pRK5-HA GST RagC 75L Citations (20)
Originally described in: The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM Science. 2008 Jun 13. 320(5882):1496-501. PubMed Journal
Articles Citing pRK5-HA GST RagC 75L
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| A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. Cully M, Genevet A, Warne P, Treins C, Liu T, Bastien J, Baum B, Tapon N, Leevers SJ, Downward J. Mol Cell Biol. 2010 Jan;30(2):481-95. doi: 10.1128/MCB.00688-09. Epub 2009 Nov 16. PubMed |
| HIF-independent role of prolyl hydroxylases in the cellular response to amino acids. Duran RV, MacKenzie ED, Boulahbel H, Frezza C, Heiserich L, Tardito S, Bussolati O, Rocha S, Hall MN, Gottlieb E. Oncogene. 2013 Sep 19;32(38):4549-56. doi: 10.1038/onc.2012.465. Epub 2012 Oct 22. PubMed |
| Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes. Martina JA, Puertollano R. J Cell Biol. 2013 Feb 18;200(4):475-91. doi: 10.1083/jcb.201209135. Epub 2013 Feb 11. PubMed |
| Preliminary functional assessment and classification of DEPDC5 variants associated with focal epilepsy. van Kranenburg M, Hoogeveen-Westerveld M, Nellist M. Hum Mutat. 2015 Feb;36(2):200-9. doi: 10.1002/humu.22723. Epub 2014 Nov 27. PubMed |
| Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity. Carroll B, Maetzel D, Maddocks OD, Otten G, Ratcliff M, Smith GR, Dunlop EA, Passos JF, Davies OR, Jaenisch R, Tee AR, Sarkar S, Korolchuk VI. Elife. 2016 Jan 7;5. pii: e11058. doi: 10.7554/eLife.11058. PubMed |
| Regulation of mTORC1 by lysosomal calcium and calmodulin. Li RJ, Xu J, Fu C, Zhang J, Zheng YG, Jia H, Liu JO. Elife. 2016 Oct 27;5. pii: e19360. doi: 10.7554/eLife.19360. PubMed |
| The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons and mice. Khayati K, Antikainen H, Bonder EM, Weber GF, Kruger WD, Jakubowski H, Dobrowolski R. FASEB J. 2017 Feb;31(2):598-609. doi: 10.1096/fj.201600915R. Epub 2016 Oct 25. PubMed |
Galectins Control mTOR in Response to Endomembrane Damage.
Jia J, Abudu YP, Claude-Taupin A, Gu Y, Kumar S, Choi SW, Peters R, Mudd MH, Allers L, Salemi M, Phinney B, Johansen T, Deretic V.
Mol Cell. 2018 Apr 5;70(1):120-135.e8. doi: 10.1016/j.molcel.2018.03.009.
PubMed
Associated Plasmids |
| Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction. Pal R, Palmieri M, Chaudhury A, Klisch TJ, di Ronza A, Neilson JR, Rodney GG, Sardiello M. Nat Commun. 2018 Oct 19;9(1):4351. doi: 10.1038/s41467-018-06844-4. PubMed |
| Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression. Ericksen RE, Lim SL, McDonnell E, Shuen WH, Vadiveloo M, White PJ, Ding Z, Kwok R, Lee P, Radda GK, Toh HC, Hirschey MD, Han W. Cell Metab. 2019 May 7;29(5):1151-1165.e6. doi: 10.1016/j.cmet.2018.12.020. Epub 2019 Jan 17. PubMed |
| The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1. Demian WL, Persaud A, Jiang C, Coyaud E, Liu S, Kapus A, Kafri R, Raught B, Rotin D. Cell Rep. 2019 May 7;27(6):1886-1896.e6. doi: 10.1016/j.celrep.2019.04.034. PubMed |
| Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex. Hirst J, Hesketh GG, Gingras AC, Robinson MS. J Cell Biol. 2021 Feb 1;220(2). pii: 211690. doi: 10.1083/jcb.202002075. PubMed |
| TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism. Alesi N, Akl EW, Khabibullin D, Liu HJ, Nidhiry AS, Garner ER, Filippakis H, Lam HC, Shi W, Viswanathan SR, Morroni M, Ferguson SM, Henske EP. Nat Commun. 2021 Jul 12;12(1):4245. doi: 10.1038/s41467-021-24499-6. PubMed |
| ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway. Wrobel M, Cendrowski J, Szymanska E, Grebowicz-Maciukiewicz M, Budick-Harmelin N, Macias M, Szybinska A, Mazur M, Kolmus K, Goryca K, Dabrowska M, Paziewska A, Mikula M, Miaczynska M. Life Sci Alliance. 2022 Mar 30;5(7). pii: 5/7/e202101239. doi: 10.26508/lsa.202101239. Print 2022 Jul. PubMed |
| Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy-lysosomal pathway. Du X, Di Malta C, Fang Z, Shen T, Niu X, Chen M, Jin B, Yu H, Lei L, Gao W, Song Y, Wang Z, Xu C, Cao Z, Liu G, Li X. Acta Pharm Sin B. 2022 Jun;12(6):2869-2886. doi: 10.1016/j.apsb.2021.12.012. Epub 2021 Dec 22. PubMed |
| Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies. Akwa Y, Di Malta C, Zallo F, Gondard E, Lunati A, Diaz-de-Grenu LZ, Zampelli A, Boiret A, Santamaria S, Martinez-Preciado M, Cortese K, Kordower JH, Matute C, Lozano AM, Capetillo-Zarate E, Vaccari T, Settembre C, Baulieu EE, Tampellini D. Autophagy. 2023 Feb;19(2):660-677. doi: 10.1080/15548627.2022.2095791. Epub 2022 Jul 22. PubMed |
| Cytoskeletal vimentin regulates cell size and autophagy through mTORC1 signaling. Mohanasundaram P, Coelho-Rato LS, Modi MK, Urbanska M, Lautenschlager F, Cheng F, Eriksson JE. PLoS Biol. 2022 Sep 13;20(9):e3001737. doi: 10.1371/journal.pbio.3001737. eCollection 2022 Sep. PubMed |
| TFEB-mediated lysosomal exocytosis alleviates high-fat diet-induced lipotoxicity in the kidney. Nakamura J, Yamamoto T, Takabatake Y, Namba-Hamano T, Minami S, Takahashi A, Matsuda J, Sakai S, Yonishi H, Maeda S, Matsui S, Matsui I, Hamano T, Takahashi M, Goto M, Izumi Y, Bamba T, Sasai M, Yamamoto M, Matsusaka T, Niimura F, Yanagita M, Nakamura S, Yoshimori T, Ballabio A, Isaka Y. JCI Insight. 2023 Feb 22;8(4):e162498. doi: 10.1172/jci.insight.162498. PubMed |
| TFEB-dependent lysosome biogenesis is required for senescence. Curnock R, Yalci K, Palmfeldt J, Jaattela M, Liu B, Carroll B. EMBO J. 2023 May 2;42(9):e111241. doi: 10.15252/embj.2022111241. Epub 2023 Mar 27. PubMed |
| Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1. Malik N, Ferreira BI, Hollstein PE, Curtis SD, Trefts E, Weiser Novak S, Yu J, Gilson R, Hellberg K, Fang L, Sheridan A, Hah N, Shadel GS, Manor U, Shaw RJ. Science. 2023 Apr 21;380(6642):eabj5559. doi: 10.1126/science.abj5559. Epub 2023 Apr 21. PubMed |
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