pBabe N-Ras 61K Citations (17)
Originally described in: Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation.Khosravi-Far R, White MA, Westwick JK, Solski PA, Chrzanowska-Wodnicka M, Van Aelst L, Wigler MH, Der CJ Mol Cell Biol. 1996 Jul . 16(7):3923-33. PubMed
Articles Citing pBabe N-Ras 61K
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| Oncogene activation in melanocytes links reactive oxygen to multinucleated phenotype and senescence. Leikam C, Hufnagel A, Schartl M, Meierjohann S. Oncogene. 2008 Nov 27;27(56):7070-82. doi: 10.1038/onc.2008.323. Epub 2008 Sep 22. PubMed |
| ERbeta regulates NSCLC phenotypes by controlling oncogenic RAS signaling. Nikolos F, Thomas C, Rajapaksa G, Bado I, Gustafsson JA. Mol Cancer Res. 2014 Jun;12(6):843-54. doi: 10.1158/1541-7786.MCR-13-0663. Epub 2014 Mar 11. PubMed |
| Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4. Catanzaro JM, Sheshadri N, Pan JA, Sun Y, Shi C, Li J, Powers RS, Crawford HC, Zong WX. Nat Commun. 2014 Apr 23;5:3729. doi: 10.1038/ncomms4729. PubMed |
| CD52 is a molecular target in advanced systemic mastocytosis. Hoermann G, Blatt K, Greiner G, Putz EM, Berger A, Herrmann H, Cerny-Reiterer S, Gleixner KV, Walz C, Hoetzenecker K, Mullauer L, Reiter A, Sotlar K, Sexl V, Valent P, Mayerhofer M. FASEB J. 2014 Aug;28(8):3540-51. doi: 10.1096/fj.14-250894. Epub 2014 Apr 23. PubMed |
| Oncolytic reovirus induces intracellular redistribution of Ras to promote apoptosis and progeny virus release. Garant KA, Shmulevitz M, Pan L, Daigle RM, Ahn DG, Gujar SA, Lee PW. Oncogene. 2015 May 11. doi: 10.1038/onc.2015.136. PubMed |
| Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia. Danis E, Yamauchi T, Echanique K, Zhang X, Haladyna JN, Riedel SS, Zhu N, Xie H, Orkin SH, Armstrong SA, Bernt KM, Neff T. Cell Rep. 2016 Mar 1;14(8):1953-65. doi: 10.1016/j.celrep.2016.01.064. Epub 2016 Feb 18. PubMed |
| Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells. Brea EJ, Oh CY, Manchado E, Budhu S, Gejman RS, Mo G, Mondello P, Han JE, Jarvis CA, Ulmert D, Xiang Q, Chang AY, Garippa RJ, Merghoub T, Wolchok JD, Rosen N, Lowe SW, Scheinberg DA. Cancer Immunol Res. 2016 Nov;4(11):936-947. doi: 10.1158/2326-6066.CIR-16-0177. Epub 2016 Sep 28. PubMed |
| Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors. Mulcahy Levy JM, Zahedi S, Griesinger AM, Morin A, Davies KD, Aisner DL, Kleinschmidt-DeMasters BK, Fitzwalter BE, Goodall ML, Thorburn J, Amani V, Donson AM, Birks DK, Mirsky DM, Hankinson TC, Handler MH, Green AL, Vibhakar R, Foreman NK, Thorburn A. Elife. 2017 Jan 17;6:e19671. doi: 10.7554/eLife.19671. PubMed |
NRAS destines tumor cells to the lungs.
Giannou AD, Marazioti A, Kanellakis NI, Giopanou I, Lilis I, Zazara DE, Ntaliarda G, Kati D, Armenis V, Giotopoulou GA, Krontira AC, Lianou M, Agalioti T, Vreka M, Papageorgopoulou M, Fouzas S, Kardamakis D, Psallidas I, Spella M, Stathopoulos GT.
EMBO Mol Med. 2017 May;9(5):672-686. doi: 10.15252/emmm.201606978.
PubMed
Associated Plasmids |
| Targeting NRASQ61K mutant delays tumor growth and angiogenesis in non-small cell lung cancer. Song Z, Liu F, Zhang J. Am J Cancer Res. 2017 Apr 1;7(4):831-844. eCollection 2017. PubMed |
| Resistance to RET-inhibition in RET-rearranged NSCLC is mediated by reactivation of RAS/MAPK signaling. Nelson-Taylor SK, Le AT, Yoo M, Schubert L, Mishall KM, Doak A, Varella-Garcia M, Tan AC, Doebele RC. Mol Cancer Ther. 2017 May 12. pii: molcanther.0008.2017. doi: 10.1158/1535-7163.MCT-17-0008. PubMed |
| Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O'Prey J, Clark W, Hedley A, Nixon C, Long JS, New M, Van Acker T, Tooze SA, Lowe SW, Dikic I, Ryan KM. Mol Cell. 2017 May 18;66(4):517-532.e9. doi: 10.1016/j.molcel.2017.04.027. PubMed |
| Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA. Hosono Y, Niknafs YS, Prensner JR, Iyer MK, Dhanasekaran SM, Mehra R, Pitchiaya S, Tien J, Escara-Wilke J, Poliakov A, Chu SC, Saleh S, Sankar K, Su F, Guo S, Qiao Y, Freier SM, Bui HH, Cao X, Malik R, Johnson TM, Beer DG, Feng FY, Zhou W, Chinnaiyan AM. Cell. 2017 Dec 14;171(7):1559-1572.e20. doi: 10.1016/j.cell.2017.11.040. PubMed |
Generation of a double binary transgenic zebrafish model to study myeloid gene regulation in response to oncogene activation in melanocytes.
Kenyon A, Gavriouchkina D, Zorman J, Chong-Morrison V, Napolitani G, Cerundolo V, Sauka-Spengler T.
Dis Model Mech. 2018 Apr 6;11(4). pii: dmm.030056. doi: 10.1242/dmm.030056.
PubMed
Associated Plasmids |
| Genomic and pathological heterogeneity in clinically diagnosed small cell lung cancer in never/light smokers identifies therapeutically targetable alterations. Ogino A, Choi J, Lin M, Wilkens MK, Calles A, Xu M, Adeni AE, Chambers ES, Capelletti M, Butaney M, Gray NS, Gokhale PC, Palakurthi S, Kirschmeier P, Oxnard GR, Sholl LM, Janne PA. Mol Oncol. 2020 Mar 19. doi: 10.1002/1878-0261.12673. PubMed |
| NRAS(Q61K) melanoma tumor formation is reduced by p38-MAPK14 activation in zebrafish models and NRAS-mutated human melanoma cells. Banik I, Cheng PF, Dooley CM, Travnickova J, Merteroglu M, Dummer R, Patton EE, Busch-Nentwich EM, Levesque MP. Pigment Cell Melanoma Res. 2021 Mar;34(2):150-162. doi: 10.1111/pcmr.12925. Epub 2020 Sep 24. PubMed |
| Clonal dynamics of BRAF-driven drug resistance in EGFR-mutant lung cancer. Schaufler D, Ast DF, Tumbrink HL, Abedpour N, Maas L, Schwabe AE, Spille I, Lennartz S, Fassunke J, Aldea M, Besse B, Planchard D, Nogova L, Michels S, Kobe C, Persigehl T, Westphal T, Koleczko S, Fischer R, Weber JP, Altmuller J, Thomas RK, Merkelbach-Bruse S, Gautschi O, Mezquita L, Buttner R, Wolf J, Peifer M, Bragelmann J, Scheffler M, Sos ML. NPJ Precis Oncol. 2021 Dec 17;5(1):102. doi: 10.1038/s41698-021-00241-9. PubMed |
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