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pRK5-HA-Ubiquitin-K48 Citations (113)

Originally described in: Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation.
Lim KL, Chew KC, Tan JM, Wang C, Chung KK, Zhang Y, Tanaka Y, Smith W, Engelender S, Ross CA, Dawson VL, Dawson TM J Neurosci. 2005 Feb 23. 25(8):2002-9. PubMed Journal

Articles Citing pRK5-HA-Ubiquitin-K48

Articles
Phosphorylation and polyubiquitination of transforming growth factor beta-activated kinase 1 are necessary for activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. Bottero V, Kerur N, Sadagopan S, Patel K, Sharma-Walia N, Chandran B. J Virol. 2011 Mar;85(5):1980-93. doi: 10.1128/JVI.01911-10. Epub 2010 Dec 15. PubMed
c-Cbl and Cbl-b ligases mediate 17-allylaminodemethoxygeldanamycin-induced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway. Oshikawa G, Nagao T, Wu N, Kurosu T, Miura O. J Biol Chem. 2011 Sep 2;286(35):30263-73. doi: 10.1074/jbc.M111.232348. Epub 2011 Jul 18. PubMed
Assessing ubiquitination of viral proteins: Lessons from flavivirus NS5. Taylor RT, Best SM. Methods. 2011 Oct;55(2):166-71. doi: 10.1016/j.ymeth.2011.08.003. Epub 2011 Aug 10. PubMed
De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF. Mahul-Mellier AL, Pazarentzos E, Datler C, Iwasawa R, AbuAli G, Lin B, Grimm S. Cell Death Differ. 2012 May;19(5):891-9. doi: 10.1038/cdd.2011.185. Epub 2011 Dec 16. PubMed
Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1. Beverly LJ, Lockwood WW, Shah PP, Erdjument-Bromage H, Varmus H. Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):E119-26. doi: 10.1073/pnas.1119167109. Epub 2012 Jan 10. PubMed
De-ubiquitinating proteases USP2a and USP2c cause apoptosis by stabilising RIP1. Mahul-Mellier AL, Datler C, Pazarentzos E, Lin B, Chaisaklert W, Abuali G, Grimm S. Biochim Biophys Acta. 2012 Aug;1823(8):1353-65. doi: 10.1016/j.bbamcr.2012.05.022. Epub 2012 May 30. PubMed
Non-covalent interaction between polyubiquitin and GTP cyclohydrolase 1 dictates its degradation. Zhao Y, Zhu H, Zou MH. PLoS One. 2012;7(9):e43306. doi: 10.1371/journal.pone.0043306. Epub 2012 Sep 12. PubMed
Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response. Radovanac K, Morgner J, Schulz JN, Blumbach K, Patterson C, Geiger T, Mann M, Krieg T, Eckes B, Fassler R, Wickstrom SA. EMBO J. 2013 May 15;32(10):1409-24. doi: 10.1038/emboj.2013.90. Epub 2013 Apr 23. PubMed
Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15. Inoue S, Hao Z, Elia AJ, Cescon D, Zhou L, Silvester J, Snow B, Harris IS, Sasaki M, Li WY, Itsumi M, Yamamoto K, Ueda T, Dominguez-Brauer C, Gorrini C, Chio II, Haight J, You-Ten A, McCracken S, Wakeham A, Ghazarian D, Penn LJ, Melino G, Mak TW. Genes Dev. 2013 May 15;27(10):1101-14. doi: 10.1101/gad.214577.113. PubMed
RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks. Bohgaki M, Bohgaki T, El Ghamrasni S, Srikumar T, Maire G, Panier S, Fradet-Turcotte A, Stewart GS, Raught B, Hakem A, Hakem R. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):20982-7. doi: 10.1073/pnas.1320302111. Epub 2013 Dec 9. PubMed
Interferon-inducible protein IFI35 negatively regulates RIG-I antiviral signaling and supports vesicular stomatitis virus replication. Das A, Dinh PX, Panda D, Pattnaik AK. J Virol. 2014 Mar;88(6):3103-13. doi: 10.1128/JVI.03202-13. Epub 2013 Dec 26. PubMed
Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase. Birsa N, Norkett R, Wauer T, Mevissen TE, Wu HC, Foltynie T, Bhatia K, Hirst WD, Komander D, Plun-Favreau H, Kittler JT. J Biol Chem. 2014 May 23;289(21):14569-82. doi: 10.1074/jbc.M114.563031. Epub 2014 Mar 26. PubMed

Associated Plasmids
HAUSP, a novel deubiquitinase for Rb - MDM2 the critical regulator. Bhattacharya S, Ghosh MK. FEBS J. 2014 Jul;281(13):3061-78. doi: 10.1111/febs.12843. Epub 2014 Jun 10. PubMed
AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions. Ribeiro-Rodrigues TM, Catarino S, Marques C, Ferreira JV, Martins-Marques T, Pereira P, Girao H. FASEB J. 2014 Nov;28(11):4629-41. doi: 10.1096/fj.13-248963. Epub 2014 Jul 28. PubMed
HTLV-1 tax stabilizes MCL-1 via TRAF6-dependent K63-linked polyubiquitination to promote cell survival and transformation. Choi YB, Harhaj EW. PLoS Pathog. 2014 Oct 23;10(10):e1004458. doi: 10.1371/journal.ppat.1004458. eCollection 2014 Oct. PubMed
Regulation of autophagy by E3 ubiquitin ligase RNF216 through BECN1 ubiquitination. Xu C, Feng K, Zhao X, Huang S, Cheng Y, Qian L, Wang Y, Sun H, Jin M, Chuang TH, Zhang Y. Autophagy. 2014;10(12):2239-50. doi: 10.4161/15548627.2014.981792. PubMed
MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1. Tang Z, Dai S, He Y, Doty RA, Shultz LD, Sampson SB, Dai C. Cell. 2015 Feb 12;160(4):729-44. doi: 10.1016/j.cell.2015.01.028. PubMed
IRGM governs the core autophagy machinery to conduct antimicrobial defense. Chauhan S, Mandell MA, Deretic V. Mol Cell. 2015 May 7;58(3):507-21. doi: 10.1016/j.molcel.2015.03.020. Epub 2015 Apr 16. PubMed
The Class II Transactivator (CIITA) is regulated by Posttranslational modification crosstalk between ERK1/2 phosphorylation, mono-ubiquitination, and Lysine (K) 63 ubiquitination. Morgan JE, Shanderson RL, Boyd NH, Cacan E, Greer SF. Biosci Rep. 2015 Jun 19. pii: BSR20150091. PubMed
Trim21 regulates Nmi-IFI35 complex-mediated inhibition of innate antiviral response. Das A, Dinh PX, Pattnaik AK. Virology. 2015 Nov;485:383-92. doi: 10.1016/j.virol.2015.08.013. Epub 2015 Sep 2. PubMed
POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation. Wang B, Ma A, Zhang L, Jin WL, Qian Y, Xu G, Qiu B, Yang Z, Liu Y, Xia Q, Liu Y. Nat Commun. 2015 Oct 29;6:8704. doi: 10.1038/ncomms9704. PubMed
The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes. Rinschen MM, Bharill P, Wu X, Kohli P, Reinert MJ, Kretz O, Martinez IS, Schermer B, Hohne M, Bartram MP, Aravamudhan S, Brooks BR, Vilchez D, Huber TB, Muller RU, Kruger M, Benzing T. Hum Mol Genet. 2016 Jan 19. pii: ddw016. PubMed
Enhanced ubiquitination and proteasomal degradation of catalytically deficient human choline acetyltransferase mutants. Morey TM, Albers S, Shilton BH, Rylett RJ. J Neurochem. 2016 May;137(4):630-46. doi: 10.1111/jnc.13574. Epub 2016 Mar 15. PubMed
Heat shock modulates the subcellular localization, stability, and activity of HIPK2. Upadhyay M, Bhadauriya P, Ganesh S. Biochem Biophys Res Commun. 2016 Apr 15;472(4):580-4. doi: 10.1016/j.bbrc.2016.03.035. Epub 2016 Mar 10. PubMed
Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio II, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, Marques A, Silvester J, Cox MA, Wakeham A, Yilmaz OH, Sabatini DM, van Es JH, Clevers H, Sato T, Mak TW. Cell Stem Cell. 2016 Aug 4;19(2):205-16. doi: 10.1016/j.stem.2016.04.002. Epub 2016 May 12. PubMed
Deubiquitinase Usp8 regulates alpha-synuclein clearance and modifies its toxicity in Lewy body disease. Alexopoulou Z, Lang J, Perrett RM, Elschami M, Hurry ME, Kim HT, Mazaraki D, Szabo A, Kessler BM, Goldberg AL, Ansorge O, Fulga TA, Tofaris GK. Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4688-97. doi: 10.1073/pnas.1523597113. Epub 2016 Jul 21. PubMed
RNF168 and USP10 regulate topoisomerase IIalpha function via opposing effects on its ubiquitylation. Guturi KK, Bohgaki M, Bohgaki T, Srikumar T, Ng D, Kumareswaran R, El Ghamrasni S, Jeon J, Patel P, Eldin MS, Bristow R, Cheung P, Stewart GS, Raught B, Hakem A, Hakem R. Nat Commun. 2016 Aug 25;7:12638. doi: 10.1038/ncomms12638. PubMed
The tumour suppressor CYLD regulates the p53 DNA damage response. Fernandez-Majada V, Welz PS, Ermolaeva MA, Schell M, Adam A, Dietlein F, Komander D, Buttner R, Thomas RK, Schumacher B, Pasparakis M. Nat Commun. 2016 Aug 26;7:12508. doi: 10.1038/ncomms12508. PubMed
CDH1 regulates E2F1 degradation in response to differentiation signals in keratinocytes. Singh RK, Dagnino L. Oncotarget. 2017 Jan 17;8(3):4977-4993. doi: 10.18632/oncotarget.13636. PubMed
GSK-3beta controls NF-kappaB activity via IKKgamma/NEMO. Medunjanin S, Schleithoff L, Fiegehenn C, Weinert S, Zuschratter W, Braun-Dullaeus RC. Sci Rep. 2016 Dec 8;6:38553. doi: 10.1038/srep38553. PubMed
TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP). Li MM, Lau Z, Cheung P, Aguilar EG, Schneider WM, Bozzacco L, Molina H, Buehler E, Takaoka A, Rice CM, Felsenfeld DP, MacDonald MR. PLoS Pathog. 2017 Jan 6;13(1):e1006145. doi: 10.1371/journal.ppat.1006145. PubMed
Polyglutamine expansion of ataxin-3 alters its degree of ubiquitination and phosphorylation at specific sites. Kristensen LV, Oppermann FS, Rauen MJ, Hartmann-Petersen R, Thirstrup K. Neurochem Int. 2017 Jan 5. pii: S0197-0186(16)30196-6. doi: 10.1016/j.neuint.2016.12.019. PubMed
The STI and UBA Domains of UBQLN1 are Critical Determinants of Substrate Interaction and Proteostasis. Kurlawala Z, Shah PP, Shah C, Beverly LJ. J Cell Biochem. 2017 Jan 11. doi: 10.1002/jcb.25880. PubMed
K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression. Hao Z, Sheng Y, Duncan GS, Li WY, Dominguez C, Sylvester J, Su YW, Lin GH, Snow BE, Brenner D, You-Ten A, Haight J, Inoue S, Wakeham A, Elford A, Hamilton S, Liang Y, Zuniga-Pflucker JC, He HH, Ohashi PS, Mak TW. Nat Commun. 2017 Jan 13;8:14003. doi: 10.1038/ncomms14003. PubMed
Ubiquitination and regulation of AURKA identifies a hypoxia-independent E3 ligase activity of VHL. Hasanov E, Chen G, Chowdhury P, Weldon J, Ding Z, Jonasch E, Sen S, Walker CL, Dere R. Oncogene. 2017 Jun 15;36(24):3450-3463. doi: 10.1038/onc.2016.495. Epub 2017 Jan 23. PubMed
A Rapid Induction Mechanism for Lin28a in Trophic Responses. Amen AM, Ruiz-Garzon CR, Shi J, Subramanian M, Pham DL, Meffert MK. Mol Cell. 2017 Feb 2;65(3):490-503.e7. doi: 10.1016/j.molcel.2016.12.025. Epub 2017 Jan 26. PubMed
Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes. Liu X, Zhao B, Sun L, Bhuripanyo K, Wang Y, Bi Y, Davuluri RV, Duong DM, Nanavati D, Yin J, Kiyokawa H. Nat Commun. 2017 Jan 30;8:14286. doi: 10.1038/ncomms14286. PubMed
Ubiquitin-specific peptidase 48 regulates Mdm2 protein levels independent of its deubiquitinase activity. Cetkovska K, Sustova H, Uldrijan S. Sci Rep. 2017 Feb 24;7:43180. doi: 10.1038/srep43180. PubMed
The papain-like protease of avian infectious bronchitis virus has deubiquitinating activity. Yu L, Zhang X, Wu T, Wang Y, Meng J, Liu Q, Niu X, Wu Y. Arch Virol. 2017 Jul;162(7):1943-1950. doi: 10.1007/s00705-017-3328-y. Epub 2017 Mar 18. PubMed
USP9X regulates centrosome duplication and promotes breast carcinogenesis. Li X, Song N, Liu L, Liu X, Ding X, Song X, Yang S, Shan L, Zhou X, Su D, Wang Y, Zhang Q, Cao C, Ma S, Yu N, Yang F, Wang Y, Yao Z, Shang Y, Shi L. Nat Commun. 2017 Mar 31;8:14866. doi: 10.1038/ncomms14866. PubMed
Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6. Kim E, Beon J, Lee S, Park SJ, Ahn H, Kim MG, Park JE, Kim W, Yuk JM, Kang SJ, Lee SH, Jo EK, Seong RH, Kim S. Sci Adv. 2017 Apr 21;3(4):e1602296. doi: 10.1126/sciadv.1602296. eCollection 2017 Apr. PubMed
UBASH3A Mediates Risk for Type 1 Diabetes Through Inhibition of T-Cell Receptor-Induced NF-kappaB Signaling. Ge Y, Paisie TK, Newman JRB, McIntyre LM, Concannon P. Diabetes. 2017 Jul;66(7):2033-2043. doi: 10.2337/db16-1023. Epub 2017 Jun 12. PubMed

Associated Plasmids
A two-amino-acid substitution in the transcription factor RORgammat disrupts its function in TH17 differentiation but not in thymocyte development. He Z, Ma J, Wang R, Zhang J, Huang Z, Wang F, Sen S, Rothenberg EV, Sun Z. Nat Immunol. 2017 Oct;18(10):1128-1138. doi: 10.1038/ni.3832. Epub 2017 Aug 28. PubMed
TRIM23 mediates virus-induced autophagy via activation of TBK1. Sparrer KMJ, Gableske S, Zurenski MA, Parker ZM, Full F, Baumgart GJ, Kato J, Pacheco-Rodriguez G, Liang C, Pornillos O, Moss J, Vaughan M, Gack MU. Nat Microbiol. 2017 Nov;2(11):1543-1557. doi: 10.1038/s41564-017-0017-2. Epub 2017 Sep 4. PubMed
Clec16a, Nrdp1, and USP8 Form a Ubiquitin-Dependent Tripartite Complex That Regulates beta-Cell Mitophagy. Pearson G, Chai B, Vozheiko T, Liu X, Kandarpa M, Piper RC, Soleimanpour SA. Diabetes. 2018 Feb;67(2):265-277. doi: 10.2337/db17-0321. Epub 2017 Nov 27. PubMed
YOD1 attenuates neurogenic proteotoxicity through its deubiquitinating activity. Tanji K, Mori F, Miki Y, Utsumi J, Sasaki H, Kakita A, Takahashi H, Wakabayashi K. Neurobiol Dis. 2018 Apr;112:14-23. doi: 10.1016/j.nbd.2018.01.006. Epub 2018 Jan 10. PubMed
Inflachromene inhibits autophagy through modulation of Beclin 1 activity. Kim YH, Kwak MS, Shin JM, Hayuningtyas RA, Choi JE, Shin JS. J Cell Sci. 2018 Feb 20;131(4). pii: jcs.211201. doi: 10.1242/jcs.211201. PubMed
OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling. Zhao Y, Mudge MC, Soll JM, Rodrigues RB, Byrum AK, Schwarzkopf EA, Bradstreet TR, Gygi SP, Edelson BT, Mosammaparast N. Mol Cell. 2018 Feb 1;69(3):505-516.e5. doi: 10.1016/j.molcel.2018.01.009. PubMed
beta-Adrenergic Receptor Trafficking, Degradation, and Cell Surface Expression Are Altered in Dermal Fibroblasts from Hypertrophic Scars. El Ayadi A, Prasai A, Wang Y, Herndon DN, Finnerty CC. J Invest Dermatol. 2018 Jul;138(7):1645-1655. doi: 10.1016/j.jid.2018.01.037. Epub 2018 Feb 22. PubMed
USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization. Yang S, Liu L, Cao C, Song N, Wang Y, Ma S, Zhang Q, Yu N, Ding X, Yang F, Tian S, Zhang K, Sun T, Yang J, Yao Z, Wu S, Shi L. Nat Commun. 2018 Mar 29;9(1):1285. doi: 10.1038/s41467-018-03588-z. PubMed
SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity. Yao F, Zhou Z, Kim J, Hang Q, Xiao Z, Ton BN, Chang L, Liu N, Zeng L, Wang W, Wang Y, Zhang P, Hu X, Su X, Liang H, Sun Y, Ma L. Nat Commun. 2018 Jun 11;9(1):2269. doi: 10.1038/s41467-018-04620-y. PubMed
TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy. Jena KK, Kolapalli SP, Mehto S, Nath P, Das B, Sahoo PK, Ahad A, Syed GH, Raghav SK, Senapati S, Chauhan S, Chauhan S. EMBO J. 2018 Sep 14;37(18). pii: embj.201798358. doi: 10.15252/embj.201798358. Epub 2018 Aug 24. PubMed
Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis. Li L, Guturi KKN, Gautreau B, Patel PS, Saad A, Morii M, Mateo F, Palomero L, Barbour H, Gomez A, Ng D, Kotlyar M, Pastrello C, Jackson HW, Khokha R, Jurisica I, Affar EB, Raught B, Sanchez O, Alaoui-Jamali M, Pujana MA, Hakem A, Hakem R. J Clin Invest. 2018 Oct 1;128(10):4525-4542. doi: 10.1172/JCI120401. Epub 2018 Aug 2. PubMed
POH1 deubiquitinates pro-interleukin-1beta and restricts inflammasome activity. Zhang L, Liu Y, Wang B, Xu G, Yang Z, Tang M, Ma A, Jing T, Xu X, Zhang X, Liu Y. Nat Commun. 2018 Oct 12;9(1):4225. doi: 10.1038/s41467-018-06455-z. PubMed
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1. Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Sen Nkwe N, Tchelougou D, Uriarte M, Bonneil E, Ceccarelli D, Mashtalir N, Tanji M, Masson JY, Thibault P, Sicheri F, Yang H, Carbone M, Therrien M, Affar EB. Nat Commun. 2018 Oct 22;9(1):4385. doi: 10.1038/s41467-018-06854-2. PubMed
Sumoylation of RORgammat regulates TH17 differentiation and thymocyte development. He Z, Zhang J, Huang Z, Du Q, Li N, Zhang Q, Chen Y, Sun Z. Nat Commun. 2018 Nov 19;9(1):4870. doi: 10.1038/s41467-018-07203-z. PubMed
The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy. Mehto S, Jena KK, Nath P, Chauhan S, Kolapalli SP, Das SK, Sahoo PK, Jain A, Taylor GA, Chauhan S. Mol Cell. 2019 Feb 7;73(3):429-445.e7. doi: 10.1016/j.molcel.2018.11.018. Epub 2019 Jan 3. PubMed
Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth. Feng X, Jia Y, Zhang Y, Ma F, Zhu Y, Hong X, Zhou Q, He R, Zhang H, Jin J, Piao D, Huang H, Li Q, Qiu X, Zhang Z. Autophagy. 2019 Jul;15(7):1130-1149. doi: 10.1080/15548627.2019.1570063. Epub 2019 Jan 27. PubMed
POH1 contributes to hyperactivation of TGF-beta signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-beta receptors and caveolin-1. Wang B, Xu X, Yang Z, Zhang L, Liu Y, Ma A, Xu G, Tang M, Jing T, Wu L, Liu Y. EBioMedicine. 2019 Mar;41:320-332. doi: 10.1016/j.ebiom.2019.01.058. Epub 2019 Feb 7. PubMed
The ATP-Binding Cassette Gene ABCF1 Functions as an E2 Ubiquitin-Conjugating Enzyme Controlling Macrophage Polarization to Dampen Lethal Septic Shock. Arora H, Wilcox SM, Johnson LA, Munro L, Eyford BA, Pfeifer CG, Welch I, Jefferies WA. Immunity. 2019 Feb 19;50(2):418-431.e6. doi: 10.1016/j.immuni.2019.01.014. Epub 2019 Feb 12. PubMed
Regulation of death receptor signaling by the autophagy protein TP53INP2. Ivanova S, Polajnar M, Narbona-Perez AJ, Hernandez-Alvarez MI, Frager P, Slobodnyuk K, Plana N, Nebreda AR, Palacin M, Gomis RR, Behrends C, Zorzano A. EMBO J. 2019 May 15;38(10). pii: embj.201899300. doi: 10.15252/embj.201899300. Epub 2019 Apr 12. PubMed
K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling. Yin Q, Han T, Fang B, Zhang G, Zhang C, Roberts ER, Izumi V, Zheng M, Jiang S, Yin X, Kim M, Cai J, Haura EB, Koomen JM, Smalley KSM, Wan L. Nat Commun. 2019 Apr 23;10(1):1870. doi: 10.1038/s41467-019-09844-0. PubMed
CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1. Douanne T, Andre-Gregoire G, Thys A, Trillet K, Gavard J, Bidere N. Cell Rep. 2019 May 7;27(6):1657-1665.e4. doi: 10.1016/j.celrep.2019.04.036. PubMed
Proteasomal Degradation of Enhancer of Zeste Homologue 2 in Cholangiocytes Promotes Biliary Fibrosis. Jalan-Sakrikar N, De Assuncao TM, Shi G, Aseem SO, Chi C, Shah VH, Huebert RC. Hepatology. 2019 May 9. doi: 10.1002/hep.30706. PubMed
USP9X-mediated deubiquitination of B-cell CLL/lymphoma 9 potentiates Wnt signaling and promotes breast carcinogenesis. Shang Z, Zhao J, Zhang Q, Cao C, Tian S, Zhang K, Liu L, Shi L, Yu N, Yang S. J Biol Chem. 2019 Jun 21;294(25):9844-9857. doi: 10.1074/jbc.RA119.007655. Epub 2019 May 9. PubMed
The deubiquitinase Otub1 controls the activation of CD8(+) T cells and NK cells by regulating IL-15-mediated priming. Zhou X, Yu J, Cheng X, Zhao B, Manyam GC, Zhang L, Schluns K, Li P, Wang J, Sun SC. Nat Immunol. 2019 Jul;20(7):879-889. doi: 10.1038/s41590-019-0405-2. Epub 2019 Jun 10. PubMed
BANK1 interacts with TRAF6 and MyD88 in innate immune signaling in B cells. Georg I, Diaz-Barreiro A, Morell M, Pey AL, Alarcon-Riquelme ME. Cell Mol Immunol. 2019 Jun 26. pii: 10.1038/s41423-019-0254-9. doi: 10.1038/s41423-019-0254-9. PubMed
Isoprenylcysteine carboxylmethyltransferase is associated with nasopharyngeal carcinoma chemoresistance and Ras activation. Zhu Y, Hu Q, Li H. Biochem Biophys Res Commun. 2019 Aug 27;516(3):784-789. doi: 10.1016/j.bbrc.2019.06.074. Epub 2019 Jun 26. PubMed
CENPV is a CYLD-interacting molecule regulating ciliary acetylated alpha-tubulin. Chiticariu E, Regamey A, Huber M, Hohl D. J Invest Dermatol. 2019 Jun 28. pii: S0022-202X(19)31800-7. doi: 10.1016/j.jid.2019.04.028. PubMed
Newcastle disease virus V protein degrades mitochondrial antiviral-signaling protein to inhibit host type I interferon production via E3 ubiquitin ligase RNF5. Sun Y, Zheng H, Yu S, Ding Y, Wu W, Mao X, Liao Y, Meng C, Rehman ZU, Tan L, Song C, Qiu X, Wu F, Ding C. J Virol. 2019 Jul 3. pii: JVI.00322-19. doi: 10.1128/JVI.00322-19. PubMed
Nedd4 E3 ligase and beta-arrestins regulate ubiquitination, trafficking, and stability of the mGlu7 receptor. Lee S, Park S, Lee H, Han S, Song JM, Han D, Suh YH. Elife. 2019 Aug 2;8. pii: 44502. doi: 10.7554/eLife.44502. PubMed
Diversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interactions. Kong W, Hayashi T, Fiches G, Xu Q, Li MZ, Que J, Liu S, Zhang W, Qi J, Santoso N, Elledge SJ, Zhu J. Genomics Proteomics Bioinformatics. 2019 Jun;17(3):319-331. doi: 10.1016/j.gpb.2018.12.010. Epub 2019 Sep 5. PubMed
beta-TrCP-mediated ubiquitination and degradation of Dlg5 regulates hepatocellular carcinoma cell proliferation. Wang D, Zhang Q, Li F, Wang C, Yang C, Yu H. Cancer Cell Int. 2019 Nov 15;19:298. doi: 10.1186/s12935-019-1029-1. eCollection 2019. PubMed
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan. Liu H, Ding J, Kohnlein K, Urban N, Ori A, Villavicencio-Lorini P, Walentek P, Klotz LO, Hollemann T, Pfirrmann T. Autophagy. 2019 Dec 3:1-17. doi: 10.1080/15548627.2019.1695399. PubMed
TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells. Maarifi G, Smith N, Maillet S, Moncorge O, Chamontin C, Edouard J, Sohm F, Blanchet FP, Herbeuval JP, Lutfalla G, Levraud JP, Arhel NJ, Nisole S. Sci Adv. 2019 Nov 20;5(11):eaax3511. doi: 10.1126/sciadv.aax3511. eCollection 2019 Nov. PubMed
SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection. Gassen NC, Niemeyer D, Muth D, Corman VM, Martinelli S, Gassen A, Hafner K, Papies J, Mosbauer K, Zellner A, Zannas AS, Herrmann A, Holsboer F, Brack-Werner R, Boshart M, Muller-Myhsok B, Drosten C, Muller MA, Rein T. Nat Commun. 2019 Dec 18;10(1):5770. doi: 10.1038/s41467-019-13659-4. PubMed
The Lysosome Pathway Degrades CD81 on the Cell Surface by Poly-ubiquitination and Clathrin-Mediated Endocytosis. Hosokawa K, Ishimaru H, Watanabe T, Fujimuro M. Biol Pharm Bull. 2020 Mar 1;43(3):540-545. doi: 10.1248/bpb.b19-01097. Epub 2019 Dec 27. PubMed
USP37 is a SNAI1 deubiquitinase. Xiao Z, Chang L, Kim J, Zhang P, Hang Q, Yap S, Guo Y, Zhou Z, Zeng L, Hu X, Siverly A, Sun Y, Ma L. Am J Cancer Res. 2019 Dec 1;9(12):2749-2759. eCollection 2019. PubMed
Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2. Chathuranga K, Kim TH, Lee H, Park JS, Kim JH, Chathuranga WAG, Ekanayaka P, Choi YJ, Lee CH, Kim CJ, Jung JU, Lee JS. EMBO J. 2020 Nov 2;39(21):e105139. doi: 10.15252/embj.2020105139. Epub 2020 Sep 16. PubMed
OTUD4 enhances TGFbeta signalling through regulation of the TGFbeta receptor complex. Jaynes PW, Iyengar PV, Lui SKL, Tan TZ, Vasilevski N, Wright SCE, Verdile G, Jeyasekharan AD, Eichhorn PJA. Sci Rep. 2020 Sep 24;10(1):15725. doi: 10.1038/s41598-020-72791-0. PubMed
RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to Drive Cell-Cycle and Cancer Progression. Kolapalli SP, Sahu R, Chauhan NR, Jena KK, Mehto S, Das SK, Jain A, Rout M, Dash R, Swain RK, Lee DY, Rusten TE, Chauhan S, Chauhan S. Cancer Res. 2021 Jan 15;81(2):315-331. doi: 10.1158/0008-5472.CAN-20-1871. Epub 2020 Oct 16. PubMed
Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m(6)A Methylation. Sun HL, Zhu AC, Gao Y, Terajima H, Fei Q, Liu S, Zhang L, Zhang Z, Harada BT, He YY, Bissonnette MB, Hung MC, He C. Mol Cell. 2020 Nov 19;80(4):633-647.e7. doi: 10.1016/j.molcel.2020.10.026. PubMed
E3 Ubiquitin Ligase APC/C(Cdh1) Regulation of Phenylalanine Hydroxylase Stability and Function. Tyagi A, Sarodaya N, Kaushal K, Chandrasekaran AP, Antao AM, Suresh B, Rhie BH, Kim KS, Ramakrishna S. Int J Mol Sci. 2020 Nov 28;21(23). pii: ijms21239076. doi: 10.3390/ijms21239076. PubMed
TRIB2 modulates proteasome function to reduce ubiquitin stability and protect liver cancer cells against oxidative stress. Guo S, Chen Y, Yang Y, Zhang X, Ma L, Xue X, Qiao Y, Wang J. Cell Death Dis. 2021 Jan 7;12(1):42. doi: 10.1038/s41419-020-03299-8. PubMed
TRIM16 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Modulating CHIP-Mediated Degradation of RUNX2. Zhao Y, Zhai Q, Liu H, Xi X, Chen S, Liu D. Front Cell Dev Biol. 2021 Jan 7;8:625105. doi: 10.3389/fcell.2020.625105. eCollection 2020. PubMed
Linkage-specific deubiquitylation by OTUD5 defines an embryonic pathway intolerant to genomic variation. Beck DB, Basar MA, Asmar AJ, Thompson JJ, Oda H, Uehara DT, Saida K, Pajusalu S, Talvik I, D'Souza P, Bodurtha J, Mu W, Baranano KW, Miyake N, Wang R, Kempers M, Tamada T, Nishimura Y, Okada S, Kosho T, Dale R, Mitra A, Macnamara E, Matsumoto N, Inazawa J, Walkiewicz M, Ounap K, Tifft CJ, Aksentijevich I, Kastner DL, Rocha PP, Werner A. Sci Adv. 2021 Jan 20;7(4). pii: 7/4/eabe2116. doi: 10.1126/sciadv.abe2116. Print 2021 Jan. PubMed
RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors. Patel PS, Abraham KJ, Guturi KKN, Halaby MJ, Khan Z, Palomero L, Ho B, Duan S, St-Germain J, Algouneh A, Mateo F, El Ghamrasni S, Barbour H, Barnes DR, Beesley J, Sanchez O, Berman HK, Brown GW, Affar EB, Chenevix-Trench G, Antoniou AC, Arrowsmith CH, Raught B, Pujana MA, Mekhail K, Hakem A, Hakem R. J Clin Invest. 2021 Feb 1;131(3). pii: 140105. doi: 10.1172/JCI140105. PubMed
The ESCRT-III molecules regulate the apical targeting of bile salt export pump. Wu SH, Chang MH, Chen YH, Wu HL, Chua HH, Chien CS, Ni YH, Chen HL, Chen HL. J Biomed Sci. 2021 Mar 9;28(1):19. doi: 10.1186/s12929-020-00706-2. PubMed
VPS13D interacts with VCP/p97 and negatively regulates endoplasmic reticulum-mitochondria interactions. Du Y, Wang J, Xiong J, Fang N, Ji WK. Mol Biol Cell. 2021 Aug 1;32(16):1474-1486. doi: 10.1091/mbc.E21-03-0097. Epub 2021 Jun 16. PubMed
EVI/WLS function is regulated by ubiquitylation and is linked to ER-associated degradation by ERLIN2. Wolf LM, Lambert AM, Haenlin J, Boutros M. J Cell Sci. 2021 Aug 15;134(16). pii: 271857. doi: 10.1242/jcs.257790. Epub 2021 Aug 18. PubMed
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Associated Plasmids
The E3 ubiquitin ligase SMURF2 stabilizes RNA editase ADAR1p110 and promotes its adenosine-to-inosine (A-to-I) editing function. Koganti P, Kadali VN, Manikoth Ayyathan D, Emanuelli A, Paolini B, Levy-Cohen G, Blank M. Cell Mol Life Sci. 2022 Apr 11;79(5):237. doi: 10.1007/s00018-022-04272-8. PubMed
Cancer-cell-secreted miR-122 suppresses O-GlcNAcylation to promote skeletal muscle proteolysis. Yan W, Cao M, Ruan X, Jiang L, Lee S, Lemanek A, Ghassemian M, Pizzo DP, Wan Y, Qiao Y, Chin AR, Duggan E, Wang D, Nolan JP, Esko JD, Schenk S, Wang SE. Nat Cell Biol. 2022 May;24(5):793-804. doi: 10.1038/s41556-022-00893-0. Epub 2022 Apr 25. PubMed
The deubiquitinase USP7 promotes HNSCC progression via deubiquitinating and stabilizing TAZ. Li J, Dai Y, Ge H, Guo S, Zhang W, Wang Y, Liu L, Cheng J, Jiang H. Cell Death Dis. 2022 Aug 5;13(8):677. doi: 10.1038/s41419-022-05113-z. PubMed
Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy. Jin S, He X, Ma L, Zhuang Z, Wang Y, Lin M, Cai S, Wei L, Wang Z, Zhao Z, Wu Y, Sun L, Li C, Xie W, Zhao Y, Songyang Z, Peng K, Zhao J, Cui J. Nat Commun. 2022 Sep 3;13(1):5204. doi: 10.1038/s41467-022-32957-y. PubMed
Elucidation of TRIM25 ubiquitination targets involved in diverse cellular and antiviral processes. Yang E, Huang S, Jami-Alahmadi Y, McInerney GM, Wohlschlegel JA, Li MMH. PLoS Pathog. 2022 Sep 6;18(9):e1010743. doi: 10.1371/journal.ppat.1010743. eCollection 2022 Sep. PubMed
DNA-Dependent Protein Kinase Mediates YB-1 (Y-Box Binding Protein)-Induced Double Strand Break Repair. Nothen T, Sarabi MA, Weinert S, Zuschratter W, Morgenroth R, Mertens PR, Braun-Dullaeus RC, Medunjanin S. Arterioscler Thromb Vasc Biol. 2023 Feb;43(2):300-311. doi: 10.1161/ATVBAHA.122.317922. Epub 2022 Dec 8. PubMed
Stabilization of MCL-1 by E3 ligase TRAF4 confers radioresistance. Li M, Gao F, Li X, Gan Y, Han S, Yu X, Liu H, Li W. Cell Death Dis. 2022 Dec 19;13(12):1053. doi: 10.1038/s41419-022-05500-6. PubMed
Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models. Han X, Mei Y, Mishra RK, Bi H, Jain AD, Schiltz GE, Zhao B, Sukhanova M, Wang P, Grigorescu AA, Weber PC, Piwinski JJ, Prado MA, Paulo JA, Stephens L, Anderson KE, Abrams CS, Yang J, Ji P. J Clin Invest. 2023 Mar 15;133(6):e159638. doi: 10.1172/JCI159638. PubMed
SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage. Wang F, Wang L, Gan S, Feng S, Ouyang S, Wang X, Yuan S. Research (Wash D C). 2023 Apr 12;6:0091. doi: 10.34133/research.0091. eCollection 2023. PubMed
KLHL7 promotes hepatocellular carcinoma progression and molecular therapy resistance by degrading RASA2. Chen L, Li Y, Chen Y. iScience. 2023 May 19;26(6):106914. doi: 10.1016/j.isci.2023.106914. eCollection 2023 Jun 16. PubMed
OTUB1 inhibits breast cancer by non-canonically stabilizing CCN6. Zhao Y, Ruan J, Li Z, Su X, Chen K, Lin Y, Cai Y, Wang P, Liu B, Schluter D, Liang G, Wang X. Clin Transl Med. 2023 Aug;13(8):e1385. doi: 10.1002/ctm2.1385. PubMed
An apicoplast-localized deubiquitinase contributes to the cell growth and apicoplast homeostasis of Toxoplasma gondii. Xia J, Yang Y, Chen X, Song K, Ma G, Yang Y, Yao C, Du A. Vet Res. 2024 Jan 17;55(1):10. doi: 10.1186/s13567-023-01261-y. PubMed
The dePARylase NUDT16 promotes radiation resistance of cancer cells by blocking SETD3 for degradation via reversing its ADP-ribosylation. Wu W, Wu W, Zhou Y, Yang Q, Zhuang S, Zhong C, Li W, Li A, Zhao W, Yin X, Zu X, Chak-Lui Wong C, Yin D, Hu K, Cai M. J Biol Chem. 2024 Mar;300(3):105671. doi: 10.1016/j.jbc.2024.105671. Epub 2024 Jan 23. PubMed
Oncolytic Newcastle disease virus induced degradation of YAP through E3 ubiquitin ligase PRKN to exacerbate ferroptosis in tumor cells. Sun Y, Tang L, Kan X, Tan L, Song C, Qiu X, Liao Y, Nair V, Ding C, Liu X, Sun Y. J Virol. 2024 Mar 19;98(3):e0189723. doi: 10.1128/jvi.01897-23. Epub 2024 Feb 27. PubMed
RNF166 promotes colorectal cancer progression by recognizing and destabilizing poly-ADP-ribosylated angiomotins. Li Y, Zhang X, Liu N, Liu R, Zhang W, Chen L, Chen Y. Cell Death Dis. 2024 Mar 13;15(3):211. doi: 10.1038/s41419-024-06595-9. PubMed
Ubiquitin-mediated regulation of APE2 protein abundance. McMahon A, Zhao J, Yan S. J Biol Chem. 2024 Jun;300(6):107337. doi: 10.1016/j.jbc.2024.107337. Epub 2024 May 4. PubMed
Proximal protein landscapes of the type I interferon signaling cascade reveal negative regulation by PJA2. Schiefer S, Hale BG. Nat Commun. 2024 May 27;15(1):4484. doi: 10.1038/s41467-024-48800-5. PubMed

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