pBabe puro HA PIK3CA H1047R Citations (35)
Originally described in: The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells.Zhao JJ, Liu Z, Wang L, Shin E, Loda MF, Roberts TM Proc Natl Acad Sci U S A. 2005 Dec 20. 102(51):18443-8. PubMed Journal
Articles Citing pBabe puro HA PIK3CA H1047R
| Articles |
|---|
| Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2. Boulbes D, Chen CH, Shaikenov T, Agarwal NK, Peterson TR, Addona TA, Keshishian H, Carr SA, Magnuson MA, Sabatini DM, Sarbassov dos D. Mol Cancer Res. 2010 Jun;8(6):896-906. doi: 10.1158/1541-7786.MCR-09-0409. Epub 2010 May 25. PubMed |
| PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling. Halilovic E, She QB, Ye Q, Pagliarini R, Sellers WR, Solit DB, Rosen N. Cancer Res. 2010 Sep 1;70(17):6804-14. doi: 10.1158/0008-5472.CAN-10-0409. Epub 2010 Aug 10. PubMed |
| K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc. Magudia K, Lahoz A, Hall A. J Cell Biol. 2012 Jul 23;198(2):185-94. doi: 10.1083/jcb.201202108. PubMed |
| Lapatinib induces p27(Kip1)-dependent G(1) arrest through both transcriptional and post-translational mechanisms. Tang L, Wang Y, Strom A, Gustafsson JA, Guan X. Cell Cycle. 2013 Aug 15;12(16):2665-74. doi: 10.4161/cc.25728. Epub 2013 Jul 29. PubMed |
| Enhanced PI3K p110alpha signaling confers acquired lapatinib resistance that can be effectively reversed by a p110alpha-selective PI3K inhibitor. Brady SW, Zhang J, Seok D, Wang H, Yu D. Mol Cancer Ther. 2014 Jan;13(1):60-70. doi: 10.1158/1535-7163.MCT-13-0518. Epub 2013 Nov 18. PubMed |
| A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations. Kohsaka S, Shukla N, Ameur N, Ito T, Ng CK, Wang L, Lim D, Marchetti A, Viale A, Pirun M, Socci ND, Qin LX, Sciot R, Bridge J, Singer S, Meyers P, Wexler LH, Barr FG, Dogan S, Fletcher JA, Reis-Filho JS, Ladanyi M. Nat Genet. 2014 Jun;46(6):595-600. doi: 10.1038/ng.2969. Epub 2014 May 4. PubMed |
| PI3kalpha and STAT1 Interplay Regulates Human Mesenchymal Stem Cell Immune Polarization. Mounayar M, Kefaloyianni E, Smith B, Solhjou Z, Maarouf OH, Azzi J, Chabtini L, Fiorina P, Kraus M, Briddell R, Fodor W, Herrlich A, Abdi R. Stem Cells. 2015 Jun;33(6):1892-901. doi: 10.1002/stem.1986. PubMed |
| Loss of LKB1 and p53 synergizes to alter fallopian tube epithelial phenotype and high-grade serous tumorigenesis. George SH, Milea A, Sowamber R, Chehade R, Tone A, Shaw PA. Oncogene. 2015 Mar 23. doi: 10.1038/onc.2015.62. PubMed |
| Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver. Li X, Tao J, Cigliano A, Sini M, Calderaro J, Azoulay D, Wang C, Liu Y, Jiang L, Evert K, Demartis MI, Ribback S, Utpatel K, Dombrowski F, Evert M, Calvisi DF, Chen X. Oncotarget. 2015 Apr 30;6(12):10102-15. PubMed |
| Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP. Ricoult SJ, Yecies JL, Ben-Sahra I, Manning BD. Oncogene. 2015 Jun 1. doi: 10.1038/onc.2015.179. PubMed |
| Differential effects of polyoma virus middle tumor antigen mutants upon gap junctional, intercellular communication. Geletu M, Guy S, Greer S, Raptis L. Exp Cell Res. 2015 Aug 15;336(2):223-31. doi: 10.1016/j.yexcr.2015.07.013. Epub 2015 Jul 14. PubMed |
Identification of an oncogenic RAB protein.
Wheeler DB, Zoncu R, Root DE, Sabatini DM, Sawyers CL.
Science. 2015 Oct 9;350(6257):211-7. doi: 10.1126/science.aaa4903. Epub 2015 Sep 3.
PubMed
Associated Plasmids |
| [C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice. Li L, Che L, Wang C, Blecha JE, Li X, VanBrocklin HF, Calvisi DF, Puchowicz M, Chen X, Seo Y. Mol Imaging Biol. 2015 Nov 13. PubMed |
Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumor formation in mice via AKT2/mTORC1 cascade.
Wang C, Che L, Hu J, Zhang S, Jiang L, Latte G, Demartis MI, Tao J, Gui B, Pilo MG, Ribback S, Dombrowski F, Evert M, Calvisi DF, Chen X.
Liver Int. 2015 Dec 30. doi: 10.1111/liv.13055.
PubMed
Associated Plasmids |
| LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer. Henry WS, Hendrickson DG, Beca F, Glass B, Lindahl-Allen M, He L, Ji Z, Struhl K, Beck AH, Rinn JL, Toker A. Oncotarget. 2016 Dec 13;7(50):81981-81994. doi: 10.18632/oncotarget.11962. PubMed |
| Repression of p63 and induction of EMT by mutant Ras in mammary epithelial cells. Yoh KE, Regunath K, Guzman A, Lee SM, Pfister NT, Akanni O, Kaufman LJ, Prives C, Prywes R. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6107-E6116. Epub 2016 Sep 28. PubMed |
| PIK3CA hotspot mutations differentially impact responses to MET targeting in MET-driven and non-driven preclinical cancer models. Nisa L, Hafliger P, Poliakova M, Giger R, Francica P, Aebersold DM, Charles RP, Zimmer Y, Medova M. Mol Cancer. 2017 May 22;16(1):93. doi: 10.1186/s12943-017-0660-5. PubMed |
| MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state. Poli V, Fagnocchi L, Fasciani A, Cherubini A, Mazzoleni S, Ferrillo S, Miluzio A, Gaudioso G, Vaira V, Turdo A, Gaggianesi M, Chinnici A, Lipari E, Bicciato S, Bosari S, Todaro M, Zippo A. Nat Commun. 2018 Mar 9;9(1):1024. doi: 10.1038/s41467-018-03264-2. PubMed |
| A simple and robust real-time qPCR method for the detection of PIK3CA mutations. Alvarez-Garcia V, Bartos C, Keraite I, Trivedi U, Brennan PM, Kersaudy-Kerhoas M, Gharbi K, Oikonomidou O, Leslie NR. Sci Rep. 2018 Mar 9;8(1):4290. doi: 10.1038/s41598-018-22473-9. PubMed |
| Mouse genetic background influences whether Hras(G12V) expression plus Cdkn2a knockdown causes angiosarcoma or undifferentiated pleomorphic sarcoma. Brandt LP, Albers J, Hejhal T, Pfundstein S, Goncalves AF, Catalano A, Wild PJ, Frew IJ. Oncotarget. 2018 Apr 13;9(28):19753-19766. doi: 10.18632/oncotarget.24831. eCollection 2018 Apr 13. PubMed |
| The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers. Razavi P, Chang MT, Xu G, Bandlamudi C, Ross DS, Vasan N, Cai Y, Bielski CM, Donoghue MTA, Jonsson P, Penson A, Shen R, Pareja F, Kundra R, Middha S, Cheng ML, Zehir A, Kandoth C, Patel R, Huberman K, Smyth LM, Jhaveri K, Modi S, Traina TA, Dang C, Zhang W, Weigelt B, Li BT, Ladanyi M, Hyman DM, Schultz N, Robson ME, Hudis C, Brogi E, Viale A, Norton L, Dickler MN, Berger MF, Iacobuzio-Donahue CA, Chandarlapaty S, Scaltriti M, Reis-Filho JS, Solit DB, Taylor BS, Baselga J. Cancer Cell. 2018 Sep 10;34(3):427-438.e6. doi: 10.1016/j.ccell.2018.08.008. PubMed |
| Regulation of glioma cell invasion by 3q26 gene products PIK3CA, SOX2 and OPA1. Schaefer T, Ramadoss A, Leu S, Tintignac L, Tostado C, Bink A, Schurch C, Muller J, Scharer J, Moffa G, Demougin P, Moes S, Stippich C, Falbo S, Neddersen H, Bucher H, Frank S, Jeno P, Lengerke C, Ritz MF, Mariani L, Boulay JL. Brain Pathol. 2018 Nov 7. doi: 10.1111/bpa.12670. PubMed |
| Modelling the MYC-driven normal-to-tumour switch in breast cancer. Lourenco C, Kalkat M, Houlahan KE, De Melo J, Longo J, Done SJ, Boutros PC, Penn LZ. Dis Model Mech. 2019 Jul 26;12(7). pii: 12/7/dmm038083. doi: 10.1242/dmm.038083. PubMed |
| ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion. Wilson MR, Reske JJ, Holladay J, Wilber GE, Rhodes M, Koeman J, Adams M, Johnson B, Su RW, Joshi NR, Patterson AL, Shen H, Leach RE, Teixeira JM, Fazleabas AT, Chandler RL. Nat Commun. 2019 Aug 7;10(1):3554. doi: 10.1038/s41467-019-11403-6. PubMed |
| Nanomedicines blocking adaptive signals in cancer cells overcome tumor TKI resistance. Kinoh H, Shibasaki H, Liu X, Yamasoba T, Cabral H, Kataoka K. J Control Release. 2020 May 10;321:132-144. doi: 10.1016/j.jconrel.2020.02.008. Epub 2020 Feb 4. PubMed |
| Macropinocytosis confers resistance to therapies targeting cancer anabolism. Jayashankar V, Edinger AL. Nat Commun. 2020 Feb 28;11(1):1121. doi: 10.1038/s41467-020-14928-3. PubMed |
| Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform. Kutys ML, Polacheck WJ, Welch MK, Gagnon KA, Koorman T, Kim S, Li L, McClatchey AI, Chen CS. Nat Commun. 2020 Jul 6;11(1):3377. doi: 10.1038/s41467-020-17102-x. PubMed |
| ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation. Wilson MR, Reske JJ, Holladay J, Neupane S, Ngo J, Cuthrell N, Wegener M, Rhodes M, Adams M, Sheridan R, Hostetter G, Alotaibi FT, Yong PJ, Anglesio MS, Lessey BA, Leach RE, Teixeira JM, Missmer SA, Fazleabas AT, Chandler RL. Cell Rep. 2020 Nov 10;33(6):108366. doi: 10.1016/j.celrep.2020.108366. PubMed |
| Targeting the Pro-survival Protein BCL-2 to Prevent Breast Cancer. Young A, Bu W, Jiang W, Ku A, Kapali J, Dhamne S, Qin L, Hilsenbeck SG, Du YN, Li Y. Cancer Prev Res (Phila). 2022 Jan;15(1):3-10. doi: 10.1158/1940-6207.CAPR-21-0031. Epub 2021 Oct 19. PubMed |
| The PIK3CA H1047R Mutation Confers Resistance to BRAF and MEK Inhibitors in A375 Melanoma Cells through the Cross-Activation of MAPK and PI3K-Akt Pathways. Candido S, Salemi R, Piccinin S, Falzone L, Libra M. Pharmaceutics. 2022 Mar 8;14(3). pii: pharmaceutics14030590. doi: 10.3390/pharmaceutics14030590. PubMed |
| Parallelized multidimensional analytic framework applied to mammary epithelial cells uncovers regulatory principles in EMT. Paul I, Bolzan D, Youssef A, Gagnon KA, Hook H, Karemore G, Oliphant MUJ, Lin W, Liu Q, Phanse S, White C, Padhorny D, Kotelnikov S, Chen CS, Hu P, Denis GV, Kozakov D, Raught B, Siggers T, Wuchty S, Muthuswamy SK, Emili A. Nat Commun. 2023 Feb 8;14(1):688. doi: 10.1038/s41467-023-36122-x. PubMed |
| Dysregulation of Mitochondrial Translation Caused by CBFB Deficiency Cooperates with Mutant PIK3CA and Is a Vulnerability in Breast Cancer. Malik N, Kim YI, Yan H, Tseng YC, du Bois W, Ayaz G, Tran AD, Vera-Ramirez L, Yang H, Michalowski AM, Kruhlak M, Lee M, Hunter KW, Huang J. Cancer Res. 2023 Apr 14;83(8):1280-1298. doi: 10.1158/0008-5472.CAN-22-2525. PubMed |
| Nuclease Enrichment and qPCR Detection of Rare Nucleotide Variants. Keraite I, Alvarez-Garcia V, Leslie NR. Methods Mol Biol. 2023;2621:41-56. doi: 10.1007/978-1-0716-2950-5_4. PubMed |
| PIK3CA mutation in endometriotic epithelial cells promotes viperin-dependent inflammatory response to insulin. Wilson MR, Harkins S, Reske JJ, Siwicki RA, Adams M, Bae-Jump VL, Teixeira JM, Chandler RL. Reprod Biol Endocrinol. 2023 May 11;21(1):43. doi: 10.1186/s12958-023-01094-6. PubMed |
| Functional impact and molecular binding modes of drugs that target the PI3K isoform p110delta. Hassenruck F, Farina-Morillas M, Neumann L, Landini F, Blakemore SJ, Rabipour M, Alvarez-Idaboy JR, Pallasch CP, Hallek M, Rebollido-Rios R, Krause G. Commun Biol. 2023 Jun 5;6(1):603. doi: 10.1038/s42003-023-04921-z. PubMed |
If you have published an article using this material, please email us at [email protected] to have your article added to this page.