HA-HIF1alpha P402A/P564A-pcDNA3 Citations (48)
Originally described in: The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo.Yan Q, Bartz S, Mao M, Li L, Kaelin WG Mol Cell Biol. 2007 Mar . 27(6):2092-102. PubMed Journal
Articles Citing HA-HIF1alpha P402A/P564A-pcDNA3
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| NF-kappaB suppresses HIF-1alpha response by competing for P300 binding. Mendonca DB, Mendonca G, Aragao FJ, Cooper LF. Biochem Biophys Res Commun. 2011 Jan 28;404(4):997-1003. doi: 10.1016/j.bbrc.2010.12.098. Epub 2010 Dec 25. PubMed |
| Interdependence of HIF-1alpha and TGF-beta/Smad3 signaling in normoxic and hypoxic renal epithelial cell collagen expression. Basu RK, Hubchak S, Hayashida T, Runyan CE, Schumacker PT, Schnaper HW. Am J Physiol Renal Physiol. 2011 Apr;300(4):F898-905. doi: 10.1152/ajprenal.00335.2010. Epub 2011 Jan 5. PubMed |
| Astrocyte pVHL and HIF-alpha isoforms are required for embryonic-to-adult vascular transition in the eye. Kurihara T, Westenskow PD, Krohne TU, Aguilar E, Johnson RS, Friedlander M. J Cell Biol. 2011 Nov 14;195(4):689-701. doi: 10.1083/jcb.201107029. PubMed |
| Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1alpha activity in hypoxia. Fujita N, Markova D, Anderson DG, Chiba K, Toyama Y, Shapiro IM, Risbud MV. J Biol Chem. 2012 May 11;287(20):16975-86. doi: 10.1074/jbc.M111.334466. Epub 2012 Mar 26. PubMed |
| The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells. Rider P, Kaplanov I, Romzova M, Bernardis L, Braiman A, Voronov E, Apte RN. Front Immunol. 2012 Sep 14;3:290. doi: 10.3389/fimmu.2012.00290. eCollection 2012. PubMed |
| Hypoxia-inducible factor (HIF)-1alpha and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1alpha level and transcriptional activity. Tran CM, Fujita N, Huang BL, Ong JR, Lyons KM, Shapiro IM, Risbud MV. J Biol Chem. 2013 May 3;288(18):12654-66. doi: 10.1074/jbc.M112.448860. Epub 2013 Mar 24. PubMed |
| TGF-beta/Smad3 activates mammalian target of rapamycin complex-1 to promote collagen production by increasing HIF-1alpha expression. Rozen-Zvi B, Hayashida T, Hubchak SC, Hanna C, Platanias LC, Schnaper HW. Am J Physiol Renal Physiol. 2013 Aug 15;305(4):F485-94. doi: 10.1152/ajprenal.00215.2013. Epub 2013 Jun 12. PubMed |
| Hypoxia-inducible factor-2alpha and TGF-beta signaling interact to promote normoxic glomerular fibrogenesis. Hanna C, Hubchak SC, Liang X, Rozen-Zvi B, Schumacker PT, Hayashida T, Schnaper HW. Am J Physiol Renal Physiol. 2013 Nov 1;305(9):F1323-31. doi: 10.1152/ajprenal.00155.2013. Epub 2013 Aug 14. PubMed |
| Gramicidin A induces metabolic dysfunction and energy depletion leading to cell death in renal cell carcinoma cells. David JM, Owens TA, Barwe SP, Rajasekaran AK. Mol Cancer Ther. 2013 Nov;12(11):2296-307. doi: 10.1158/1535-7163.MCT-13-0445. Epub 2013 Sep 4. PubMed |
| Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes. Taniguchi CM, Finger EC, Krieg AJ, Wu C, Diep AN, LaGory EL, Wei K, McGinnis LM, Yuan J, Kuo CJ, Giaccia AJ. Nat Med. 2013 Oct;19(10):1325-30. doi: 10.1038/nm.3294. Epub 2013 Sep 15. PubMed |
| Combined targeting of PDK1 and EGFR triggers regression of glioblastoma by reversing the Warburg effect. Velpula KK, Bhasin A, Asuthkar S, Tsung AJ. Cancer Res. 2013 Dec 15;73(24):7277-89. doi: 10.1158/0008-5472.CAN-13-1868. Epub 2013 Oct 22. PubMed |
| Paradoxical regulation of hypoxia inducible factor-1alpha (HIF-1alpha) by histone deacetylase inhibitor in diffuse large B-cell lymphoma. Bhalla S, Evens AM, Prachand S, Schumacker PT, Gordon LI. PLoS One. 2013 Nov 27;8(11):e81333. doi: 10.1371/journal.pone.0081333. eCollection 2013. PubMed |
| Gramicidin A blocks tumor growth and angiogenesis through inhibition of hypoxia-inducible factor in renal cell carcinoma. David JM, Owens TA, Inge LJ, Bremner RM, Rajasekaran AK. Mol Cancer Ther. 2014 Apr;13(4):788-99. doi: 10.1158/1535-7163.MCT-13-0891. Epub 2014 Feb 3. PubMed |
| HIF-1alpha downregulation and apoptosis in hypoxic prostate tumor cells infected with oncolytic mammalian orthoreovirus. Gupta-Saraf P, Miller CL. Oncotarget. 2014 Jan 30;5(2):561-74. PubMed |
| Convergence of hypoxia and TGFbeta pathways on cell cycle regulation in human hematopoietic stem/progenitor cells. Wierenga AT, Vellenga E, Schuringa JJ. PLoS One. 2014 Mar 31;9(3):e93494. doi: 10.1371/journal.pone.0093494. eCollection 2014. PubMed |
| Hypoxia reduces and redirects selenoprotein biosynthesis. Becker NP, Martitz J, Renko K, Stoedter M, Hybsier S, Cramer T, Schomburg L. Metallomics. 2014 May;6(5):1079-86. doi: 10.1039/c4mt00004h. PubMed |
| Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis. Joshi HP, Subramanian IV, Schnettler EK, Ghosh G, Rupaimoole R, Evans C, Saluja M, Jing Y, Cristina I, Roy S, Zeng Y, Shah VH, Sood AK, Ramakrishnan S. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5331-6. doi: 10.1073/pnas.1317242111. Epub 2014 Mar 24. PubMed |
| Hypoxia-inducible factor-1alpha induces ErbB4 signaling in the differentiating mammary gland. Paatero I, Seagroves TN, Vaparanta K, Han W, Jones FE, Johnson RS, Elenius K. J Biol Chem. 2014 Aug 8;289(32):22459-69. doi: 10.1074/jbc.M113.533497. Epub 2014 Jun 25. PubMed |
| Hypoxia promotes colon cancer dissemination through up-regulation of cell migration-inducing protein (CEMIP). Evensen NA, Li Y, Kuscu C, Liu J, Cathcart J, Banach A, Zhang Q, Li E, Joshi S, Yang J, Denoya PI, Pastorekova S, Zucker S, Shroyer KR, Cao J. Oncotarget. 2015 Aug 21;6(24):20723-39. PubMed |
| Estrogen Receptor beta2 Induces Hypoxia Signature of Gene Expression by Stabilizing HIF-1alpha in Prostate Cancer. Dey P, Velazquez-Villegas LA, Faria M, Turner A, Jonsson P, Webb P, Williams C, Gustafsson JA, Strom AM. PLoS One. 2015 May 26;10(5):e0128239. doi: 10.1371/journal.pone.0128239. eCollection 2015. PubMed |
| HIF-1alpha/MDR1 pathway confers chemoresistance to cisplatin in bladder cancer. Sun Y, Guan Z, Liang L, Cheng Y, Zhou J, Li J, Xu Y. Oncol Rep. 2015 Dec 29. doi: 10.3892/or.2015.4536. PubMed |
| Hypoxia-inducible factor-1alpha promotes glomerulosclerosis and regulates COL1A2 expression through interactions with Smad3. Baumann B, Hayashida T, Liang X, Schnaper HW. Kidney Int. 2016 Oct;90(4):797-808. doi: 10.1016/j.kint.2016.05.026. Epub 2016 Aug 5. PubMed |
| FGF11 induced by hypoxia interacts with HIF-1alpha and enhances its stability. Lee KW, Yim HS, Shin J, Lee C, Lee JH, Jeong JY. FEBS Lett. 2016 Dec 27. doi: 10.1002/1873-3468.12547. PubMed |
| GATA3 interacts with and stabilizes HIF-1alpha to enhance cancer cell invasiveness. Lin MC, Lin JJ, Hsu CL, Juan HF, Lou PJ, Huang MC. Oncogene. 2017 Jul 27;36(30):4243-4252. doi: 10.1038/onc.2017.8. Epub 2017 Mar 6. PubMed |
| Amplified centrosomes and mitotic index display poor concordance between patient tumors and cultured cancer cells. Mittal K, Choi DH, Ogden A, Donthamsetty S, Melton BD, Gupta MV, Pannu V, Cantuaria G, Varambally S, Reid MD, Jonsdottir K, Janssen EA, Aleskandarany MA, Ellis IO, Rakha EA, Rida PC, Aneja R. Sci Rep. 2017 Mar 8;7:43984. doi: 10.1038/srep43984. PubMed |
| Nkx3.2 induces oxygen concentration-independent and lysosome-dependent degradation of HIF-1alpha to modulate hypoxic responses in chondrocytes. Im S, Kim DW. Cell Signal. 2017 Aug;36:127-138. doi: 10.1016/j.cellsig.2017.05.001. Epub 2017 May 4. PubMed |
| Hypoxia-inducible factor-1alpha plays roles in Epstein-Barr virus's natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter. Kraus RJ, Yu X, Cordes BA, Sathiamoorthi S, Iempridee T, Nawandar DM, Ma S, Romero-Masters JC, McChesney KG, Lin Z, Makielski KR, Lee DL, Lambert PF, Johannsen EC, Kenney SC, Mertz JE. PLoS Pathog. 2017 Jun 15;13(6):e1006404. doi: 10.1371/journal.ppat.1006404. eCollection 2017 Jun. PubMed |
| XIAP upregulates expression of HIF target genes by targeting HIF1alpha for Lys63-linked polyubiquitination. Park CV, Ivanova IG, Kenneth NS. Nucleic Acids Res. 2017 Jun 28. doi: 10.1093/nar/gkx549. PubMed |
| Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1. Rosner M, Pham HTT, Moriggl R, Hengstschlager M. Nat Commun. 2017 Sep 19;8(1):595. doi: 10.1038/s41467-017-00661-x. PubMed |
| HIF1-alpha expressing cells induce a hypoxic-like response in neighbouring cancer cells. Harrison H, Pegg HJ, Thompson J, Bates C, Shore P. BMC Cancer. 2018 Jun 20;18(1):674. doi: 10.1186/s12885-018-4577-1. PubMed |
| Macrophage-Specific Hypoxia-Inducible Factor-1alpha Contributes to Impaired Autophagic Flux in Nonalcoholic Steatohepatitis. Wang X, de Carvalho Ribeiro M, Iracheta-Vellve A, Lowe P, Ambade A, Satishchandran A, Bukong T, Catalano D, Kodys K, Szabo G. Hepatology. 2019 Feb;69(2):545-563. doi: 10.1002/hep.30215. Epub 2019 Jan 4. PubMed |
| Resveratrol integrates metabolic and growth effects in PC3 prostate cancer cells-involvement of prolyl hydroxylase and hypoxia inducible factor-1. Fonseca J, Moradi F, Maddalena LA, Ferreira-Tollstadius B, Selim S, Stuart JA. Oncol Lett. 2019 Jan;17(1):697-705. doi: 10.3892/ol.2018.9526. Epub 2018 Sep 28. PubMed |
| MYC Regulates the HIF2alpha Stemness Pathway via Nanog and Sox2 to Maintain Self-Renewal in Cancer Stem Cells versus Non-Stem Cancer Cells. Das B, Pal B, Bhuyan R, Li H, Sarma A, Gayan S, Talukdar J, Sandhya S, Bhuyan S, Gogoi G, Gouw AM, Baishya D, Gotlib JR, Kataki AC, Felsher DW. Cancer Res. 2019 Jul 2. pii: 0008-5472.CAN-18-2847. doi: 10.1158/0008-5472.CAN-18-2847. PubMed |
| A hierarchical network of hypoxia-inducible factor and SMAD proteins governs procollagen lysyl hydroxylase 2 induction by hypoxia and transforming growth factor beta1. Rosell-Garcia T, Palomo-Alvarez O, Rodriguez-Pascual F. J Biol Chem. 2019 Sep 27;294(39):14308-14318. doi: 10.1074/jbc.RA119.007674. Epub 2019 Aug 7. PubMed |
| Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes. Khan H, Anshu A, Prasad A, Roy S, Jeffery J, Kittipongdaja W, Yang DT, Schieke SM. Cell Rep. 2019 Dec 3;29(10):3009-3018.e4. doi: 10.1016/j.celrep.2019.11.007. PubMed |
| DEAD Box Protein Family Member DDX28 Is a Negative Regulator of Hypoxia-Inducible Factor 2alpha- and Eukaryotic Initiation Factor 4E2-Directed Hypoxic Translation. Evagelou SL, Bebenek O, Specker EJ, Uniacke J. Mol Cell Biol. 2020 Feb 27;40(6). pii: MCB.00610-19. doi: 10.1128/MCB.00610-19. Print 2020 Feb 27. PubMed |
| Non-viral gene delivery of HIF-1alpha promotes angiogenesis in human adipose-derived stem cells. Est-Witte SE, Farris AL, Tzeng SY, Hutton DL, Gong DH, Calabresi KG, Grayson WL, Green JJ. Acta Biomater. 2020 Sep 1;113:279-288. doi: 10.1016/j.actbio.2020.06.042. Epub 2020 Jul 2. PubMed |
| Enhancer-bound Nrf2 licenses HIF-1alpha transcription under hypoxia to promote cisplatin resistance in hepatocellular carcinoma cells. Jin X, Gong L, Peng Y, Li L, Liu G. Aging (Albany NY). 2020 Dec 3;13(1):364-375. doi: 10.18632/aging.202137. Epub 2020 Dec 3. PubMed |
| FIH-1-modulated HIF-1alpha C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling. Li ZL, Wang B, Lv LL, Tang TT, Wen Y, Cao JY, Zhu XX, Feng ST, Crowley SD, Liu BC. Acta Pharmacol Sin. 2021 Dec;42(12):2106-2119. doi: 10.1038/s41401-021-00617-4. Epub 2021 Mar 3. PubMed |
| Hypoxia-Inducible Factor 1 Alpha-Mediated RelB/APOBEC3B Down-regulation Allows Hepatitis B Virus Persistence. Riedl T, Faure-Dupuy S, Rolland M, Schuehle S, Hizir Z, Calderazzo S, Zhuang X, Wettengel J, Lopez MA, Barnault R, Mirakaj V, Prokosch S, Heide D, Leuchtenberger C, Schneider M, Hessling B, Stottmeier B, Wessbecher IM, Schirmacher P, McKeating JA, Protzer U, Durantel D, Lucifora J, Dejardin E, Heikenwalder M. Hepatology. 2021 May 15. doi: 10.1002/hep.31902. PubMed |
| Hypoxia-Induced MALAT1 Promotes the Proliferation and Migration of Breast Cancer Cells by Sponging MiR-3064-5p. Shih CH, Chuang LL, Tsai MH, Chen LH, Chuang EY, Lu TP, Lai LC. Front Oncol. 2021 May 3;11:658151. doi: 10.3389/fonc.2021.658151. eCollection 2021. PubMed |
| Hypoxia-inducible factor 1-alpha enhances the secretome to rejuvenate adult cardiosphere-derived cells. Saha P, Kim M, Tulshyan A, Guo Y, Mishra R, Li D, Civin CI, Kaushal S, Sharma S. J Thorac Cardiovasc Surg. 2021 Jul 17. pii: S0022-5223(21)01046-1. doi: 10.1016/j.jtcvs.2021.07.015. PubMed |
| HIF2 Regulates Intestinal Wnt5a Expression. Garcia Garcia CJ, Acevedo Diaz AC, Kumari N, Govindaraju S, de la Cruz Bonilla M, San Lucas FA, Nguyen ND, Jimenez Sacarello I, Piwnica-Worms H, Maitra A, Taniguchi CM. Front Oncol. 2021 Nov 25;11:769385. doi: 10.3389/fonc.2021.769385. eCollection 2021. PubMed |
| Hypoxia-induced HIF1alpha activation regulates small extracellular vesicle release in human embryonic kidney cells. Muniz-Garcia A, Romero M, Falcomicronn-Perez JM, Murray P, Zorzano A, Mora S. Sci Rep. 2022 Jan 27;12(1):1443. doi: 10.1038/s41598-022-05161-7. PubMed |
| Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation. Medeiros PJ, Pascetta SA, Kirsh SM, Al-Khazraji BK, Uniacke J. J Biol Chem. 2022 Mar;298(3):101645. doi: 10.1016/j.jbc.2022.101645. Epub 2022 Jan 27. PubMed |
| Endothelial PPARdelta facilitates the post-ischemic vascular repair through interaction with HIF1alpha. Wu Y, Tang X, Lee S, Hong H, Cao X, Lau CW, Liu B, Chawla A, Ma RCW, Huang Y, Lui KO, Tian XY. Theranostics. 2022 Jan 24;12(4):1855-1869. doi: 10.7150/thno.69017. eCollection 2022. PubMed |
| Regulatory mechanisms and function of hypoxia-induced long noncoding RNA NDRG1-OT1 in breast cancer cells. Chao HH, Luo JL, Hsu MH, Chen LH, Lu TP, Tsai MH, Chuang EY, Chuang LL, Lai LC. Cell Death Dis. 2022 Sep 20;13(9):807. doi: 10.1038/s41419-022-05253-2. PubMed |
| Hypoxia regulates CD9 expression and dissemination of B lymphoblasts. Rouger-Gaudichon J, Cousin E, Jakobczyk H, Debaize L, Rio AG, Forestier A, Arnaud MP, Villacreces A, Praloran V, Jacamo R, Galibert MD, Troadec MB, Gandemer V. Leuk Res. 2022 Dec;123:106964. doi: 10.1016/j.leukres.2022.106964. Epub 2022 Sep 28. PubMed |
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