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Raptor_1 shRNA Citations (26)

Originally described in: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM Science 2005 Feb 18;307(5712):1098-101. PubMed Journal

Articles Citing Raptor_1 shRNA

Articles
Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes. Kudchodkar SB, Yu Y, Maguire TG, Alwine JC. Proc Natl Acad Sci U S A. 2006 Sep 19. 103(38):14182-7. PubMed
PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. Wang L, Harris TE, Roth RA, Lawrence JC. J Biol Chem. 2007 Jul 6. 282(27):20036-44. PubMed

Associated Plasmids
eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy. Ramirez-Valle F, Braunstein S, Zavadil J, Formenti SC, Schneider RJ. J Cell Biol. 2008 Apr 21;181(2):293-307. doi: 10.1083/jcb.200710215. PubMed
TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Copp J, Manning G, Hunter T. Cancer Res. 2009 Mar 1. 69(5):1821-7. PubMed
The changing role of mTOR kinase in the maintenance of protein synthesis during human cytomegalovirus infection. Clippinger AJ, Maguire TG, Alwine JC. J Virol. 2011 Apr;85(8):3930-9. doi: 10.1128/JVI.01913-10. Epub 2011 Feb 9. PubMed
LAMTOR1 depletion induces p53-dependent apoptosis via aberrant lysosomal activation. Malek M, Guillaumot P, Huber AL, Lebeau J, Petrilli V, Kfoury A, Mikaelian I, Renno T, Manie SN. Cell Death Dis. 2012 Apr 19;3:e300. doi: 10.1038/cddis.2012.39. PubMed
Epigallocatechin-3-gallate diminishes cytokine-stimulated Cyr61 expression in human osteoblastic cells: a therapeutic potential for arthritis. Wu PH, Lin SK, Lee BS, Kok SH, Wang JH, Hou KL, Yang H, Lai EH, Wang JS, Hong CY. Rheumatology (Oxford). 2012 Nov;51(11):1953-65. doi: 10.1093/rheumatology/kes174. Epub 2012 Jul 28. PubMed
mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state. Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D. Cell. 2013 Feb 14;152(4):778-90. doi: 10.1016/j.cell.2013.01.023. Epub 2013 Feb 7. PubMed
Genetic and pharmacologic inhibition of mTORC1 promotes EMT by a TGF-beta-independent mechanism. Mikaelian I, Malek M, Gadet R, Viallet J, Garcia A, Girard-Gagnepain A, Hesling C, Gillet G, Gonzalo P, Rimokh R, Billaud M. Cancer Res. 2013 Nov 15;73(22):6621-31. doi: 10.1158/0008-5472.CAN-13-0560. Epub 2013 Sep 27. PubMed
Inhibition of mTORC1 induces loss of E-cadherin through AKT/GSK-3beta signaling-mediated upregulation of E-cadherin repressor complexes in non-small cell lung cancer cells. Kim EY, Kim A, Kim SK, Kim HJ, Chang J, Ahn CM, Chang YS. Respir Res. 2014 Feb 26;15:26. doi: 10.1186/1465-9921-15-26. PubMed
Prostate cancer ETS rearrangements switch a cell migration gene expression program from RAS/ERK to PI3K/AKT regulation. Selvaraj N, Budka JA, Ferris MW, Jerde TJ, Hollenhorst PC. Mol Cancer. 2014 Mar 19;13:61. doi: 10.1186/1476-4598-13-61. PubMed
PGE2-induced colon cancer growth is mediated by mTORC1. Dufour M, Faes S, Dormond-Meuwly A, Demartines N, Dormond O. Biochem Biophys Res Commun. 2014 Sep 5;451(4):587-91. doi: 10.1016/j.bbrc.2014.08.032. Epub 2014 Aug 13. PubMed
A critical role for the mTORC2 pathway in lung fibrosis. Chang W, Wei K, Ho L, Berry GJ, Jacobs SS, Chang CH, Rosen GD. PLoS One. 2014 Aug 27;9(8):e106155. doi: 10.1371/journal.pone.0106155. eCollection 2014. PubMed
mTOR inhibition induces compensatory, therapeutically targetable MEK activation in renal cell carcinoma. Bailey ST, Zhou B, Damrauer JS, Krishnan B, Wilson HL, Smith AM, Li M, Yeh JJ, Kim WY. PLoS One. 2014 Sep 2;9(9):e104413. doi: 10.1371/journal.pone.0104413. eCollection 2014. PubMed
La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1). Fonseca BD, Zakaria C, Jia JJ, Graber TE, Svitkin Y, Tahmasebi S, Healy D, Hoang HD, Jensen JM, Diao IT, Lussier A, Dajadian C, Padmanabhan N, Wang W, Matta-Camacho E, Hearnden J, Smith EM, Tsukumo Y, Yanagiya A, Morita M, Petroulakis E, Gonzalez JL, Hernandez G, Alain T, Damgaard CK. J Biol Chem. 2015 Jun 26;290(26):15996-6020. doi: 10.1074/jbc.M114.621730. Epub 2015 May 4. PubMed
Identification of an oncogenic RAB protein. Wheeler DB, Zoncu R, Root DE, Sabatini DM, Sawyers CL. Science. 2015 Oct 9;350(6257):211-7. doi: 10.1126/science.aaa4903. Epub 2015 Sep 3. PubMed

Associated Plasmids
mTORC1 and CK2 coordinate ternary and eIF4F complex assembly. Gandin V, Masvidal L, Cargnello M, Gyenis L, McLaughlan S, Cai Y, Tenkerian C, Morita M, Balanathan P, Jean-Jean O, Stambolic V, Trost M, Furic L, Larose L, Koromilas AE, Asano K, Litchfield D, Larsson O, Topisirovic I. Nat Commun. 2016 Apr 4;7:11127. doi: 10.1038/ncomms11127. PubMed
Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation. Feehan RP, Shantz LM. Cell Signal. 2016 Aug;28(8):798-809. doi: 10.1016/j.cellsig.2016.03.013. Epub 2016 Apr 4. PubMed
Rictor/mTORC2 drives progression and therapeutic resistance of HER2-amplified breast cancers. Morrison-Joly M, Hicks DJ, Jones B, Sanchez V, Estrada MV, Young C, Williams M, Rexer BN, Sarbassov DD, Muller WJ, Brantley-Sieders D, Cook RS. Cancer Res. 2016 Apr 25. pii: canres.3393.2015. PubMed
Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors. Faes S, Duval AP, Planche A, Uldry E, Santoro T, Pythoud C, Stehle JC, Horlbeck J, Letovanec I, Riggi N, Demartines N, Dormond O. Mol Cancer. 2016 Dec 5;15(1):78. PubMed
Pegylated IFN-alpha suppresses hepatitis C virus by promoting the DAPK-mTOR pathway. Liu WL, Yang HC, Hsu CS, Wang CC, Wang TS, Kao JH, Chen DS. Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14799-14804. doi: 10.1073/pnas.1618517114. Epub 2016 Dec 6. PubMed
Knocking down raptor in human keratinocytes affects ornithine decarboxylase in a post-transcriptional Manner following ultraviolet B exposure. Stump CL, Feehan RP, Jordan T, Shantz LM, Nowotarski SL. Amino Acids. 2019 Apr 10. pii: 10.1007/s00726-019-02732-3. doi: 10.1007/s00726-019-02732-3. PubMed
mTORC1 induces eukaryotic translation initiation factor 4E interaction with TOS-S6 kinase 1 and its activation. Majeed ST, Batool A, Majeed R, Bhat NN, Zargar MA, Andrabi KI. Cell Cycle. 2021 May;20(9):839-854. doi: 10.1080/15384101.2021.1901038. Epub 2021 May 3. PubMed
Mitochondrial-encoded MOTS-c prevents pancreatic islet destruction in autoimmune diabetes. Kong BS, Min SH, Lee C, Cho YM. Cell Rep. 2021 Jul 27;36(4):109447. doi: 10.1016/j.celrep.2021.109447. PubMed
Ras-mediated activation of mTORC2 promotes breast epithelial cell migration and invasion. Collins SE, Wiegand ME, Werner AN, Brown IN, Mundo MI, Swango DJ, Mouneimne G, Charest PG. Mol Biol Cell. 2023 Feb 1;34(2):ar9. doi: 10.1091/mbc.E22-06-0236. Epub 2022 Dec 21. PubMed
MTORC2 is a physiological hydrophobic motif kinase of S6 Kinase 1. Majeed ST, Majeed R, Malik AA, Andrabi KI. Biochim Biophys Acta Mol Cell Res. 2023 Apr;1870(4):119449. doi: 10.1016/j.bbamcr.2023.119449. Epub 2023 Feb 28. PubMed

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