pRK5-HA-Ubiquitin-K63 Citations (124)
Originally described in: Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation.Lim KL, Chew KC, Tan JM, Wang C, Chung KK, Zhang Y, Tanaka Y, Smith W, Engelender S, Ross CA, Dawson VL, Dawson TM J Neurosci. 2005 Feb 23. 25(8):2002-9. PubMed Journal
Articles Citing pRK5-HA-Ubiquitin-K63
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| ErbB2 trafficking and degradation associated with K48 and K63 polyubiquitination. Marx C, Held JM, Gibson BW, Benz CC. Cancer Res. 2010 May 1;70(9):3709-17. doi: 10.1158/0008-5472.CAN-09-3768. Epub 2010 Apr 20. PubMed |
| Phosphorylation and polyubiquitination of transforming growth factor beta-activated kinase 1 are necessary for activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. Bottero V, Kerur N, Sadagopan S, Patel K, Sharma-Walia N, Chandran B. J Virol. 2011 Mar;85(5):1980-93. doi: 10.1128/JVI.01911-10. Epub 2010 Dec 15. PubMed |
| Recruitment of APPL1 to ubiquitin-rich aggresomes in response to proteasomal impairment. Pilecka I, Sadowski L, Kalaidzidis Y, Miaczynska M. Exp Cell Res. 2011 May 1;317(8):1093-107. doi: 10.1016/j.yexcr.2011.02.002. Epub 2011 Feb 19. PubMed |
| Assessing ubiquitination of viral proteins: Lessons from flavivirus NS5. Taylor RT, Best SM. Methods. 2011 Oct;55(2):166-71. doi: 10.1016/j.ymeth.2011.08.003. Epub 2011 Aug 10. PubMed |
| De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF. Mahul-Mellier AL, Pazarentzos E, Datler C, Iwasawa R, AbuAli G, Lin B, Grimm S. Cell Death Differ. 2012 May;19(5):891-9. doi: 10.1038/cdd.2011.185. Epub 2011 Dec 16. PubMed |
| Structural basis of cytotoxicity mediated by the type III secretion toxin ExoU from Pseudomonas aeruginosa. Gendrin C, Contreras-Martel C, Bouillot S, Elsen S, Lemaire D, Skoufias DA, Huber P, Attree I, Dessen A. PLoS Pathog. 2012;8(4):e1002637. doi: 10.1371/journal.ppat.1002637. Epub 2012 Apr 5. PubMed |
| De-ubiquitinating proteases USP2a and USP2c cause apoptosis by stabilising RIP1. Mahul-Mellier AL, Datler C, Pazarentzos E, Lin B, Chaisaklert W, Abuali G, Grimm S. Biochim Biophys Acta. 2012 Aug;1823(8):1353-65. doi: 10.1016/j.bbamcr.2012.05.022. Epub 2012 May 30. PubMed |
| Non-covalent interaction between polyubiquitin and GTP cyclohydrolase 1 dictates its degradation. Zhao Y, Zhu H, Zou MH. PLoS One. 2012;7(9):e43306. doi: 10.1371/journal.pone.0043306. Epub 2012 Sep 12. PubMed |
| Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response. Radovanac K, Morgner J, Schulz JN, Blumbach K, Patterson C, Geiger T, Mann M, Krieg T, Eckes B, Fassler R, Wickstrom SA. EMBO J. 2013 May 15;32(10):1409-24. doi: 10.1038/emboj.2013.90. Epub 2013 Apr 23. PubMed |
| Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15. Inoue S, Hao Z, Elia AJ, Cescon D, Zhou L, Silvester J, Snow B, Harris IS, Sasaki M, Li WY, Itsumi M, Yamamoto K, Ueda T, Dominguez-Brauer C, Gorrini C, Chio II, Haight J, You-Ten A, McCracken S, Wakeham A, Ghazarian D, Penn LJ, Melino G, Mak TW. Genes Dev. 2013 May 15;27(10):1101-14. doi: 10.1101/gad.214577.113. PubMed |
| RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks. Bohgaki M, Bohgaki T, El Ghamrasni S, Srikumar T, Maire G, Panier S, Fradet-Turcotte A, Stewart GS, Raught B, Hakem A, Hakem R. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):20982-7. doi: 10.1073/pnas.1320302111. Epub 2013 Dec 9. PubMed |
| MEKK3 and TAK1 synergize to activate IKK complex in Helicobacter pylori infection. Sokolova O, Maubach G, Naumann M. Biochim Biophys Acta. 2014 Apr;1843(4):715-24. doi: 10.1016/j.bbamcr.2014.01.006. Epub 2014 Jan 11. PubMed |
| Activation of duck RIG-I by TRIM25 is independent of anchored ubiquitin. Miranzo-Navarro D, Magor KE. PLoS One. 2014 Jan 23;9(1):e86968. doi: 10.1371/journal.pone.0086968. eCollection 2014. PubMed |
Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase.
Birsa N, Norkett R, Wauer T, Mevissen TE, Wu HC, Foltynie T, Bhatia K, Hirst WD, Komander D, Plun-Favreau H, Kittler JT.
J Biol Chem. 2014 May 23;289(21):14569-82. doi: 10.1074/jbc.M114.563031. Epub 2014 Mar 26.
PubMed
Associated Plasmids |
| AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions. Ribeiro-Rodrigues TM, Catarino S, Marques C, Ferreira JV, Martins-Marques T, Pereira P, Girao H. FASEB J. 2014 Nov;28(11):4629-41. doi: 10.1096/fj.13-248963. Epub 2014 Jul 28. PubMed |
| Lysine 63-linked TANK-binding kinase 1 ubiquitination by mindbomb E3 ubiquitin protein ligase 2 is mediated by the mitochondrial antiviral signaling protein. Ye JS, Kim N, Lee KJ, Nam YR, Lee U, Joo CH. J Virol. 2014 Nov;88(21):12765-76. doi: 10.1128/JVI.02037-14. Epub 2014 Aug 20. PubMed |
| HTLV-1 tax stabilizes MCL-1 via TRAF6-dependent K63-linked polyubiquitination to promote cell survival and transformation. Choi YB, Harhaj EW. PLoS Pathog. 2014 Oct 23;10(10):e1004458. doi: 10.1371/journal.ppat.1004458. eCollection 2014 Oct. PubMed |
| Regulation of autophagy by E3 ubiquitin ligase RNF216 through BECN1 ubiquitination. Xu C, Feng K, Zhao X, Huang S, Cheng Y, Qian L, Wang Y, Sun H, Jin M, Chuang TH, Zhang Y. Autophagy. 2014;10(12):2239-50. doi: 10.4161/15548627.2014.981792. PubMed |
| IRGM governs the core autophagy machinery to conduct antimicrobial defense. Chauhan S, Mandell MA, Deretic V. Mol Cell. 2015 May 7;58(3):507-21. doi: 10.1016/j.molcel.2015.03.020. Epub 2015 Apr 16. PubMed |
| Pellino-1 positively regulates Toll-like Receptor (TLR) 2 and TLR4 signaling and is suppressed upon induction of endotoxin tolerance. Murphy M, Xiong Y, Pattabiraman G, Qiu F, Medvedev AE. J Biol Chem. 2015 Jun 16. pii: jbc.M115.640128. PubMed |
| The Class II Transactivator (CIITA) is regulated by Posttranslational modification crosstalk between ERK1/2 phosphorylation, mono-ubiquitination, and Lysine (K) 63 ubiquitination. Morgan JE, Shanderson RL, Boyd NH, Cacan E, Greer SF. Biosci Rep. 2015 Jun 19. pii: BSR20150091. PubMed |
| Dynamic Arginine Methylation of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6 Regulates Toll-like Receptor Signaling. Tikhanovich I, Kuravi S, Artigues A, Villar MT, Dorko K, Nawabi A, Roberts B, Weinman SA. J Biol Chem. 2015 Sep 4;290(36):22236-49. doi: 10.1074/jbc.M115.653543. Epub 2015 Jul 28. PubMed |
| Trim21 regulates Nmi-IFI35 complex-mediated inhibition of innate antiviral response. Das A, Dinh PX, Pattnaik AK. Virology. 2015 Nov;485:383-92. doi: 10.1016/j.virol.2015.08.013. Epub 2015 Sep 2. PubMed |
| Regulation of E2 promoter binding factor 1 (E2F1) transcriptional activity through a deubiquitinating enzyme, UCH37. Mahanic CS, Budhavarapu V, Graves JD, Li G, Lin WC. J Biol Chem. 2015 Oct 30;290(44):26508-22. doi: 10.1074/jbc.M115.659425. Epub 2015 Sep 22. PubMed |
| POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation. Wang B, Ma A, Zhang L, Jin WL, Qian Y, Xu G, Qiu B, Yang Z, Liu Y, Xia Q, Liu Y. Nat Commun. 2015 Oct 29;6:8704. doi: 10.1038/ncomms9704. PubMed |
| Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease. Zhou Q, Wang H, Schwartz DM, Stoffels M, Park YH, Zhang Y, Yang D, Demirkaya E, Takeuchi M, Tsai WL, Lyons JJ, Yu X, Ouyang C, Chen C, Chin DT, Zaal K, Chandrasekharappa SC, P Hanson E, Yu Z, Mullikin JC, Hasni SA, Wertz IE, Ombrello AK, Stone DL, Hoffmann P, Jones A, Barham BK, Leavis HL, van Royen-Kerkof A, Sibley C, Batu ED, Gul A, Siegel RM, Boehm M, Milner JD, Ozen S, Gadina M, Chae J, Laxer RM, Kastner DL, Aksentijevich I. Nat Genet. 2016 Jan;48(1):67-73. doi: 10.1038/ng.3459. Epub 2015 Dec 7. PubMed |
| Enhanced ubiquitination and proteasomal degradation of catalytically deficient human choline acetyltransferase mutants. Morey TM, Albers S, Shilton BH, Rylett RJ. J Neurochem. 2016 May;137(4):630-46. doi: 10.1111/jnc.13574. Epub 2016 Mar 15. PubMed |
| Heat shock modulates the subcellular localization, stability, and activity of HIPK2. Upadhyay M, Bhadauriya P, Ganesh S. Biochem Biophys Res Commun. 2016 Apr 15;472(4):580-4. doi: 10.1016/j.bbrc.2016.03.035. Epub 2016 Mar 10. PubMed |
| Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio II, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, Marques A, Silvester J, Cox MA, Wakeham A, Yilmaz OH, Sabatini DM, van Es JH, Clevers H, Sato T, Mak TW. Cell Stem Cell. 2016 Aug 4;19(2):205-16. doi: 10.1016/j.stem.2016.04.002. Epub 2016 May 12. PubMed |
| Deubiquitinase Usp8 regulates alpha-synuclein clearance and modifies its toxicity in Lewy body disease. Alexopoulou Z, Lang J, Perrett RM, Elschami M, Hurry ME, Kim HT, Mazaraki D, Szabo A, Kessler BM, Goldberg AL, Ansorge O, Fulga TA, Tofaris GK. Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4688-97. doi: 10.1073/pnas.1523597113. Epub 2016 Jul 21. PubMed |
| RNF168 and USP10 regulate topoisomerase IIalpha function via opposing effects on its ubiquitylation. Guturi KK, Bohgaki M, Bohgaki T, Srikumar T, Ng D, Kumareswaran R, El Ghamrasni S, Jeon J, Patel P, Eldin MS, Bristow R, Cheung P, Stewart GS, Raught B, Hakem A, Hakem R. Nat Commun. 2016 Aug 25;7:12638. doi: 10.1038/ncomms12638. PubMed |
| The tumour suppressor CYLD regulates the p53 DNA damage response. Fernandez-Majada V, Welz PS, Ermolaeva MA, Schell M, Adam A, Dietlein F, Komander D, Buttner R, Thomas RK, Schumacher B, Pasparakis M. Nat Commun. 2016 Aug 26;7:12508. doi: 10.1038/ncomms12508. PubMed |
| Lys-63-linked Ubiquitination of gamma-Aminobutyric Acid (GABA), Type B1, at Multiple Sites by the E3 Ligase Mind Bomb-2 Targets GABAB Receptors to Lysosomal Degradation. Zemoura K, Trumpler C, Benke D. J Biol Chem. 2016 Oct 7;291(41):21682-21693. Epub 2016 Aug 29. PubMed |
| CDH1 regulates E2F1 degradation in response to differentiation signals in keratinocytes. Singh RK, Dagnino L. Oncotarget. 2017 Jan 17;8(3):4977-4993. doi: 10.18632/oncotarget.13636. PubMed |
| GSK-3beta controls NF-kappaB activity via IKKgamma/NEMO. Medunjanin S, Schleithoff L, Fiegehenn C, Weinert S, Zuschratter W, Braun-Dullaeus RC. Sci Rep. 2016 Dec 8;6:38553. doi: 10.1038/srep38553. PubMed |
| TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP). Li MM, Lau Z, Cheung P, Aguilar EG, Schneider WM, Bozzacco L, Molina H, Buehler E, Takaoka A, Rice CM, Felsenfeld DP, MacDonald MR. PLoS Pathog. 2017 Jan 6;13(1):e1006145. doi: 10.1371/journal.ppat.1006145. PubMed |
| Polyglutamine expansion of ataxin-3 alters its degree of ubiquitination and phosphorylation at specific sites. Kristensen LV, Oppermann FS, Rauen MJ, Hartmann-Petersen R, Thirstrup K. Neurochem Int. 2017 Jan 5. pii: S0197-0186(16)30196-6. doi: 10.1016/j.neuint.2016.12.019. PubMed |
| K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression. Hao Z, Sheng Y, Duncan GS, Li WY, Dominguez C, Sylvester J, Su YW, Lin GH, Snow BE, Brenner D, You-Ten A, Haight J, Inoue S, Wakeham A, Elford A, Hamilton S, Liang Y, Zuniga-Pflucker JC, He HH, Ohashi PS, Mak TW. Nat Commun. 2017 Jan 13;8:14003. doi: 10.1038/ncomms14003. PubMed |
| Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes. Liu X, Zhao B, Sun L, Bhuripanyo K, Wang Y, Bi Y, Davuluri RV, Duong DM, Nanavati D, Yin J, Kiyokawa H. Nat Commun. 2017 Jan 30;8:14286. doi: 10.1038/ncomms14286. PubMed |
| The papain-like protease of avian infectious bronchitis virus has deubiquitinating activity. Yu L, Zhang X, Wu T, Wang Y, Meng J, Liu Q, Niu X, Wu Y. Arch Virol. 2017 Jul;162(7):1943-1950. doi: 10.1007/s00705-017-3328-y. Epub 2017 Mar 18. PubMed |
| USP9X regulates centrosome duplication and promotes breast carcinogenesis. Li X, Song N, Liu L, Liu X, Ding X, Song X, Yang S, Shan L, Zhou X, Su D, Wang Y, Zhang Q, Cao C, Ma S, Yu N, Yang F, Wang Y, Yao Z, Shang Y, Shi L. Nat Commun. 2017 Mar 31;8:14866. doi: 10.1038/ncomms14866. PubMed |
| Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6. Kim E, Beon J, Lee S, Park SJ, Ahn H, Kim MG, Park JE, Kim W, Yuk JM, Kang SJ, Lee SH, Jo EK, Seong RH, Kim S. Sci Adv. 2017 Apr 21;3(4):e1602296. doi: 10.1126/sciadv.1602296. eCollection 2017 Apr. PubMed |
| Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination. Wald JH, Hatakeyama J, Printsev I, Cuevas A, Fry WHD, Saldana MJ, VanderVorst K, Rowson-Hodel A, Angelastro JM, Sweeney C, Carraway KL Rd. Oncogene. 2017 Sep 7;36(36):5158-5167. doi: 10.1038/onc.2017.126. Epub 2017 May 8. PubMed |
UBASH3A Mediates Risk for Type 1 Diabetes Through Inhibition of T-Cell Receptor-Induced NF-kappaB Signaling.
Ge Y, Paisie TK, Newman JRB, McIntyre LM, Concannon P.
Diabetes. 2017 Jul;66(7):2033-2043. doi: 10.2337/db16-1023. Epub 2017 Jun 12.
PubMed
Associated Plasmids |
| A two-amino-acid substitution in the transcription factor RORgammat disrupts its function in TH17 differentiation but not in thymocyte development. He Z, Ma J, Wang R, Zhang J, Huang Z, Wang F, Sen S, Rothenberg EV, Sun Z. Nat Immunol. 2017 Oct;18(10):1128-1138. doi: 10.1038/ni.3832. Epub 2017 Aug 28. PubMed |
| TRIM23 mediates virus-induced autophagy via activation of TBK1. Sparrer KMJ, Gableske S, Zurenski MA, Parker ZM, Full F, Baumgart GJ, Kato J, Pacheco-Rodriguez G, Liang C, Pornillos O, Moss J, Vaughan M, Gack MU. Nat Microbiol. 2017 Nov;2(11):1543-1557. doi: 10.1038/s41564-017-0017-2. Epub 2017 Sep 4. PubMed |
| Clec16a, Nrdp1, and USP8 Form a Ubiquitin-Dependent Tripartite Complex That Regulates beta-Cell Mitophagy. Pearson G, Chai B, Vozheiko T, Liu X, Kandarpa M, Piper RC, Soleimanpour SA. Diabetes. 2018 Feb;67(2):265-277. doi: 10.2337/db17-0321. Epub 2017 Nov 27. PubMed |
| YOD1 attenuates neurogenic proteotoxicity through its deubiquitinating activity. Tanji K, Mori F, Miki Y, Utsumi J, Sasaki H, Kakita A, Takahashi H, Wakabayashi K. Neurobiol Dis. 2018 Apr;112:14-23. doi: 10.1016/j.nbd.2018.01.006. Epub 2018 Jan 10. PubMed |
| OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling. Zhao Y, Mudge MC, Soll JM, Rodrigues RB, Byrum AK, Schwarzkopf EA, Bradstreet TR, Gygi SP, Edelson BT, Mosammaparast N. Mol Cell. 2018 Feb 1;69(3):505-516.e5. doi: 10.1016/j.molcel.2018.01.009. PubMed |
| beta-Adrenergic Receptor Trafficking, Degradation, and Cell Surface Expression Are Altered in Dermal Fibroblasts from Hypertrophic Scars. El Ayadi A, Prasai A, Wang Y, Herndon DN, Finnerty CC. J Invest Dermatol. 2018 Jul;138(7):1645-1655. doi: 10.1016/j.jid.2018.01.037. Epub 2018 Feb 22. PubMed |
| USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization. Yang S, Liu L, Cao C, Song N, Wang Y, Ma S, Zhang Q, Yu N, Ding X, Yang F, Tian S, Zhang K, Sun T, Yang J, Yao Z, Wu S, Shi L. Nat Commun. 2018 Mar 29;9(1):1285. doi: 10.1038/s41467-018-03588-z. PubMed |
| Ca(2+)/Calmodulin-Dependent Protein Kinase II (CaMKII) beta-Dependent Phosphorylation of GABAB1 Triggers Lysosomal Degradation of GABAB Receptors via Mind Bomb-2 (MIB2)-Mediated Lys-63-Linked Ubiquitination. Zemoura K, Balakrishnan K, Grampp T, Benke D. Mol Neurobiol. 2019 Feb;56(2):1293-1309. doi: 10.1007/s12035-018-1142-5. Epub 2018 Jun 7. PubMed |
| SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity. Yao F, Zhou Z, Kim J, Hang Q, Xiao Z, Ton BN, Chang L, Liu N, Zeng L, Wang W, Wang Y, Zhang P, Hu X, Su X, Liang H, Sun Y, Ma L. Nat Commun. 2018 Jun 11;9(1):2269. doi: 10.1038/s41467-018-04620-y. PubMed |
| TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy. Jena KK, Kolapalli SP, Mehto S, Nath P, Das B, Sahoo PK, Ahad A, Syed GH, Raghav SK, Senapati S, Chauhan S, Chauhan S. EMBO J. 2018 Sep 14;37(18). pii: embj.201798358. doi: 10.15252/embj.201798358. Epub 2018 Aug 24. PubMed |
| Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis. Li L, Guturi KKN, Gautreau B, Patel PS, Saad A, Morii M, Mateo F, Palomero L, Barbour H, Gomez A, Ng D, Kotlyar M, Pastrello C, Jackson HW, Khokha R, Jurisica I, Affar EB, Raught B, Sanchez O, Alaoui-Jamali M, Pujana MA, Hakem A, Hakem R. J Clin Invest. 2018 Oct 1;128(10):4525-4542. doi: 10.1172/JCI120401. Epub 2018 Aug 2. PubMed |
| POH1 deubiquitinates pro-interleukin-1beta and restricts inflammasome activity. Zhang L, Liu Y, Wang B, Xu G, Yang Z, Tang M, Ma A, Jing T, Xu X, Zhang X, Liu Y. Nat Commun. 2018 Oct 12;9(1):4225. doi: 10.1038/s41467-018-06455-z. PubMed |
| Alternative Splice Forms of CYLD Mediate Ubiquitination of SMAD7 to Prevent TGFB Signaling and Promote Colitis. Tang Y, Reissig S, Glasmacher E, Regen T, Wanke F, Nikolaev A, Gerlach K, Popp V, Karram K, Fantini MC, Schattenberg JM, Galle PR, Neurath MF, Weigmann B, Kurschus FC, Hovelmeyer N, Waisman A. Gastroenterology. 2019 Feb;156(3):692-707.e7. doi: 10.1053/j.gastro.2018.10.023. Epub 2018 Oct 10. PubMed |
| Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1. Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Sen Nkwe N, Tchelougou D, Uriarte M, Bonneil E, Ceccarelli D, Mashtalir N, Tanji M, Masson JY, Thibault P, Sicheri F, Yang H, Carbone M, Therrien M, Affar EB. Nat Commun. 2018 Oct 22;9(1):4385. doi: 10.1038/s41467-018-06854-2. PubMed |
| Sumoylation of RORgammat regulates TH17 differentiation and thymocyte development. He Z, Zhang J, Huang Z, Du Q, Li N, Zhang Q, Chen Y, Sun Z. Nat Commun. 2018 Nov 19;9(1):4870. doi: 10.1038/s41467-018-07203-z. PubMed |
| The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy. Mehto S, Jena KK, Nath P, Chauhan S, Kolapalli SP, Das SK, Sahoo PK, Jain A, Taylor GA, Chauhan S. Mol Cell. 2019 Feb 7;73(3):429-445.e7. doi: 10.1016/j.molcel.2018.11.018. Epub 2019 Jan 3. PubMed |
| Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth. Feng X, Jia Y, Zhang Y, Ma F, Zhu Y, Hong X, Zhou Q, He R, Zhang H, Jin J, Piao D, Huang H, Li Q, Qiu X, Zhang Z. Autophagy. 2019 Jul;15(7):1130-1149. doi: 10.1080/15548627.2019.1570063. Epub 2019 Jan 27. PubMed |
| POH1 contributes to hyperactivation of TGF-beta signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-beta receptors and caveolin-1. Wang B, Xu X, Yang Z, Zhang L, Liu Y, Ma A, Xu G, Tang M, Jing T, Wu L, Liu Y. EBioMedicine. 2019 Mar;41:320-332. doi: 10.1016/j.ebiom.2019.01.058. Epub 2019 Feb 7. PubMed |
| The ATP-Binding Cassette Gene ABCF1 Functions as an E2 Ubiquitin-Conjugating Enzyme Controlling Macrophage Polarization to Dampen Lethal Septic Shock. Arora H, Wilcox SM, Johnson LA, Munro L, Eyford BA, Pfeifer CG, Welch I, Jefferies WA. Immunity. 2019 Feb 19;50(2):418-431.e6. doi: 10.1016/j.immuni.2019.01.014. Epub 2019 Feb 12. PubMed |
| A novel inhibitor of nuclear factor kappa-B kinase subunit gamma mutation identified in an incontinentia pigmenti patient with syndromic tooth agenesis. Sun S, Li F, Liu Y, Qu H, Wong SW, Zeng L, Yu M, Feng H, Liu H, Han D. Arch Oral Biol. 2019 May;101:100-107. doi: 10.1016/j.archoralbio.2019.03.013. Epub 2019 Mar 18. PubMed |
| Regulation of death receptor signaling by the autophagy protein TP53INP2. Ivanova S, Polajnar M, Narbona-Perez AJ, Hernandez-Alvarez MI, Frager P, Slobodnyuk K, Plana N, Nebreda AR, Palacin M, Gomis RR, Behrends C, Zorzano A. EMBO J. 2019 May 15;38(10). pii: embj.201899300. doi: 10.15252/embj.201899300. Epub 2019 Apr 12. PubMed |
| K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling. Yin Q, Han T, Fang B, Zhang G, Zhang C, Roberts ER, Izumi V, Zheng M, Jiang S, Yin X, Kim M, Cai J, Haura EB, Koomen JM, Smalley KSM, Wan L. Nat Commun. 2019 Apr 23;10(1):1870. doi: 10.1038/s41467-019-09844-0. PubMed |
| CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1. Douanne T, Andre-Gregoire G, Thys A, Trillet K, Gavard J, Bidere N. Cell Rep. 2019 May 7;27(6):1657-1665.e4. doi: 10.1016/j.celrep.2019.04.036. PubMed |
| Proteasomal Degradation of Enhancer of Zeste Homologue 2 in Cholangiocytes Promotes Biliary Fibrosis. Jalan-Sakrikar N, De Assuncao TM, Shi G, Aseem SO, Chi C, Shah VH, Huebert RC. Hepatology. 2019 May 9. doi: 10.1002/hep.30706. PubMed |
| USP9X-mediated deubiquitination of B-cell CLL/lymphoma 9 potentiates Wnt signaling and promotes breast carcinogenesis. Shang Z, Zhao J, Zhang Q, Cao C, Tian S, Zhang K, Liu L, Shi L, Yu N, Yang S. J Biol Chem. 2019 Jun 21;294(25):9844-9857. doi: 10.1074/jbc.RA119.007655. Epub 2019 May 9. PubMed |
| The deubiquitinase Otub1 controls the activation of CD8(+) T cells and NK cells by regulating IL-15-mediated priming. Zhou X, Yu J, Cheng X, Zhao B, Manyam GC, Zhang L, Schluns K, Li P, Wang J, Sun SC. Nat Immunol. 2019 Jul;20(7):879-889. doi: 10.1038/s41590-019-0405-2. Epub 2019 Jun 10. PubMed |
| BANK1 interacts with TRAF6 and MyD88 in innate immune signaling in B cells. Georg I, Diaz-Barreiro A, Morell M, Pey AL, Alarcon-Riquelme ME. Cell Mol Immunol. 2019 Jun 26. pii: 10.1038/s41423-019-0254-9. doi: 10.1038/s41423-019-0254-9. PubMed |
| Isoprenylcysteine carboxylmethyltransferase is associated with nasopharyngeal carcinoma chemoresistance and Ras activation. Zhu Y, Hu Q, Li H. Biochem Biophys Res Commun. 2019 Aug 27;516(3):784-789. doi: 10.1016/j.bbrc.2019.06.074. Epub 2019 Jun 26. PubMed |
| CENPV is a CYLD-interacting molecule regulating ciliary acetylated alpha-tubulin. Chiticariu E, Regamey A, Huber M, Hohl D. J Invest Dermatol. 2019 Jun 28. pii: S0022-202X(19)31800-7. doi: 10.1016/j.jid.2019.04.028. PubMed |
| Newcastle disease virus V protein degrades mitochondrial antiviral-signaling protein to inhibit host type I interferon production via E3 ubiquitin ligase RNF5. Sun Y, Zheng H, Yu S, Ding Y, Wu W, Mao X, Liao Y, Meng C, Rehman ZU, Tan L, Song C, Qiu X, Wu F, Ding C. J Virol. 2019 Jul 3. pii: JVI.00322-19. doi: 10.1128/JVI.00322-19. PubMed |
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