SIRT6 Flag Citations (26)

Originally described in: The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.
North BJ, Marshall BL, Borra MT, Denu JM, Verdin E Mol Cell. 2003 Feb . 11(2):437-44. PubMed Journal

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Articles Citing SIRT6 Flag

Articles
Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation. Pickard A, Wong PP, McCance DJ. J Cell Sci. 2010 Nov 1;123(Pt 21):3718-26. doi: 10.1242/jcs.068924. Epub 2010 Oct 12. PubMed
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. Sundaresan NR, Vasudevan P, Zhong L, Kim G, Samant S, Parekh V, Pillai VB, Ravindra PV, Gupta M, Jeevanandam V, Cunningham JM, Deng CX, Lombard DB, Mostoslavsky R, Gupta MP. Nat Med. 2012 Nov;18(11):1643-50. doi: 10.1038/nm.2961. Epub 2012 Oct 21. PubMed
Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation. Fatoba ST, Tognetti S, Berto M, Leo E, Mulvey CM, Godovac-Zimmermann J, Pommier Y, Okorokov AL. Nucleic Acids Res. 2013 Apr;41(7):4065-79. doi: 10.1093/nar/gkt131. Epub 2013 Feb 28. PubMed
The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination. Ronnebaum SM, Wu Y, McDonough H, Patterson C. Mol Cell Biol. 2013 Nov;33(22):4461-72. doi: 10.1128/MCB.00480-13. Epub 2013 Sep 16. PubMed
A proteomic perspective of Sirtuin 6 (SIRT6) phosphorylation and interactions and their dependence on its catalytic activity. Miteva YV, Cristea IM. Mol Cell Proteomics. 2014 Jan;13(1):168-83. doi: 10.1074/mcp.M113.032847. Epub 2013 Oct 25. PubMed
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. Thirumurthi U, Shen J, Xia W, LaBaff AM, Wei Y, Li CW, Chang WC, Chen CH, Lin HK, Yu D, Hung MC. Sci Signal. 2014 Jul 29;7(336):ra71. doi: 10.1126/scisignal.2005076. PubMed
Restoring SIRT6 Expression in Hutchinson-Gilford Progeria Syndrome Cells Impedes Premature Senescence and Formation of Dysmorphic Nuclei. Endisha H, Merrill-Schools J, Zhao M, Bristol M, Wang X, Kubben N, Elmore LW. Pathobiology. 2015 Feb 28;82(1):9-20. PubMed
SIRT6 protects cardiomyocytes against ischemia/reperfusion injury by augmenting FoxO3alpha-dependent antioxidant defense mechanisms. Wang XX, Wang XL, Tong MM, Gan L, Chen H, Wu SS, Chen JX, Li RL, Wu Y, Zhang HY, Zhu Y, Li YX, He JH, Wang M, Jiang W. Basic Res Cardiol. 2016 Mar;111(2):13. doi: 10.1007/s00395-016-0531-z. Epub 2016 Jan 19. PubMed
p53-dependent SIRT6 expression protects Abeta42-induced DNA damage. Jung ES, Choi H, Song H, Hwang YJ, Kim A, Ryu H, Mook-Jung I. Sci Rep. 2016 May 9;6:25628. doi: 10.1038/srep25628. PubMed
Acetylation of Mammalian ADA3 Is Required for Its Functional Roles in Histone Acetylation and Cell Proliferation. Mohibi S, Srivastava S, Bele A, Mirza S, Band H, Band V. Mol Cell Biol. 2016 Sep 12;36(19):2487-502. doi: 10.1128/MCB.00342-16. Print 2016 Oct 1. PubMed
SIRT6 Is a Positive Regulator of Aldose Reductase Expression in U937 and HeLa cells under Osmotic Stress: In Vitro and In Silico Insights. Timucin AC, Basaga H. PLoS One. 2016 Aug 18;11(8):e0161494. doi: 10.1371/journal.pone.0161494. eCollection 2016. PubMed
SIRT6 protects against lipopolysaccharide (LPS)-induced apoptosis in human dental pulp cells by deacetylation of Ku70. Chen W, Chen X, Sun Y. Biochem Biophys Res Commun. 2016 Nov 1. pii: S0006-291X(16)31832-0. doi: 10.1016/j.bbrc.2016.10.137. PubMed
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells. Huang N, Liu Z, Zhu J, Cui Z, Li Y, Yu Y, Sun F, Pan Q, Yang Q. Tumour Biol. 2017 Jun;39(6):1010428317708532. doi: 10.1177/1010428317708532. PubMed
The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat. Long D, Wu H, Tsang AW, Poole LB, Yoza BK, Wang X, Vachharajani V, Furdui CM, McCall CE. Sci Rep. 2017 Sep 8;7(1):11005. doi: 10.1038/s41598-017-11388-6. PubMed
Overexpression of SIRT6 attenuates the tumorigenicity of hepatocellular carcinoma cells. Wang Y, Pan T, Wang H, Li L, Li J, Zhang D, Yang H. Oncotarget. 2017 Jul 17;8(44):76223-76230. doi: 10.18632/oncotarget.19297. eCollection 2017 Sep 29. PubMed
Aberrant SIRT6 expression contributes to melanoma growth: Role of the autophagy paradox and IGF-AKT signaling. Wang L, Guo W, Ma J, Dai W, Liu L, Guo S, Chen J, Wang H, Yang Y, Yi X, Wang G, Gao T, Zhu G, Li C. Autophagy. 2018;14(3):518-533. doi: 10.1080/15548627.2017.1384886. Epub 2017 Dec 31. PubMed
SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation. Sarikhani M, Mishra S, Maity S, Kotyada C, Wolfgeher D, Gupta MP, Singh M, Sundaresan NR. Elife. 2018 Mar 5;7. pii: 32952. doi: 10.7554/eLife.32952. PubMed
Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria. Qian M, Liu Z, Peng L, Tang X, Meng F, Ao Y, Zhou M, Wang M, Cao X, Qin B, Wang Z, Zhou Z, Wang G, Gao Z, Xu J, Liu B. Elife. 2018 May 2;7. pii: 34836. doi: 10.7554/eLife.34836. PubMed
Protective effects of SIRT6 against lipopolysaccharide (LPS) are mediated by deacetylation of Ku70. Zhang L, Bai L, Ren Q, Sun G, Si Y. Mol Immunol. 2018 Sep;101:312-318. doi: 10.1016/j.molimm.2018.07.009. Epub 2018 Jul 20. PubMed
Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1. Li X, Li S, Li B, Li Y, Aman S, Xia K, Yang Y, Ahmad B, Wu H. NPJ Precis Oncol. 2021 Mar 19;5(1):20. doi: 10.1038/s41698-021-00158-3. PubMed
Upregulating sirtuin 6 ameliorates glycolysis, EMT and distant metastasis of pancreatic adenocarcinoma with kruppel-like factor 10 deficiency. Tsai YC, Chen SL, Peng SL, Tsai YL, Chang ZM, Chang VH, Ch'ang HJ. Exp Mol Med. 2021 Oct;53(10):1623-1635. doi: 10.1038/s12276-021-00687-8. Epub 2021 Oct 26. PubMed
Sirt6 protects cardiomyocytes against doxorubicin-induced cardiotoxicity by inhibiting P53/Fas-dependent cell death and augmenting endogenous antioxidant defense mechanisms. Wu S, Lan J, Li L, Wang X, Tong M, Fu L, Zhang Y, Xu J, Chen X, Chen H, Li R, Wu Y, Xin J, Yan X, Li H, Xue K, Li X, Zhuo C, Jiang W. Cell Biol Toxicol. 2021 Oct 28. pii: 10.1007/s10565-021-09649-2. doi: 10.1007/s10565-021-09649-2. PubMed
Interplay between protein acetylation and ubiquitination controls MCL1 protein stability. Shimizu K, Gi M, Suzuki S, North BJ, Watahiki A, Fukumoto S, Asara JM, Tokunaga F, Wei W, Inuzuka H. Cell Rep. 2021 Nov 9;37(6):109988. doi: 10.1016/j.celrep.2021.109988. PubMed
Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43. Garcia Morato J, Hans F, von Zweydorf F, Feederle R, Elsasser SJ, Skodras AA, Gloeckner CJ, Buratti E, Neumann M, Kahle PJ. Nat Commun. 2022 Mar 9;13(1):1223. doi: 10.1038/s41467-022-28822-7. PubMed
SIRT6 promotes mitochondrial fission and subsequent cellular invasion in ovarian cancer. Bandopadhyay S, Prasad P, Ray U, Das Ghosh D, Roy SS. FEBS Open Bio. 2022 Sep;12(9):1657-1676. doi: 10.1002/2211-5463.13452. Epub 2022 Jun 24. PubMed
MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC. Zhao K, Zheng M, Su Z, Ghosh S, Zhang C, Zhong W, Ho JWK, Jin G, Zhou Z. Cell Rep. 2023 Aug 29;42(8):112939. doi: 10.1016/j.celrep.2023.112939. Epub 2023 Aug 10. PubMed

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