HA-Ubiquitin Citations (165)
Originally described in: Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein.Kamitani T, Kito K, Nguyen HP, Yeh ET J Biol Chem. 1997 Nov 7. 272(45):28557-62. PubMed Journal
Articles Citing HA-Ubiquitin
| Articles |
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| Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment. Mookerjee S, Papanikolaou T, Guyenet SJ, Sampath V, Lin A, Vitelli C, DeGiacomo F, Sopher BL, Chen SF, La Spada AR, Ellerby LM. J Neurosci. 2009 Dec 2;29(48):15134-44. doi: 10.1523/JNEUROSCI.4720-09.2009. PubMed |
| SLUG-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination. Mittal MK, Singh K, Misra S, Chaudhuri G. J Biol Chem. 2011 Jan 7;286(1):469-79. doi: 10.1074/jbc.M110.164384. Epub 2010 Nov 2. PubMed |
| Serine phosphorylation regulates disabled-1 early isoform turnover independently of Reelin. Gao Z, Godbout R. Cell Signal. 2011 Mar;23(3):555-65. doi: 10.1016/j.cellsig.2010.11.007. Epub 2010 Nov 25. PubMed |
| Ubiquitination of BST-2 protein by HIV-1 Vpu protein does not require lysine, serine, or threonine residues within the BST-2 cytoplasmic domain. Gustin JK, Douglas JL, Bai Y, Moses AV. J Biol Chem. 2012 Apr 27;287(18):14837-50. doi: 10.1074/jbc.M112.349928. Epub 2012 Mar 1. PubMed |
| FANCL ubiquitinates beta-catenin and enhances its nuclear function. Dao KH, Rotelli MD, Petersen CL, Kaech S, Nelson WD, Yates JE, Hanlon Newell AE, Olson SB, Druker BJ, Bagby GC. Blood. 2012 Jul 12;120(2):323-34. doi: 10.1182/blood-2011-11-388355. Epub 2012 May 31. PubMed |
| Hydrogen sulfide inhibits the translational expression of hypoxia-inducible factor-1alpha. Wu B, Teng H, Yang G, Wu L, Wang R. Br J Pharmacol. 2012 Dec;167(7):1492-505. doi: 10.1111/j.1476-5381.2012.02113.x. PubMed |
| c-IAP1 binds and processes PCSK9 protein: linking the c-IAP1 in a TNF-alpha pathway to PCSK9-mediated LDLR degradation pathway. Xu W, Liu L, Hornby D. Molecules. 2012 Oct 15;17(10):12086-101. doi: 10.3390/molecules171012086. PubMed |
| Downregulation of TRAF2 mediates NIK-induced pancreatic cancer cell proliferation and tumorigenicity. Doppler H, Liou GY, Storz P. PLoS One. 2013;8(1):e53676. doi: 10.1371/journal.pone.0053676. Epub 2013 Jan 3. PubMed |
| Supervillin-mediated suppression of p53 protein enhances cell survival. Fang Z, Luna EJ. J Biol Chem. 2013 Mar 15;288(11):7918-29. doi: 10.1074/jbc.M112.416842. Epub 2013 Feb 4. PubMed |
| Activation of duck RIG-I by TRIM25 is independent of anchored ubiquitin. Miranzo-Navarro D, Magor KE. PLoS One. 2014 Jan 23;9(1):e86968. doi: 10.1371/journal.pone.0086968. eCollection 2014. PubMed |
| A COFRADIC protocol to study protein ubiquitination. Stes E, Laga M, Walton A, Samyn N, Timmerman E, De Smet I, Goormachtig S, Gevaert K. J Proteome Res. 2014 Jun 6;13(6):3107-13. doi: 10.1021/pr4012443. Epub 2014 May 20. PubMed |
| BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria. Choubey V, Cagalinec M, Liiv J, Safiulina D, Hickey MA, Kuum M, Liiv M, Anwar T, Eskelinen EL, Kaasik A. Autophagy. 2014 Jun;10(6):1105-19. doi: 10.4161/auto.28615. PubMed |
| 14-3-3epsilon and zeta regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain. Toyo-oka K, Wachi T, Hunt RF, Baraban SC, Taya S, Ramshaw H, Kaibuchi K, Schwarz QP, Lopez AF, Wynshaw-Boris A. J Neurosci. 2014 Sep 3;34(36):12168-81. doi: 10.1523/JNEUROSCI.2513-13.2014. PubMed |
| APC/C(Cdh1) controls CtIP stability during the cell cycle and in response to DNA damage. Lafranchi L, de Boer HR, de Vries EG, Ong SE, Sartori AA, van Vugt MA. EMBO J. 2014 Dec 1;33(23):2860-79. doi: 10.15252/embj.201489017. Epub 2014 Oct 27. PubMed |
| The GST-BHMT assay reveals a distinct mechanism underlying proteasome inhibition-induced macroautophagy in mammalian cells. Rui YN, Xu Z, Chen Z, Zhang S. Autophagy. 2015;11(5):812-32. doi: 10.1080/15548627.2015.1034402. PubMed |
| Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation. Satpathy S, Wagner SA, Beli P, Gupta R, Kristiansen TA, Malinova D, Francavilla C, Tolar P, Bishop GA, Hostager BS, Choudhary C. Mol Syst Biol. 2015 Jun 2;11(6):810. doi: 10.15252/msb.20145880. PubMed |
| Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-Mediated Degradation. Li Q, Li Y, Gu B, Fang L, Zhou P, Bao S, Huang L, Dai X. J Biol Chem. 2015 Jul 13. pii: jbc.M115.639419. PubMed |
| PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection. Zhang Y, Mao D, Roswit WT, Jin X, Patel AC, Patel DA, Agapov E, Wang Z, Tidwell RM, Atkinson JJ, Huang G, McCarthy R, Yu J, Yun NE, Paessler S, Lawson TG, Omattage NS, Brett TJ, Holtzman MJ. Nat Immunol. 2015 Dec;16(12):1215-27. doi: 10.1038/ni.3279. Epub 2015 Oct 19. PubMed |
| p38gamma and delta promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation. Gonzalez-Teran B, Lopez JA, Rodriguez E, Leiva L, Martinez-Martinez S, Bernal JA, Jimenez-Borreguero LJ, Redondo JM, Vazquez J, Sabio G. Nat Commun. 2016 Jan 22;7:10477. doi: 10.1038/ncomms10477. PubMed |
| Studying Coxiella burnetii Type IV Substrates in the Yeast Saccharomyces cerevisiae: Focus on Subcellular Localization and Protein Aggregation. Rodriguez-Escudero M, Cid VJ, Molina M, Schulze-Luehrmann J, Luhrmann A, Rodriguez-Escudero I. PLoS One. 2016 Jan 28;11(1):e0148032. doi: 10.1371/journal.pone.0148032. eCollection 2016. PubMed |
| Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in giant axonal neuropathy. Israeli E, Dryanovski DI, Schumacker PT, Chandel NS, Singer JD, Julien JP, Goldman RD, Opal P. Hum Mol Genet. 2016 Jun 1;25(11):2143-2157. doi: 10.1093/hmg/ddw081. Epub 2016 Mar 21. PubMed |
An E3-ligase-based method for ablating inhibitory synapses.
Gross GG, Straub C, Perez-Sanchez J, Dempsey WP, Junge JA, Roberts RW, Trinh LA, Fraser SE, De Koninck Y, De Koninck P, Sabatini BL, Arnold DB.
Nat Methods. 2016 Jun 6. doi: 10.1038/nmeth.3894.
PubMed
Associated Plasmids |
| Over-expression of ASIC1a promotes proliferation via activation of the beta-catenin/LEF-TCF axis and is associated with disease outcome in liver cancer. Jin C, Yuan FL, Gu YL, Li X, Liu MF, Shen XM, Liu B, Zhu MQ. Oncotarget. 2017 Apr 18;8(16):25977-25988. doi: 10.18632/oncotarget.10774. PubMed |
| Cellular stress induces TRB3/USP9x-dependent Notch activation in cancer. Izrailit J, Jaiswal A, Zheng W, Moran MF, Reedijk M. Oncogene. 2016 Sep 5. doi: 10.1038/onc.2016.276. PubMed |
Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model.
Lasagna-Reeves CA, de Haro M, Hao S, Park J, Rousseaux MW, Al-Ramahi I, Jafar-Nejad P, Vilanova-Velez L, See L, De Maio A, Nitschke L, Wu Z, Troncoso JC, Westbrook TF, Tang J, Botas J, Zoghbi HY.
Neuron. 2016 Oct 19;92(2):407-418. doi: 10.1016/j.neuron.2016.09.022. Epub 2016 Oct 6.
PubMed
Associated Plasmids |
| Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer. Ni T, Li XY, Lu N, An T, Liu ZP, Fu R, Lv WC, Zhang YW, Xu XJ, Grant Rowe R, Lin YS, Scherer A, Feinberg T, Zheng XQ, Chen BA, Liu XS, Guo QL, Wu ZQ, Weiss SJ. Nat Cell Biol. 2016 Nov;18(11):1221-1232. doi: 10.1038/ncb3425. Epub 2016 Oct 17. PubMed |
| Prognostic significance of USP33 in advanced colorectal cancer patients: new insights into beta-arrestin-dependent ERK signaling. Liu H, Zhang Q, Li K, Gong Z, Liu Z, Xu Y, Swaney MH, Xiao K, Chen Y. Oncotarget. 2016 Dec 6;7(49):81223-81240. doi: 10.18632/oncotarget.13219. PubMed |
| De-ubiquitinating enzyme, USP11, promotes transforming growth factor beta-1 signaling through stabilization of transforming growth factor beta receptor II. Jacko AM, Nan L, Li S, Tan J, Zhao J, Kass DJ, Zhao Y. Cell Death Dis. 2016 Nov 17;7(11):e2474. doi: 10.1038/cddis.2016.371. PubMed |
| Berberine Suppresses Cyclin D1 Expression through Proteasomal Degradation in Human Hepatoma Cells. Wang N, Wang X, Tan HY, Li S, Tsang CM, Tsao SW, Feng Y. Int J Mol Sci. 2016 Nov 15;17(11). pii: E1899. PubMed |
| Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity. Du WW, Fang L, Yang W, Wu N, Awan FM, Yang Z, Yang BB. Cell Death Differ. 2017 Feb;24(2):357-370. doi: 10.1038/cdd.2016.133. Epub 2016 Nov 25. PubMed |
Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling.
Cai H, Liu A.
Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14751-14756. doi: 10.1073/pnas.1612520114. Epub 2016 Dec 5.
PubMed
Associated Plasmids |
| TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas. Liu Z, Yanagisawa K, Griesing S, Iwai M, Kano K, Hotta N, Kajino T, Suzuki M, Takahashi T. Oncogene. 2017 Jun 29;36(26):3740-3748. doi: 10.1038/onc.2016.524. Epub 2017 Feb 13. PubMed |
| Missing-in-metastasis protein downregulates CXCR4 by promoting ubiquitylation and interaction with small Rab GTPases. Li L, Baxter SS, Gu N, Ji M, Zhan X. J Cell Sci. 2017 Apr 15;130(8):1475-1485. doi: 10.1242/jcs.198937. Epub 2017 Mar 6. PubMed |
| PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation. Gupta A, Anjomani-Virmouni S, Koundouros N, Dimitriadi M, Choo-Wing R, Valle A, Zheng Y, Chiu YH, Agnihotri S, Zadeh G, Asara JM, Anastasiou D, Arends MJ, Cantley LC, Poulogiannis G. Mol Cell. 2017 Mar 16;65(6):999-1013.e7. doi: 10.1016/j.molcel.2017.02.019. PubMed |
| RSPO2 suppresses colorectal cancer metastasis by counteracting the Wnt5a/Fzd7-driven noncanonical Wnt pathway. Dong X, Liao W, Zhang L, Tu X, Hu J, Chen T, Dai X, Xiong Y, Liang W, Ding C, Liu R, Dai J, Wang O, Lu L, Lu X. Cancer Lett. 2017 Aug 28;402:153-165. doi: 10.1016/j.canlet.2017.05.024. Epub 2017 Jun 6. PubMed |
| Regulation of glycolytic metabolism by autophagy in liver cancer involves selective autophagic degradation of HK2 (hexokinase 2). Jiao L, Zhang HL, Li DD, Yang KL, Tang J, Li X, Ji J, Yu Y, Wu RY, Ravichandran S, Liu JJ, Feng GK, Chen MS, Zeng YX, Deng R, Zhu XF. Autophagy. 2018;14(4):671-684. doi: 10.1080/15548627.2017.1381804. Epub 2017 Dec 17. PubMed |
| SUMO Modification of the RNA-Binding Protein La Regulates Cell Proliferation and STAT3 Protein Stability. Kota V, Sommer G, Hazard ES, Hardiman G, Twiss JL, Heise T. Mol Cell Biol. 2017 Dec 29;38(2). pii: MCB.00129-17. doi: 10.1128/MCB.00129-17. Print 2018 Jan 15. PubMed |
| Caspase-10: a molecular switch from cell-autonomous apoptosis to communal cell death in response to chemotherapeutic drug treatment. Mohr A, Deedigan L, Jencz S, Mehrabadi Y, Houlden L, Albarenque SM, Zwacka RM. Cell Death Differ. 2018 Feb;25(2):340-352. doi: 10.1038/cdd.2017.164. Epub 2017 Nov 3. PubMed |
| A Parkinson's disease gene, DJ-1, repairs brain injury through Sox9 stabilization and astrogliosis. Choi DJ, Eun JH, Kim BG, Jou I, Park SM, Joe EH. Glia. 2018 Feb;66(2):445-458. doi: 10.1002/glia.23258. Epub 2017 Nov 6. PubMed |
| KCTD5 and Ubiquitin Proteasome Signaling Are Required for Helicobacter pylori Adherence. Alvarez A, Uribe F, Canales J, Romero C, Soza A, Pena MA, Antonelli M, Almarza O, Cerda O, Toledo H. Front Cell Infect Microbiol. 2017 Oct 24;7:450. doi: 10.3389/fcimb.2017.00450. eCollection 2017. PubMed |
| FBXO31 Suppresses Gastric Cancer EMT by Targeting Snail1 for Proteasomal Degradation. Zou S, Ma C, Yang F, Xu X, Jia J, Liu Z. Mol Cancer Res. 2018 Feb;16(2):286-295. doi: 10.1158/1541-7786.MCR-17-0432. Epub 2017 Nov 8. PubMed |
| An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis. Zhang H, Wang L, Wong EYM, Tsang SL, Xu PX, Lendahl U, Sham MH. Elife. 2017 Nov 15;6. pii: 30126. doi: 10.7554/eLife.30126. PubMed |
| STX3 represses the stability of the tumor suppressor PTEN to activate the PI3K-Akt-mTOR signaling and promotes the growth of breast cancer cells. Nan H, Han L, Ma J, Yang C, Su R, He J. Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1684-1692. doi: 10.1016/j.bbadis.2018.01.031. Epub 2018 Feb 2. PubMed |
| BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage. Biswas K, Philip S, Yadav A, Martin BK, Burkett S, Singh V, Babbar A, North SL, Chang S, Sharan SK. Nat Commun. 2018 Feb 7;9(1):537. doi: 10.1038/s41467-018-03020-6. PubMed |
| The HNF-1beta-USP28-Claspin pathway upregulates DNA damage-induced Chk1 activation in ovarian clear cell carcinoma. Ito F, Yoshimoto C, Yamada Y, Sudo T, Kobayashi H. Oncotarget. 2018 Apr 3;9(25):17512-17522. doi: 10.18632/oncotarget.24776. eCollection 2018 Apr 3. PubMed |
| Isoxanthohumol stimulates ubiquitin-proteasome-dependent degradation of precursor forms of sterol regulatory element-binding proteins. Inoue J, Miyata S, Shimizu M, Sato R. Biosci Biotechnol Biochem. 2018 Sep;82(9):1591-1598. doi: 10.1080/09168451.2018.1478715. Epub 2018 May 26. PubMed |
| The kinase activity of the channel-kinase protein TRPM7 regulates stability and localization of the TRPM7 channel in polarized epithelial cells. Cai N, Lou L, Al-Saadi N, Tetteh S, Runnels LW. J Biol Chem. 2018 Jul 20;293(29):11491-11504. doi: 10.1074/jbc.RA118.001925. Epub 2018 Jun 4. PubMed |
| p38delta MAPK regulates aggresome biogenesis by phosphorylating SQSTM1 in response to proteasomal stress. Zhang C, Gao J, Li M, Deng Y, Jiang C. J Cell Sci. 2018 Jul 26;131(14). pii: jcs.216671. doi: 10.1242/jcs.216671. PubMed |
| The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding. Madigan JP, Hou F, Ye L, Hu J, Dong A, Tempel W, Yohe ME, Randazzo PA, Jenkins LMM, Gottesman MM, Tong Y. J Biol Chem. 2018 Oct 19;293(42):16142-16159. doi: 10.1074/jbc.RA118.003525. Epub 2018 Aug 24. PubMed |
| A catalogue of somatic NRF2 gain-of-function mutations in cancer. Kerins MJ, Ooi A. Sci Rep. 2018 Aug 27;8(1):12846. doi: 10.1038/s41598-018-31281-0. PubMed |
| UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy. Shorrock HK, van der Hoorn D, Boyd PJ, Llavero Hurtado M, Lamont DJ, Wirth B, Sleigh JN, Schiavo G, Wishart TM, Groen EJN, Gillingwater TH. Brain. 2018 Oct 1;141(10):2878-2894. doi: 10.1093/brain/awy237. PubMed |
| E3 ubiquitin ligases LNX1 and LNX2 localize at neuronal gap junctions formed by connexin36 in rodent brain and molecularly interact with connexin36. Lynn BD, Li X, Hormuzdi SG, Griffiths EK, McGlade CJ, Nagy JI. Eur J Neurosci. 2018 Nov;48(9):3062-3081. doi: 10.1111/ejn.14198. Epub 2018 Nov 2. PubMed |
| Murine Leukemia Virus Glycosylated Gag Reduces Murine SERINC5 Protein Expression at Steady-State Levels via the Endosome/Lysosome Pathway to Counteract SERINC5 Antiretroviral Activity. Li S, Ahmad I, Shi J, Wang B, Yu C, Zhang L, Zheng YH. J Virol. 2019 Jan 4;93(2). pii: JVI.01651-18. doi: 10.1128/JVI.01651-18. Print 2019 Jan 15. PubMed |
| Neuronal Expression of UBQLN2(P497H) Exacerbates TDP-43 Pathology in TDP-43(G348C) Mice through Interaction with Ubiquitin. Picher-Martel V, Renaud L, Bareil C, Julien JP. Mol Neurobiol. 2018 Oct 30. pii: 10.1007/s12035-018-1411-3. doi: 10.1007/s12035-018-1411-3. PubMed |
| KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Vaseva AV, Blake DR, Gilbert TSK, Ng S, Hostetter G, Azam SH, Ozkan-Dagliyan I, Gautam P, Bryant KL, Pearce KH, Herring LE, Han H, Graves LM, Witkiewicz AK, Knudsen ES, Pecot CV, Rashid N, Houghton PJ, Wennerberg K, Cox AD, Der CJ. Cancer Cell. 2018 Nov 12;34(5):807-822.e7. doi: 10.1016/j.ccell.2018.10.001. PubMed |
| Elevated histone H3 acetylation and loss of the Sp1-HDAC1 complex de-repress the GM2-synthase gene in renal cell carcinoma. Banerjee A, Mahata B, Dhir A, Mandal TK, Biswas K. J Biol Chem. 2019 Jan 18;294(3):1005-1018. doi: 10.1074/jbc.RA118.004485. Epub 2018 Nov 21. PubMed |
| Repair pathway for PARP-1 DNA-protein crosslinks. Prasad R, Horton JK, Dai DP, Wilson SH. DNA Repair (Amst). 2019 Jan;73:71-77. doi: 10.1016/j.dnarep.2018.11.004. Epub 2018 Nov 12. PubMed |
| TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression. Fong KW, Zhao JC, Song B, Zheng B, Yu J. Nat Commun. 2018 Nov 27;9(1):5007. doi: 10.1038/s41467-018-07475-5. PubMed |
| Miro proteins prime mitochondria for Parkin translocation and mitophagy. Safiulina D, Kuum M, Choubey V, Gogichaishvili N, Liiv J, Hickey MA, Cagalinec M, Mandel M, Zeb A, Liiv M, Kaasik A. EMBO J. 2019 Jan 15;38(2). pii: embj.201899384. doi: 10.15252/embj.201899384. Epub 2018 Nov 30. PubMed |
| Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication. Ling H, Peng L, Wang J, Rahhal R, Seto E. Cell Rep. 2018 Dec 4;25(10):2851-2865.e3. doi: 10.1016/j.celrep.2018.11.025. PubMed |
| O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity. Li T, Li X, Attri KS, Liu C, Li L, Herring LE, Asara JM, Lei YL, Singh PK, Gao C, Wen H. Cell Host Microbe. 2018 Dec 12;24(6):791-803.e6. doi: 10.1016/j.chom.2018.11.001. PubMed |
| Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Teyra J, Singer AU, Schmitges FW, Jaynes P, Kit Leng Lui S, Polyak MJ, Fodil N, Krieger JR, Tong J, Schwerdtfeger C, Brasher BB, Ceccarelli DFJ, Moffat J, Sicheri F, Moran MF, Gros P, Eichhorn PJA, Lenter M, Boehmelt G, Sidhu SS. Structure. 2019 Apr 2;27(4):590-605.e5. doi: 10.1016/j.str.2019.01.002. Epub 2019 Jan 31. PubMed |
| Regulation of death receptor signaling by the autophagy protein TP53INP2. Ivanova S, Polajnar M, Narbona-Perez AJ, Hernandez-Alvarez MI, Frager P, Slobodnyuk K, Plana N, Nebreda AR, Palacin M, Gomis RR, Behrends C, Zorzano A. EMBO J. 2019 May 15;38(10). pii: embj.201899300. doi: 10.15252/embj.201899300. Epub 2019 Apr 12. PubMed |
| Enhanced Replication of Mouse Adenovirus Type 1 following Virus-Induced Degradation of Protein Kinase R (PKR). Goodman DE, Pretto CD, Krepostman TA, Carnahan KE, Spindler KR. MBio. 2019 Apr 23;10(2). pii: mBio.00668-19. doi: 10.1128/mBio.00668-19. PubMed |
| TSPYL5 Depletion Induces Specific Death of ALT Cells through USP7-Dependent Proteasomal Degradation of POT1. Episkopou H, Diman A, Claude E, Viceconte N, Decottignies A. Mol Cell. 2019 Aug 8;75(3):469-482.e6. doi: 10.1016/j.molcel.2019.05.027. Epub 2019 Jul 2. PubMed |
| RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres. Barroso-Gonzalez J, Garcia-Exposito L, Hoang SM, Lynskey ML, Roncaioli JL, Ghosh A, Wallace CT, Modesti M, Bernstein KA, Sarkar SN, Watkins SC, O'Sullivan RJ. Mol Cell. 2019 Oct 3;76(1):11-26.e7. doi: 10.1016/j.molcel.2019.06.043. Epub 2019 Aug 7. PubMed |
| The tumor suppressor FBXO31 preserves genomic integrity by regulating DNA replication and segregation through precise control of cyclin A levels. Dutta P, Islam S, Choppara S, Sengupta P, Kumar A, Kumar A, Wani MR, Chatterjee S, Santra MK. J Biol Chem. 2019 Oct 11;294(41):14879-14895. doi: 10.1074/jbc.RA118.007055. Epub 2019 Aug 14. PubMed |
| Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation. Mayor-Ruiz C, Jaeger MG, Bauer S, Brand M, Sin C, Hanzl A, Mueller AC, Menche J, Winter GE. Mol Cell. 2019 Aug 22;75(4):849-858.e8. doi: 10.1016/j.molcel.2019.07.013. PubMed |
| CYP1B1 prevents proteasome-mediated XIAP degradation by inducing PKCepsilon activation and phosphorylation of XIAP. Baek HS, Kwon YJ, Ye DJ, Cho E, Kwon TU, Chun YJ. Biochim Biophys Acta Mol Cell Res. 2019 Dec;1866(12):118553. doi: 10.1016/j.bbamcr.2019.118553. Epub 2019 Sep 4. PubMed |
| Blockade of Glutathione Metabolism in IDH1-Mutated Glioma. Tang X, Fu X, Liu Y, Yu D, Cai SJ, Yang C. Mol Cancer Ther. 2020 Jan;19(1):221-230. doi: 10.1158/1535-7163.MCT-19-0103. Epub 2019 Sep 23. PubMed |
| The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer. Yan Y, Ma J, Wang D, Lin D, Pang X, Wang S, Zhao Y, Shi L, Xue H, Pan Y, Zhang J, Wahlestedt C, Giles FJ, Chen Y, Gleave ME, Collins CC, Ye D, Wang Y, Huang H. EMBO Mol Med. 2019 Nov 7;11(11):e10659. doi: 10.15252/emmm.201910659. Epub 2019 Sep 26. PubMed |
| Vaccinia Virus Ankyrin-Repeat/F-Box Protein Targets Interferon-Induced IFITs for Proteasomal Degradation. Liu R, Olano LR, Mirzakhanyan Y, Gershon PD, Moss B. Cell Rep. 2019 Oct 22;29(4):816-828.e6. doi: 10.1016/j.celrep.2019.09.039. PubMed |
| The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-beta/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer. Fukui S, Nagasaka K, Miyagawa Y, Kikuchi-Koike R, Kawata Y, Kanda R, Ichinose T, Sugihara T, Hiraike H, Wada-Hiraike O, Sasajima Y, Ayabe T. Oncotarget. 2019 Oct 15;10(57):5932-5948. doi: 10.18632/oncotarget.27219. eCollection 2019 Oct 15. PubMed |
Negative regulation of autophagy by UBA6-BIRC6-mediated ubiquitination of LC3.
Jia R, Bonifacino JS.
Elife. 2019 Nov 6;8. pii: 50034. doi: 10.7554/eLife.50034.
PubMed
Associated Plasmids |
| NEDD4 family ubiquitin ligases associate with LCMV Z's PPXY domain and are required for virus budding, but not via direct ubiquitination of Z. Ziegler CM, Dang L, Eisenhauer P, Kelly JA, King BR, Klaus JP, Manuelyan I, Mattice EB, Shirley DJ, Weir ME, Bruce EA, Ballif BA, Botten J. PLoS Pathog. 2019 Nov 11;15(11):e1008100. doi: 10.1371/journal.ppat.1008100. eCollection 2019 Nov. PubMed |
| SET8 localization to chromatin flanking DNA damage is dependent on RNF168 ubiquitin ligase. Dulev S, Lin S, Liu Q, Cetintas VB, Batada NN. Cell Cycle. 2020 Jan;19(1):15-23. doi: 10.1080/15384101.2019.1690231. Epub 2019 Nov 24. PubMed |
| The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I. Jureka AS, Kleinpeter AB, Tipper JL, Harrod KS, Petit CM. J Biol Chem. 2020 Jan 24;295(4):1153-1164. doi: 10.1074/jbc.RA119.011410. Epub 2019 Dec 16. PubMed |
| The regulation of p53, p38 MAPK, JNK and XBP-1s by sphingosine kinases in human embryonic kidney cells. Alsanafi M, Kelly SL, McNaughton M, Merrill AH Jr, Pyne NJ, Pyne S. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Apr;1865(4):158631. doi: 10.1016/j.bbalip.2020.158631. Epub 2020 Jan 15. PubMed |
| Loss of HSPA9 induces peroxisomal degradation by increasing pexophagy. Jo DS, Park SJ, Kim AK, Park NY, Kim JB, Bae JE, Park HJ, Shin JH, Chang JW, Kim PK, Jung YK, Koh JY, Choe SK, Lee KS, Cho DH. Autophagy. 2020 Nov;16(11):1989-2003. doi: 10.1080/15548627.2020.1712812. Epub 2020 Jan 22. PubMed |
| A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation. Kim JM, Yang YS, Park KH, Ge X, Xu R, Li N, Song M, Chun H, Bok S, Charles JF, Filhol-Cochet O, Boldyreff B, Dinter T, Yu PB, Kon N, Gu W, Takarada T, Greenblatt MB, Shim JH. Nat Commun. 2020 May 8;11(1):2289. doi: 10.1038/s41467-020-16038-6. PubMed |
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