar 26. PubMed
Loss of DEPTOR in renal tubules protects against cisplatin-induced acute kidney injury. Wang C, Dai H, Xiong Z, Song Q, Zou Z, Li M, Nie J, Bai X, Chen Z. Cell Death Dis. 2018 May 1;9(5):441. doi: 10.1038/s41419-018-0483-3. PubMed
Phosphoproteome Analysis Reveals Estrogen-ER Pathway as a Modulator of mTOR Activity Via DEPTOR. Cuesta R, Gritsenko MA, Petyuk VA, Shukla AK, Tsai CF, Liu T, McDermott JE, Holz MK. Mol Cell Proteomics. 2019 Aug;18(8):1607-1618. doi: 10.1074/mcp.RA119.001506. Epub 2019 Jun 12. PubMed
DEPTOR Prevents Osteoarthritis Development Via Interplay With TRC8 to Reduce Endoplasmic Reticulum Stress in Chondrocytes. Li K, Yang P, Zhang Y, Zhang Y, Cao H, Liu P, Huang B, Xu S, Lai P, Lei G, Liu J, Tang Y, Bai X, Zou Z. J Bone Miner Res. 2021 Feb;36(2):400-411. doi: 10.1002/jbmr.4176. Epub 2020 Sep 24. PubMed
mTOR modulates resistance to gemcitabine in lung cancer in an MTORC2 dependent mechanism. Chawsheen MA, Dash PR. Cell Signal. 2021 May;81:109934. doi: 10.1016/j.cellsig.2021.109934. Epub 2021 Feb 3. PubMed
Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons. Kim SG, Lee S, Kim Y, Park J, Woo D, Kim D, Li Y, Shin W, Kang H, Yook C, Lee M, Kim K, Roh JD, Ryu J, Jung H, Um SM, Yang E, Kim H, Han J, Heo WD, Kim E. Nat Commun. 2021 May 11;12(1):2695. doi: 10.1038/s41467-021-22908-4. PubMed
Regulation of human mTOR complexes by DEPTOR. Walchli M, Berneiser K, Mangia F, Imseng S, Craigie LM, Stuttfeld E, Hall MN, Maier T. Elife. 2021 Sep 14;10. pii: 70871. doi: 10.7554/eLife.70871. PubMed
DEPTOR exacerbates bone-fat imbalance in osteoporosis by transcriptionally modulating BMSC differentiation. Ouyang Z, Kang D, Li K, Liang G, Liu Z, Mai Q, Chen Q, Yao C, Wei R, Tan X, Bai X, Huang B, Li Q. Biomed Pharmacother. 2022 Jul;151:113164. doi: 10.1016/j.biopha.2022.113164. Epub 2022 May 24. PubMed

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