HA GSK3 beta S9A pcDNA3 Citations (61)
Originally described in: Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation.Stambolic V, Woodgett JR Biochem J. 1994 Nov 1. 303 ( Pt 3)():701-4. PubMed
Articles Citing HA GSK3 beta S9A pcDNA3
| Articles |
|---|
| Glycogen synthase kinase 3beta is a novel regulator of high glucose- and high insulin-induced extracellular matrix protein synthesis in renal proximal tubular epithelial cells. Mariappan MM, Shetty M, Sataranatarajan K, Choudhury GG, Kasinath BS. J Biol Chem. 2008 Nov 7. 283(45):30566-75. PubMed |
| IFN-beta production by TLR4-stimulated innate immune cells is negatively regulated by GSK3-beta. Wang H, Garcia CA, Rehani K, Cekic C, Alard P, Kinane DF, Mitchell T, Martin M. J Immunol. 2008 Nov 15;181(10):6797-802. PubMed |
| c-jun controls the ability of IL-12 to induce IL-10 production from human memory CD4+ T cells. Garcia CA, Wang H, Benakanakere MR, Barrett E, Kinane DF, Martin M. J Immunol. 2009 Oct 1;183(7):4475-82. doi: 10.4049/jimmunol.0901283. Epub 2009 Sep 4. PubMed |
| GSK3beta is a negative regulator of the transcriptional coactivator MAML1. Saint Just Ribeiro M, Hansson ML, Lindberg MJ, Popko-Scibor AE, Wallberg AE. Nucleic Acids Res. 2009 Nov;37(20):6691-700. doi: 10.1093/nar/gkp724. Epub 2009 Sep 8. PubMed |
| The role of glycogen synthase kinase 3 in regulating IFN-beta-mediated IL-10 production. Wang H, Brown J, Garcia CA, Tang Y, Benakanakere MR, Greenway T, Alard P, Kinane DF, Martin M. J Immunol. 2011 Jan 15;186(2):675-84. doi: 10.4049/jimmunol.1001473. Epub 2010 Dec 15. PubMed |
| Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores. Martin VA, Wang WH, Lipchik AM, Parker LL, He Y, Zhang S, Zhang ZY, Geahlen RL. Cell Signal. 2012 May;24(5):1064-73. doi: 10.1016/j.cellsig.2012.01.001. Epub 2012 Jan 11. PubMed |
| Formin mDia1 mediates vascular remodeling via integration of oxidative and signal transduction pathways. Toure F, Fritz G, Li Q, Rai V, Daffu G, Zou YS, Rosario R, Ramasamy R, Alberts AS, Yan SF, Schmidt AM. Circ Res. 2012 May 11;110(10):1279-93. doi: 10.1161/CIRCRESAHA.111.262519. Epub 2012 Apr 17. PubMed |
| The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells. Hiyama A, Arai F, Sakai D, Yokoyama K, Mochida J. Arthritis Res Ther. 2012 May 2;14(3):R105. doi: 10.1186/ar3830. PubMed |
| Perifosine enhances mTORC1-targeted cancer therapy by activation of GSK3beta in NSCLC cells. Ma Z, Zhu L, Luo X, Zhai S, Li P, Wang X. Cancer Biol Ther. 2012 Sep;13(11):1009-17. doi: 10.4161/cbt.20989. Epub 2012 Jul 24. PubMed |
| TGFbeta overrides HNF4alpha tumor suppressing activity through GSK3beta inactivation: implication for hepatocellular carcinoma gene therapy. Cozzolino AM, Alonzi T, Santangelo L, Mancone C, Conti B, Steindler C, Musone M, Cicchini C, Tripodi M, Marchetti A. J Hepatol. 2013 Jan;58(1):65-72. doi: 10.1016/j.jhep.2012.08.023. Epub 2012 Sep 4. PubMed |
| A comprehensive small interfering RNA screen identifies signaling pathways required for gephyrin clustering. Wuchter J, Beuter S, Treindl F, Herrmann T, Zeck G, Templin MF, Volkmer H. J Neurosci. 2012 Oct 17;32(42):14821-34. doi: 10.1523/JNEUROSCI.1261-12.2012. PubMed |
| Klebsiella pneumoniae targets an EGF receptor-dependent pathway to subvert inflammation. Frank CG, Reguerio V, Rother M, Moranta D, Maeurer AP, Garmendia J, Meyer TF, Bengoechea JA. Cell Microbiol. 2013 Jul;15(7):1212-33. doi: 10.1111/cmi.12110. Epub 2013 Feb 17. PubMed |
| ErbB2-dependent chemotaxis requires microtubule capture and stabilization coordinated by distinct signaling pathways. Benseddik K, Sen Nkwe N, Daou P, Verdier-Pinard P, Badache A. PLoS One. 2013;8(1):e55211. doi: 10.1371/journal.pone.0055211. Epub 2013 Jan 29. PubMed |
| Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression. Patel R, Gao M, Ahmad I, Fleming J, Singh LB, Rai TS, McKie AB, Seywright M, Barnetson RJ, Edwards J, Sansom OJ, Leung HY. J Clin Invest. 2013 Mar;123(3):1157-75. doi: 10.1172/JCI63672. Epub 2013 Feb 22. PubMed |
| Amyloid-beta oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons. Ramser EM, Gan KJ, Decker H, Fan EY, Suzuki MM, Ferreira ST, Silverman MA. Mol Biol Cell. 2013 Aug;24(16):2494-505. doi: 10.1091/mbc.E12-12-0858. Epub 2013 Jun 19. PubMed |
| Loss of IGFBP7 expression and persistent AKT activation contribute to SMARCB1/Snf5-mediated tumorigenesis. Darr J, Klochendler A, Isaac S, Eden A. Oncogene. 2014 Jun 5;33(23):3024-32. doi: 10.1038/onc.2013.261. Epub 2013 Jul 15. PubMed |
| Glucocorticoid receptor beta regulates injury-mediated astrocyte activation and contributes to glioma pathogenesis via modulation of beta-catenin/TCF transcriptional activity. Yin Y, Zhang X, Li Z, Deng L, Jiao G, Zhang B, Xie P, Mu H, Qiao W, Zou J. Neurobiol Dis. 2013 Nov;59:165-76. doi: 10.1016/j.nbd.2013.07.013. Epub 2013 Jul 30. PubMed |
| Concerted suppression of STAT3 and GSK3beta is involved in growth inhibition of non-small cell lung cancer by Xanthatin. Tao L, Fan F, Liu Y, Li W, Zhang L, Ruan J, Shen C, Sheng X, Zhu Z, Wang A, Chen W, Huang S, Lu Y. PLoS One. 2013 Nov 28;8(11):e81945. doi: 10.1371/journal.pone.0081945. eCollection 2013. PubMed |
| Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL. Osorio C, Chacon PJ, White M, Kisiswa L, Wyatt S, Rodriguez-Tebar A, Davies AM. Mol Cell Neurosci. 2014 Mar;59:24-36. doi: 10.1016/j.mcn.2014.01.002. Epub 2014 Jan 18. PubMed |
| Enhanced myeloid differentiation factor 88 promotes tumor metastasis via induction of epithelial-mesenchymal transition in human hepatocellular carcinoma. Jia RJ, Cao L, Zhang L, Jing W, Chen R, Zhu MH, Guo SW, Wu GB, Fan XY, Wang H, Zhang YY, Zhou XY, Zhao J, Guo YJ. Cell Death Dis. 2014 Mar 6;5:e1103. doi: 10.1038/cddis.2014.71. PubMed |
| Telomerase stimulates ribosomal DNA transcription under hyperproliferative conditions. Gonzalez OG, Assfalg R, Koch S, Schelling A, Meena JK, Kraus J, Lechel A, Katz SF, Benes V, Scharffetter-Kochanek K, Kestler HA, Gunes C, Iben S. Nat Commun. 2014 Aug 13;5:4599. doi: 10.1038/ncomms5599. PubMed |
| Amplified lipid rafts of malignant cells constitute a target for inhibition of aberrantly active NFAT and melanoma tumor growth by the aminobisphosphonate zoledronic acid. Levin-Gromiko U, Koshelev V, Kushnir P, Fedida-Metula S, Voronov E, Fishman D. Carcinogenesis. 2014 Nov;35(11):2555-66. doi: 10.1093/carcin/bgu178. Epub 2014 Aug 20. PubMed |
| Nerve growth factor (NGF) regulates activity of nuclear factor of activated T-cells (NFAT) in neurons via the phosphatidylinositol 3-kinase (PI3K)-Akt-glycogen synthase kinase 3beta (GSK3beta) pathway. Kim MS, Shutov LP, Gnanasekaran A, Lin Z, Rysted JE, Ulrich JD, Usachev YM. J Biol Chem. 2014 Nov 7;289(45):31349-60. doi: 10.1074/jbc.M114.587188. Epub 2014 Sep 17. PubMed |
| GSK3beta-dependent phosphorylation alters DNA binding, transactivity and half-life of the transcription factor USF2. Horbach T, Chi TF, Gotz C, Sharma S, Juffer AH, Dimova EY, Kietzmann T. PLoS One. 2014 Sep 19;9(9):e107914. doi: 10.1371/journal.pone.0107914. eCollection 2014. PubMed |
| Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress. Vene R, Cardinali B, Arena G, Ferrari N, Benelli R, Minghelli S, Poggi A, Noonan DM, Albini A, Tosetti F. Neoplasia. 2014 Sep;16(9):710-22. doi: 10.1016/j.neo.2014.07.012. PubMed |
| GSK-3beta Phosphorylation of Cytoplasmic Dynein Reduces Ndel1 Binding to Intermediate Chains and Alters Dynein Motility. Gao FJ, Hebbar S, Gao XA, Alexander M, Pandey JP, Walla MD, Cotham WE, King SJ, Smith DS. Traffic. 2015 May 22. doi: 10.1111/tra.12304. PubMed |
| Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma. Georgy SR, Cangkrama M, Srivastava S, Partridge D, Auden A, Dworkin S, McLean CA, Jane SM, Darido C. J Natl Cancer Inst. 2015 Jun 10;107(9). pii: djv152. doi: 10.1093/jnci/djv152. Print 2015 Sep. PubMed |
| Stringent Control of NFE2L3 (Nuclear Factor, Erythroid 2-Like 3; NRF3) Protein Degradation by FBW7 (F-box/WD Repeat-containing Protein 7) and Glycogen Synthase Kinase 3 (GSK3). Kannan MB, Dodard-Friedman I, Blank V. J Biol Chem. 2015 Oct 23;290(43):26292-302. doi: 10.1074/jbc.M115.666446. Epub 2015 Aug 25. PubMed |
| Glycogen synthase kinase-3beta modulation of glucocorticoid responsiveness in COPD. Ngkelo A, Hoffmann RF, Durham AL, Marwick JA, Brandenburg SM, de Bruin HG, Jonker MR, Rossios C, Tsitsiou E, Caramori G, Contoli M, Casolari P, Monaco F, Ando F, Speciale G, Kilty I, Chung KF, Papi A, Lindsay MA, Ten Hacken NH, van den Berge M, Timens W, Barnes PJ, van Oosterhout AJ, Adcock IM, Kirkham PA, Heijink IH. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1112-23. doi: 10.1152/ajplung.00077.2015. Epub 2015 Aug 28. PubMed |
| Resolvin D1, resolvin D2 and maresin 1 activate the GSK3beta anti-inflammatory axis in TLR4-engaged human monocytes. Gu Z, Lamont GJ, Lamont RJ, Uriarte SM, Wang H, Scott DA. Innate Immun. 2016 Apr;22(3):186-95. doi: 10.1177/1753425916628618. Epub 2016 Feb 15. PubMed |
| mTORC1 is necessary but mTORC2 and GSK3beta are inhibitory for AKT3-induced axon regeneration in the central nervous system. Miao L, Yang L, Huang H, Liang F, Ling C, Hu Y. Elife. 2016 Mar 30;5. pii: e14908. doi: 10.7554/eLife.14908. PubMed |
| Xanthatin anti-tumor cytotoxicity is mediated via glycogen synthase kinase-3beta and beta-catenin. Tao L, Sheng X, Zhang L, Li W, Wei Z, Zhu P, Zhang F, Wang A, Woodgett JR, Lu Y. Biochem Pharmacol. 2016 Jun 16. pii: S0006-2952(16)30135-6. doi: 10.1016/j.bcp.2016.06.009. PubMed |
SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage.
Hong X, Liu W, Song R, Shah JJ, Feng X, Tsang CK, Morgan KM, Bunting SF, Inuzuka H, Zheng XF, Shen Z, Sabaawy HE, Liu L, Pine SR.
Nucleic Acids Res. 2016 Oct 14;44(18):8855-8869. Epub 2016 Aug 26.
PubMed
Associated Plasmids |
| Leishmania donovani inhibits macrophage apoptosis and pro-inflammatory response through AKT-mediated regulation of beta-catenin and FOXO-1. Gupta P, Srivastav S, Saha S, Das PK, Ukil A. Cell Death Differ. 2016 Nov 1;23(11):1815-1826. doi: 10.1038/cdd.2016.101. Epub 2016 Sep 23. PubMed |
| GSK-3beta/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy. Duran J, Oyarce C, Pavez M, Valladares D, Basualto-Alarcon C, Lagos D, Barrientos G, Troncoso MF, Ibarra C, Estrada M. PLoS One. 2016 Dec 15;11(12):e0168255. doi: 10.1371/journal.pone.0168255. eCollection 2016. PubMed |
| Inhibition of glycogen synthase kinase 3 beta (GSK3beta) suppresses the progression of esophageal squamous cell carcinoma by modifying STAT3 activity. Gao S, Li S, Duan X, Gu Z, Ma Z, Yuan X, Feng X, Wang H. Mol Carcinog. 2017 Jun 2. doi: 10.1002/mc.22685. PubMed |
| GSK3alpha and GSK3beta Phosphorylate Arc and Regulate its Degradation. Gozdz A, Nikolaienko O, Urbanska M, Cymerman IA, Sitkiewicz E, Blazejczyk M, Dadlez M, Bramham CR, Jaworski J. Front Mol Neurosci. 2017 Jun 16;10:192. doi: 10.3389/fnmol.2017.00192. eCollection 2017. PubMed |
| Cathepsin L promotes ionizing radiation-induced U251 glioma cell migration and invasion through regulating the GSK-3beta/CUX1 pathway. Fei Y, Xiong Y, Shen X, Zhao Y, Zhu Y, Wang L, Liang Z. Cell Signal. 2018 Apr;44:62-71. doi: 10.1016/j.cellsig.2018.01.012. Epub 2018 Jan 10. PubMed |
| GSK3beta modulates NF-kappaB activation and RelB degradation through site-specific phosphorylation of BCL10. Abd-Ellah A, Voogdt C, Krappmann D, Moller P, Marienfeld RB. Sci Rep. 2018 Jan 22;8(1):1352. doi: 10.1038/s41598-018-19822-z. PubMed |
| Modulation of GSK3beta autoinhibition by Thr-7 and Thr-8. Tong Y, Park S, Wu D, Harris TE, Moskaluk CA, Brautigan DL, Fu Z. FEBS Lett. 2018 Feb;592(4):537-546. doi: 10.1002/1873-3468.12990. Epub 2018 Feb 8. PubMed |
| GSK3 is a negative regulator of the thermogenic program in brown adipocytes. Markussen LK, Winther S, Wicksteed B, Hansen JB. Sci Rep. 2018 Feb 22;8(1):3469. doi: 10.1038/s41598-018-21795-y. PubMed |
| SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation. Sarikhani M, Mishra S, Maity S, Kotyada C, Wolfgeher D, Gupta MP, Singh M, Sundaresan NR. Elife. 2018 Mar 5;7. pii: 32952. doi: 10.7554/eLife.32952. PubMed |
| GSK3beta Regulates Brain Energy Metabolism. Martin SA, Souder DC, Miller KN, Clark JP, Sagar AK, Eliceiri KW, Puglielli L, Beasley TM, Anderson RM. Cell Rep. 2018 May 15;23(7):1922-1931.e4. doi: 10.1016/j.celrep.2018.04.045. PubMed |
| AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells. Pei S, Minhajuddin M, Adane B, Khan N, Stevens BM, Mack SC, Lai S, Rich JN, Inguva A, Shannon KM, Kim H, Tan AC, Myers JR, Ashton JM, Neff T, Pollyea DA, Smith CA, Jordan CT. Cell Stem Cell. 2018 Jul 5;23(1):86-100.e6. doi: 10.1016/j.stem.2018.05.021. Epub 2018 Jun 14. PubMed |
| DYRK1B regulates Hedgehog-induced microtubule acetylation. Singh R, Holz PS, Roth K, Hupfer A, Meissner W, Muller R, Buchholz M, Gress TM, Elsasser HP, Jacob R, Lauth M. Cell Mol Life Sci. 2019 Jan;76(1):193-207. doi: 10.1007/s00018-018-2942-5. Epub 2018 Oct 13. PubMed |
| Copy Number Variants in miR-138 as a Potential Risk Factor for Early-Onset Alzheimer's Disease. Boscher E, Husson T, Quenez O, Laquerriere A, Marguet F, Cassinari K, Wallon D, Martinaud O, Charbonnier C, Nicolas G, Deleuze JF, Boland A, Lathrop M, Frebourg T, Campion D, Hebert SS, Rovelet-Lecrux A. J Alzheimers Dis. 2019;68(3):1243-1255. doi: 10.3233/JAD-180940. PubMed |
| REDD1 Activates a ROS-Generating Feedback Loop in the Retina of Diabetic Mice. Miller WP, Toro AL, Barber AJ, Dennis MD. Invest Ophthalmol Vis Sci. 2019 May 1;60(6):2369-2379. doi: 10.1167/iovs.19-26606. PubMed |
| High specificity of widely used phospho-tau antibodies validated using a quantitative whole-cell based assay. Li D, Cho YK. J Neurochem. 2020 Jan;152(1):122-135. doi: 10.1111/jnc.14830. Epub 2019 Sep 4. PubMed |
| Icariside II, a phosphodiesterase 5 inhibitor, attenuates cerebral ischaemia/reperfusion injury by inhibiting glycogen synthase kinase-3beta-mediated activation of autophagy. Gao J, Long L, Xu F, Feng L, Liu Y, Shi J, Gong Q. Br J Pharmacol. 2019 Oct 28. doi: 10.1111/bph.14912. PubMed |
| PKCgamma promotes axonal remodeling in the cortico-spinal tract via GSK3beta/beta-catenin signaling after traumatic brain injury. Zhang B, Li Z, Zhang R, Hu Y, Jiang Y, Cao T, Wang J, Gong L, Ji L, Mu H, Yang X, Dai Y, Jiang C, Yin Y, Zou J. Sci Rep. 2019 Nov 19;9(1):17078. doi: 10.1038/s41598-019-53225-y. PubMed |
| Glycogen synthase kinase-3ss supports serotonin transporter function and trafficking in a phosphorylation-dependent manner. Ragu Varman D, Jayanthi LD, Ramamoorthy S. J Neurochem. 2021 Feb;156(4):445-464. doi: 10.1111/jnc.15152. Epub 2020 Sep 7. PubMed |
| HGF protected against diabetic nephropathy via autophagy-lysosome pathway in podocyte by modulating PI3K/Akt-GSK3beta-TFEB axis. Hou B, Li Y, Li X, Zhang C, Zhao Z, Chen Q, Zhang N, Li H. Cell Signal. 2020 Nov;75:109744. doi: 10.1016/j.cellsig.2020.109744. Epub 2020 Aug 19. PubMed |
| Klebsiella pneumoniae Reduces SUMOylation To Limit Host Defense Responses. Sa-Pessoa J, Przybyszewska K, Vasconcelos FN, Dumigan A, Frank CG, Hobley L, Bengoechea JA. mBio. 2020 Sep 29;11(5). pii: mBio.01733-20. doi: 10.1128/mBio.01733-20. PubMed |
| Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m(6)A Methylation. Sun HL, Zhu AC, Gao Y, Terajima H, Fei Q, Liu S, Zhang L, Zhang Z, Harada BT, He YY, Bissonnette MB, Hung MC, He C. Mol Cell. 2020 Nov 19;80(4):633-647.e7. doi: 10.1016/j.molcel.2020.10.026. PubMed |
| Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3beta and inhibiting Tau hyperphosphorylation. Giovinazzo D, Bursac B, Sbodio JI, Nalluru S, Vignane T, Snowman AM, Albacarys LM, Sedlak TW, Torregrossa R, Whiteman M, Filipovic MR, Snyder SH, Paul BD. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4). pii: 2017225118. doi: 10.1073/pnas.2017225118. PubMed |
| The small molecule DIPQUO promotes osteogenic differentiation via inhibition of glycogen synthase kinase 3-beta signaling. Cook B, Walker N, Zhang Q, Chen S, Evans T. J Biol Chem. 2021 Jan-Jun;296:100696. doi: 10.1016/j.jbc.2021.100696. Epub 2021 Apr 22. PubMed |
| Nrf2-mediated liver protection by 18beta-glycyrrhetinic acid against pyrrolizidine alkaloid-induced toxicity through PI3K/Akt/GSK3beta pathway. Wang Z, Ma J, He Y, Miu KK, Yao S, Tang C, Ye Y, Lin G. Phytomedicine. 2022 Jul 20;102:154162. doi: 10.1016/j.phymed.2022.154162. Epub 2022 May 13. PubMed |
| Alzheimer's disease: Ablating single master site abolishes tau hyperphosphorylation. Stefanoska K, Gajwani M, Tan ARP, Ahel HI, Asih PR, Volkerling A, Poljak A, Ittner A. Sci Adv. 2022 Jul 8;8(27):eabl8809. doi: 10.1126/sciadv.abl8809. Epub 2022 Jul 6. PubMed |
| Npp1 prevents external tooth root resorption by regulation of cervical cementum integrity. Choi H, Yang L, Liu Y, Jeong JK, Cho ES. Sci Rep. 2022 Dec 7;12(1):21158. doi: 10.1038/s41598-022-25846-3. PubMed |
| New insights into the regulation of Cystathionine beta synthase (CBS), an enzyme involved in intellectual deficiency in Down syndrome. Conan P, Leon A, Caroff N, Rollet C, Chair L, Martin J, Bihel F, Mignen O, Voisset C, Friocourt G. Front Neurosci. 2023 Jan 9;16:1110163. doi: 10.3389/fnins.2022.1110163. eCollection 2022. PubMed |
| Drebrin Regulates Collateral Axon Branching in Cortical Layer II/III Somatosensory Neurons. Dorskind JM, Sudarsanam S, Hand RA, Ziak J, Amoah-Dankwah M, Guzman-Clavel L, Soto-Vargas JL, Kolodkin AL. J Neurosci. 2023 Nov 15;43(46):7745-7765. doi: 10.1523/JNEUROSCI.0553-23.2023. Epub 2023 Oct 5. PubMed |
If you have published an article using this material, please email us at [email protected] to have your article added to this page.