pcDNA3-FLAG-Rheb Citations (9)
Originally described in: Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells.Urano J, Sato T, Matsuo T, Otsubo Y, Yamamoto M, Tamanoi F Proc Natl Acad Sci U S A. 2007 Feb 27. 104(9):3514-9. PubMed Journal
Articles Citing pcDNA3-FLAG-Rheb
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| cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity. Xie J, Ponuwei GA, Moore CE, Willars GB, Tee AR, Herbert TP. Cell Signal. 2011 Dec;23(12):1927-35. doi: 10.1016/j.cellsig.2011.06.025. Epub 2011 Jul 6. PubMed |
| Molecular Mechanism for the Control of Eukaryotic Elongation Factor 2 Kinase by pH: Role in Cancer Cell Survival. Xie J, Mikolajek H, Pigott CR, Hooper KJ, Mellows T, Moore CE, Mohammed H, Werner JM, Thomas GJ, Proud CG. Mol Cell Biol. 2015 May;35(10):1805-24. doi: 10.1128/MCB.00012-15. Epub 2015 Mar 16. PubMed |
| Point mutations of the mTOR-RHEB pathway in renal cell carcinoma. Ghosh AP, Marshall CB, Coric T, Shim EH, Kirkman R, Ballestas ME, Ikura M, Bjornsti MA, Sudarshan S. Oncotarget. 2015 Jul 20;6(20):17895-910. PubMed |
| The Andes Virus Nucleocapsid Protein Directs Basal Endothelial Cell Permeability by Activating RhoA. Gorbunova EE, Simons MJ, Gavrilovskaya IN, Mackow ER. MBio. 2016 Oct 25;7(5). pii: e01747-16. doi: 10.1128/mBio.01747-16. PubMed |
| mTOR Inhibition via Displacement of Phosphatidic Acid Induces Enhanced Cytotoxicity Specifically in Cancer Cells. Nguyen TL, Nokin MJ, Egorov M, Tome M, Bodineau C, Di Primo C, Minder L, Wdzieczak-Bakala J, Garcia-Alvarez MC, Bignon J, Thoison O, Delpech B, Surpateanu G, Frapart YM, Peyrot F, Abbas K, Teres S, Evrard S, Khatib AM, Soubeyran P, Iorga BI, Duran RV, Collin P. Cancer Res. 2018 Sep 15;78(18):5384-5397. doi: 10.1158/0008-5472.CAN-18-0232. Epub 2018 Jul 27. PubMed |
| Intersectin-1 interacts with the golgin GCC88 to couple the actin network and Golgi architecture. Makhoul C, Gosavi P, Duffield R, Delbridge B, Williamson NA, Gleeson PA. Mol Biol Cell. 2019 Feb 1;30(3):370-386. doi: 10.1091/mbc.E18-05-0313. Epub 2018 Dec 12. PubMed |
| Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis. Viscarra JA, Wang Y, Nguyen HP, Choi YG, Sul HS. Nat Commun. 2020 Feb 7;11(1):796. doi: 10.1038/s41467-020-14617-1. PubMed |
BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation.
da Silva Rosa SC, Martens MD, Field JT, Nguyen L, Kereliuk SM, Hai Y, Chapman D, Diehl-Jones W, Aliani M, West AR, Thliveris J, Ghavami S, Rampitsch C, Dolinsky VW, Gordon JW.
Autophagy. 2021 Sep;17(9):2257-2272. doi: 10.1080/15548627.2020.1821548. Epub 2020 Oct 12.
PubMed
Associated Plasmids |
| Translation initiation factor eIF3a regulates glucose metabolism and cell proliferation via promoting small GTPase Rheb synthesis and AMPK activation. Ma S, Dong Z, Huang Y, Liu JY, Zhang JT. J Biol Chem. 2022 Jul;298(7):102044. doi: 10.1016/j.jbc.2022.102044. Epub 2022 May 18. PubMed |
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