pCMV-HA-MyD88 Citations (18)

Originally described in: Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis.
Jiang Z, Georgel P, Li C, Choe J, Crozat K, Rutschmann S, Du X, Bigby T, Mudd S, Sovath S, Wilson IA, Olson A, Beutler B Proc Natl Acad Sci U S A. 2006 Jul 18. 103(29):10961-6. PubMed Journal

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Articles Citing pCMV-HA-MyD88

Articles
Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway. Cao W, Manicassamy S, Tang H, Kasturi SP, Pirani A, Murthy N, Pulendran B. Nat Immunol. 2008 Oct;9(10):1157-64. doi: 10.1038/ni.1645. Epub 2008 Aug 31. PubMed
Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88. Kissner TL, Ruthel G, Alam S, Mann E, Ajami D, Rebek M, Larkin E, Fernandez S, Ulrich RG, Ping S, Waugh DS, Rebek J Jr, Saikh KU. PLoS One. 2012;7(7):e40773. doi: 10.1371/journal.pone.0040773. Epub 2012 Jul 27. PubMed
IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex. Zhou AY, Shen RR, Kim E, Lock YJ, Xu M, Chen ZJ, Hahn WC. Cell Rep. 2013 Mar 28;3(3):724-33. doi: 10.1016/j.celrep.2013.01.031. Epub 2013 Feb 28. PubMed
IRF-5 and NF-kappaB p50 co-regulate IFN-beta and IL-6 expression in TLR9-stimulated human plasmacytoid dendritic cells. Steinhagen F, McFarland AP, Rodriguez LG, Tewary P, Jarret A, Savan R, Klinman DM. Eur J Immunol. 2013 Jul;43(7):1896-906. doi: 10.1002/eji.201242792. Epub 2013 May 28. PubMed
HIV-2 Vpx protein interacts with interferon regulatory factor 5 (IRF5) and inhibits its function. Cheng X, Ratner L. J Biol Chem. 2014 Mar 28;289(13):9146-57. doi: 10.1074/jbc.M113.534321. Epub 2014 Feb 14. PubMed
Structure-Based Design and Synthesis of a Small Molecule that Exhibits Anti-inflammatory Activity by Inhibition of MyD88-mediated Signaling to Bacterial Toxin Exposure. Alam S, Javor S, Degardin M, Ajami D, Rebek M, Kissner TL, Waag DM, Rebek J Jr, Saikh KU. Chem Biol Drug Des. 2015 Aug;86(2):200-9. doi: 10.1111/cbdd.12477. Epub 2014 Dec 8. PubMed
Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen. Olson MA, Lee MS, Kissner TL, Alam S, Waugh DS, Saikh KU. Sci Rep. 2015 Sep 18;5:14246. doi: 10.1038/srep14246. PubMed
Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1alpha-Mediated Inflammatory Disease. Gurung P, Fan G, Lukens JR, Vogel P, Tonks NK, Kanneganti TD. Immunity. 2017 Apr 18;46(4):635-648. doi: 10.1016/j.immuni.2017.03.014. Epub 2017 Apr 11. PubMed
A Pseudomonas aeruginosa TIR effector mediates immune evasion by targeting UBAP1 and TLR adaptors. Imbert PR, Louche A, Luizet JB, Grandjean T, Bigot S, Wood TE, Gagne S, Blanco A, Wunderley L, Terradot L, Woodman P, Garvis S, Filloux A, Guery B, Salcedo SP. EMBO J. 2017 Jul 3;36(13):1869-1887. doi: 10.15252/embj.201695343. Epub 2017 May 8. PubMed
HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes. Moreno-Gonzalo O, Ramirez-Huesca M, Blas-Rus N, Cibrian D, Saiz ML, Jorge I, Camafeita E, Vazquez J, Sanchez-Madrid F. PLoS Pathog. 2017 Dec 27;13(12):e1006799. doi: 10.1371/journal.ppat.1006799. eCollection 2017 Dec. PubMed
Small Molecule Analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling. Suckling CJ, Alam S, Olson MA, Saikh KU, Harnett MM, Harnett W. Sci Rep. 2018 Feb 1;8(1):2123. doi: 10.1038/s41598-018-20388-z. PubMed
OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling. Zhao Y, Mudge MC, Soll JM, Rodrigues RB, Byrum AK, Schwarzkopf EA, Bradstreet TR, Gygi SP, Edelson BT, Mosammaparast N. Mol Cell. 2018 Feb 1;69(3):505-516.e5. doi: 10.1016/j.molcel.2018.01.009. PubMed
Development of a Novel Backbone Cyclic Peptide Inhibitor of the Innate Immune TLR/IL1R Signaling Protein MyD88. Dishon S, Schumacher A, Fanous J, Talhami A, Kassis I, Karussis D, Gilon C, Hoffman A, Nussbaum G. Sci Rep. 2018 Jun 21;8(1):9476. doi: 10.1038/s41598-018-27773-8. PubMed
MyD88 Regulates the Expression of SMAD4 and the Iron Regulatory Hormone Hepcidin. Samba-Mondonga M, Calve A, Mallette FA, Santos MM. Front Cell Dev Biol. 2018 Aug 31;6:105. doi: 10.3389/fcell.2018.00105. eCollection 2018. PubMed
O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3. Li X, Gong W, Wang H, Li T, Attri KS, Lewis RE, Kalil AC, Bhinderwala F, Powers R, Yin G, Herring LE, Asara JM, Lei YL, Yang X, Rodriguez DA, Yang M, Green DR, Singh PK, Wen H. Immunity. 2019 Mar 19;50(3):576-590.e6. doi: 10.1016/j.immuni.2019.01.007. Epub 2019 Feb 12. PubMed
Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus. Jiang SH, Athanasopoulos V, Ellyard JI, Chuah A, Cappello J, Cook A, Prabhu SB, Cardenas J, Gu J, Stanley M, Roco JA, Papa I, Yabas M, Walters GD, Burgio G, McKeon K, Byers JM, Burrin C, Enders A, Miosge LA, Canete PF, Jelusic M, Tasic V, Lungu AC, Alexander SI, Kitching AR, Fulcher DA, Shen N, Arsov T, Gatenby PA, Babon JJ, Mallon DF, de Lucas Collantes C, Stone EA, Wu P, Field MA, Andrews TD, Cho E, Pascual V, Cook MC, Vinuesa CG. Nat Commun. 2019 May 17;10(1):2201. doi: 10.1038/s41467-019-10242-9. PubMed
The miRNA-149-5p/MyD88 axis is responsible for ursolic acid-mediated attenuation of the stemness and chemoresistance of non-small cell lung cancer cells. Chen Q, Luo J, Wu C, Lu H, Cai S, Bao C, Liu D, Kong J. Environ Toxicol. 2019 Dec 19. doi: 10.1002/tox.22891. PubMed
Porphyromonas gingivalis induction of TLR2 association with Vinculin enables PI3K activation and immune evasion. Pandi K, Angabo S, Gnanasekaran J, Makkawi H, Eli-Berchoer L, Glaser F, Nussbaum G. PLoS Pathog. 2023 Apr 6;19(4):e1011284. doi: 10.1371/journal.ppat.1011284. eCollection 2023 Apr. PubMed

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