pLKO.1-TSC2 Citations (13)

Originally described in: Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.
Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH Nat Cell Biol. 2007 Mar . 9(3):316-23. PubMed Journal

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Articles Citing pLKO.1-TSC2

Articles
A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation. Munkley J, Rajan P, Lafferty NP, Dalgliesh C, Jackson RM, Robson CN, Leung HY, Elliott DJ. Oncotarget. 2014 Jan 15;5(1):131-9. PubMed
Inhibition of mTORC1 induces loss of E-cadherin through AKT/GSK-3beta signaling-mediated upregulation of E-cadherin repressor complexes in non-small cell lung cancer cells. Kim EY, Kim A, Kim SK, Kim HJ, Chang J, Ahn CM, Chang YS. Respir Res. 2014 Feb 26;15:26. doi: 10.1186/1465-9921-15-26. PubMed
Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death. Yang CS, Matsuura K, Huang NJ, Robeson AC, Huang B, Zhang L, Kornbluth S. Oncogene. 2014 Aug 25. doi: 10.1038/onc.2014.271. PubMed
Improvement of mTORC1-driven overproduction of apoB-containing triacylglyceride-rich lipoproteins by short-chain fatty acids, 4-phenylbutyric acid and (R)-alpha-lipoic acid, in human hepatocellular carcinoma cells. Roberts JL, He B, Erickson A, Moreau R. Biochim Biophys Acta. 2016 Mar;1861(3):166-76. doi: 10.1016/j.bbalip.2015.12.001. Epub 2015 Dec 8. PubMed
Dual modulation of MCL-1 and mTOR determines the response to sunitinib. Elgendy M, Abdel-Aziz AK, Renne SL, Bornaghi V, Procopio G, Colecchia M, Kanesvaran R, Toh CK, Bossi D, Pallavicini I, Perez-Gracia JL, Lozano MD, Giandomenico V, Mercurio C, Lanfrancone L, Fazio N, Nole F, Teh BT, Renne G, Minucci S. J Clin Invest. 2017 Jan 3;127(1):153-168. doi: 10.1172/JCI84386. Epub 2016 Nov 28. PubMed
Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death. Thiepold AL, Lorenz NI, Foltyn M, Engel AL, Dive I, Urban H, Heller S, Bruns I, Hofmann U, Drose S, Harter PN, Mittelbronn M, Steinbach JP, Ronellenfitsch MW. Brain. 2017 Oct 1;140(10):2623-2638. doi: 10.1093/brain/awx196. PubMed
Nox4 is a Target for Tuberin Deficiency Syndrome. Shi Q, Viswanadhapalli S, Friedrichs WE, Velagapudi C, Szyndralewiez C, Bansal S, Bhat MA, Choudhury GG, Abboud HE. Sci Rep. 2018 Feb 28;8(1):3781. doi: 10.1038/s41598-018-21838-4. PubMed
Piperine potentiates curcumin-mediated repression of mTORC1 signaling in human intestinal epithelial cells: implications for the inhibition of protein synthesis and TNFalpha signaling. Kaur H, He B, Zhang C, Rodriguez E, Hage DS, Moreau R. J Nutr Biochem. 2018 Jul;57:276-286. doi: 10.1016/j.jnutbio.2018.04.010. Epub 2018 Apr 25. PubMed
DISC1 promotes translation maintenance during sodium arsenite-induced oxidative stress. Fuentes-Villalobos F, Farkas C, Riquelme-Barrios S, Armijo ME, Soto-Rifo R, Pincheira R, Castro AF. Biochim Biophys Acta Gene Regul Mech. 2019 Jun;1862(6):657-669. doi: 10.1016/j.bbagrm.2019.05.001. Epub 2019 May 7. PubMed
R-alpha-Lipoic Acid and 4-Phenylbutyric Acid Have Distinct Hypolipidemic Mechanisms in Hepatic Cells. He B, Moreau R. Biomedicines. 2020 Aug 15;8(8). pii: biomedicines8080289. doi: 10.3390/biomedicines8080289. PubMed
Curcumin steers THP-1 cells under LPS and mTORC1 challenges toward phenotypically resting, low cytokine-producing macrophages. Kaur H, Moreau R. J Nutr Biochem. 2021 Feb;88:108553. doi: 10.1016/j.jnutbio.2020.108553. Epub 2020 Nov 18. PubMed
Chylomicron production is repressed by RPTOR knockdown, R-alpha-lipoic acid and 4-phenylbutyric acid in human enterocyte-like Caco-2 cells. He B, Wang Z, Moreau R. J Nutr Biochem. 2022 Oct;108:109087. doi: 10.1016/j.jnutbio.2022.109087. Epub 2022 Jun 10. PubMed
Tuberin levels during cellular differentiation in brain development. Fidalgo da Silva E, Abu Khatir B, Drouillard C, Hinch I, Davis GO, Sameem M, Patel R, Fong J, Lubanska D, Porter LA. Differentiation. 2023 Mar-Apr;130:43-50. doi: 10.1016/j.diff.2022.12.004. Epub 2022 Dec 24. PubMed

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