Rictor_2 shRNA Citations (15)

Originally described in: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM Science 2005 Feb 18;307(5712):1098-101. PubMed Journal

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Articles Citing Rictor_2 shRNA

Articles
mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. Masri J, Bernath A, Martin J, Jo OD, Vartanian R, Funk A, Gera J. Cancer Res. 2007 Dec 15. 67(24):11712-20. PubMed
Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor. Hoang B, Frost P, Shi Y, Belanger E, Benavides A, Pezeshkpour G, Cappia S, Guglielmelli T, Gera J, Lichtenstein A. Blood. 2010 Nov 25;116(22):4560-8. doi: 10.1182/blood-2010-05-285726. Epub 2010 Aug 4. PubMed
Alcohol-induced modulation of rictor and mTORC2 activity in C2C12 myoblasts. Hong-Brown LQ, Brown CR, Navaratnarajah M, Huber DS, Lang CH. Alcohol Clin Exp Res. 2011 Aug;35(8):1445-53. doi: 10.1111/j.1530-0277.2011.01480.x. Epub 2011 Mar 25. PubMed
Epigallocatechin-3-gallate diminishes cytokine-stimulated Cyr61 expression in human osteoblastic cells: a therapeutic potential for arthritis. Wu PH, Lin SK, Lee BS, Kok SH, Wang JH, Hou KL, Yang H, Lai EH, Wang JS, Hong CY. Rheumatology (Oxford). 2012 Nov;51(11):1953-65. doi: 10.1093/rheumatology/kes174. Epub 2012 Jul 28. PubMed
Genetic and pharmacologic inhibition of mTORC1 promotes EMT by a TGF-beta-independent mechanism. Mikaelian I, Malek M, Gadet R, Viallet J, Garcia A, Girard-Gagnepain A, Hesling C, Gillet G, Gonzalo P, Rimokh R, Billaud M. Cancer Res. 2013 Nov 15;73(22):6621-31. doi: 10.1158/0008-5472.CAN-13-0560. Epub 2013 Sep 27. PubMed
Inhibition of mTORC1 induces loss of E-cadherin through AKT/GSK-3beta signaling-mediated upregulation of E-cadherin repressor complexes in non-small cell lung cancer cells. Kim EY, Kim A, Kim SK, Kim HJ, Chang J, Ahn CM, Chang YS. Respir Res. 2014 Feb 26;15:26. doi: 10.1186/1465-9921-15-26. PubMed
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W. Nature. 2014 Apr 24;508(7497):541-5. doi: 10.1038/nature13079. Epub 2014 Mar 9. PubMed
mTORC1 and CK2 coordinate ternary and eIF4F complex assembly. Gandin V, Masvidal L, Cargnello M, Gyenis L, McLaughlan S, Cai Y, Tenkerian C, Morita M, Balanathan P, Jean-Jean O, Stambolic V, Trost M, Furic L, Larose L, Koromilas AE, Asano K, Litchfield D, Larsson O, Topisirovic I. Nat Commun. 2016 Apr 4;7:11127. doi: 10.1038/ncomms11127. PubMed
Rictor/mTORC2 drives progression and therapeutic resistance of HER2-amplified breast cancers. Morrison-Joly M, Hicks DJ, Jones B, Sanchez V, Estrada MV, Young C, Williams M, Rexer BN, Sarbassov DD, Muller WJ, Brantley-Sieders D, Cook RS. Cancer Res. 2016 Apr 25. pii: canres.3393.2015. PubMed
mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan KL, Mischel PS. Mol Cell. 2017 Jul 6;67(1):128-138.e7. doi: 10.1016/j.molcel.2017.05.030. Epub 2017 Jun 22. PubMed
mTORC2 regulates hedgehog pathway activity by promoting stability to Gli2 protein and its nuclear translocation. Maiti S, Mondal S, Satyavarapu EM, Mandal C. Cell Death Dis. 2017 Jul 13;8(7):e2926. doi: 10.1038/cddis.2017.296. PubMed
An Autocrine Wnt5a Loop Promotes NF-kappaB Pathway Activation and Cytokine/Chemokine Secretion in Melanoma. Barbero G, Castro MV, Villanueva MB, Quezada MJ, Fernandez NB, DeMorrow S, Lopez-Bergami P. Cells. 2019 Sep 10;8(9). pii: cells8091060. doi: 10.3390/cells8091060. PubMed
An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells. Zhan H, Bhattacharya S, Cai H, Iglesias PA, Huang CH, Devreotes PN. Dev Cell. 2020 Sep 14;54(5):608-623.e5. doi: 10.1016/j.devcel.2020.08.001. Epub 2020 Sep 1. PubMed
Epithelial-mesenchymal reprogramming by KLF4-regulated Rictor expression contributes to metastasis of non-small cell lung cancer cells. Zhou H, Guan Q, Hou X, Liu L, Zhou L, Li W, Liu H. Int J Biol Sci. 2022 Jul 18;18(13):4869-4883. doi: 10.7150/ijbs.73548. eCollection 2022. PubMed
mTORC2 promotes pancreatic cancer progression and parp inhibitor resistance. Bu C, Zhao L, Wang L, Yu Z, Zhou J. Oncol Res. 2023 Jun 27;31(4):495-503. doi: 10.32604/or.2023.029309. eCollection 2023. PubMed

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