FHRE-Luc Citations (43)
Originally described in: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME Cell 1999 Mar 19;96(6):857-68. PubMed Journal
Articles Citing FHRE-Luc
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| Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? Jung-Hynes B, Nihal M, Zhong W, Ahmad N. J Biol Chem. 2009 Feb 6. 284(6):3823-32. PubMed |
| Rac1 promotes TGF-beta-stimulated mesangial cell type I collagen expression through a PI3K/Akt-dependent mechanism. Hubchak SC, Sparks EE, Hayashida T, Schnaper HW. Am J Physiol Renal Physiol. 2009 Nov;297(5):F1316-23. doi: 10.1152/ajprenal.00345.2009. Epub 2009 Sep 2. PubMed |
| Effects of FoxO4 overexpression on cholesterol biosynthesis, triacylglycerol accumulation, and glucose uptake. Zhu J, Mounzih K, Chehab EF, Mitro N, Saez E, Chehab FF. J Lipid Res. 2010 Jun;51(6):1312-24. doi: 10.1194/jlr.M001586. Epub 2009 Dec 25. PubMed |
| Detection of a functional xenobiotic response element in a widely employed FoxO-responsive reporter construct. Eckers A, Sauerbier E, Anwar-Mohamed A, Hamann I, Esser C, Schroeder P, El-Kadi AO, Klotz LO. Arch Biochem Biophys. 2011 Dec 15;516(2):138-45. doi: 10.1016/j.abb.2011.10.006. Epub 2011 Oct 15. PubMed |
| NAMPT pathway is involved in the FOXO3a-mediated regulation of GADD45A expression. Thakur BK, Lippka Y, Dittrich T, Chandra P, Skokowa J, Welte K. Biochem Biophys Res Commun. 2012 Apr 20;420(4):714-20. doi: 10.1016/j.bbrc.2012.03.017. Epub 2012 Mar 10. PubMed |
| Phosphatidylinositol 3-kinase and Rab5 GTPase inversely regulate the Smad anchor for receptor activation (SARA) protein independently of transforming growth factor-beta1. Runyan CE, Liu Z, Schnaper HW. J Biol Chem. 2012 Oct 19;287(43):35815-24. doi: 10.1074/jbc.M112.380493. Epub 2012 Aug 31. PubMed |
| Trastuzumab-resistant cells rely on a HER2-PI3K-FoxO-survivin axis and are sensitive to PI3K inhibitors. Chakrabarty A, Bhola NE, Sutton C, Ghosh R, Kuba MG, Dave B, Chang JC, Arteaga CL. Cancer Res. 2013 Feb 1;73(3):1190-200. doi: 10.1158/0008-5472.CAN-12-2440. Epub 2012 Nov 29. PubMed |
| Melatonin induces transcriptional regulation of Bim by FoxO3a in HepG2 cells. Carbajo-Pescador S, Steinmetz C, Kashyap A, Lorenz S, Mauriz JL, Heise M, Galle PR, Gonzalez-Gallego J, Strand S. Br J Cancer. 2013 Feb 5;108(2):442-9. doi: 10.1038/bjc.2012.563. Epub 2012 Dec 20. PubMed |
| Measles virus nucleocapsid protein, a key contributor to Paget's disease, increases IL-6 expression via down-regulation of FoxO3/Sirt1 signaling. Wang FM, Sarmasik A, Hiruma Y, Sun Q, Sammut B, Windle JJ, Roodman GD, Galson DL. Bone. 2013 Mar;53(1):269-76. doi: 10.1016/j.bone.2012.12.007. Epub 2012 Dec 20. PubMed |
| Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol. Xia N, Strand S, Schlufter F, Siuda D, Reifenberg G, Kleinert H, Forstermann U, Li H. Nitric Oxide. 2013 Aug 1;32:29-35. doi: 10.1016/j.niox.2013.04.001. Epub 2013 Apr 10. PubMed |
| Quercetin induces growth arrest through activation of FOXO1 transcription factor in EGFR-overexpressing oral cancer cells. Huang CY, Chan CY, Chou IT, Lien CH, Hung HC, Lee MF. J Nutr Biochem. 2013 Sep;24(9):1596-603. doi: 10.1016/j.jnutbio.2013.01.010. Epub 2013 Apr 22. PubMed |
| SIRT1 protein, by blocking the activities of transcription factors FoxO1 and FoxO3, inhibits muscle atrophy and promotes muscle growth. Lee D, Goldberg AL. J Biol Chem. 2013 Oct 18;288(42):30515-26. doi: 10.1074/jbc.M113.489716. Epub 2013 Sep 3. PubMed |
| The soluble Decoy Receptor 3 is regulated by a PI3K-dependent mechanism and promotes migration and invasion in renal cell carcinoma. Weissinger D, Tagscherer KE, Macher-Goppinger S, Haferkamp A, Wagener N, Roth W. Mol Cancer. 2013 Oct 10;12(1):120. doi: 10.1186/1476-4598-12-120. PubMed |
| HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy. Beharry AW, Sandesara PB, Roberts BM, Ferreira LF, Senf SM, Judge AR. J Cell Sci. 2014 Apr 1;127(Pt 7):1441-53. doi: 10.1242/jcs.136390. Epub 2014 Jan 24. PubMed |
| Cell differentiation versus cell death: extracellular glucose is a key determinant of cell fate following oxidative stress exposure. Poulsen RC, Knowles HJ, Carr AJ, Hulley PA. Cell Death Dis. 2014 Feb 20;5:e1074. doi: 10.1038/cddis.2014.52. PubMed |
| Forkhead transcription factor FOXO1 inhibits nuclear factor-kappaB in gastric cancer. Yu DA, Yoon J, Ko YS, Park J, Kim SY, Kim MA, Kim JH, Jung J, Cheon Y, Lee HS, Kim WH, Lee BL. APMIS. 2014 Sep;122(9):848-55. doi: 10.1111/apm.12247. Epub 2014 Mar 28. PubMed |
| Regulation of the tumor suppressor FOXO3 by the thromboxane-A2 receptors in urothelial cancer. Sobolesky PM, Halushka PV, Garrett-Mayer E, Smith MT, Moussa O. PLoS One. 2014 Sep 9;9(9):e107530. doi: 10.1371/journal.pone.0107530. eCollection 2014. PubMed |
| RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress response. Zhang T, Baldie G, Periz G, Wang J. PLoS Genet. 2014 Oct 16;10(10):e1004693. doi: 10.1371/journal.pgen.1004693. eCollection 2014 Oct. PubMed |
| Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension. Savai R, Al-Tamari HM, Sedding D, Kojonazarov B, Muecke C, Teske R, Capecchi MR, Weissmann N, Grimminger F, Seeger W, Schermuly RT, Pullamsetti SS. Nat Med. 2014 Nov;20(11):1289-300. doi: 10.1038/nm.3695. Epub 2014 Oct 26. PubMed |
| Resveratrol prevents oxidative stress-induced senescence and proliferative dysfunction by activating the AMPK-FOXO3 cascade in cultured primary human keratinocytes. Ido Y, Duranton A, Lan F, Weikel KA, Breton L, Ruderman NB. PLoS One. 2015 Feb 3;10(2):e0115341. doi: 10.1371/journal.pone.0115341. eCollection 2015. PubMed |
| MicroRNA-3127 promotes cell proliferation and tumorigenicity in hepatocellular carcinoma by disrupting of PI3K/AKT negative regulation. Jiang J, Zhang Y, Guo Y, Yu C, Chen M, Li Z, Tian S, Sun C. Oncotarget. 2015 Mar 20;6(8):6359-72. PubMed |
| The transcription factor FoxK participates with Nup98 to regulate antiviral gene expression. Panda D, Gold B, Tartell MA, Rausch K, Casas-Tinto S, Cherry S. MBio. 2015 Apr 7;6(2). pii: e02509-14. doi: 10.1128/mBio.02509-14. PubMed |
| Loss of FOXO1 promotes gastric tumour growth and metastasis through upregulation of human epidermal growth factor receptor 2/neu expression. Ko YS, Cho SJ, Park J, Kim Y, Choi YJ, Pyo JS, Jang BG, Park JW, Kim WH, Lee BL. Br J Cancer. 2015 Oct 20;113(8):1186-96. doi: 10.1038/bjc.2015.273. Epub 2015 Oct 8. PubMed |
| Effects of phycocyanin on INS-1 pancreatic beta-cell mediated by PI3K/Akt/FoxO1 signaling pathway. Gao Y, Liao G, Xiang C, Yang X, Cheng X, Ou Y. Int J Biol Macromol. 2016 Feb;83:185-94. doi: 10.1016/j.ijbiomac.2015.11.054. Epub 2015 Nov 23. PubMed |
| Activation of the phosphatidylinositol 3-kinase/Akt pathway by viral interferon regulatory factor 2 of Kaposi's sarcoma-associated herpesvirus. Kim Y, Cha S, Seo T. Biochem Biophys Res Commun. 2016 Feb 12;470(3):650-6. doi: 10.1016/j.bbrc.2016.01.087. Epub 2016 Jan 18. PubMed |
| c-Jun N-terminal kinase activation has a prognostic implication and is negatively associated with FOXO1 activation in gastric cancer. Choi Y, Park J, Choi Y, Ko YS, Yu DA, Kim Y, Pyo JS, Jang BG, Kim MA, Kim WH, Lee BL. BMC Gastroenterol. 2016 Jun 6;16(1):59. doi: 10.1186/s12876-016-0473-9. PubMed |
| Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity. Yoon SP, Kim J. Anat Cell Biol. 2016 Sep;49(3):165-176. Epub 2016 Sep 29. PubMed |
| REP1 inhibits FOXO3-mediated apoptosis to promote cancer cell survival. Song KH, Woo SR, Chung JY, Lee HJ, Oh SJ, Hong SO, Shim J, Kim YN, Rho SB, Hong SM, Cho H, Hibi M, Bae DJ, Kim SY, Kim MG, Kim TW, Bae YK. Cell Death Dis. 2017 Jan 5;8(1):e2536. doi: 10.1038/cddis.2016.462. PubMed |
| Akt3 is a privileged first responder in isozyme-specific electrophile response. Long MJ, Parvez S, Zhao Y, Surya SL, Wang Y, Zhang S, Aye Y. Nat Chem Biol. 2017 Mar;13(3):333-338. doi: 10.1038/nchembio.2284. Epub 2017 Jan 23. PubMed |
| AMP-activated protein kinase alpha1 promotes atherogenesis by increasing monocyte-to-macrophage differentiation. Zhang M, Zhu H, Ding Y, Liu Z, Cai Z, Zou MH. J Biol Chem. 2017 May 12;292(19):7888-7903. doi: 10.1074/jbc.M117.779447. Epub 2017 Mar 22. PubMed |
| FOXO1 Suppression is a Determinant of Acquired Lapatinib-Resistance in HER2-Positive Gastric Cancer Cells Through MET Upregulation. Park J, Choi Y, Ko YS, Kim Y, Pyo JS, Jang BG, Kim MA, Lee JS, Chang MS, Park JW, Lee BL. Cancer Res Treat. 2018 Jan;50(1):239-254. doi: 10.4143/crt.2016.580. Epub 2017 Mar 24. PubMed |
| Flavonoids as Putative Inducers of the Transcription Factors Nrf2, FoxO, and PPARgamma. Pallauf K, Duckstein N, Hasler M, Klotz LO, Rimbach G. Oxid Med Cell Longev. 2017;2017:4397340. doi: 10.1155/2017/4397340. Epub 2017 Jul 6. PubMed |
| FOXO1 reduces tumorsphere formation capacity and has crosstalk with LGR5 signaling in gastric cancer cells. Choi Y, Park J, Ko YS, Kim Y, Pyo JS, Jang BG, Kim MA, Lee JS, Chang MS, Lee BL. Biochem Biophys Res Commun. 2017 Nov 25;493(3):1349-1355. doi: 10.1016/j.bbrc.2017.09.163. Epub 2017 Sep 29. PubMed |
| Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins. Hellinger R, Thell K, Vasileva M, Muhammad T, Gunasekera S, Kummel D, Goransson U, Becker CW, Gruber CW. Front Chem. 2017 Oct 11;5:73. doi: 10.3389/fchem.2017.00073. eCollection 2017. PubMed |
| Foxo-dependent Par-4 Upregulation Prevents Long-term Survival of Residual Cells Following PI3K-Akt Inhibition. Damrauer JS, Phelps SN, Amuchastegui K, Lupo R, Mabe NW, Walens A, Kroger BR, Alvarez JV. Mol Cancer Res. 2018 Apr;16(4):599-609. doi: 10.1158/1541-7786.MCR-17-0492. Epub 2018 Jan 12. PubMed |
| FOXO1 cysteine-612 mediates stimulatory effects of the coregulators CBP and PGC1alpha on FOXO1 basal transcriptional activity. Tsitsipatis D, Gopal K, Steinbrenner H, Klotz LO. Free Radic Biol Med. 2018 Apr;118:98-107. doi: 10.1016/j.freeradbiomed.2018.02.034. Epub 2018 Mar 2. PubMed |
| beta-arrestin1-medieated inhibition of FOXO3a contributes to prostate cancer cell growth in vitro and in vivo. Kong Z, Deng T, Zhang M, Zhao Z, Liu Y, Luo L, Cai C, Wu W, Duan X. Cancer Sci. 2018 Jun;109(6):1834-1842. doi: 10.1111/cas.13619. Epub 2018 May 26. PubMed |
| Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but independent of TRAIL. Feehan RP, Nelson AM, Shantz LM. Cell Signal. 2018 Dec;52:35-47. doi: 10.1016/j.cellsig.2018.08.018. Epub 2018 Aug 30. PubMed |
| Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis. Choi S, Jeong HJ, Kim H, Choi D, Cho SC, Seong JK, Koo SH, Kang JS. Autophagy. 2019 Jun;15(6):1069-1081. doi: 10.1080/15548627.2019.1569931. Epub 2019 Feb 5. PubMed |
| FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, He X, Wang S, Ding J, Chan P, Zhang W, Song M, Izpisua Belmonte JC, Qu J, Tang F, Liu GH. Cell Stem Cell. 2019 Mar 7;24(3):447-461.e8. doi: 10.1016/j.stem.2018.12.002. Epub 2019 Jan 17. PubMed |
| CTRP9 Mediates Protective Effects in Cardiomyocytes via AMPK- and Adiponectin Receptor-Mediated Induction of Anti-Oxidant Response. Niemann B, Li L, Siegler D, Siegler BH, Knapp F, Hanna J, Aslam M, Kracht M, Schulz R, Rohrbach S. Cells. 2020 May 15;9(5). pii: cells9051229. doi: 10.3390/cells9051229. PubMed |
| ERK Inhibitor LY3214996-Based Treatment Strategies for RAS-Driven Lung Cancer. Kohler J, Zhao Y, Li J, Gokhale PC, Tiv HL, Knott AR, Wilkens MK, Soroko KM, Lin M, Ambrogio C, Musteanu M, Ogino A, Choi J, Bahcall M, Bertram AA, Chambers ES, Paweletz CP, Bhagwat SV, Manro JR, Tiu RV, Janne PA. Mol Cancer Ther. 2021 Apr;20(4):641-654. doi: 10.1158/1535-7163.MCT-20-0531. Epub 2021 Feb 3. PubMed |
| Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors. Nataraj NB, Noronha A, Lee JS, Ghosh S, Mohan Raju HR, Sekar A, Zuckerman B, Lindzen M, Tarcitano E, Srivastava S, Selitrennik M, Livneh I, Drago-Garcia D, Rueda O, Caldas C, Lev S, Geiger T, Ciechanover A, Ulitsky I, Seger R, Ruppin E, Yarden Y. Cell Rep. 2022 Feb 22;38(8):110418. doi: 10.1016/j.celrep.2022.110418. PubMed |
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