Flag-SIRT1 Citations (41)
Originally described in: Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME Science 2004 Mar 26;303(5666):2011-5. Epub 2004 Feb 19. PubMed Journal
Articles Citing Flag-SIRT1
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| Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation. Pickard A, Wong PP, McCance DJ. J Cell Sci. 2010 Nov 1;123(Pt 21):3718-26. doi: 10.1242/jcs.068924. Epub 2010 Oct 12. PubMed |
| Effect of nitroxoline on angiogenesis and growth of human bladder cancer. Shim JS, Matsui Y, Bhat S, Nacev BA, Xu J, Bhang HE, Dhara S, Han KC, Chong CR, Pomper MG, So A, Liu JO. J Natl Cancer Inst. 2010 Dec 15;102(24):1855-73. doi: 10.1093/jnci/djq457. Epub 2010 Nov 18. PubMed |
| Acetylation of pregnane X receptor protein determines selective function independent of ligand activation. Biswas A, Pasquel D, Tyagi RK, Mani S. Biochem Biophys Res Commun. 2011 Mar 18;406(3):371-6. doi: 10.1016/j.bbrc.2011.02.048. Epub 2011 Feb 15. PubMed |
| Measles virus nucleocapsid protein, a key contributor to Paget's disease, increases IL-6 expression via down-regulation of FoxO3/Sirt1 signaling. Wang FM, Sarmasik A, Hiruma Y, Sun Q, Sammut B, Windle JJ, Roodman GD, Galson DL. Bone. 2013 Mar;53(1):269-76. doi: 10.1016/j.bone.2012.12.007. Epub 2012 Dec 20. PubMed |
| Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation. Snider NT, Leonard JM, Kwan R, Griggs NW, Rui L, Omary MB. J Cell Biol. 2013 Feb 4;200(3):241-7. doi: 10.1083/jcb.201209028. Epub 2013 Jan 28. PubMed |
| Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase. Madabushi A, Hwang BJ, Jin J, Lu AL. Biochem J. 2013 Nov 15;456(1):89-98. doi: 10.1042/BJ20130670. PubMed |
| FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes. Singh BK, Sinha RA, Zhou J, Xie SY, You SH, Gauthier K, Yen PM. J Biol Chem. 2013 Oct 18;288(42):30365-72. doi: 10.1074/jbc.M113.504845. Epub 2013 Aug 30. PubMed |
| MicroRNA-142 reduces monoamine oxidase A expression and activity in neuronal cells by downregulating SIRT1. Chaudhuri AD, Yelamanchili SV, Fox HS. PLoS One. 2013 Nov 11;8(11):e79579. doi: 10.1371/journal.pone.0079579. eCollection 2013. PubMed |
| Resveratrol differentially regulates NAMPT and SIRT1 in Hepatocarcinoma cells and primary human hepatocytes. Schuster S, Penke M, Gorski T, Petzold-Quinque S, Damm G, Gebhardt R, Kiess W, Garten A. PLoS One. 2014 Mar 6;9(3):e91045. doi: 10.1371/journal.pone.0091045. eCollection 2014. PubMed |
| The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase. Krapivinsky G, Krapivinsky L, Manasian Y, Clapham DE. Cell. 2014 May 22;157(5):1061-72. doi: 10.1016/j.cell.2014.03.046. PubMed |
| Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis. Liu TF, Vachharajani V, Millet P, Bharadwaj MS, Molina AJ, McCall CE. J Biol Chem. 2015 Jan 2;290(1):396-408. doi: 10.1074/jbc.M114.566349. Epub 2014 Nov 17. PubMed |
| Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth. Sun T, Li X, Zhang P, Chen WD, Zhang HL, Li DD, Deng R, Qian XJ, Jiao L, Ji J, Li YT, Wu RY, Yu Y, Feng GK, Zhu XF. Nat Commun. 2015 May 26;6:7215. doi: 10.1038/ncomms8215. PubMed |
| CTGF siRNA ameliorates tubular cell apoptosis and tubulointerstitial fibrosis in obstructed mouse kidneys in a Sirt1-independent manner. Ren Y, Du C, Yan L, Wei J, Wu H, Shi Y, Duan H. Drug Des Devel Ther. 2015 Jul 31;9:4155-71. doi: 10.2147/DDDT.S86748. eCollection 2015. PubMed |
| Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs. Kim HN, Han L, Iyer S, de Cabo R, Zhao H, O'Brien CA, Manolagas SC, Almeida M. Mol Endocrinol. 2015 Oct;29(10):1498-509. doi: 10.1210/me.2015-1133. Epub 2015 Aug 19. PubMed |
| SIRT1 contributes to aldose reductase expression through modulating NFAT5 under osmotic stress: In vitro and in silico insights. Timucin AC, Bodur C, Basaga H. Cell Signal. 2015 Nov;27(11):2160-72. doi: 10.1016/j.cellsig.2015.08.013. Epub 2015 Aug 20. PubMed |
| Resveratrol via sirtuin-1 downregulates RE1-silencing transcription factor (REST) expression preventing PCB-95-induced neuronal cell death. Guida N, Laudati G, Anzilotti S, Secondo A, Montuori P, Di Renzo G, Canzoniero LM, Formisano L. Toxicol Appl Pharmacol. 2015 Nov 1;288(3):387-98. doi: 10.1016/j.taap.2015.08.010. Epub 2015 Aug 22. PubMed |
| Chemical proteomics reveals a gammaH2AX-53BP1 interaction in the DNA damage response. Kleiner RE, Verma P, Molloy KR, Chait BT, Kapoor TM. Nat Chem Biol. 2015 Oct;11(10):807-14. doi: 10.1038/nchembio.1908. Epub 2015 Sep 7. PubMed |
| Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1. Lee WY, Lee WT, Cheng CH, Chen KC, Chou CM, Chung CH, Sun MS, Cheng HW, Ho MN, Lin CW. Oncotarget. 2015 Sep 29;6(29):27580-95. doi: 10.18632/oncotarget.4768. PubMed |
| Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion. Wu Y, Liu X, Zhou Q, Huang C, Meng X, Xu F, Li J. Toxicol Appl Pharmacol. 2015 Dec 1;289(2):163-76. doi: 10.1016/j.taap.2015.09.028. Epub 2015 Oct 3. PubMed |
| Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. Singh BK, Sinha RA, Zhou J, Tripathi M, Ohba K, Wang ME, Astapova I, Ghosh S, Hollenberg AN, Gauthier K, Yen PM. J Biol Chem. 2016 Jan 1;291(1):198-214. doi: 10.1074/jbc.M115.668673. Epub 2015 Oct 9. PubMed |
| Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity. Pasquel D, Doricakova A, Li H, Kortagere S, Krasowski MD, Biswas A, Walton WG, Redinbo MR, Dvorak Z, Mani S. Biochim Biophys Acta. 2016 Sep;1859(9):1155-69. doi: 10.1016/j.bbagrm.2016.01.006. Epub 2016 Feb 23. PubMed |
| SIRT1 at the crossroads of AKT1 and ERbeta in malignant pleural mesothelioma cells. Pinton G, Zonca S, Manente AG, Cavaletto M, Borroni E, Daga A, Jithesh PV, Fennell D, Nilsson S, Moro L. Oncotarget. 2016 Mar 22;7(12):14366-79. doi: 10.18632/oncotarget.7321. PubMed |
| BRCA1 inhibits AR-mediated proliferation of breast cancer cells through the activation of SIRT1. Zhang W, Luo J, Yang F, Wang Y, Yin Y, Strom A, Gustafsson JA, Guan X. Sci Rep. 2016 Feb 23;6:22034. doi: 10.1038/srep22034. PubMed |
| The functional consequences of age-related changes in microRNA expression in skeletal muscle. Soriano-Arroquia A, House L, Tregilgas L, Canty-Laird E, Goljanek-Whysall K. Biogerontology. 2016 Jun;17(3):641-54. doi: 10.1007/s10522-016-9638-8. Epub 2016 Feb 27. PubMed |
| The Deacetylase SIRT1 Regulates the Replication Properties of Human Papillomavirus 16 E1 and E2. Das D, Smith N, Wang X, Morgan IM. J Virol. 2017 Apr 28;91(10). pii: JVI.00102-17. doi: 10.1128/JVI.00102-17. Print 2017 May 15. PubMed |
| SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease. Singh P, Hanson PS, Morris CM. BMC Neurosci. 2017 Jun 2;18(1):46. doi: 10.1186/s12868-017-0364-1. PubMed |
| Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury. Hong Q, Zhang L, Das B, Li Z, Liu B, Cai G, Chen X, Chuang PY, He JC, Lee K. Kidney Int. 2018 Jun;93(6):1330-1343. doi: 10.1016/j.kint.2017.12.008. Epub 2018 Feb 22. PubMed |
| MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes. Dhar SS, Zhao D, Lin T, Gu B, Pal K, Wu SJ, Alam H, Lv J, Yun K, Gopalakrishnan V, Flores ER, Northcott PA, Rajaram V, Li W, Shilatifard A, Sillitoe RV, Chen K, Lee MG. Mol Cell. 2018 Jun 7;70(5):825-841.e6. doi: 10.1016/j.molcel.2018.04.028. Epub 2018 May 31. PubMed |
| Werner Helicase Control of Human Papillomavirus 16 E1-E2 DNA Replication Is Regulated by SIRT1 Deacetylation. Das D, Bristol ML, Smith NW, James CD, Wang X, Pichierri P, Morgan IM. MBio. 2019 Mar 19;10(2). pii: mBio.00263-19. doi: 10.1128/mBio.00263-19. PubMed |
| A Yeast Suppressor Screen Used To Identify Mammalian SIRT1 as a Proviral Factor for Middle East Respiratory Syndrome Coronavirus Replication. Weston S, Matthews KL, Lent R, Vlk A, Haupt R, Kingsbury T, Frieman MB. J Virol. 2019 Jul 30;93(16). pii: JVI.00197-19. doi: 10.1128/JVI.00197-19. Print 2019 Aug 15. PubMed |
| Inhibition of SIRT1/2 upregulates HSPA5 acetylation and induces pro-survival autophagy via ATF4-DDIT4-mTORC1 axis in human lung cancer cells. Mu N, Lei Y, Wang Y, Wang Y, Duan Q, Ma G, Liu X, Su L. Apoptosis. 2019 Oct;24(9-10):798-811. doi: 10.1007/s10495-019-01559-3. PubMed |
| A New Regulatory Mechanism Between P53 And YAP Crosstalk By SIRT1 Mediated Deacetylation To Regulate Cell Cycle And Apoptosis In A549 Cell Lines. Yuan F, Wang J, Li R, Zhao X, Zhang Y, Liu B, Lei Y, Hu Y. Cancer Manag Res. 2019 Sep 23;11:8619-8633. doi: 10.2147/CMAR.S214826. eCollection 2019. PubMed |
| A conserved mechanism of sirtuin signalling through steroid hormone receptors. Bayele HK. Biosci Rep. 2019 Dec 20;39(12). pii: 221190. doi: 10.1042/BSR20193535. PubMed |
| SRT1720-induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA-dependent phosphorylation of AMPKalpha at Ser485. Sung JY, Kim SG, Cho DH, Kim JR, Choi HC. FEBS Open Bio. 2020 May 18. doi: 10.1002/2211-5463.12895. PubMed |
| p33ING1b regulates acetylation of p53 in oral squamous cell carcinoma via SIR2. Li XH, Li D, Liu C, Zhang MM, Guan XJ, Fu YP. Cancer Cell Int. 2020 Aug 18;20:398. doi: 10.1186/s12935-020-01489-0. eCollection 2020. PubMed |
| Prednisolone suppresses adriamycin-induced vascular smooth muscle cell senescence and inflammatory response via the SIRT1-AMPK signaling pathway. Sung JY, Kim SG, Kim JR, Choi HC. PLoS One. 2020 Sep 30;15(9):e0239976. doi: 10.1371/journal.pone.0239976. eCollection 2020. PubMed |
| SIRT1 Protects Dopaminergic Neurons in Parkinson's Disease Models via PGC-1alpha-Mediated Mitochondrial Biogenesis. Chen Y, Jiang Y, Yang Y, Huang X, Sun C. Neurotox Res. 2021 Oct;39(5):1393-1404. doi: 10.1007/s12640-021-00392-4. Epub 2021 Jul 12. PubMed |
| JNK-mediated Ser27 phosphorylation and stabilization of SIRT1 promote growth and progression of colon cancer through deacetylation-dependent activation of Snail. Lee YH, Kim SJ, Fang X, Song NY, Kim DH, Suh J, Na HK, Kim KO, Baek JH, Surh YJ. Mol Oncol. 2022 Apr;16(7):1555-1571. doi: 10.1002/1878-0261.13143. Epub 2022 Jan 4. PubMed |
| SIRT1 attenuates neuroinflammation by deacetylating HSPA4 in a mouse model of Parkinson's disease. Yang Y, Zhang S, Guan J, Jiang Y, Zhang J, Luo L, Sun C. Biochim Biophys Acta Mol Basis Dis. 2022 May 1;1868(5):166365. doi: 10.1016/j.bbadis.2022.166365. Epub 2022 Feb 11. PubMed |
| Short-chain fatty acids ameliorate necrotizing enterocolitis-like intestinal injury through enhancing Notch1-mediated single immunoglobulin interleukin-1-related receptor, toll-interacting protein, and A20 induction. Yu W, Venkatraman A, Menden HL, Martinez M, Umar S, Sampath V. Am J Physiol Gastrointest Liver Physiol. 2023 Jan 1;324(1):G24-G37. doi: 10.1152/ajpgi.00057.2022. Epub 2022 Nov 21. PubMed |
| Sirtuin 5-mediated deacetylation of TAZ at K54 promotes melanoma development. Kim G, Bhattarai PY, Lim SC, Lee KY, Choi HS. Cell Oncol (Dordr). 2023 Dec 19. doi: 10.1007/s13402-023-00910-w. PubMed |
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