pcDNA3 Flag TSC2 Citations (19)
Originally described in: Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC Mol Cell. 2002 Jul . 10(1):151-62. PubMed Journal
Articles Citing pcDNA3 Flag TSC2
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| Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes. Miyazaki M, McCarthy JJ, Esser KA. FEBS J. 2010 May;277(9):2180-91. doi: 10.1111/j.1742-4658.2010.07635.x. PubMed |
| The Andes Virus Nucleocapsid Protein Directs Basal Endothelial Cell Permeability by Activating RhoA. Gorbunova EE, Simons MJ, Gavrilovskaya IN, Mackow ER. MBio. 2016 Oct 25;7(5). pii: e01747-16. doi: 10.1128/mBio.01747-16. PubMed |
| RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death. Fettweis G, Di Valentin E, L'homme L, Lassence C, Dequiedt F, Fillet M, Coupienne I, Piette J. Biochim Biophys Acta. 2016 Oct 27. pii: S0167-4889(16)30276-2. doi: 10.1016/j.bbamcr.2016.10.014. PubMed |
| Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia. Lim JS, Gopalappa R, Kim SH, Ramakrishna S, Lee M, Kim WI, Kim J, Park SM, Lee J, Oh JH, Kim HD, Park CH, Lee JS, Kim S, Kim DS, Han JM, Kang HC, Kim HH, Lee JH. Am J Hum Genet. 2017 Mar 2;100(3):454-472. doi: 10.1016/j.ajhg.2017.01.030. Epub 2017 Feb 16. PubMed |
| Functional validation of the oncogenic cooperativity and targeting potential of tuberous sclerosis mutation in medulloblastoma using a MYC-amplified model cell line. Henderson JJ, Wagner JP, Hofmann NE, Eide CA, Cho YJ, Druker BJ, Davare MA. Pediatr Blood Cancer. 2017 Apr 14. doi: 10.1002/pbc.26553. PubMed |
| Rheb localized on the Golgi membrane activates lysosome-localized mTORC1 at the Golgi-lysosome contact site. Hao F, Kondo K, Itoh T, Ikari S, Nada S, Okada M, Noda T. J Cell Sci. 2018 Jan 29;131(3). pii: jcs.208017. doi: 10.1242/jcs.208017. PubMed |
| CBAP modulates Akt-dependent TSC2 phosphorylation to promote Rheb-mTORC1 signaling and growth of T-cell acute lymphoblastic leukemia. Chiang YJ, Liao WT, Ho KC, Wang SH, Chen YG, Ho CL, Huang SF, Shih LY, Yang-Yen HF, Yen JJ. Oncogene. 2019 Feb;38(9):1432-1447. doi: 10.1038/s41388-018-0507-6. Epub 2018 Sep 28. PubMed |
| A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-beta oligomers. Norambuena A, Wallrabe H, Cao R, Wang DB, Silva A, Svindrych Z, Periasamy A, Hu S, Tanzi RE, Kim DY, Bloom GS. EMBO J. 2018 Nov 15;37(22):e100241. doi: 10.15252/embj.2018100241. Epub 2018 Oct 22. PubMed |
| PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress. Ranek MJ, Kokkonen-Simon KM, Chen A, Dunkerly-Eyring BL, Vera MP, Oeing CU, Patel CH, Nakamura T, Zhu G, Bedja D, Sasaki M, Holewinski RJ, Van Eyk JE, Powell JD, Lee DI, Kass DA. Nature. 2019 Feb;566(7743):264-269. doi: 10.1038/s41586-019-0895-y. Epub 2019 Jan 30. PubMed |
| Oncogenic KRAS signaling activates mTORC1 through COUP-TFII-mediated lactate production. Byun JK, Park M, Yun JW, Lee J, Kim JS, Cho SJ, Lee YM, Lee IK, Choi YK, Park KG. EMBO Rep. 2019 Jun;20(6). pii: embr.201847451. doi: 10.15252/embr.201847451. Epub 2019 Apr 15. PubMed |
| Cdk4 and Cdk6 Couple the Cell-Cycle Machinery to Cell Growth via mTORC1. Romero-Pozuelo J, Figlia G, Kaya O, Martin-Villalba A, Teleman AA. Cell Rep. 2020 Apr 14;31(2):107504. doi: 10.1016/j.celrep.2020.03.068. PubMed |
| Amino Acid-Mediated Intracellular Ca(2+) Rise Modulates mTORC1 by Regulating the TSC2-Rheb Axis through Ca(2+)/Calmodulin. Amemiya Y, Nakamura N, Ikeda N, Sugiyama R, Ishii C, Maki M, Shibata H, Takahara T. Int J Mol Sci. 2021 Jun 27;22(13). pii: ijms22136897. doi: 10.3390/ijms22136897. PubMed |
| Hypo-Expression of Tuberin Promotes Adenomyosis via the mTOR1-Autophagy Axis. Gu NH, Li GJ, Yang BX, You M, Lin Y, Sun F, Xu H. Front Cell Dev Biol. 2021 Jul 29;9:710407. doi: 10.3389/fcell.2021.710407. eCollection 2021. PubMed |
Development of a versatile HPLC-based method to evaluate the activation status of small GTPases.
Araki M, Yoshimoto K, Ohta M, Katada T, Kontani K.
J Biol Chem. 2021 Nov 18:101428. doi: 10.1016/j.jbc.2021.101428.
PubMed
Associated Plasmids |
| Rap_GAP Domain of TSC2 Contributes to Tumor Suppression Through mTOR Signaling in Human Hepatocellular Carcinoma. Cui M, Jiang W, Sheng J, Wu J, Zhang X. DNA Cell Biol. 2022 Feb;41(2):215-224. doi: 10.1089/dna.2021.0769. PubMed |
| Exosomal miR-673-5p from fibroblasts promotes Schwann cell-mediated peripheral neuron myelination by targeting the TSC2/mTORC1/SREBP2 axis. Zhao Y, Liang Y, Xu Z, Liu J, Liu X, Ma J, Sun C, Yang Y. J Biol Chem. 2022 Mar;298(3):101718. doi: 10.1016/j.jbc.2022.101718. Epub 2022 Feb 11. PubMed |
Rheb regulates nuclear mTORC1 activity independent of farnesylation.
Zhong Y, Zhou X, Guan KL, Zhang J.
Cell Chem Biol. 2022 Jun 16;29(6):1037-1045.e4. doi: 10.1016/j.chembiol.2022.02.006. Epub 2022 Mar 15.
PubMed
Associated Plasmids |
| Dock7 regulates AKT and mTOR/S6K activity required for the transformed phenotypes and survival of cancer cells. Teran OY, Zanotelli MR, Lin MJ, Cerione RA, Wilson KF. bioRxiv. 2023 Jan 3:2023.01.03.522657. doi: 10.1101/2023.01.03.522657. Preprint. PubMed |
| Tumor-derived exosomal miR-148b-3p mediates M2 macrophage polarization via TSC2/mTORC1 to promote breast cancer migration and invasion. Hao C, Sheng Z, Wang W, Feng R, Zheng Y, Xiao Q, Zhang B. Thorac Cancer. 2023 Jun;14(16):1477-1491. doi: 10.1111/1759-7714.14891. Epub 2023 May 5. PubMed |
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