pBabe-Puro-Myr-Flag-AKT1 Citations (23)
Originally described in: Integrative Genomic Approaches Identify IKBKE as a Breast Cancer Oncogene.Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, Hirozane-Kishikawa T, Hill DE, Vidal M, Meyerson M, Grenier JK, Hinkle G, Root DE, Roberts TM, Lander ES, Polyak K, Hahn WC Cell. 2007 Jun 15. 129(6):1065-1079. PubMed Journal
Articles Citing pBabe-Puro-Myr-Flag-AKT1
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| Prodigiosin down-regulates SKP2 to induce p27(KIP1) stabilization and antiproliferation in human lung adenocarcinoma cells. Hsieh HY, Shieh JJ, Chen CJ, Pan MY, Yang SY, Lin SC, Chang JS, Lee AY, Chang CC. Br J Pharmacol. 2012 Aug;166(7):2095-108. doi: 10.1111/j.1476-5381.2012.01921.x. PubMed |
| The scaffold protein MEK Partner 1 is required for the survival of estrogen receptor positive breast cancer cells. Marina M, Wang L, Conrad SE. Cell Commun Signal. 2012 Jul 9;10(1):18. doi: 10.1186/1478-811X-10-18. PubMed |
| The TSC-mTOR pathway regulates macrophage polarization. Byles V, Covarrubias AJ, Ben-Sahra I, Lamming DW, Sabatini DM, Manning BD, Horng T. Nat Commun. 2013;4:2834. doi: 10.1038/ncomms3834. PubMed |
| Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2. Wang C, Qin L, Manes TD, Kirkiles-Smith NC, Tellides G, Pober JS. J Exp Med. 2014 Mar 10;211(3):395-404. doi: 10.1084/jem.20131125. Epub 2014 Feb 10. PubMed |
| AKT regulates NPM dependent ARF localization and p53mut stability in tumors. Hamilton G, Abraham AG, Morton J, Sampson O, Pefani DE, Khoronenkova S, Grawenda A, Papaspyropoulos A, Jamieson N, McKay C, Sansom O, Dianov GL, O'Neill E. Oncotarget. 2014 Aug 15;5(15):6142-67. PubMed |
| FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth. Tancioni I, Miller NL, Uryu S, Lawson C, Jean C, Chen XL, Kleinschmidt EG, Schlaepfer DD. Breast Cancer Res. 2015 Mar 28;17:47. doi: 10.1186/s13058-015-0551-x. PubMed |
| Complement membrane attack complexes activate noncanonical NF-kappaB by forming an Akt+ NIK+ signalosome on Rab5+ endosomes. Jane-wit D, Surovtseva YV, Qin L, Li G, Liu R, Clark P, Manes TD, Wang C, Kashgarian M, Kirkiles-Smith NC, Tellides G, Pober JS. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9686-91. doi: 10.1073/pnas.1503535112. Epub 2015 Jul 20. PubMed |
Identification of an oncogenic RAB protein.
Wheeler DB, Zoncu R, Root DE, Sabatini DM, Sawyers CL.
Science. 2015 Oct 9;350(6257):211-7. doi: 10.1126/science.aaa4903. Epub 2015 Sep 3.
PubMed
Associated Plasmids |
| Tangeretin derivative, 5-acetyloxy-6,7,8,4'-tetramethoxyflavone induces G2/M arrest, apoptosis and autophagy in human non-small cell lung cancer cells in vitro and in vivo. Li YR, Li S, Ho CT, Chang YH, Tan KT, Chung TW, Wang BY, Chen YK, Lin CC. Cancer Biol Ther. 2016;17(1):48-64. doi: 10.1080/15384047.2015.1108491. PubMed |
| DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets. Hanaford AR, Archer TC, Price A, Kahlert UD, Maciaczyk J, Nikkhah G, Kim JW, Ehrenberger T, Clemons PA, Dancik V, Seashore-Ludlow B, Viswanathan V, Stewart ML, Rees MG, Shamji A, Schreiber S, Fraenkel E, Pomeroy SL, Mesirov JP, Tamayo P, Eberhart CG, Raabe EH. Clin Cancer Res. 2016 Mar 24. PubMed |
| Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein-protein interaction module. Yim N, Ryu SW, Choi K, Lee KR, Lee S, Choi H, Kim J, Shaker MR, Sun W, Park JH, Kim D, Heo WD, Choi C. Nat Commun. 2016 Jul 22;7:12277. doi: 10.1038/ncomms12277. PubMed |
| Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress. Huang, Li T, Wang L, Zhang L, Yan R, Li K, Xing S, Wu G, Hu L, Jia W, Lin SC, Dang CV, Song L, Gao P, Zhang H. Cell Res. 2016 Oct;26(10):1112-1130. doi: 10.1038/cr.2016.109. Epub 2016 Sep 20. PubMed |
| p70S6K1 (S6K1)-mediated Phosphorylation Regulates Phosphatidylinositol 4-Phosphate 5-Kinase Type I gamma Degradation and Cell Invasion. Jafari N, Zheng Q, Li L, Li W, Qi L, Xiao J, Gao T, Huang C. J Biol Chem. 2016 Dec 2;291(49):25729-25741. Epub 2016 Oct 25. PubMed |
| Direct activation of PP2A for the treatment of tyrosine kinase inhibitor-resistant lung adenocarcinoma. Tohme R, Izadmehr S, Gandhe S, Tabaro G, Vallabhaneni S, Thomas A, Vasireddi N, Dhawan NS, Ma'ayan A, Sharma N, Galsky MD, Ohlmeyer M, Sangodkar J, Narla G. JCI Insight. 2019 Feb 21;4(4). pii: 125693. doi: 10.1172/jci.insight.125693. eCollection 2019 Feb 21. PubMed |
| Loss of G-Protein Pathway Suppressor 2 Promotes Tumor Growth Through Activation of AKT Signaling. Chan S, Smith E, Gao Y, Kwan J, Blum BC, Tilston-Lunel AM, Turcinovic I, Varelas X, Cardamone MD, Monti S, Emili A, Perissi V. Front Cell Dev Biol. 2021 Jan 7;8:608044. doi: 10.3389/fcell.2020.608044. eCollection 2020. PubMed |
| PP2A-activating Drugs Enhance FLT3 Inhibitor Efficacy through AKT Inhibition-Dependent GSK-3beta-Mediated c-Myc and Pim-1 Proteasomal Degradation. Scarpa M, Singh P, Bailey CM, Lee JK, Kapoor S, Lapidus RG, Niyongere S, Sangodkar J, Wang Y, Perrotti D, Narla G, Baer MR. Mol Cancer Ther. 2021 Apr;20(4):676-690. doi: 10.1158/1535-7163.MCT-20-0663. Epub 2021 Feb 10. PubMed |
| Ras/ERK and PI3K/AKT signaling differentially regulate oncogenic ERG mediated transcription in prostate cells. Strittmatter BG, Jerde TJ, Hollenhorst PC. PLoS Genet. 2021 Jul 27;17(7):e1009708. doi: 10.1371/journal.pgen.1009708. eCollection 2021 Jul. PubMed |
| Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, Riley AK, Nkinsi NT, Kamlapurkar S, Parrish PCR, Lo A, Duke F, Chen J, Fung I, Watson J, Rees M, Gabel AM, Thomas JD, Bradley RK, Lee JK, Hatch EM, Baine MK, Rekhtman N, Ladanyi M, Piccioni F, Berger AH. Nat Commun. 2021 Aug 9;12(1):4789. doi: 10.1038/s41467-021-24841-y. PubMed |
| Expression of oncogenic HRAS in human Rh28 and RMS-YM rhabdomyosarcoma cells leads to oncogene-induced senescence. Li JJ, Kovach AR, DeMonia M, Slemmons KK, Oristian KM, Chen C, Linardic CM. Sci Rep. 2021 Aug 13;11(1):16505. doi: 10.1038/s41598-021-95355-2. PubMed |
| ZNF768 links oncogenic RAS to cellular senescence. Villot R, Poirier A, Bakan I, Boulay K, Fernandez E, Devillers R, Gama-Braga L, Tribouillard L, Gagne A, Duchesne E, Caron D, Berube JS, Berube JC, Coulombe Y, Orain M, Gelinas Y, Gobeil S, Bosse Y, Masson JY, Elowe S, Bilodeau S, Manem V, Joubert P, Mallette FA, Laplante M. Nat Commun. 2021 Aug 17;12(1):4841. doi: 10.1038/s41467-021-24932-w. PubMed |
| ZAP70 Activation Compensates for Loss of Class IA PI3K Isoforms Through Activation of the JAK-STAT3 Pathway. Demir M, Cizmecioglu O. Cancer Diagn Progn. 2022 May 3;2(3):391-404. doi: 10.21873/cdp.10122. eCollection 2022 May-Jun. PubMed |
| BCL2L11 Induction Mediates Sensitivity to Src and MEK1/2 Inhibition in Thyroid Cancer. Rose MM, Espinoza VL, Hoff KJ, Pike LA, Sharma V, Hofmann MC, Tan AC, Pozdeyev N, Schweppe RE. Cancers (Basel). 2023 Jan 6;15(2):378. doi: 10.3390/cancers15020378. PubMed |
| AKT-independent signaling in PIK3CA-mutant thyroid cancer mediates resistance to dual SRC and MEK1/2 inhibition. Rose MM, Nassar KW, Sharma V, Schweppe RE. Med Oncol. 2023 Sep 15;40(10):299. doi: 10.1007/s12032-023-02118-2. PubMed |
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