PIK3CA - Exon9 E545K Citations (12)

Originally described in: High frequency of mutations of the PIK3CA gene in human cancers.
Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE Science. 2004 Apr 23. 304(5670):554. PubMed Journal

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Articles Citing PIK3CA - Exon9 E545K

Articles
p53 in trichostatin A induced C6 glioma cell death. Hsu YF, Sheu JR, Hsiao G, Lin CH, Chang TH, Chiu PT, Wang CY, Hsu MJ. Biochim Biophys Acta. 2011 May;1810(5):504-13. doi: 10.1016/j.bbagen.2011.02.006. Epub 2011 Mar 2. PubMed
Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade. Chang HL, Chen CY, Hsu YF, Kuo WS, Ou G, Chiu PT, Huang YH, Hsu MJ. Biochim Biophys Acta. 2013 Aug;1830(8):4053-64. doi: 10.1016/j.bbagen.2013.04.011. Epub 2013 Apr 12. PubMed
IKKbeta regulates endothelial thrombomodulin in a Klf2-dependent manner. Pathak R, Shao L, Chafekar SM, Feng W, Ponnappan U, Fink LM, Zhou D, Hauer-Jensen M. J Thromb Haemost. 2014 Sep;12(9):1533-44. doi: 10.1111/jth.12664. Epub 2014 Aug 11. PubMed
The effects of a novel aliphatic-chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death. Huang YH, Huang SW, Hsu YF, Ou G, Huang WJ, Hsu MJ. Sci Rep. 2015 Oct 29;5:15900. doi: 10.1038/srep15900. PubMed
The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR. Zhao S, Cao Y, Liu SB, Wang XA, Bao RF, Shu YJ, Hu YP, Zhang YJ, Jiang L, Zhang F, Liang HB, Li HF, Ma Q, Xu Y, Wang Z, Zhang YC, Chen L, Zhou J, Liu YB. J Exp Clin Cancer Res. 2016 Jun 18;35(1):97. doi: 10.1186/s13046-016-0370-7. PubMed
p120-Catenin Downregulation and PIK3CA Mutations Cooperate to Induce Invasion through MMP1 in HNSCC. Kidacki M, Lehman HL, Green MV, Warrick JI, Stairs DB. Mol Cancer Res. 2017 Jun 21. pii: molcanres.0108.2017. doi: 10.1158/1541-7786.MCR-17-0108. PubMed
Inhibitory effect of PDGF-BB and serum-stimulated responses in vascular smooth muscle cell proliferation by hinokitiol via up-regulation of p21 and p53. Li JY, Liu CP, Shiao WC, Jayakumar T, Li YS, Chang NC, Huang SY, Hsieh CY. Arch Med Sci. 2018 Apr;14(3):579-587. doi: 10.5114/aoms.2018.75085. Epub 2018 Apr 16. PubMed
Targeted therapy in patients with PIK3CA-related overgrowth syndrome. Venot Q, Blanc T, Rabia SH, Berteloot L, Ladraa S, Duong JP, Blanc E, Johnson SC, Hoguin C, Boccara O, Sarnacki S, Boddaert N, Pannier S, Martinez F, Magassa S, Yamaguchi J, Knebelmann B, Merville P, Grenier N, Joly D, Cormier-Daire V, Michot C, Bole-Feysot C, Picard A, Soupre V, Lyonnet S, Sadoine J, Slimani L, Chaussain C, Laroche-Raynaud C, Guibaud L, Broissand C, Amiel J, Legendre C, Terzi F, Canaud G. Nature. 2018 Jun;558(7711):540-546. doi: 10.1038/s41586-018-0217-9. Epub 2018 Jun 13. PubMed
WMJ-S-001, a Novel Aliphatic Hydroxamate-Based Compound, Suppresses Lymphangiogenesis Through p38mapk-p53-survivin Signaling Cascade. Huang SW, Yang HY, Huang WJ, Chen WC, Yu MC, Wang SW, Hsu YF, Hsu MJ. Front Oncol. 2019 Nov 6;9:1188. doi: 10.3389/fonc.2019.01188. eCollection 2019. PubMed
Lovastatin-mediated MCF-7 cancer cell death involves LKB1-AMPK-p38MAPK-p53-survivin signalling cascade. Huang SW, Chyuan IT, Shiue C, Yu MC, Hsu YF, Hsu MJ. J Cell Mol Med. 2020 Jan;24(2):1822-1836. doi: 10.1111/jcmm.14879. Epub 2019 Dec 10. PubMed
Introduction and expression of PIK3CA(E545K) in a papillary thyroid cancer BRAF(V600E) cell line leads to a dedifferentiated aggressive phenotype. Pinto N, Ruicci KM, Khan MI, Shaikh MH, Zeng YFP, Yoo J, Fung K, MacNeil SD, Mendez A, Mymryk JS, Barrett JW, Boutros PC, Nichols AC. J Otolaryngol Head Neck Surg. 2022 Feb 22;51(1):7. doi: 10.1186/s40463-022-00558-w. PubMed
Reciprocal regulation of Daxx and PIK3CA promotes colorectal cancer cell growth. Huang YS, Wu CC, Chang CC, Huang SF, Kuo HY, Shih HM. Cell Mol Life Sci. 2022 Jun 19;79(7):367. doi: 10.1007/s00018-022-04399-8. PubMed

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