myc-mTOR Citations (32)
Originally described in: Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM Curr Biol 2004 Jul 27;14(14):1296-302. PubMed Journal
Articles Citing myc-mTOR
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| Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells. Schmitz F, Heit A, Dreher S, Eisenacher K, Mages J, Haas T, Krug A, Janssen KP, Kirschning CJ, Wagner H. Eur J Immunol. 2008 Nov;38(11):2981-92. doi: 10.1002/eji.200838761. PubMed |
| Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition. Dunlop EA, Dodd KM, Seymour LA, Tee AR. Cell Signal. 2009 Mar 9. ():. PubMed |
| Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth. Acosta-Jaquez HA, Keller JA, Foster KG, Ekim B, Soliman GA, Ballif BA, Fingar DC. Mol Cell Biol. 2009 Jun 1. ():. PubMed |
| A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. Cully M, Genevet A, Warne P, Treins C, Liu T, Bastien J, Baum B, Tapon N, Leevers SJ, Downward J. Mol Cell Biol. 2010 Jan;30(2):481-95. doi: 10.1128/MCB.00688-09. Epub 2009 Nov 16. PubMed |
| mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action. Soliman GA, Acosta-Jaquez HA, Dunlop EA, Ekim B, Maj NE, Tee AR, Fingar DC. J Biol Chem. 2010 Mar 12. 285(11):7866-79. PubMed |
| Germline mutations in TMEM127 confer susceptibility to pheochromocytoma. Qin Y, Yao L, King EE, Buddavarapu K, Lenci RE, Chocron ES, Lechleiter JD, Sass M, Aronin N, Schiavi F, Boaretto F, Opocher G, Toledo RA, Toledo SP, Stiles C, Aguiar RC, Dahia PL. Nat Genet. 2010 Mar;42(3):229-33. doi: 10.1038/ng.533. Epub 2010 Feb 14. PubMed |
| JNK signaling promotes intestinal tumorigenesis through activation of mTOR complex 1 in Apc(Delta716) mice. Fujishita T, Aoki M, Taketo MM. Gastroenterology. 2011 May;140(5):1556-63.e6. doi: 10.1053/j.gastro.2011.02.007. Epub 2011 Feb 12. PubMed |
| ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding. Dunlop EA, Hunt DK, Acosta-Jaquez HA, Fingar DC, Tee AR. Autophagy. 2011 Jul;7(7):737-47. Epub 2011 Jul 1. PubMed |
| mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression. Ekim B, Magnuson B, Acosta-Jaquez HA, Keller JA, Feener EP, Fingar DC. Mol Cell Biol. 2011 Jul;31(14):2787-801. doi: 10.1128/MCB.05437-11. Epub 2011 May 16. PubMed |
| cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity. Xie J, Ponuwei GA, Moore CE, Willars GB, Tee AR, Herbert TP. Cell Signal. 2011 Dec;23(12):1927-35. doi: 10.1016/j.cellsig.2011.06.025. Epub 2011 Jul 6. PubMed |
| Mammalian target of rapamycin signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain. Paliouras GN, Hamilton LK, Aumont A, Joppe SE, Barnabe-Heider F, Fernandes KJ. J Neurosci. 2012 Oct 24;32(43):15012-26. doi: 10.1523/JNEUROSCI.2248-12.2012. PubMed |
| The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1. Han J, Li E, Chen L, Zhang Y, Wei F, Liu J, Deng H, Wang Y. Nature. 2015 Aug 13;524(7564):243-6. doi: 10.1038/nature14557. Epub 2015 Jul 6. PubMed |
| Point mutations of the mTOR-RHEB pathway in renal cell carcinoma. Ghosh AP, Marshall CB, Coric T, Shim EH, Kirkman R, Ballestas ME, Ikura M, Bjornsti MA, Sudarshan S. Oncotarget. 2015 Jul 20;6(20):17895-910. PubMed |
| Metformin Treatment Does Not Inhibit Growth of Pancreatic Cancer Patient-Derived Xenografts. Lipner MB, Marayati R, Deng Y, Wang X, Raftery L, O'Neil BH, Yeh JJ. PLoS One. 2016 Jan 13;11(1):e0147113. doi: 10.1371/journal.pone.0147113. eCollection 2016. PubMed |
| p38gamma and delta promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation. Gonzalez-Teran B, Lopez JA, Rodriguez E, Leiva L, Martinez-Martinez S, Bernal JA, Jimenez-Borreguero LJ, Redondo JM, Vazquez J, Sabio G. Nat Commun. 2016 Jan 22;7:10477. doi: 10.1038/ncomms10477. PubMed |
| HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth. Su KH, Cao J, Tang Z, Dai S, He Y, Sampson SB, Benjamin IJ, Dai C. Nat Cell Biol. 2016 May;18(5):527-39. doi: 10.1038/ncb3335. Epub 2016 Apr 4. PubMed |
| Role of Host Type IA Phosphoinositide 3-Kinase Pathway Components in Invasin-Mediated Internalization of Yersinia enterocolitica. Dowd GC, Bhalla M, Kean B, Thomas R, Ireton K. Infect Immun. 2016 May 24;84(6):1826-41. doi: 10.1128/IAI.00142-16. Print 2016 Jun. PubMed |
| The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Carbonneau M, M Gagne L, Lalonde ME, Germain MA, Motorina A, Guiot MC, Secco B, Vincent EE, Tumber A, Hulea L, Bergeman J, Oppermann U, Jones RG, Laplante M, Topisirovic I, Petrecca K, Huot ME, Mallette FA. Nat Commun. 2016 Sep 14;7:12700. doi: 10.1038/ncomms12700. PubMed |
| Regulation of mTORC1 by lysosomal calcium and calmodulin. Li RJ, Xu J, Fu C, Zhang J, Zheng YG, Jia H, Liu JO. Elife. 2016 Oct 27;5. pii: e19360. doi: 10.7554/eLife.19360. PubMed |
| Cellular vacuolization caused by overexpression of the PIKfyve-binding deficient Vac14L156R is rescued by starvation and inhibition of vacuolar-ATPase. Schulze U, Vollenbroker B, Kuhnl A, Granado D, Bayraktar S, Rescher U, Pavenstadt H, Weide T. Biochim Biophys Acta. 2017 May;1864(5):749-759. doi: 10.1016/j.bbamcr.2017.02.012. Epub 2017 Feb 16. PubMed |
| Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes. Oka SI, Hirata T, Suzuki W, Naito D, Chen Y, Chin A, Yaginuma H, Saito T, Nagarajan N, Zhai P, Bhat S, Schesing K, Shao D, Hirabayashi Y, Yodoi J, Sciarretta S, Sadoshima J. J Biol Chem. 2017 Nov 17;292(46):18988-19000. doi: 10.1074/jbc.M117.807735. Epub 2017 Sep 22. PubMed |
| Oxysterol-binding protein-related protein 5 (ORP5) promotes cell proliferation by activation of mTORC1 signaling. Du X, Zadoorian A, Lukmantara IE, Qi Y, Brown AJ, Yang H. J Biol Chem. 2018 Mar 9;293(10):3806-3818. doi: 10.1074/jbc.RA117.001558. Epub 2018 Jan 22. PubMed |
| The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex. Wu R, Dang F, Li P, Wang P, Xu Q, Liu Z, Li Y, Wu Y, Chen Y, Liu Y. Cell Metab. 2019 Mar 5;29(3):653-667.e6. doi: 10.1016/j.cmet.2018.11.006. Epub 2018 Dec 6. PubMed |
| Phosphorylation at distinct subcellular locations underlies specificity in mTORC2-mediated activation of SGK1 and Akt. Gleason CE, Oses-Prieto JA, Li KH, Saha B, Situ G, Burlingame AL, Pearce D. J Cell Sci. 2019 Apr 9;132(7). pii: jcs.224931. doi: 10.1242/jcs.224931. PubMed |
Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy.
Vargas JNS, Wang C, Bunker E, Hao L, Maric D, Schiavo G, Randow F, Youle RJ.
Mol Cell. 2019 Apr 18;74(2):347-362.e6. doi: 10.1016/j.molcel.2019.02.010. Epub 2019 Mar 7.
PubMed
Associated Plasmids |
| PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation. Li T, Han J, Jia L, Hu X, Chen L, Wang Y. Protein Cell. 2019 Aug;10(8):583-594. doi: 10.1007/s13238-019-0618-z. Epub 2019 Mar 18. PubMed |
| Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling. Jung JW, Macalino SJY, Cui M, Kim JE, Kim HJ, Song DG, Nam SH, Kim S, Choi S, Lee JW. Cell Metab. 2019 Jun 4;29(6):1306-1319.e7. doi: 10.1016/j.cmet.2019.03.005. Epub 2019 Apr 4. PubMed |
| The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection. Zhang Y, Thery F, Wu NC, Luhmann EK, Dussurget O, Foecke M, Bredow C, Jimenez-Fernandez D, Leandro K, Beling A, Knobeloch KP, Impens F, Cossart P, Radoshevich L. Nat Commun. 2019 Nov 26;10(1):5383. doi: 10.1038/s41467-019-13393-x. PubMed |
| mTORC1 induces eukaryotic translation initiation factor 4E interaction with TOS-S6 kinase 1 and its activation. Majeed ST, Batool A, Majeed R, Bhat NN, Zargar MA, Andrabi KI. Cell Cycle. 2021 May;20(9):839-854. doi: 10.1080/15384101.2021.1901038. Epub 2021 May 3. PubMed |
| The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt. Tooley AS, Kazyken D, Bodur C, Gonzalez IE, Fingar DC. J Biol Chem. 2021 Aug;297(2):100942. doi: 10.1016/j.jbc.2021.100942. Epub 2021 Jul 8. PubMed |
| MicroRNAs 21 and 199a-3p Regulate Axon Growth Potential through Modulation of Pten and mTor mRNAs. Kar AN, Lee SJ, Sahoo PK, Thames E, Yoo S, Houle JD, Twiss JL. eNeuro. 2021 Aug 11;8(4). pii: ENEURO.0155-21.2021. doi: 10.1523/ENEURO.0155-21.2021. Print 2021 Jul-Aug. PubMed |
| Dock7 regulates AKT and mTOR/S6K activity required for the transformed phenotypes and survival of cancer cells. Teran OY, Zanotelli MR, Lin MJ, Cerione RA, Wilson KF. bioRxiv. 2023 Jan 3:2023.01.03.522657. doi: 10.1101/2023.01.03.522657. Preprint. PubMed |
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