human beta-catenin pcDNA3 Citations (52)
Originally described in: Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression.Kolligs FT, Hu G, Dang CV, Fearon ER Mol Cell Biol. 1999 Aug . 19(8):5696-706. PubMed
Articles Citing human beta-catenin pcDNA3
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| A re-evaluation of two key reagents for in vivo studies of Wnt signaling. Ahrens MJ, Romereim S, Dudley AT. Dev Dyn. 2011 Sep;240(9):2060-8. doi: 10.1002/dvdy.22704. Epub 2011 Jul 25. PubMed |
| Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and beta-catenin activity in colon cancer cells. Hinkel I, Duluc I, Martin E, Guenot D, Freund JN, Gross I. Gastroenterology. 2012 Apr;142(4):875-885.e3. doi: 10.1053/j.gastro.2011.12.037. Epub 2011 Dec 24. PubMed |
| Regulation of the DLG tumor suppressor by beta-catenin. Subbaiah VK, Narayan N, Massimi P, Banks L. Int J Cancer. 2012 Nov 15;131(10):2223-33. doi: 10.1002/ijc.27519. Epub 2012 Mar 28. PubMed |
| The Cdc42/Rac nucleotide exchange factor protein beta1Pix (Pak-interacting exchange factor) modulates beta-catenin transcriptional activity in colon cancer cells: evidence for direct interaction of beta1PIX with beta-catenin. Chahdi A, Raufman JP. J Biol Chem. 2013 Nov 22;288(47):34019-29. doi: 10.1074/jbc.M113.480103. Epub 2013 Oct 15. PubMed |
| DKK1 promotes hepatocellular carcinoma cell migration and invasion through beta-catenin/MMP7 signaling pathway. Chen L, Li M, Li Q, Wang CJ, Xie SQ. Mol Cancer. 2013 Dec 10;12:157. doi: 10.1186/1476-4598-12-157. PubMed |
| Deregulated WNT signaling in childhood T-cell acute lymphoblastic leukemia. Ng OH, Erbilgin Y, Firtina S, Celkan T, Karakas Z, Aydogan G, Turkkan E, Yildirmak Y, Timur C, Zengin E, van Dongen JJ, Staal FJ, Ozbek U, Sayitoglu M. Blood Cancer J. 2014 Mar 14;4:e192. doi: 10.1038/bcj.2014.12. PubMed |
| Ras regulates SCF(beta-TrCP) protein activity and specificity via its effector protein NORE1A. Schmidt ML, Donninger H, Clark GJ. J Biol Chem. 2014 Nov 7;289(45):31102-10. doi: 10.1074/jbc.M114.594283. Epub 2014 Sep 12. PubMed |
| Protein kinase A activation enhances beta-catenin transcriptional activity through nuclear localization to PML bodies. Zhang M, Mahoney E, Zuo T, Manchanda PK, Davuluri RV, Kirschner LS. PLoS One. 2014 Oct 9;9(10):e109523. doi: 10.1371/journal.pone.0109523. eCollection 2014. PubMed |
| beta-catenin links von Hippel-Lindau to aurora kinase A and loss of primary cilia in renal cell carcinoma. Dere R, Perkins AL, Bawa-Khalfe T, Jonasch D, Walker CL. J Am Soc Nephrol. 2015 Mar;26(3):553-64. doi: 10.1681/ASN.2013090984. Epub 2014 Oct 13. PubMed |
SOX9 inhibits beta-TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties.
Deng W, Vanderbilt DB, Lin CC, Martin KH, Brundage KM, Ruppert JM.
J Cell Sci. 2015 Jan 27. pii: jcs.162164.
PubMed
Associated Plasmids |
| Kruppel-like factor 5 incorporates into the beta-catenin/TCF complex in response to LPA in colon cancer cells. Guo L, He P, No YR, Yun CC. Cell Signal. 2015 May;27(5):961-8. doi: 10.1016/j.cellsig.2015.02.005. Epub 2015 Feb 12. PubMed |
| Inhibition of glycogen synthase kinase-3 beta induces apoptosis and mitotic catastrophe by disrupting centrosome regulation in cancer cells. Yoshino Y, Ishioka C. Sci Rep. 2015 Aug 21;5:13249. doi: 10.1038/srep13249. PubMed |
| DNA damage induced apoptosis suppressor (DDIAS) is upregulated via ERK5/MEF2B signaling and promotes beta-catenin-mediated invasion. Im JY, Yoon SH, Kim BK, Ban HS, Won KJ, Chung KS, Jung KE, Won M. Biochim Biophys Acta. 2016 Nov;1859(11):1449-1458. doi: 10.1016/j.bbagrm.2016.07.003. Epub 2016 Jul 10. PubMed |
| Axitinib blocks Wnt/beta-catenin signaling and directs asymmetric cell division in cancer. Qu Y, Gharbi N, Yuan X, Olsen JR, Blicher P, Dalhus B, Brokstad KA, Lin B, Oyan AM, Zhang W, Kalland KH, Ke X. Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9339-44. doi: 10.1073/pnas.1604520113. Epub 2016 Aug 1. PubMed |
| Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of beta-catenin signaling. Berwick DC, Javaheri B, Wetzel A, Hopkinson M, Nixon-Abell J, Granno S, Pitsillides AA, Harvey K. Mol Neurodegener. 2017 Jan 19;12(1):9. doi: 10.1186/s13024-017-0153-4. PubMed |
| Genetic basis of calcifying cystic odontogenic tumors. Yukimori A, Oikawa Y, Morita KI, Nguyen CTK, Harada H, Yamaguchi S, Kayamori K, Yamaguchi A, Ikeda T, Sakamoto K. PLoS One. 2017 Jun 28;12(6):e0180224. doi: 10.1371/journal.pone.0180224. eCollection 2017. PubMed |
| beta-TrCP1 Is a Vacillatory Regulator of Wnt Signaling. Long MJ, Lin HY, Parvez S, Zhao Y, Poganik JR, Huang P, Aye Y. Cell Chem Biol. 2017 Aug 17;24(8):944-957.e7. doi: 10.1016/j.chembiol.2017.06.009. Epub 2017 Jul 20. PubMed |
| Ergosterol peroxide inhibits ovarian cancer cell growth through multiple pathways. Tan W, Pan M, Liu H, Tian H, Ye Q, Liu H. Onco Targets Ther. 2017 Jul 13;10:3467-3474. doi: 10.2147/OTT.S139009. eCollection 2017. PubMed |
| APC downregulated 1 inhibits breast cancer cell invasion by inhibiting the canonical WNT signaling pathway. Cho SG. Oncol Lett. 2017 Oct;14(4):4845-4852. doi: 10.3892/ol.2017.6801. Epub 2017 Aug 23. PubMed |
| Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers. Blakely CM, Watkins TBK, Wu W, Gini B, Chabon JJ, McCoach CE, McGranahan N, Wilson GA, Birkbak NJ, Olivas VR, Rotow J, Maynard A, Wang V, Gubens MA, Banks KC, Lanman RB, Caulin AF, St John J, Cordero AR, Giannikopoulos P, Simmons AD, Mack PC, Gandara DR, Husain H, Doebele RC, Riess JW, Diehn M, Swanton C, Bivona TG. Nat Genet. 2017 Dec;49(12):1693-1704. doi: 10.1038/ng.3990. Epub 2017 Nov 6. PubMed |
| Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning. Yang Y, Xiong D, Pipathsouk A, Weiner OD, Wu M. Dev Cell. 2017 Nov 20;43(4):507-521.e4. doi: 10.1016/j.devcel.2017.10.028. PubMed |
| High expression of beta-catenin contributes to the crizotinib resistant phenotype in the stem-like cell population in neuroblastoma. Alshareef A, Gupta N, Zhang HF, Wu C, Haque M, Lai R. Sci Rep. 2017 Dec 4;7(1):16863. doi: 10.1038/s41598-017-17319-9. PubMed |
| Beta-catenin cleavage enhances transcriptional activation. Goretsky T, Bradford EM, Ye Q, Lamping OF, Vanagunas T, Moyer MP, Keller PC, Sinh P, Llovet JM, Gao T, She QB, Li L, Barrett TA. Sci Rep. 2018 Jan 12;8(1):671. doi: 10.1038/s41598-017-18421-8. PubMed |
| USP20 positively regulates tumorigenesis and chemoresistance through beta-catenin stabilization. Wu C, Luo K, Zhao F, Yin P, Song Y, Deng M, Huang J, Chen Y, Li L, Lee S, Kim J, Zhou Q, Tu X, Nowsheen S, Luo Q, Gao X, Lou Z, Liu Z, Yuan J. Cell Death Differ. 2018 Nov;25(10):1855-1869. doi: 10.1038/s41418-018-0138-z. Epub 2018 Jun 4. PubMed |
| GSK-3beta Inhibitor Alsterpaullone Attenuates MPP(+)-Induced Cell Damage in a c-Myc-Dependent Manner in SH-SY5Y Cells. Wang J, Li Y, Gao L, Yan F, Gao G, Li L. Front Cell Neurosci. 2018 Aug 30;12:283. doi: 10.3389/fncel.2018.00283. eCollection 2018. PubMed |
| beta-Catenin expression is associated with cell invasiveness in pancreatic cancer. Nan JN, Kim OR, Lee MA. Korean J Intern Med. 2018 Oct 26. pii: kjim.2017.155. doi: 10.3904/kjim.2017.155. PubMed |
| Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output. Miller CJ, Lou HJ, Simpson C, van de Kooij B, Ha BH, Fisher OS, Pirman NL, Boggon TJ, Rinehart J, Yaffe MB, Linding R, Turk BE. PLoS Biol. 2019 Mar 21;17(3):e2006540. doi: 10.1371/journal.pbio.2006540. eCollection 2019 Mar. PubMed |
| Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation. Wang CH, Hung PW, Chiang CW, Lombes M, Chen CH, Lee KH, Lo YC, Wu MH, Chang WC, Lin DY. Biochim Biophys Acta Mol Cell Res. 2019 Aug;1866(8):1282-1297. doi: 10.1016/j.bbamcr.2019.03.014. Epub 2019 Mar 29. PubMed |
| Promotion of growth factor signaling as a critical function of beta-catenin during HCC progression. Kim E, Lisby A, Ma C, Lo N, Ehmer U, Hayer KE, Furth EE, Viatour P. Nat Commun. 2019 Apr 23;10(1):1909. doi: 10.1038/s41467-019-09780-z. PubMed |
| Translation of the circular RNA circbeta-catenin promotes liver cancer cell growth through activation of the Wnt pathway. Liang WC, Wong CW, Liang PP, Shi M, Cao Y, Rao ST, Tsui SK, Waye MM, Zhang Q, Fu WM, Zhang JF. Genome Biol. 2019 Apr 26;20(1):84. doi: 10.1186/s13059-019-1685-4. PubMed |
| Deoxynivalenol induces inhibition of cell proliferation via the Wnt/beta-catenin signaling pathway. Tang S, Chen S, Huang B, Jiang J, Wen J, Deng Y. Biochem Pharmacol. 2019 Aug;166:12-22. doi: 10.1016/j.bcp.2019.05.009. Epub 2019 May 7. PubMed |
| Downregulated Wnt/beta-catenin signalling in the Down syndrome hippocampus. Granno S, Nixon-Abell J, Berwick DC, Tosh J, Heaton G, Almudimeegh S, Nagda Z, Rain JC, Zanda M, Plagnol V, Tybulewicz VLJ, Cleverley K, Wiseman FK, Fisher EMC, Harvey K. Sci Rep. 2019 May 13;9(1):7322. doi: 10.1038/s41598-019-43820-4. PubMed |
| Deacetylation of beta-catenin by SIRT1 regulates self-renewal and oncogenesis of liver cancer stem cells. Chen X, Huan H, Liu C, Luo Y, Shen J, Zhuo Y, Zhang Z, Qian C. Cancer Lett. 2019 Oct 28;463:1-10. doi: 10.1016/j.canlet.2019.07.021. Epub 2019 Aug 5. PubMed |
Luminescent and fluorescent triple reporter plasmid constructs for Wnt, Hedgehog and Notch pathway.
Maier J, Elmenofi S, Taschauer A, Anton M, Sami H, Ogris M.
PLoS One. 2019 Dec 20;14(12):e0226570. doi: 10.1371/journal.pone.0226570. eCollection 2019.
PubMed
Associated Plasmids |
| beta-Catenin Preserves the Stem State of Murine Bone Marrow Stromal Cells Through Activation of EZH2. Sen B, Paradise CR, Xie Z, Sankaran J, Uzer G, Styner M, Meyer M, Dudakovic A, van Wijnen AJ, Rubin J. J Bone Miner Res. 2020 Jun;35(6):1149-1162. doi: 10.1002/jbmr.3975. Epub 2020 Feb 24. PubMed |
| SLC6A14, a Na+/Cl--coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling. Sikder MOF, Sivaprakasam S, Brown TP, Thangaraju M, Bhutia YD, Ganapathy V. Biochem J. 2020 Apr 30;477(8):1409-1425. doi: 10.1042/BCJ20200099. PubMed |
| Cinobufagin Suppresses Melanoma Cell Growth by Inhibiting LEF1. Kim GH, Fang XQ, Lim WJ, Park J, Kang TB, Kim JH, Lim JH. Int J Mol Sci. 2020 Sep 13;21(18). pii: ijms21186706. doi: 10.3390/ijms21186706. PubMed |
| Thermofluidic heat exchangers for actuation of transcription in artificial tissues. Corbett DC, Fabyan WB, Grigoryan B, O'Connor CE, Johansson F, Batalov I, Regier MC, DeForest CA, Miller JS, Stevens KR. Sci Adv. 2020 Sep 30;6(40). pii: 6/40/eabb9062. doi: 10.1126/sciadv.abb9062. Print 2020 Sep. PubMed |
| The RNA helicase DDX3 induces neural crest by promoting AKT activity. Perfetto M, Xu X, Lu C, Shi Y, Yousaf N, Li J, Yien YY, Wei S. Development. 2021 Jan 19;148(2). pii: dev.184341. doi: 10.1242/dev.184341. PubMed |
| The GSK3beta-beta-catenin-TCF1 pathway improves naive T cell activation in old adults by upregulating miR-181a. Ye Z, Gould TM, Zhang H, Jin J, Weyand CM, Goronzy JJ. NPJ Aging Mech Dis. 2021 Feb 8;7(1):4. doi: 10.1038/s41514-021-00056-9. PubMed |
| A role for PAK1 mediated phosphorylation of beta-catenin Ser552 in the regulation of insulin secretion. Sorrenson B, Dissanayake WC, Hu F, Lee KL, Shepherd PR. Biochem J. 2021 Apr 30;478(8):1605-1615. doi: 10.1042/BCJ20200862. PubMed |
| Ubiquitin-specific protease 53 promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. Baek D, Park KH, Lee KM, Jung S, Joung S, Kim J, Lee JW. Cell Death Dis. 2021 Mar 4;12(3):238. doi: 10.1038/s41419-021-03517-x. PubMed |
| Pharmacological targeting of the novel beta-catenin chromatin-associated kinase p38alpha in colorectal cancer stem cell tumorspheres and organoids. Lepore Signorile M, Grossi V, Di Franco S, Forte G, Disciglio V, Fasano C, Sanese P, De Marco K, Susca FC, Mangiapane LR, Nicotra A, Di Carlo G, Dituri F, Giannelli G, Ingravallo G, Canettieri G, Stassi G, Simone C. Cell Death Dis. 2021 Mar 25;12(4):316. doi: 10.1038/s41419-021-03572-4. PubMed |
| Pyrvinium Treatment Confers Hepatic Metabolic Benefits via beta-Catenin Downregulation and AMPK Activation. Zhou S, Obianom ON, Huang J, Guo D, Yang H, Li Q, Shu Y. Pharmaceutics. 2021 Mar 4;13(3). pii: pharmaceutics13030330. doi: 10.3390/pharmaceutics13030330. PubMed |
| Mastermind Like Transcriptional Coactivator 3 (MAML3) Drives Neuroendocrine Tumor Progression. Alzofon N, Koc K, Panwell K, Pozdeyev N, Marshall CB, Albuja-Cruz M, Raeburn CD, Nathanson KL, Cohen DL, Wierman ME, Kiseljak-Vassiliades K, Fishbein L. Mol Cancer Res. 2021 Sep;19(9):1476-1485. doi: 10.1158/1541-7786.MCR-20-0992. Epub 2021 May 13. PubMed |
| SOX9 promotes epidermal growth factor receptor-tyrosine kinase inhibitor resistance via targeting beta-catenin and epithelial to mesenchymal transition in lung cancer. Tripathi SK, Biswal BK. Life Sci. 2021 Jul 15;277:119608. doi: 10.1016/j.lfs.2021.119608. Epub 2021 May 11. PubMed |
| MiRNA-146a/AKT/beta-Catenin Activation Regulates Cancer Stem Cell Phenotype in Oral Squamous Cell Carcinoma by Targeting CD24. Ghuwalewala S, Ghatak D, Das S, Roy S, Das P, Butti R, Gorain M, Nath S, Kundu GC, Roychoudhury S. Front Oncol. 2021 Oct 12;11:651692. doi: 10.3389/fonc.2021.651692. eCollection 2021. PubMed |
| Heparanase-Induced Activation of AKT Stabilizes beta-Catenin and Modulates Wnt/beta-Catenin Signaling during Herpes Simplex Virus 1 Infection. Koujah L, Madavaraju K, Agelidis AM, Patil CD, Shukla D. mBio. 2021 Dec 21;12(6):e0279221. doi: 10.1128/mBio.02792-21. Epub 2021 Nov 9. PubMed |
| HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia. Luo H, Zhu G, Eshelman MA, Fung TK, Lai Q, Wang F, Zeisig BB, Lesperance J, Ma X, Chen S, Cesari N, Cogle C, Chen B, Xu B, Yang FC, So CWE, Qiu Y, Xu M, Huang S. Mol Cell. 2022 Feb 17;82(4):833-851.e11. doi: 10.1016/j.molcel.2022.01.014. PubMed |
| ASPM Promotes the Progression of Anaplastic Thyroid Carcinomas by Regulating the Wnt/beta-Catenin Signaling Pathway. Jiang L, Zhang S, An N, Chai G, Ye C. Int J Endocrinol. 2022 Mar 27;2022:5316102. doi: 10.1155/2022/5316102. eCollection 2022. PubMed |
| Melatonin and andrographolide synergize to inhibit the colospheroid phenotype by targeting Wnt/beta-catenin signaling. Sokolov D, Sharda N, Giri B, Hassan MS, Singh D, Tarasiewicz A, Lohr C, von Holzen U, Kristian T, Waddell J, Reiter RJ, Ahmed H, Banerjee A. J Pineal Res. 2022 Aug;73(1):e12808. doi: 10.1111/jpi.12808. Epub 2022 Jun 5. PubMed |
| RON-augmented cholesterol biosynthesis in breast cancer metastatic progression and recurrence. Hunt BG, Davis JC, Fox LH, Vicente-Munoz S, Lester C, Wells SI, Waltz SE. Oncogene. 2023 May;42(21):1716-1727. doi: 10.1038/s41388-023-02688-5. Epub 2023 Apr 7. PubMed |
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