pBABE-puro-hTERT Citations (34)
Originally described in: Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization.Counter CM, Hahn WC, Wei W, Caddle SD, Beijersbergen RL, Lansdorp PM, Sedivy JM, Weinberg RA Proc Natl Acad Sci U S A 1998 Dec 8;95(25):14723-8. PubMed Journal
Articles Citing pBABE-puro-hTERT
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| Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells. Chapman EJ, Kelly G, Knowles MA. Mol Cancer Res. 2008 Jul;6(7):1154-68. doi: 10.1158/1541-7786.MCR-07-2168. PubMed |
| Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts. Walter K, Omura N, Hong SM, Griffith M, Vincent A, Borges M, Goggins M. Clin Cancer Res. 2010 Mar 15;16(6):1781-9. doi: 10.1158/1078-0432.CCR-09-1913. Epub 2010 Mar 9. PubMed |
| Culture, immortalization, and characterization of human meibomian gland epithelial cells. Liu S, Hatton MP, Khandelwal P, Sullivan DA. Invest Ophthalmol Vis Sci. 2010 Aug;51(8):3993-4005. doi: 10.1167/iovs.09-5108. Epub 2010 Mar 24. PubMed |
| Acycloguanosyl 5'-thymidyltriphosphate, a thymidine analogue prodrug activated by telomerase, reduces pancreatic tumor growth in mice. Polvani S, Calamante M, Foresta V, Ceni E, Mordini A, Quattrone A, D'Amico M, Luchinat C, Bertini I, Galli A. Gastroenterology. 2011 Feb;140(2):709-720.e9. doi: 10.1053/j.gastro.2010.10.050. Epub 2010 Oct 30. PubMed |
| Telomerase efficiently elongates highly transcribing telomeres in human cancer cells. Farnung BO, Brun CM, Arora R, Lorenzi LE, Azzalin CM. PLoS One. 2012;7(4):e35714. doi: 10.1371/journal.pone.0035714. Epub 2012 Apr 27. PubMed |
| Telomerase immortalization of human corneal endothelial cells yields functional hexagonal monolayers. Schmedt T, Chen Y, Nguyen TT, Li S, Bonanno JA, Jurkunas UV. PLoS One. 2012;7(12):e51427. doi: 10.1371/journal.pone.0051427. Epub 2012 Dec 21. PubMed |
| Constitutive expression of human telomerase enhances the proliferation potential of human mesenchymal stem cells. Bischoff DS, Makhijani NS, Yamaguchi DT. Biores Open Access. 2012 Dec;1(6):273-9. doi: 10.1089/biores.2012.0252. PubMed |
| Induction of STEAP4 correlates with 1,25-dihydroxyvitamin D3 stimulation of adipogenesis in mesenchymal progenitor cells derived from human adipose tissue. Narvaez CJ, Simmons KM, Brunton J, Salinero A, Chittur SV, Welsh JE. J Cell Physiol. 2013 Oct;228(10):2024-36. doi: 10.1002/jcp.24371. PubMed |
| Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cells. Mazumdar T, Sandhu R, Qadan M, DeVecchio J, Magloire V, Agyeman A, Li B, Houghton JA. PLoS One. 2013 Sep 25;8(9):e75253. doi: 10.1371/journal.pone.0075253. eCollection 2013. PubMed |
| Generation and characterization of an immortalized human mesenchymal stromal cell line. Skarn M, Noordhuis P, Wang MY, Veuger M, Kresse SH, Egeland EV, Micci F, Namlos HM, Hakelien AM, Olafsrud SM, Lorenz S, Haraldsen G, Kvalheim G, Meza-Zepeda LA, Myklebost O. Stem Cells Dev. 2014 Oct 1;23(19):2377-89. doi: 10.1089/scd.2013.0599. Epub 2014 Jun 30. PubMed |
| The use of transformed IMR90 cell model to identify the potential extra-telomeric effects of hTERT in cell migration and DNA damage response. Cao X, Kong CM, Mathi KM, Lim YP, Cacheux-Rataboul V, Wang X. BMC Biochem. 2014 Aug 7;15:17. doi: 10.1186/1471-2091-15-17. PubMed |
| hTERT-immortalized ovine microglia propagate natural scrapie isolates. Munoz-Gutierrez JF, Schneider DA, Baszler TV, Greenlee JJ, Nicholson EM, Stanton JB. Virus Res. 2015 Feb 16;198:35-43. doi: 10.1016/j.virusres.2014.10.028. Epub 2015 Jan 12. PubMed |
| Transcriptome Profiling of the Virus-Induced Innate Immune Response in Pteropus vampyrus and Its Attenuation by Nipah Virus Interferon Antagonist Functions. Glennon NB, Jabado O, Lo MK, Shaw ML. J Virol. 2015 Aug 1;89(15):7550-66. doi: 10.1128/JVI.00302-15. Epub 2015 May 13. PubMed |
| Humanization of the mouse mammary gland. Wronski A, Arendt LM, Kuperwasser C. Methods Mol Biol. 2015;1293:173-86. doi: 10.1007/978-1-4939-2519-3_10. PubMed |
| Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. Panneer Selvam S, De Palma RM, Oaks JJ, Oleinik N, Peterson YK, Stahelin RV, Skordalakes E, Ponnusamy S, Garrett-Mayer E, Smith CD, Ogretmen B. Sci Signal. 2015 Jun 16;8(381):ra58. doi: 10.1126/scisignal.aaa4998. PubMed |
| In vitro and in vivo correlates of physiological and neoplastic human Fallopian tube stem cells. Yamamoto Y, Ning G, Howitt BE, Mehra K, Wu L, Wang X, Hong Y, Kern F, Wei TS, Zhang T, Nagarajan N, Basuli D, Torti S, Brewer M, Choolani M, McKeon F, Crum CP, Xian W. J Pathol. 2016 Mar;238(4):519-30. doi: 10.1002/path.4649. Epub 2016 Jan 9. PubMed |
| Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence. Patel PL, Suram A, Mirani N, Bischof O, Herbig U. Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E5024-33. doi: 10.1073/pnas.1602379113. Epub 2016 Aug 8. PubMed |
| Potent EMT and CSC Phenotypes are Induced by Oncostatin-M in Pancreatic Cancer. Smigiel JM, Parameswaran N, Jackson MW. Mol Cancer Res. 2017 Jan 4. pii: molcanres.0337.2016. doi: 10.1158/1541-7786.MCR-16-0337. PubMed |
| Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism. Reynolds JJ, Bicknell LS, Carroll P, Higgs MR, Shaheen R, Murray JE, Papadopoulos DK, Leitch A, Murina O, Tarnauskaite Z, Wessel SR, Zlatanou A, Vernet A, von Kriegsheim A, Mottram RM, Logan CV, Bye H, Li Y, Brean A, Maddirevula S, Challis RC, Skouloudaki K, Almoisheer A, Alsaif HS, Amar A, Prescott NJ, Bober MB, Duker A, Faqeih E, Seidahmed MZ, Al Tala S, Alswaid A, Ahmed S, Al-Aama JY, Altmuller J, Al Balwi M, Brady AF, Chessa L, Cox H, Fischetto R, Heller R, Henderson BD, Hobson E, Nurnberg P, Percin EF, Peron A, Spaccini L, Quigley AJ, Thakur S, Wise CA, Yoon G, Alnemer M, Tomancak P, Yigit G, Taylor AM, Reijns MA, Simpson MA, Cortez D, Alkuraya FS, Mathew CG, Jackson AP, Stewart GS. Nat Genet. 2017 Apr;49(4):537-549. doi: 10.1038/ng.3790. Epub 2017 Feb 13. PubMed |
| Hypoxia-inducible factor-1alpha plays roles in Epstein-Barr virus's natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter. Kraus RJ, Yu X, Cordes BA, Sathiamoorthi S, Iempridee T, Nawandar DM, Ma S, Romero-Masters JC, McChesney KG, Lin Z, Makielski KR, Lee DL, Lambert PF, Johannsen EC, Kenney SC, Mertz JE. PLoS Pathog. 2017 Jun 15;13(6):e1006404. doi: 10.1371/journal.ppat.1006404. eCollection 2017 Jun. PubMed |
| Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres. Dagg RA, Pickett HA, Neumann AA, Napier CE, Henson JD, Teber ET, Arthur JW, Reynolds CP, Murray J, Haber M, Sobinoff AP, Lau LMS, Reddel RR. Cell Rep. 2017 Jun 20;19(12):2544-2556. doi: 10.1016/j.celrep.2017.05.087. PubMed |
| Telomerase reverse transcriptase promotes chemoresistance by suppressing cisplatin-dependent apoptosis in osteosarcoma cells. Zhang Z, Yu L, Dai G, Xia K, Liu G, Song Q, Tao C, Gao T, Guo W. Sci Rep. 2017 Aug 1;7(1):7070. doi: 10.1038/s41598-017-07204-w. PubMed |
| Transformation of mouse T cells requires MYC and AKT activity in conjunction with inhibition of intrinsic apoptosis. Hogstrand K, Darmanin S, Forshell TP, Grandien A. Oncotarget. 2018 Apr 20;9(30):21396-21410. doi: 10.18632/oncotarget.25113. eCollection 2018 Apr 20. PubMed |
| Telomerase reverse transcriptase coordinates with the epithelial-to-mesenchymal transition through a feedback loop to define properties of breast cancer stem cells. El-Badawy A, Ghoneim NI, Nasr MA, Elkhenany H, Ahmed TA, Ahmed SM, El-Badri N. Biol Open. 2018 Jul 25;7(7). pii: bio.034181. doi: 10.1242/bio.034181. PubMed |
| MYC-driven malignant transformation of mature murine B cells requires inhibition of both intrinsic apoptosis and p53 activity. Hogstrand K, Grandien A. Eur J Immunol. 2019 Mar;49(3):375-385. doi: 10.1002/eji.201847585. Epub 2018 Oct 12. PubMed |
| Telomerase reverse transcriptase activates transcription of miR500A to inhibit Hedgehog signalling and promote cell invasiveness. Bernabe-Garcia M, Martinez-Balsalobre E, Garcia-Moreno D, Garcia-Castillo J, Revilla-Nuin B, Blanco-Alcaina E, Mulero V, Alcaraz-Perez F, Cayuela ML. Mol Oncol. 2021 Jul;15(7):1818-1834. doi: 10.1002/1878-0261.12943. Epub 2021 May 2. PubMed |
| Impaired protein hydroxylase activity causes replication stress and developmental abnormalities in humans. Fletcher SC, Hall C, Kennedy TJ, Pajusalu S, Wojcik MH, Boora U, Li C, Oja KT, Hendrix E, Westrip CA, Andrijes R, Piasecka SK, Singh M, El-Asrag ME, Ptasinska A, Tillmann V, Higgs MR, Carere DA, Beggs AD, Pappas J, Rabin R, Smerdon SJ, Stewart GS, Ounap K, Coleman ML. J Clin Invest. 2023 Apr 3;133(7):e152784. doi: 10.1172/JCI152784. PubMed |
| TERT Extra-Telomeric Roles: Antioxidant Activity and Mitochondrial Protection. Marinaccio J, Micheli E, Udroiu I, Di Nottia M, Carrozzo R, Baranzini N, Grimaldi A, Leone S, Moreno S, Muzzi M, Sgura A. Int J Mol Sci. 2023 Feb 23;24(5):4450. doi: 10.3390/ijms24054450. PubMed |
| Pro-tumor Tfh2 cells induce detrimental IgG4 production and PGE(2)-dependent IgE inhibition in pancreatic cancer. De Monte L, Clemente F, Ruggiero E, Pini R, Ceraolo MG, Schiavo Lena M, Balestrieri C, Lazarevic D, Belfiori G, Crippa S, Balzano G, Falconi M, Doglioni C, Bonini C, Reni M, Protti MP. EBioMedicine. 2023 Nov;97:104819. doi: 10.1016/j.ebiom.2023.104819. Epub 2023 Sep 28. PubMed |
| Electroporation-based Easi-CRISPR yields biallelic insertions of EGFP-HiBiT cassette in immortalized chicken oviduct epithelial cells. Liu L, Wei J, Chen C, Liang Q, Wang B, Wu W, Li G, Zheng X. Poult Sci. 2023 Dec;102(12):103112. doi: 10.1016/j.psj.2023.103112. Epub 2023 Sep 14. PubMed |
| Adipogenic characterization of immortalized CD55(+) progenitor cells from human white adipose tissue. Couchet M, Gao H, Klingelhuber F, Jalkanen J, De Castro Barbosa T, Omar-Hmeadi M, Massier L, Krahmer N, Mejhert N, Ryden M. Adipocyte. 2023 Nov 20:2283213. doi: 10.1080/21623945.2023.2283213. PubMed |
| Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer. Alaimo A, Genovesi S, Annesi N, De Felice D, Subedi S, Macchia A, La Manna F, Ciani Y, Vannuccini F, Mugoni V, Notarangelo M, Libergoli M, Broso F, Taulli R, Ala U, Savino A, Cortese M, Mirzaaghaei S, Poli V, Bonapace IM, Papotti MG, Molinaro L, Doglioni C, Caffo O, Anesi A, Nagler M, Bertalot G, Carbone FG, Barbareschi M, Basso U, Dassi E, Pizzato M, Romanel A, Demichelis F, Kruithof-de Julio M, Lunardi A. EMBO J. 2024 Mar;43(5):780-805. doi: 10.1038/s44318-024-00040-5. Epub 2024 Feb 5. PubMed |
| Urine-derived podocytes from steroid resistant nephrotic syndrome patients as a model for renal-progenitor derived extracellular vesicles effect and drug screening. Tanzi A, Buono L, Grange C, Iampietro C, Brossa A, Arcolino FO, Arigoni M, Calogero R, Perin L, Deaglio S, Levtchenko E, Peruzzi L, Bussolati B. Res Sq [Preprint]. 2024 Feb 28:rs.3.rs-3959549. doi: 10.21203/rs.3.rs-3959549/v1. PubMed |
| Comparative Analysis of Primary Ovarian Cancer Cells and Established Cell Lines as a New Tool for Studies on Ovarian Cancer Cell Complexity. Szyposzynska A, Bielawska-Pohl A, Paprocka M, Bar J, Murawski M, Klimczak A. Int J Mol Sci. 2024 May 15;25(10):5384. doi: 10.3390/ijms25105384. PubMed |
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