Raptor_2 shRNA Citations (19)

Originally described in: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM Science 2005 Feb 18;307(5712):1098-101. PubMed Journal

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Articles Citing Raptor_2 shRNA

Articles
Raptor is phosphorylated by cdc2 during mitosis. Gwinn DM, Asara JM, Shaw RJ. PLoS One. 2010 . 5(2):e9197. PubMed
Regulation of TFEB and V-ATPases by mTORC1. Pena-Llopis S, Vega-Rubin-de-Celis S, Schwartz JC, Wolff NC, Tran TA, Zou L, Xie XJ, Corey DR, Brugarolas J. EMBO J. 2011 Jul 29;30(16):3242-58. doi: 10.1038/emboj.2011.257. PubMed
Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells. Wang C, Yi T, Qin L, Maldonado RA, von Andrian UH, Kulkarni S, Tellides G, Pober JS. J Clin Invest. 2013 Apr;123(4):1677-93. doi: 10.1172/JCI66204. Epub 2013 Mar 8. PubMed
Genetic and pharmacologic inhibition of mTORC1 promotes EMT by a TGF-beta-independent mechanism. Mikaelian I, Malek M, Gadet R, Viallet J, Garcia A, Girard-Gagnepain A, Hesling C, Gillet G, Gonzalo P, Rimokh R, Billaud M. Cancer Res. 2013 Nov 15;73(22):6621-31. doi: 10.1158/0008-5472.CAN-13-0560. Epub 2013 Sep 27. PubMed
Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2. Wang C, Qin L, Manes TD, Kirkiles-Smith NC, Tellides G, Pober JS. J Exp Med. 2014 Mar 10;211(3):395-404. doi: 10.1084/jem.20131125. Epub 2014 Feb 10. PubMed
Inhibition of mTORC1 induces loss of E-cadherin through AKT/GSK-3beta signaling-mediated upregulation of E-cadherin repressor complexes in non-small cell lung cancer cells. Kim EY, Kim A, Kim SK, Kim HJ, Chang J, Ahn CM, Chang YS. Respir Res. 2014 Feb 26;15:26. doi: 10.1186/1465-9921-15-26. PubMed
Improvement of mTORC1-driven overproduction of apoB-containing triacylglyceride-rich lipoproteins by short-chain fatty acids, 4-phenylbutyric acid and (R)-alpha-lipoic acid, in human hepatocellular carcinoma cells. Roberts JL, He B, Erickson A, Moreau R. Biochim Biophys Acta. 2016 Mar;1861(3):166-76. doi: 10.1016/j.bbalip.2015.12.001. Epub 2015 Dec 8. PubMed
Rictor/mTORC2 drives progression and therapeutic resistance of HER2-amplified breast cancers. Morrison-Joly M, Hicks DJ, Jones B, Sanchez V, Estrada MV, Young C, Williams M, Rexer BN, Sarbassov DD, Muller WJ, Brantley-Sieders D, Cook RS. Cancer Res. 2016 Apr 25. pii: canres.3393.2015. PubMed
Tuberous sclerosis complex inactivation disrupts melanogenesis via mTORC1 activation. Cao J, Tyburczy ME, Moss J, Darling TN, Widlund HR, Kwiatkowski DJ. J Clin Invest. 2017 Jan 3;127(1):349-364. doi: 10.1172/JCI84262. Epub 2016 Dec 5. PubMed
Defects in autophagosome-lysosome fusion underlie Vici syndrome, a neurodevelopmental disorder with multisystem involvement. Hori I, Otomo T, Nakashima M, Miya F, Negishi Y, Shiraishi H, Nonoda Y, Magara S, Tohyama J, Okamoto N, Kumagai T, Shimoda K, Yukitake Y, Kajikawa D, Morio T, Hattori A, Nakagawa M, Ando N, Nishino I, Kato M, Tsunoda T, Saitsu H, Kanemura Y, Yamasaki M, Kosaki K, Matsumoto N, Yoshimori T, Saitoh S. Sci Rep. 2017 Jun 14;7(1):3552. doi: 10.1038/s41598-017-02840-8. PubMed
A Ragulator-BORC interaction controls lysosome positioning in response to amino acid availability. Pu J, Keren-Kaplan T, Bonifacino JS. J Cell Biol. 2017 Dec 4;216(12):4183-4197. doi: 10.1083/jcb.201703094. Epub 2017 Oct 9. PubMed
Piperine potentiates curcumin-mediated repression of mTORC1 signaling in human intestinal epithelial cells: implications for the inhibition of protein synthesis and TNFalpha signaling. Kaur H, He B, Zhang C, Rodriguez E, Hage DS, Moreau R. J Nutr Biochem. 2018 Jul;57:276-286. doi: 10.1016/j.jnutbio.2018.04.010. Epub 2018 Apr 25. PubMed
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma. Sun H, Yang W, Tian Y, Zeng X, Zhou J, Mok MTS, Tang W, Feng Y, Xu L, Chan AWH, Tong JH, Cheung YS, Lai PBS, Wang HKS, Tsang SW, Chow KL, Hu M, Liu R, Huang L, Yang B, Yang P, To KF, Sung JJY, Wong GLH, Wong VWS, Cheng ASL. Nat Commun. 2018 Dec 6;9(1):5214. doi: 10.1038/s41467-018-07402-8. PubMed
Glutamine deprivation alters the origin and function of cancer cell exosomes. Fan SJ, Kroeger B, Marie PP, Bridges EM, Mason JD, McCormick K, Zois CE, Sheldon H, Khalid Alham N, Johnson E, Ellis M, Stefana MI, Mendes CC, Wainwright SM, Cunningham C, Hamdy FC, Morris JF, Harris AL, Wilson C, Goberdhan DC. EMBO J. 2020 Aug 17;39(16):e103009. doi: 10.15252/embj.2019103009. Epub 2020 Jul 28. PubMed
R-alpha-Lipoic Acid and 4-Phenylbutyric Acid Have Distinct Hypolipidemic Mechanisms in Hepatic Cells. He B, Moreau R. Biomedicines. 2020 Aug 15;8(8). pii: biomedicines8080289. doi: 10.3390/biomedicines8080289. PubMed
Curcumin represses mTORC1 signaling in Caco-2 cells by a two-sided mechanism involving the loss of IRS-1 and activation of AMPK. Kaur H, Moreau R. Cell Signal. 2021 Feb;78:109842. doi: 10.1016/j.cellsig.2020.109842. Epub 2020 Nov 22. PubMed
A compendium of kinetic modulatory profiles identifies ferroptosis regulators. Conlon M, Poltorack CD, Forcina GC, Armenta DA, Mallais M, Perez MA, Wells A, Kahanu A, Magtanong L, Watts JL, Pratt DA, Dixon SJ. Nat Chem Biol. 2021 Jun;17(6):665-674. doi: 10.1038/s41589-021-00751-4. Epub 2021 Mar 8. PubMed
Chylomicron production is repressed by RPTOR knockdown, R-alpha-lipoic acid and 4-phenylbutyric acid in human enterocyte-like Caco-2 cells. He B, Wang Z, Moreau R. J Nutr Biochem. 2022 Oct;108:109087. doi: 10.1016/j.jnutbio.2022.109087. Epub 2022 Jun 10. PubMed
Raptor knockdown concurrently increases the electrical resistance and paracellular permeability of Caco-2 cell monolayers. Kaur H, Moreau R. Life Sci. 2022 Nov 1;308:120989. doi: 10.1016/j.lfs.2022.120989. Epub 2022 Sep 21. PubMed

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