pcDNA3 MDM2 WT Citations (19)
Originally described in: HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation.Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC Nat Cell Biol. 2001 Nov . 3(11):973-82. PubMed Journal
Articles Citing pcDNA3 MDM2 WT
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| p53-mediated heterochromatin reorganization regulates its cell fate decisions. Mungamuri SK, Benson EK, Wang S, Gu W, Lee SW, Aaronson SA. Nat Struct Mol Biol. 2012 Apr 1;19(5):478-84, S1. doi: 10.1038/nsmb.2271. PubMed |
| Aciculatin induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivo. Lai CY, Tsai AC, Chen MC, Chang LH, Sun HL, Chang YL, Chen CC, Teng CM, Pan SL. PLoS One. 2012;7(8):e42192. doi: 10.1371/journal.pone.0042192. Epub 2012 Aug 13. PubMed |
| Bcl11a is essential for lymphoid development and negatively regulates p53. Yu Y, Wang J, Khaled W, Burke S, Li P, Chen X, Yang W, Jenkins NA, Copeland NG, Zhang S, Liu P. J Exp Med. 2012 Dec 17;209(13):2467-83. doi: 10.1084/jem.20121846. Epub 2012 Dec 10. PubMed |
| HAUSP, a novel deubiquitinase for Rb - MDM2 the critical regulator. Bhattacharya S, Ghosh MK. FEBS J. 2014 Jul;281(13):3061-78. doi: 10.1111/febs.12843. Epub 2014 Jun 10. PubMed |
| The transcription factor MEF/Elf4 is dually modulated by p53-MDM2 axis and MEF-MDM2 autoregulatory mechanism. Suico MA, Fukuda R, Miyakita R, Koyama K, Taura M, Shuto T, Kai H. J Biol Chem. 2014 Sep 19;289(38):26143-54. doi: 10.1074/jbc.M114.580209. Epub 2014 Jul 31. PubMed |
| p53 protein aggregation promotes platinum resistance in ovarian cancer. Yang-Hartwich Y, Soteras MG, Lin ZP, Holmberg J, Sumi N, Craveiro V, Liang M, Romanoff E, Bingham J, Garofalo F, Alvero A, Mor G. Oncogene. 2014 Sep 29. doi: 10.1038/onc.2014.296. PubMed |
| Phosphorylation of murine double minute-2 on Ser166 is downstream of VEGF-A in exercised skeletal muscle and regulates primary endothelial cell migration and FoxO gene expression. Aiken J, Roudier E, Ciccone J, Drouin G, Stromberg A, Vojnovic J, Olfert IM, Haas T, Gustafsson T, Grenier G, Birot O. FASEB J. 2016 Mar;30(3):1120-34. doi: 10.1096/fj.15-276964. Epub 2015 Nov 17. PubMed |
| USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation. Mungamuri SK, Qiao RF, Yao S, Manfredi JJ, Gu W, Aaronson SA. Cell Rep. 2016 Mar 22;14(11):2528-37. doi: 10.1016/j.celrep.2016.02.049. Epub 2016 Mar 10. PubMed |
| miR-5003-3p promotes epithelial-mesenchymal transition in breast cancer cells through Snail stabilization and direct targeting of E-cadherin. Kwak SY, Yoo JO, An HJ, Bae IH, Park MJ, Kim J, Han YH. J Mol Cell Biol. 2016 Jun 9. pii: mjw026. PubMed |
| p53-Pirh2 Complex Promotes Twist1 Degradation and Inhibits EMT. Yang-Hartwich Y, Tedja R, Roberts CM, Goodner-Bingham J, Cardenas C, Gurea M, Sumi NJ, Alvero AB, Glackin CA, Mor G. Mol Cancer Res. 2019 Jan;17(1):153-164. doi: 10.1158/1541-7786.MCR-18-0238. Epub 2018 Aug 21. PubMed |
| Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases. Pascoe N, Seetharaman A, Teyra J, Manczyk N, Satori MA, Tjandra D, Makhnevych T, Schwerdtfeger C, Brasher BB, Moffat J, Costanzo M, Boone C, Sicheri F, Sidhu SS. J Mol Biol. 2019 Mar 15;431(6):1160-1171. doi: 10.1016/j.jmb.2019.02.007. Epub 2019 Feb 11. PubMed |
| TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis. Niederkorn M, Hueneman K, Choi K, Varney ME, Romano L, Pujato MA, Greis KD, Inoue JI, Meetei R, Starczynowski DT. Cell Rep. 2020 Feb 25;30(8):2776-2790.e6. doi: 10.1016/j.celrep.2020.01.093. PubMed |
| PBK attenuates paclitaxel-induced autophagic cell death by suppressing p53 in H460 non-small-cell lung cancer cells. Park JH, Park SA, Lee YJ, Park HW, Oh SM. FEBS Open Bio. 2020 May;10(5):937-950. doi: 10.1002/2211-5463.12855. Epub 2020 Apr 14. PubMed |
| TRIM71 binds to IMP1 and is capable of positive and negative regulation of target RNAs. Foster DJ, Chang HM, Haswell JR, Gregory RI, Slack FJ. Cell Cycle. 2020 Sep;19(18):2314-2326. doi: 10.1080/15384101.2020.1804232. Epub 2020 Aug 20. PubMed |
| Urolithin A Inhibits Epithelial-Mesenchymal Transition in Lung Cancer Cells via P53-Mdm2-Snail Pathway. Cheng F, Dou J, Zhang Y, Wang X, Wei H, Zhang Z, Cao Y, Wu Z. Onco Targets Ther. 2021 May 17;14:3199-3208. doi: 10.2147/OTT.S305595. eCollection 2021. PubMed |
| Nuclear Receptor PXR Confers Irradiation Resistance by Promoting DNA Damage Response Through Stabilization of ATF3. Niu X, Cui H, Gu X, Wu T, Sun M, Zhou C, Ma M. Front Oncol. 2022 Mar 16;12:837980. doi: 10.3389/fonc.2022.837980. eCollection 2022. PubMed |
Transient inhibition of p53 enhances prime editing and cytosine base-editing efficiencies in human pluripotent stem cells.
Li M, Zhong A, Wu Y, Sidharta M, Beaury M, Zhao X, Studer L, Zhou T.
Nat Commun. 2022 Oct 27;13(1):6354. doi: 10.1038/s41467-022-34045-7.
PubMed
Associated Plasmids |
| Hyperhomocysteinemia activates NLRP3 inflammasome to cause hepatic steatosis and insulin resistance via MDM2-mediated ubiquitination of HSF1. Xiang W, Yang Y, Weng L, Ye Z, Ding P, Li H, Sun J, Zeng C. Int Immunopharmacol. 2023 May;118:110085. doi: 10.1016/j.intimp.2023.110085. Epub 2023 Apr 3. PubMed |
| Cell cycle arrest and p53 prevent ON-target megabase-scale rearrangements induced by CRISPR-Cas9. Cullot G, Boutin J, Fayet S, Prat F, Rosier J, Cappellen D, Lamrissi I, Pennamen P, Bouron J, Amintas S, Thibault C, Moranvillier I, Laharanne E, Merlio JP, Guyonnet-Duperat V, Blouin JM, Richard E, Dabernat S, Moreau-Gaudry F, Bedel A. Nat Commun. 2023 Jul 10;14(1):4072. doi: 10.1038/s41467-023-39632-w. PubMed |
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