pMDLg/pRRE Citations (764)
Originally described in: A third-generation lentivirus vector with a conditional packaging system.Dull T, Zufferey R, Kelly M, Mandel RJ, Nguyen M, Trono D, Naldini L J Virol. 1998 Nov . 72(11):8463-71. PubMed
Articles Citing pMDLg/pRRE
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| Determination of the transforming activities of adenovirus oncogenes. Nevels M, Dobner T. Methods Mol Med. 2007;131:187-95. PubMed |
| Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (KSHV) upregulates survivin expression in KSHV-Associated B-lymphoma cells and contributes to their proliferation. Lu J, Verma SC, Murakami M, Cai Q, Kumar P, Xiao B, Robertson ES. J Virol. 2009 Jul;83(14):7129-41. doi: 10.1128/JVI.00397-09. Epub 2009 May 13. PubMed |
| In vivo genetic manipulation of the rat trophoblast cell lineage using lentiviral vector delivery. Lee DS, Rumi MA, Konno T, Soares MJ. Genesis. 2009 Jul;47(7):433-9. doi: 10.1002/dvg.20518. PubMed |
Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins.
Krupka N, Strappe P, Götz J, Ittner LM.
Plasmid. 2010 Feb 2. ():.
PubMed
Associated Plasmids |
| The cell-specific induction of CXC chemokine ligand 9 mediated by IFN-gamma in microglia of the central nervous system is determined by the myeloid transcription factor PU.1. Ellis SL, Gysbers V, Manders PM, Li W, Hofer MJ, Muller M, Campbell IL. J Immunol. 2010 Aug 1;185(3):1864-77. doi: 10.4049/jimmunol.1000900. Epub 2010 Jun 28. PubMed |
| EGFR/Met association regulates EGFR TKI resistance in breast cancer. Mueller KL, Yang ZQ, Haddad R, Ethier SP, Boerner JL. J Mol Signal. 2010 Jul 12;5:8. doi: 10.1186/1750-2187-5-8. PubMed |
| Combining theoretical analysis and experimental data generation reveals IRF9 as a crucial factor for accelerating interferon alpha-induced early antiviral signalling. Maiwald T, Schneider A, Busch H, Sahle S, Gretz N, Weiss TS, Kummer U, Klingmuller U. FEBS J. 2010 Nov;277(22):4741-54. doi: 10.1111/j.1742-4658.2010.07880.x. Epub 2010 Oct 21. PubMed |
| Adenovirus membrane penetration activates the NLRP3 inflammasome. Barlan AU, Griffin TM, McGuire KA, Wiethoff CM. J Virol. 2011 Jan;85(1):146-55. doi: 10.1128/JVI.01265-10. Epub 2010 Oct 27. PubMed |
| Evidence that the lipid phosphatase SHIP-1 regulates T lymphocyte morphology and motility. Harris SJ, Parry RV, Foster JG, Blunt MD, Wang A, Marelli-Berg F, Westwick J, Ward SG. J Immunol. 2011 Apr 15;186(8):4936-45. doi: 10.4049/jimmunol.1002350. Epub 2011 Mar 14. PubMed |
| Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib. Irwin ME, Mueller KL, Bohin N, Ge Y, Boerner JL. J Cell Physiol. 2011 Sep;226(9):2316-28. doi: 10.1002/jcp.22570. PubMed |
| Adenovirus type 5 rupture of lysosomes leads to cathepsin B-dependent mitochondrial stress and production of reactive oxygen species. McGuire KA, Barlan AU, Griffin TM, Wiethoff CM. J Virol. 2011 Oct;85(20):10806-13. doi: 10.1128/JVI.00675-11. Epub 2011 Aug 10. PubMed |
| FOSL1 is integral to establishing the maternal-fetal interface. Kent LN, Rumi MA, Kubota K, Lee DS, Soares MJ. Mol Cell Biol. 2011 Dec;31(23):4801-13. doi: 10.1128/MCB.05780-11. Epub 2011 Sep 26. PubMed |
| Epstein-Barr virus nuclear antigen 3C stabilizes Gemin3 to block p53-mediated apoptosis. Cai Q, Guo Y, Xiao B, Banerjee S, Saha A, Lu J, Glisovic T, Robertson ES. PLoS Pathog. 2011 Dec;7(12):e1002418. doi: 10.1371/journal.ppat.1002418. Epub 2011 Dec 8. PubMed |
| The cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancer. Al Sorkhy M, Ferraiuolo RM, Jalili E, Malysa A, Fratiloiu AR, Sloane BF, Porter LA. BMC Cancer. 2012 Jan 26;12:45. doi: 10.1186/1471-2407-12-45. PubMed |
| RGB marking with lentiviral vectors for multicolor clonal cell tracking. Weber K, Thomaschewski M, Benten D, Fehse B. Nat Protoc. 2012 Apr 5;7(5):839-49. doi: 10.1038/nprot.2012.026. PubMed |
Identification of the human PMR1 mRNA endonuclease as an alternatively processed product of the gene for peroxidasin-like protein.
Gu SQ, Bakthavachalu B, Han J, Patil DP, Otsuka Y, Guda C, Schoenberg DR.
RNA. 2012 Jun;18(6):1186-96. doi: 10.1261/rna.031369.111. Epub 2012 Apr 27.
PubMed
Associated Plasmids |
| Inverted Alu dsRNA structures do not affect localization but can alter translation efficiency of human mRNAs independent of RNA editing. Capshew CR, Dusenbury KL, Hundley HA. Nucleic Acids Res. 2012 Sep 1;40(17):8637-45. Epub 2012 Jun 25. PubMed |
| Fibroblast-secreted hepatocyte growth factor mediates epidermal growth factor receptor tyrosine kinase inhibitor resistance in triple-negative breast cancers through paracrine activation of Met. Mueller KL, Madden JM, Zoratti GL, Kuperwasser C, List K, Boerner JL. Breast Cancer Res. 2012 Jul 12;14(4):R104. doi: 10.1186/bcr3224. PubMed |
| Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress. Siroky BJ, Yin H, Babcock JT, Lu L, Hellmann AR, Dixon BP, Quilliam LA, Bissler JJ. Am J Physiol Renal Physiol. 2012 Sep 15;303(6):F831-44. doi: 10.1152/ajprenal.00441.2011. Epub 2012 Jul 11. PubMed |
| Loss of NF1 expression in human endothelial cells promotes autonomous proliferation and altered vascular morphogenesis. Bajaj A, Li QF, Zheng Q, Pumiglia K. PLoS One. 2012;7(11):e49222. doi: 10.1371/journal.pone.0049222. Epub 2012 Nov 7. PubMed |
| Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells. Holkers M, Maggio I, Liu J, Janssen JM, Miselli F, Mussolino C, Recchia A, Cathomen T, Goncalves MA. Nucleic Acids Res. 2013 Mar 1;41(5):e63. doi: 10.1093/nar/gks1446. Epub 2012 Dec 28. PubMed |
| Patient-derived models of human breast cancer: protocols for in vitro and in vivo applications in tumor biology and translational medicine. DeRose YS, Gligorich KM, Wang G, Georgelas A, Bowman P, Courdy SJ, Welm AL, Welm BE. Curr Protoc Pharmacol. 2013 Mar;Chapter 14:Unit14.23. doi: 10.1002/0471141755.ph1423s60. PubMed |
| Sigma-1 receptor regulates early steps of viral RNA replication at the onset of hepatitis C virus infection. Friesland M, Mingorance L, Chung J, Chisari FV, Gastaminza P. J Virol. 2013 Jun;87(11):6377-90. doi: 10.1128/JVI.03557-12. Epub 2013 Mar 27. PubMed |
| A systematic approach to the establishment and characterization of endothelial progenitor cells for gene therapy. Werling NJ, Thorpe R, Zhao Y. Hum Gene Ther Methods. 2013 Jun;24(3):171-84. doi: 10.1089/hgtb.2012.146. Epub 2013 Apr 30. PubMed |
| Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein. Vogt DA, Camus G, Herker E, Webster BR, Tsou CL, Greene WC, Yen TS, Ott M. PLoS Pathog. 2013;9(4):e1003302. doi: 10.1371/journal.ppat.1003302. Epub 2013 Apr 11. PubMed |
| Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response. Babcock JT, Nguyen HB, He Y, Hendricks JW, Wek RC, Quilliam LA. J Biol Chem. 2013 May 31;288(22):15687-98. doi: 10.1074/jbc.M112.431056. Epub 2013 Apr 23. PubMed |
| A robust method to derive functional neural crest cells from human pluripotent stem cells. Kreitzer FR, Salomonis N, Sheehan A, Huang M, Park JS, Spindler MJ, Lizarraga P, Weiss WA, So PL, Conklin BR. Am J Stem Cells. 2013 Jun 30;2(2):119-31. Print 2013. PubMed |
| Pid1 induces insulin resistance in both human and mouse skeletal muscle during obesity. Bonala S, McFarlane C, Ang J, Lim R, Lee M, Chua H, Lokireddy S, Sreekanth P, Leow MK, Meng KC, Shyong TE, Lee YS, Gluckman PD, Sharma M, Kambadur R. Mol Endocrinol. 2013 Sep;27(9):1518-35. doi: 10.1210/me.2013-1048. Epub 2013 Aug 8. PubMed |
| The zinc finger transcription factor ZXDC activates CCL2 gene expression by opposing BCL6-mediated repression. Ramsey JE, Fontes JD. Mol Immunol. 2013 Dec;56(4):768-80. doi: 10.1016/j.molimm.2013.07.001. Epub 2013 Aug 14. PubMed |
| The ING4 Binding with p53 and Induced p53 Acetylation were Attenuated by Human Papillomavirus 16 E6. Guo Y, Meng X, Wang Q, Wang Y, Shang H. PLoS One. 2013 Aug 13;8(8):e71453. doi: 10.1371/journal.pone.0071453. eCollection 2013. PubMed |
| Noninvasive visualization of tumor growth in a human colorectal liver metastases xenograft model using bioluminescence in vivo imaging. Thalheimer A, Korb D, Bonicke L, Wiegering A, Muhling B, Schneider M, Koch S, Riedel SS, Germer CT, Beilhack A, Brandlein S, Otto C. J Surg Res. 2013 Nov;185(1):143-51. doi: 10.1016/j.jss.2013.03.024. Epub 2013 Mar 30. PubMed |
| Determination of the transforming activities of adenovirus oncogenes. Speiseder T, Nevels M, Dobner T. Methods Mol Biol. 2014;1089:105-15. doi: 10.1007/978-1-62703-679-5_8. PubMed |
Parallel measurement of dynamic changes in translation rates in single cells.
Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, Meyer T.
Nat Methods. 2014 Jan;11(1):86-93. doi: 10.1038/nmeth.2729. Epub 2013 Nov 10.
PubMed
Associated Plasmids |
| A tumor suppressor function for the lipid phosphatase INPP4B in melanocytic neoplasms. Perez-Lorenzo R, Gill KZ, Shen CH, Zhao FX, Zheng B, Schulze HJ, Silvers DN, Brunner G, Horst BA. J Invest Dermatol. 2014 May;134(5):1359-68. doi: 10.1038/jid.2013.511. Epub 2013 Nov 28. PubMed |
| Automated analysis of clonal cancer cells by intravital imaging. Coffey SE, Giedt RJ, Weissleder R. Intravital. 2013 Jul;2(3). doi: 10.4161/intv.26138. PubMed |
| A human torque teno virus encodes a microRNA that inhibits interferon signaling. Kincaid RP, Burke JM, Cox JC, de Villiers EM, Sullivan CS. PLoS Pathog. 2013;9(12):e1003818. doi: 10.1371/journal.ppat.1003818. Epub 2013 Dec 19. PubMed |
| The FOS transcription factor family differentially controls trophoblast migration and invasion. Renaud SJ, Kubota K, Rumi MA, Soares MJ. J Biol Chem. 2014 Feb 21;289(8):5025-39. doi: 10.1074/jbc.M113.523746. Epub 2013 Dec 30. PubMed |
| Generation of transgene-free mouse induced pluripotent stem cells using an excisable lentiviral system. Varga E, Nemes C, Davis RP, Ujhelly O, Klincumhom N, Polgar Z, Muenthaisong S, Pirity MK, Dinnyes A. Exp Cell Res. 2014 Apr 1;322(2):335-44. doi: 10.1016/j.yexcr.2014.02.006. Epub 2014 Feb 18. PubMed |
| Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis. Sakurai T, Woolls MJ, Jin SW, Murakami M, Simons M. PLoS One. 2014 Mar 6;9(6):e90736. doi: 10.1371/journal.pone.0090736. eCollection 2014. PubMed |
| The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment. Skibinski A, Breindel JL, Prat A, Galvan P, Smith E, Rolfs A, Gupta PB, Labaer J, Kuperwasser C. Cell Rep. 2014 Mar 27;6(6):1059-72. doi: 10.1016/j.celrep.2014.02.038. Epub 2014 Mar 6. PubMed |
MYPT1 regulates contractility and microtubule acetylation to modulate integrin adhesions and matrix assembly.
Joo EE, Yamada KM.
Nat Commun. 2014 Mar 25;5:3510. doi: 10.1038/ncomms4510.
PubMed
Associated Plasmids |
| Transdifferentiation of mouse fibroblasts and hepatocytes to functional neurons. Marro S, Yang N. Methods Mol Biol. 2014;1150:237-46. doi: 10.1007/978-1-4939-0512-6_16. PubMed |
| Human papillomavirus 16 E6 contributes HIF-1alpha induced Warburg effect by attenuating the VHL-HIF-1alpha interaction. Guo Y, Meng X, Ma J, Zheng Y, Wang Q, Wang Y, Shang H. Int J Mol Sci. 2014 May 7;15(5):7974-86. doi: 10.3390/ijms15057974. PubMed |
| FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. Hirose Y, Johnson ZI, Schoepflin ZR, Markova DZ, Chiba K, Toyama Y, Shapiro IM, Risbud MV. J Biol Chem. 2014 Jul 25;289(30):20594-605. PubMed |
| Live cell imaging of primary rat neonatal cardiomyocytes following adenoviral and lentiviral transduction using confocal spinning disk microscopy. Sakurai T, Lanahan A, Woolls MJ, Li N, Tirziu D, Murakami M. J Vis Exp. 2014 Jun 24;(88):e51666. doi: 10.3791/51666. PubMed |
| Lentiviral gene transduction of mouse and human hematopoietic stem cells. van Til NP, Wagemaker G. Methods Mol Biol. 2014;1185:311-9. doi: 10.1007/978-1-4939-1133-2_21. PubMed |
| StUbEx: Stable tagged ubiquitin exchange system for the global investigation of cellular ubiquitination. Akimov V, Henningsen J, Hallenborg P, Rigbolt KT, Jensen SS, Nielsen MM, Kratchmarova I, Blagoev B. J Proteome Res. 2014 Sep 5;13(9):4192-204. doi: 10.1021/pr500549h. Epub 2014 Aug 15. PubMed |
| Phosphorylation site dynamics of early T-cell receptor signaling. Chylek LA, Akimov V, Dengjel J, Rigbolt KT, Hu B, Hlavacek WS, Blagoev B. PLoS One. 2014 Aug 22;9(8):e104240. doi: 10.1371/journal.pone.0104240. eCollection 2014. PubMed |
| Pcgf6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ESCs and functions in iPS reprogramming. Zdzieblo D, Li X, Lin Q, Zenke M, Illich DJ, Becker M, Muller AM. Stem Cells. 2014 Dec;32(12):3112-25. doi: 10.1002/stem.1826. PubMed |
| Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice. Tang X, Benesch MG, Dewald J, Zhao YY, Patwardhan N, Santos WL, Curtis JM, McMullen TP, Brindley DN. J Lipid Res. 2014 Nov;55(11):2389-400. doi: 10.1194/jlr.M053462. Epub 2014 Sep 10. PubMed |
| HBZ stimulates brain-derived neurotrophic factor/TrkB autocrine/paracrine signaling to promote survival of human T-cell leukemia virus type 1-Infected T cells. Polakowski N, Terol M, Hoang K, Nash I, Laverdure S, Gazon H, Belrose G, Mesnard JM, Cesaire R, Peloponese JM, Lemasson I. J Virol. 2014 Nov;88(22):13482-94. doi: 10.1128/JVI.02285-14. Epub 2014 Sep 10. PubMed |
| Establishment of a cell line with stable expression of mCherry-EGFP tandem fluorescent-tagged LC3B for studying the impact of HIV-1 infection on autophagic flux. Liu B, Liu C, Zhao X, Shen W, Qian L, Wei Y, Kong X. J Virol Methods. 2014 Dec;209:95-102. doi: 10.1016/j.jviromet.2014.09.012. Epub 2014 Sep 18. PubMed |
| ETS1 is a genome-wide effector of RAS/ERK signaling in epithelial cells. Plotnik JP, Budka JA, Ferris MW, Hollenhorst PC. Nucleic Acids Res. 2014 Oct 29;42(19):11928-40. doi: 10.1093/nar/gku929. Epub 2014 Oct 7. PubMed |
| In vivo shRNA screens in solid tumors. Gargiulo G, Serresi M, Cesaroni M, Hulsman D, van Lohuizen M. Nat Protoc. 2014 Dec;9(12):2880-902. doi: 10.1038/nprot.2014.185. Epub 2014 Nov 20. PubMed |
| A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth. Schell JC, Olson KA, Jiang L, Hawkins AJ, Van Vranken JG, Xie J, Egnatchik RA, Earl EG, DeBerardinis RJ, Rutter J. Mol Cell. 2014 Nov 6;56(3):400-13. doi: 10.1016/j.molcel.2014.09.026. Epub 2014 Oct 21. PubMed |
| Fanconi anemia gene editing by the CRISPR/Cas9 system. Osborn MJ, Gabriel R, Webber BR, DeFeo AP, McElroy AN, Jarjour J, Starker CG, Wagner JE, Joung JK, Voytas DF, von Kalle C, Schmidt M, Blazar BR, Tolar J. Hum Gene Ther. 2015 Feb;26(2):114-26. doi: 10.1089/hum.2014.111. PubMed |
| MicroRNA-22 regulates smooth muscle cell differentiation from stem cells by targeting methyl CpG-binding protein 2. Zhao H, Wen G, Huang Y, Yu X, Chen Q, Afzal TA, Luong le A, Zhu J, Ye S, Zhang L, Xiao Q. Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):918-29. doi: 10.1161/ATVBAHA.114.305212. Epub 2015 Feb 26. PubMed |
| Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2. Fieber C, Janos M, Koestler T, Gratz N, Li XD, Castiglia V, Aberle M, Sauert M, Wegner M, Alexopoulou L, Kirschning CJ, Chen ZJ, von Haeseler A, Kovarik P. PLoS One. 2015 Mar 10;10(3):e0119727. doi: 10.1371/journal.pone.0119727. eCollection 2015. PubMed |
| Sustained regeneration of high-volume adipose tissue for breast reconstruction using computer aided design and biomanufacturing. Chhaya MP, Melchels FP, Holzapfel BM, Baldwin JG, Hutmacher DW. Biomaterials. 2015 Jun;52:551-60. doi: 10.1016/j.biomaterials.2015.01.025. Epub 2015 Mar 18. PubMed |
| Ebola Virus Glycoprotein Promotes Enhanced Viral Egress by Preventing Ebola VP40 From Associating With the Host Restriction Factor BST2/Tetherin. Gustin JK, Bai Y, Moses AV, Douglas JL. J Infect Dis. 2015 Mar 27. pii: jiv125. PubMed |
| Lentiviral vectors for retrograde delivery of recombinases and transactivators. Wickersham IR, Sullivan HA, Pao GM, Hamanaka H, Goosens KA, Verma IM, Seung HS. Cold Spring Harb Protoc. 2015 Apr 1;2015(4):368-74. doi: 10.1101/pdb.prot075879. PubMed |
| Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth. Raiborg C, Wenzel EM, Pedersen NM, Olsvik H, Schink KO, Schultz SW, Vietri M, Nisi V, Bucci C, Brech A, Johansen T, Stenmark H. Nature. 2015 Apr 9;520(7546):234-8. doi: 10.1038/nature14359. PubMed |
| alpha6beta1- and alphaV-integrins are required for long-term self-renewal of murine embryonic stem cells in the absence of LIF. Cattavarayane S, Palovuori R, Tanjore Ramanathan J, Manninen A. BMC Cell Biol. 2015 Feb 27;16:3. doi: 10.1186/s12860-015-0051-y. PubMed |
| Ex vivo aorta patch model for analysis of cellular adhesion. Lin YN, Thata RN, Failla AV, Geissen M, Daum G, Windhorst S. Tissue Cell. 2015 Jun;47(3):266-72. doi: 10.1016/j.tice.2015.03.004. Epub 2015 Mar 23. PubMed |
| Single-step cloning-screening method: a new tool for developing and studying high-titer viral vector producer cells. Rodrigues AF, Formas-Oliveira AS, Guerreiro MR, Tomas HA, Alves PM, Coroadinha AS. Gene Ther. 2015 Sep;22(9):685-95. doi: 10.1038/gt.2015.44. Epub 2015 May 4. PubMed |
| Viral-mediated Labeling and Transplantation of Medial Ganglionic Eminence (MGE) Cells for In Vivo Studies. Vogt D, Wu PR, Sorrells SF, Arnold C, Alvarez-Buylla A, Rubenstein JL. J Vis Exp. 2015 Apr 23;(98). doi: 10.3791/52740. PubMed |
| An alternative pluripotent state confers interspecies chimaeric competency. Wu J, Okamura D, Li M, Suzuki K, Luo C, Ma L, He Y, Li Z, Benner C, Tamura I, Krause MN, Nery JR, Du T, Zhang Z, Hishida T, Takahashi Y, Aizawa E, Kim NY, Lajara J, Guillen P, Campistol JM, Esteban CR, Ross PJ, Saghatelian A, Ren B, Ecker JR, Izpisua Belmonte JC. Nature. 2015 May 21;521(7552):316-21. doi: 10.1038/nature14413. Epub 2015 May 6. PubMed |
| Comparative analysis of lentiviral vectors and modular protein nanovectors for traumatic brain injury gene therapy. Negro-Demontel ML, Saccardo P, Giacomini C, Yanez-Munoz RJ, Ferrer-Miralles N, Vazquez E, Villaverde A, Peluffo H. Mol Ther Methods Clin Dev. 2014 Oct 15;1:14047. doi: 10.1038/mtm.2014.47. eCollection 2014. PubMed |
Akt signaling dynamics in individual cells.
Gross SM, Rotwein P.
J Cell Sci. 2015 Jun 3. pii: jcs.168773.
PubMed
Associated Plasmids |
| Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing. Vietri M, Schink KO, Campsteijn C, Wegner CS, Schultz SW, Christ L, Thoresen SB, Brech A, Raiborg C, Stenmark H. Nature. 2015 Jun 11;522(7555):231-5. doi: 10.1038/nature14408. Epub 2015 Jun 3. PubMed |
| More Tricks with Tetramers: A Practical Guide to Staining T cells with peptide-MHC Multimers. Dolton G, Tungatt K, Lloyd A, Bianchi V, Theaker SM, Trimby A, Holland CJ, Donia M, Godkin AJ, Cole DK, Straten PT, Peakman M, Svane IM, Sewell AK. Immunology. 2015 Jun 16. doi: 10.1111/imm.12499. PubMed |
| Lack of Rybp in Mouse Embryonic Stem Cells Impairs Cardiac Differentiation. Ujhelly O, Szabo V, Kovacs G, Vajda F, Mallok S, Prorok J, Acsai K, Hegedus Z, Krebs S, Dinnyes A, Pirity MK. Stem Cells Dev. 2015 Jun 25. PubMed |
| Drosophila homologue of Diaphanous 1 (DIAPH1) controls the metastatic potential of colon cancer cells by regulating microtubule-dependent adhesion. Lin YN, Bhuwania R, Gromova K, Failla AV, Lange T, Riecken K, Linder S, Kneussel M, Izbicki JR, Windhorst S. Oncotarget. 2015 Jul 30;6(21):18577-89. PubMed |
NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets.
Bouveret R, Waardenberg AJ, Schonrock N, Ramialison M, Doan T, de Jong D, Bondue A, Kaur G, Mohamed S, Fonoudi H, Chen CM, Wouters MA, Bhattacharya S, Plachta N, Dunwoodie SL, Chapman G, Blanpain C, Harvey RP.
Elife. 2015 Jul 6;4. doi: 10.7554/eLife.06942.
PubMed
Associated Plasmids |
| Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA). Hannafon BN, Carpenter KJ, Berry WL, Janknecht R, Dooley WC, Ding WQ. Mol Cancer. 2015 Jul 16;14:133. doi: 10.1186/s12943-015-0400-7. PubMed |
| RhoB upregulation leads to either apoptosis or cytostasis through differential target selection. Marlow LA, Bok I, Smallridge RC, Copland JA. Endocr Relat Cancer. 2015 Oct;22(5):777-92. doi: 10.1530/ERC-14-0302. Epub 2015 Jul 23. PubMed |
| Scalable Electrophysiological Investigation of iPS Cell-Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy. Friedrichs S, Malan D, Voss Y, Sasse P. J Clin Med. 2015 Jan 8;4(1):102-23. doi: 10.3390/jcm4010102. PubMed |
| Separating myoblast differentiation from muscle cell fusion using IGF-I and the p38 MAP kinase inhibitor SB202190. Gardner S, Gross SM, David LL, Klimek JE, Rotwein P. Am J Physiol Cell Physiol. 2015 Oct 1;309(7):C491-500. doi: 10.1152/ajpcell.00184.2015. Epub 2015 Aug 5. PubMed |
| CRISPR/Cas9 System as an Agent for Eliminating Polyomavirus JC Infection. Wollebo HS, Bellizzi A, Kaminski R, Hu W, White MK, Khalili K. PLoS One. 2015 Sep 11;10(9):e0136046. doi: 10.1371/journal.pone.0136046. eCollection 2015. PubMed |
| Exogenous marker-engineered mesenchymal stem cells detect cancer and metastases in a simple blood assay. Liu L, Zhang SX, Aeran R, Liao W, Lu M, Polovin G, Pone EJ, Zhao W. Stem Cell Res Ther. 2015 Sep 21;6:181. doi: 10.1186/s13287-015-0151-9. PubMed |
| The role of APC/C in replication stress and origin of genomic instability. Greil C, Krohs J, Schnerch D, Follo M, Felthaus J, Engelhardt M, Wasch R. Oncogene. 2015 Oct 12. doi: 10.1038/onc.2015.367. PubMed |
| Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line. Sluch VM, Davis CH, Ranganathan V, Kerr JM, Krick K, Martin R, Berlinicke CA, Marsh-Armstrong N, Diamond JS, Mao HQ, Zack DJ. Sci Rep. 2015 Nov 13;5:16595. doi: 10.1038/srep16595. PubMed |
| Non-epigenetic function of HDAC8 in regulating breast cancer stem cells by maintaining Notch1 protein stability. Chao MW, Chu PC, Chuang HC, Shen FH, Chou CC, Hsu EC, Himmel LE, Huang HL, Tu HJ, Kulp SK, Teng CM, Chen CS. Oncotarget. 2016 Jan 12;7(2):1796-807. doi: 10.18632/oncotarget.6427. PubMed |
| C/EBPgamma is a critical regulator of cellular stress response networks through heterodimerization with ATF4. Huggins CJ, Mayekar MK, Martin N, Saylor KL, Gonit M, Jailwala P, Kasoji M, Haines DC, Quinones OA, Johnson PF. Mol Cell Biol. 2015 Dec 14. pii: MCB.00911-15. PubMed |
| Long-acting cocaine hydrolase for addiction therapy. Chen X, Xue L, Hou S, Jin Z, Zhang T, Zheng F, Zhan CG. Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):422-7. doi: 10.1073/pnas.1517713113. Epub 2015 Dec 28. PubMed |
| A Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation Initiation. Leen EN, Sorgeloos F, Correia S, Chaudhry Y, Cannac F, Pastore C, Xu Y, Graham SC, Matthews SJ, Goodfellow IG, Curry S. PLoS Pathog. 2016 Jan 6;12(1):e1005379. doi: 10.1371/journal.ppat.1005379. eCollection 2016 Jan. PubMed |
NBR1 enables autophagy-dependent focal adhesion turnover.
Kenific CM, Stehbens SJ, Goldsmith J, Leidal AM, Faure N, Ye J, Wittmann T, Debnath J.
J Cell Biol. 2016 Feb 29;212(5):577-590. Epub 2016 Feb 22.
PubMed
Associated Plasmids |
| Integrin-linked kinase as a novel molecular switch of the IL-6-NF-kappaB signaling loop in breast cancer. Hsu EC, Kulp SK, Huang HL, Tu HJ, Chao MW, Tseng YC, Yang MC, Salunke SB, Sullivan NJ, Chen WC, Zhang J, Teng CM, Fu WM, Sun D, Wicha MS, Shapiro CL, Chen CS. Carcinogenesis. 2016 Apr;37(4):430-42. doi: 10.1093/carcin/bgw020. Epub 2016 Feb 19. PubMed |
| Neuronal Orphan G-Protein Coupled Receptor Proteins Mediate Plasmalogens-Induced Activation of ERK and Akt Signaling. Hossain MS, Mineno K, Katafuchi T. PLoS One. 2016 Mar 2;11(3):e0150846. doi: 10.1371/journal.pone.0150846. eCollection 2016. PubMed |
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| Evaluation of Immortalized AVPV- and Arcuate-Specific Neuronal Kisspeptin Cell Lines to Elucidate Potential Mechanisms of Estrogen Responsiveness and Temporal Gene Expression in Females. Jacobs DC, Veitch RE, Chappell PE. Endocrinology. 2016 Sep;157(9):3410-9. doi: 10.1210/en.2016-1294. Epub 2016 Jul 13. PubMed |
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| Optimal Lentivirus Production and Cell Culture Conditions Necessary to Successfully Transduce Primary Human Bronchial Epithelial Cells. Baumlin-Schmid N, Salathe M, Fregien NL. J Vis Exp. 2016 Jul 22;(113). doi: 10.3791/54176. PubMed |
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| Negative Feedback Regulation of HIV-1 by Gene Editing Strategy. Kaminski R, Chen Y, Salkind J, Bella R, Young WB, Ferrante P, Karn J, Malcolm T, Hu W, Khalili K. Sci Rep. 2016 Aug 16;6:31527. doi: 10.1038/srep31527. PubMed |
| Functional receptor molecules CD300lf and CD300ld within the CD300 family enable murine noroviruses to infect cells. Haga K, Fujimoto A, Takai-Todaka R, Miki M, Doan YH, Murakami K, Yokoyama M, Murata K, Nakanishi A, Katayama K. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6248-E6255. Epub 2016 Sep 28. PubMed |
| The A2b adenosine receptor antagonist PSB-603 promotes oxidative phosphorylation and ROS production in colorectal cancer cells via adenosine receptor-independent mechanism. Molck C, Ryall J, Failla LM, Coates JL, Pascussi JM, Heath JK, Stewart G, Hollande F. Cancer Lett. 2016 Dec 1;383(1):135-143. doi: 10.1016/j.canlet.2016.09.018. Epub 2016 Sep 28. PubMed |
| LDB1 overexpression is a negative prognostic factor in colorectal cancer. Garcia SA, Swiersy A, Radhakrishnan P, Branchi V, Kanth Nanduri L, Gyorffy B, Betzler AM, Bork U, Kahlert C, Reissfelder C, Rahbari NN, Weitz J, Scholch S. Oncotarget. 2016 Dec 20;7(51):84258-84270. doi: 10.18632/oncotarget.12481. PubMed |
| Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer. Ni T, Li XY, Lu N, An T, Liu ZP, Fu R, Lv WC, Zhang YW, Xu XJ, Grant Rowe R, Lin YS, Scherer A, Feinberg T, Zheng XQ, Chen BA, Liu XS, Guo QL, Wu ZQ, Weiss SJ. Nat Cell Biol. 2016 Nov;18(11):1221-1232. doi: 10.1038/ncb3425. Epub 2016 Oct 17. PubMed |
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| MIR144* inhibits antimicrobial responses against Mycobacterium tuberculosis in human monocytes and macrophages by targeting the autophagy protein DRAM2. Kim JK, Lee HM, Park KS, Shin DM, Kim TS, Kim YS, Suh HW, Kim SY, Kim IS, Kim JM, Son JW, Sohn KM, Jung SS, Chung C, Han SB, Yang CS, Jo EK. Autophagy. 2016 Oct 20:1-19. doi: 10.1080/15548627.2016.1241922. PubMed |
| The Hippo pathway regulates human megakaryocytic differentiation. Lorthongpanich C, Jiamvoraphong N, Supraditaporn K, Klaihmon P, U-Pratya Y, Issaragrisil S. Thromb Haemost. 2017 Jan 5;117(1):116-126. doi: 10.1160/TH16-07-0564. Epub 2016 Oct 27. PubMed |
| The Andes Virus Nucleocapsid Protein Directs Basal Endothelial Cell Permeability by Activating RhoA. Gorbunova EE, Simons MJ, Gavrilovskaya IN, Mackow ER. MBio. 2016 Oct 25;7(5). pii: e01747-16. doi: 10.1128/mBio.01747-16. PubMed |
| HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia. Chakraborty D, Cui W, Rosario GX, Scott RL, Dhakal P, Renaud SJ, Tachibana M, Rumi MA, Mason CW, Krieg AJ, Soares MJ. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7212-E7221. Epub 2016 Nov 2. PubMed |
| Cellular effects of fluorodeoxyglucose: Global changes in the lipidome and alteration in intracellular transport. Kavaliauskiene S, Torgersen ML, Lingelem AB, Klokk TI, Lintonen T, Simolin H, Ekroos K, Skotland T, Sandvig K. Oncotarget. 2016 Nov 29;7(48):79885-79900. doi: 10.18632/oncotarget.13089. PubMed |
| Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6. Mouillesseaux KP, Wiley DS, Saunders LM, Wylie LA, Kushner EJ, Chong DC, Citrin KM, Barber AT, Park Y, Kim JD, Samsa LA, Kim J, Liu J, Jin SW, Bautch VL. Nat Commun. 2016 Nov 11;7:13247. doi: 10.1038/ncomms13247. PubMed |
In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration.
Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M, Aizawa E, Guo S, Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X, Jafari M, Esteban CR, Berggren WT, Lajara J, Nunez-Delicado E, Guillen P, Campistol JM, Matsuzaki F, Liu GH, Magistretti P, Zhang K, Callaway EM, Zhang K, Belmonte JC.
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| miRNAsong: a web-based tool for generation and testing of miRNA sponge constructs in silico. Barta T, Peskova L, Hampl A. Sci Rep. 2016 Nov 18;6:36625. doi: 10.1038/srep36625. PubMed |
| The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport. Torgersen ML, Klokk TI, Kavaliauskiene S, Klose C, Simons K, Skotland T, Sandvig K. Oncotarget. 2016 Dec 27;7(52):86871-86888. doi: 10.18632/oncotarget.13508. PubMed |
| ICAM-5/Telencephalin Is a Functional Entry Receptor for Enterovirus D68. Wei W, Guo H, Chang J, Yu Y, Liu G, Zhang N, Willard SH, Zheng S, Yu XF. Cell Host Microbe. 2016 Nov 9;20(5):631-641. doi: 10.1016/j.chom.2016.09.013. Epub 2016 Oct 27. PubMed |
| Monitoring Synapses Via Trans-Synaptic GFP Complementation. Tsetsenis T. Methods Mol Biol. 2017;1538:45-52. PubMed |
| Caspase-2-mediated cell death is required for deleting aneuploid cells. Dawar S, Lim Y, Puccini J, White M, Thomas P, Bouchier-Hayes L, Green DR, Dorstyn L, Kumar S. Oncogene. 2016 Dec 19. doi: 10.1038/onc.2016.423. PubMed |
| A Photoactivatable Innate Immune Receptor for Optogenetic Inflammation. Moser BA, Esser-Kahn AP. ACS Chem Biol. 2016 Dec 29. doi: 10.1021/acschembio.6b01012. PubMed |
| An enzymatic assay based on luciferase Ebola virus-like particles for evaluation of virolytic activity of antimicrobial peptides. Peskova M, Heger Z, Janda P, Adam V, Pekarik V. Peptides. 2016 Dec 22;88:87-96. doi: 10.1016/j.peptides.2016.12.015. PubMed |
| De-immunized and Functional Therapeutic (DeFT) versions of a long lasting recombinant alpha interferon for antiviral therapy. Mufarrege EF, Giorgetti S, Etcheverrigaray M, Terry F, Martin W, De Groot AS. Clin Immunol. 2017 Jan 10;176:31-41. doi: 10.1016/j.clim.2017.01.003. PubMed |
| Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease. Chao MP, Gentles AJ, Chatterjee S, Lan F, Reinisch A, Corces MR, Xavy S, Shen J, Haag D, Chanda S, Sinha R, Morganti RM, Nishimura T, Ameen M, Wu H, Wernig M, Wu JC, Majeti R. Cell Stem Cell. 2017 Mar 2;20(3):329-344.e7. doi: 10.1016/j.stem.2016.11.018. Epub 2017 Jan 12. PubMed |
Pooled CRISPR screening with single-cell transcriptome readout.
Datlinger P, Rendeiro AF, Schmidl C, Krausgruber T, Traxler P, Klughammer J, Schuster LC, Kuchler A, Alpar D, Bock C.
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| Interaction with ZMYND11 mediates opposing roles of Ras-responsive transcription factors ETS1 and ETS2. Plotnik JP, Hollenhorst PC. Nucleic Acids Res. 2017 May 5;45(8):4452-4462. doi: 10.1093/nar/gkx039. PubMed |
| Interspecies Chimerism with Mammalian Pluripotent Stem Cells. Wu J, Platero-Luengo A, Sakurai M, Sugawara A, Gil MA, Yamauchi T, Suzuki K, Bogliotti YS, Cuello C, Morales Valencia M, Okumura D, Luo J, Vilarino M, Parrilla I, Soto DA, Martinez CA, Hishida T, Sanchez-Bautista S, Martinez-Martinez ML, Wang H, Nohalez A, Aizawa E, Martinez-Redondo P, Ocampo A, Reddy P, Roca J, Maga EA, Esteban CR, Berggren WT, Nunez Delicado E, Lajara J, Guillen I, Guillen P, Campistol JM, Martinez EA, Ross PJ, Izpisua Belmonte JC. Cell. 2017 Jan 26;168(3):473-486.e15. doi: 10.1016/j.cell.2016.12.036. PubMed |
| Inhibition of serotonin receptor type 1 in acute myeloid leukemia impairs leukemia stem cell functionality: a promising novel therapeutic target. Etxabe A, Lara-Castillo MC, Cornet-Masana JM, Banus-Mulet A, Nomdedeu M, Torrente MA, Pratcorona M, Diaz-Beya M, Esteve J, Risueno RM. Leukemia. 2017 Nov;31(11):2288-2302. doi: 10.1038/leu.2017.52. Epub 2017 Feb 14. PubMed |
| Enhancement of beta-Globin Gene Expression in Thalassemic IVS2-654 Induced Pluripotent Stem Cell-Derived Erythroid Cells by Modified U7 snRNA. Phanthong P, Borwornpinyo S, Kitiyanant N, Jearawiriyapaisarn N, Nuntakarn L, Saetan J, Nualkaew T, Sa-Ngiamsuntorn K, Anurathapan U, Dinnyes A, Kitiyanant Y, Hongeng S. Stem Cells Transl Med. 2017 Apr;6(4):1059-1069. doi: 10.1002/sctm.16-0121. Epub 2017 Feb 18. PubMed |
| Reduction of Ether-Type Glycerophospholipids, Plasmalogens, by NF-kappaB Signal Leading to Microglial Activation. Hossain MS, Abe Y, Ali F, Youssef M, Honsho M, Fujiki Y, Katafuchi T. J Neurosci. 2017 Apr 12;37(15):4074-4092. doi: 10.1523/JNEUROSCI.3941-15.2017. Epub 2017 Mar 14. PubMed |
| Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability. Stratford JK, Yan F, Hill RA, Major MB, Graves LM, Der CJ, Yeh JJ. PLoS One. 2017 Apr 5;12(4):e0174863. doi: 10.1371/journal.pone.0174863. eCollection 2017. PubMed |
| Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model. Rivetti di Val Cervo P, Romanov RA, Spigolon G, Masini D, Martin-Montanez E, Toledo EM, La Manno G, Feyder M, Pifl C, Ng YH, Sanchez SP, Linnarsson S, Wernig M, Harkany T, Fisone G, Arenas E. Nat Biotechnol. 2017 May;35(5):444-452. doi: 10.1038/nbt.3835. Epub 2017 Apr 10. PubMed |
| Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases. Amici A, Grolla AA, Del Grosso E, Bellini R, Bianchi M, Travelli C, Garavaglia S, Sorci L, Raffaelli N, Ruggieri S, Genazzani AA, Orsomando G. Cell Chem Biol. 2017 May 18;24(5):553-564.e4. doi: 10.1016/j.chembiol.2017.03.010. Epub 2017 Apr 13. PubMed |
| Effects of altered sialic acid biosynthesis on N-linked glycan branching and cell surface interactions. Pham ND, Pang PC, Krishnamurthy S, Wands AM, Grassi P, Dell A, Haslam SM, Kohler JJ. J Biol Chem. 2017 Jun 9;292(23):9637-9651. doi: 10.1074/jbc.M116.764597. Epub 2017 Apr 19. PubMed |
| Glucose Can Epigenetically Alter the Gene Expression of Neurotrophic Factors in the Murine Brain Cells. Hossain MS, Oomura Y, Katafuchi T. Mol Neurobiol. 2017 May 13. doi: 10.1007/s12035-017-0578-3. PubMed |
| Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration. Horibata S, Rogers KE, Sadegh D, Anguish LJ, McElwee JL, Shah P, Thompson PR, Coonrod SA. BMC Cancer. 2017 May 26;17(1):378. doi: 10.1186/s12885-017-3354-x. PubMed |
| Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells. Balasubramaniam SL, Gopalakrishnapillai A, Petrelli NJ, Barwe SP. J Biol Chem. 2017 Jul 7;292(27):11388-11399. doi: 10.1074/jbc.M116.752352. Epub 2017 May 26. PubMed |
| PI3K class II alpha regulates delta-opioid receptor export from the trans-Golgi network. Shiwarski DJ, Darr M, Telmer CA, Bruchez MP, Puthenveedu MA. Mol Biol Cell. 2017 Aug 1;28(16):2202-2219. doi: 10.1091/mbc.E17-01-0030. Epub 2017 May 31. PubMed |
| Generation of Induced Pluripotent Stem Cells in Defined Three-Dimensional Hydrogels. Caiazzo M, Tabata Y, Lutolf M. Methods Mol Biol. 2017;1612:65-78. doi: 10.1007/978-1-4939-7021-6_5. PubMed |
| Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells. Huang HL, Wu HY, Chu PC, Lai IL, Huang PH, Kulp SK, Pan SL, Teng CM, Chen CS. Oncogenesis. 2017 Jul 10;6(7):e359. doi: 10.1038/oncsis.2017.61. PubMed |
| Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping. Morgan SL, Mariano NC, Bermudez A, Arruda NL, Wu F, Luo Y, Shankar G, Jia L, Chen H, Hu JF, Hoffman AR, Huang CC, Pitteri SJ, Wang KC. Nat Commun. 2017 Jul 13;8:15993. doi: 10.1038/ncomms15993. PubMed |
| CRISPR/Cas9-Mediated Scanning for Regulatory Elements Required for HPRT1 Expression via Thousands of Large, Programmed Genomic Deletions. Gasperini M, Findlay GM, McKenna A, Milbank JH, Lee C, Zhang MD, Cusanovich DA, Shendure J. Am J Hum Genet. 2017 Aug 3;101(2):192-205. doi: 10.1016/j.ajhg.2017.06.010. Epub 2017 Jul 14. PubMed |
| Intratumoral Lentivector-Mediated TGF-beta1 Gene Downregulation As a Potent Strategy for Enhancing the Antitumor Effect of Therapy Composed of Cyclophosphamide and Dendritic Cells. Rossowska J, Anger N, Szczygiel A, Mierzejewska J, Pajtasz-Piasecka E. Front Immunol. 2017 Jun 30;8:713. doi: 10.3389/fimmu.2017.00713. eCollection 2017. PubMed |
| Development of Hepatocyte-like Cell Derived from Human Induced Pluripotent Stem cell as a Host for Clinically Isolated Hepatitis C Virus. Sa-Ngiamsuntorn K, Hongeng S, Wongkajornsilp A. Curr Protoc Stem Cell Biol. 2017 Aug 14;42:4A.13.1-4A.13.34. doi: 10.1002/cpsc.35. PubMed |
| ESRRA (estrogen-related receptor alpha) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense. Kim SY, Yang CS, Lee HM, Kim JK, Kim YS, Kim YR, Kim JS, Kim TS, Yuk JM, Dufour CR, Lee SH, Kim JM, Choi HS, Giguere V, Jo EK. Autophagy. 2018;14(1):152-168. doi: 10.1080/15548627.2017.1339001. Epub 2017 Sep 1. PubMed |
| Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation. Roy K, Jerman S, Jozsef L, McNamara T, Onyekaba G, Sun Z, Marin EP. J Biol Chem. 2017 Oct 27;292(43):17703-17717. doi: 10.1074/jbc.M117.792937. Epub 2017 Aug 28. PubMed |
| Assessment of selected media supplements to improve F/HN lentiviral vector production yields. Gelinas JF, Davies LA, Gill DR, Hyde SC. Sci Rep. 2017 Aug 31;7(1):10198. doi: 10.1038/s41598-017-07893-3. PubMed |
| Replacing reprogramming factors with antibodies selected from combinatorial antibody libraries. Blanchard JW, Xie J, El-Mecharrafie N, Gross S, Lee S, Lerner RA, Baldwin KK. Nat Biotechnol. 2017 Oct;35(10):960-968. doi: 10.1038/nbt.3963. Epub 2017 Sep 11. PubMed |
| Optimized PEI-based Transfection Method for Transient Transfection and Lentiviral Production. Yang S, Zhou X, Li R, Fu X, Sun P. Curr Protoc Chem Biol. 2017 Sep 14;9(3):147-157. doi: 10.1002/cpch.25. PubMed |
| Strategies to Develop Therapeutic N- and O-Hyperglycosylated Proteins. Gugliotta A, Ceaglio N, Etcheverrigaray M, Kratje R, Oggero M. Methods Mol Biol. 2018;1674:163-181. doi: 10.1007/978-1-4939-7312-5_13. PubMed |
| CRISPR-Cas9 mediated gene knockout in human coronary artery endothelial cells reveals a pro-inflammatory role of TLR2. Wang Y, Chen L, Tian Z, Shen X, Wang X, Wu H, Wang Y, Zou J, Liang J. Cell Biol Int. 2018 Feb;42(2):187-193. doi: 10.1002/cbin.10885. Epub 2017 Nov 9. PubMed |
| MCT1 and MCT4 Expression and Lactate Flux Activity Increase During White and Brown Adipogenesis and Impact Adipocyte Metabolism. Petersen C, Nielsen MD, Andersen ES, Basse AL, Isidor MS, Markussen LK, Viuff BM, Lambert IH, Hansen JB, Pedersen SF. Sci Rep. 2017 Oct 12;7(1):13101. doi: 10.1038/s41598-017-13298-z. PubMed |
ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase.
Chi X, Britt EC, Shows HW, Hjelmaas AJ, Shetty SK, Cushing EM, Li W, Dou A, Zhang R, Davies BSJ.
Mol Metab. 2017 Oct;6(10):1137-1149. doi: 10.1016/j.molmet.2017.06.014. Epub 2017 Jun 29.
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| Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages. Ehrnstrom B, Beckwith KS, Yurchenko M, Moen SH, Kojen JF, Lentini G, Teti G, Damas JK, Espevik T, Stenvik J. Front Immunol. 2017 Oct 3;8:1243. doi: 10.3389/fimmu.2017.01243. eCollection 2017. PubMed |
| High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer. Wang L, Leite de Oliveira R, Wang C, Fernandes Neto JM, Mainardi S, Evers B, Lieftink C, Morris B, Jochems F, Willemsen L, Beijersbergen RL, Bernards R. Cell Rep. 2017 Oct 17;21(3):773-783. doi: 10.1016/j.celrep.2017.09.085. PubMed |
| MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke. Tseng KY, Anttila JE, Khodosevich K, Tuominen RK, Lindahl M, Domanskyi A, Airavaara M. Mol Ther. 2018 Jan 3;26(1):238-255. doi: 10.1016/j.ymthe.2017.09.019. Epub 2017 Sep 21. PubMed |
Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells.
Haimovich G, Ecker CM, Dunagin MC, Eggan E, Raj A, Gerst JE, Singer RH.
Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9873-E9882. doi: 10.1073/pnas.1706365114. Epub 2017 Oct 24.
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| Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation. O'Farrell F, Lobert VH, Sneeggen M, Jain A, Katheder NS, Wenzel EM, Schultz SW, Tan KW, Brech A, Stenmark H, Rusten TE. Nat Cell Biol. 2017 Dec;19(12):1412-1423. doi: 10.1038/ncb3631. Epub 2017 Oct 30. PubMed |
| StUbEx PLUS-A Modified Stable Tagged Ubiquitin Exchange System for Peptide Level Purification and In-Depth Mapping of Ubiquitination Sites. Akimov V, Olsen LCB, Hansen SVF, Barrio-Hernandez I, Puglia M, Jensen SS, Solov'yov IA, Kratchmarova I, Blagoev B. J Proteome Res. 2018 Jan 5;17(1):296-304. doi: 10.1021/acs.jproteome.7b00566. Epub 2017 Nov 1. PubMed |
| Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation. Meyerson NR, Zhou L, Guo YR, Zhao C, Tao YJ, Krug RM, Sawyer SL. Cell Host Microbe. 2017 Nov 8;22(5):627-638.e7. doi: 10.1016/j.chom.2017.10.003. Epub 2017 Nov 5. PubMed |
| C/EBPbeta mediates RNA polymerase III-driven transcription of oncomiR-138 in malignant gliomas. Di Pascale F, Nama S, Muhuri M, Quah S, Ismail HM, Chan XHD, Sundaram GM, Ramalingam R, Burke B, Sampath P. Nucleic Acids Res. 2018 Jan 9;46(1):336-349. doi: 10.1093/nar/gkx1105. PubMed |
| Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis. Kishore M, Cheung KCP, Fu H, Bonacina F, Wang G, Coe D, Ward EJ, Colamatteo A, Jangani M, Baragetti A, Matarese G, Smith DM, Haas R, Mauro C, Wraith DC, Okkenhaug K, Catapano AL, De Rosa V, Norata GD, Marelli-Berg FM. Immunity. 2017 Nov 21;47(5):875-889.e10. doi: 10.1016/j.immuni.2017.10.017. PubMed |
| Inhibition of ID1-BMPR2 Intrinsic Signaling Sensitizes Glioma Stem Cells to Differentiation Therapy. Jin X, Jin X, Kim LJY, Dixit D, Jeon HY, Kim EJ, Kim JK, Lee SY, Yin J, Rich JN, Kim H. Clin Cancer Res. 2018 Jan 15;24(2):383-394. doi: 10.1158/1078-0432.CCR-17-1529. Epub 2017 Dec 5. PubMed |
| Manufacture of Third-Generation Lentivirus for Preclinical Use, with Process Development Considerations for Translation to Good Manufacturing Practice. Gandara C, Affleck V, Stoll EA. Hum Gene Ther Methods. 2018 Feb;29(1):1-15. doi: 10.1089/hgtb.2017.098. Epub 2018 Jan 24. PubMed |
| Requirement of Treg-intrinsic CTLA4/PKCeta signaling pathway for suppressing tumor immunity. Pedros C, Canonigo-Balancio AJ, Kong KF, Altman A. JCI Insight. 2017 Dec 7;2(23). pii: 95692. doi: 10.1172/jci.insight.95692. PubMed |
| Primary Ovarian Insufficiency and Azoospermia in Carriers of a Homozygous PSMC3IP Stop Gain Mutation. Al-Agha AE, Ahmed IA, Nuebel E, Moriwaki M, Moore B, Peacock KA, Mosbruger T, Neklason DW, Jorde LB, Yandell M, Welt CK. J Clin Endocrinol Metab. 2018 Feb 1;103(2):555-563. doi: 10.1210/jc.2017-01966. PubMed |
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| A first-in-class inhibitor, MLN4924 (pevonedistat), induces cell-cycle arrest, senescence, and apoptosis in human renal cell carcinoma by suppressing UBE2M-dependent neddylation modification. Xu B, Deng Y, Bi R, Guo H, Shu C, Shah NK, Chang J, Liu G, Du Y, Wei W, Wang C. Cancer Chemother Pharmacol. 2018 Jun;81(6):1083-1093. doi: 10.1007/s00280-018-3582-z. Epub 2018 Apr 17. PubMed |
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| Targeted Gene Editing of Glia Maturation Factor in Microglia: a Novel Alzheimer's Disease Therapeutic Target. Raikwar SP, Thangavel R, Dubova I, Selvakumar GP, Ahmed ME, Kempuraj D, Zaheer SA, Iyer SS, Zaheer A. Mol Neurobiol. 2019 Jan;56(1):378-393. doi: 10.1007/s12035-018-1068-y. Epub 2018 Apr 27. PubMed |
| A Raf-Competitive K-Ras Binder Can Fail to Functionally Antagonize Signaling. Kauke MJ, Tisdale AW, Kelly RL, Braun CJ, Hemann MT, Wittrup KD. Mol Cancer Ther. 2018 Aug;17(8):1773-1780. doi: 10.1158/1535-7163.MCT-17-0645. Epub 2018 May 2. PubMed |
| Tissue-selective restriction of RNA editing of CaV1.3 by splicing factor SRSF9. Huang H, Kapeli K, Jin W, Wong YP, Arumugam TV, Koh JH, Srimasorn S, Mallilankaraman K, Chua JJE, Yeo GW, Soong TW. Nucleic Acids Res. 2018 Aug 21;46(14):7323-7338. doi: 10.1093/nar/gky348. PubMed |
| An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential. Wang L, Leite de Oliveira R, Huijberts S, Bosdriesz E, Pencheva N, Brunen D, Bosma A, Song JY, Zevenhoven J, Los-de Vries GT, Horlings H, Nuijen B, Beijnen JH, Schellens JHM, Bernards R. Cell. 2018 May 31;173(6):1413-1425.e14. doi: 10.1016/j.cell.2018.04.012. Epub 2018 May 10. PubMed |
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| Moderate UV Exposure Enhances Learning and Memory by Promoting a Novel Glutamate Biosynthetic Pathway in the Brain. Zhu H, Wang N, Yao L, Chen Q, Zhang R, Qian J, Hou Y, Guo W, Fan S, Liu S, Zhao Q, Du F, Zuo X, Guo Y, Xu Y, Li J, Xue T, Zhong K, Song X, Huang G, Xiong W. Cell. 2018 Jun 14;173(7):1716-1727.e17. doi: 10.1016/j.cell.2018.04.014. Epub 2018 May 17. PubMed |
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| Host phosphatidic acid phosphatase lipin1 is rate limiting for functional hepatitis C virus replicase complex formation. Mingorance L, Castro V, Avila-Perez G, Calvo G, Rodriguez MJ, Carrascosa JL, Perez-Del-Pulgar S, Forns X, Gastaminza P. PLoS Pathog. 2018 Sep 18;14(9):e1007284. doi: 10.1371/journal.ppat.1007284. eCollection 2018 Sep. PubMed |
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| Lentiviral-based reporter constructs for profiling chondrogenic activity in primary equine cell populations. Martin-Pena A, Porter RM, Plumton G, McCarrel TM, Morton AJ, Guijarro MV, Ghivizzani SC, Sharma B, Palmer GD. Eur Cell Mater. 2018 Oct 12;36:156-170. doi: 10.22203/eCM.v036a12. PubMed |
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| RbAp48 Protein Is a Critical Component of GPR158/OCN Signaling and Ameliorates Age-Related Memory Loss. Kosmidis S, Polyzos A, Harvey L, Youssef M, Denny CA, Dranovsky A, Kandel ER. Cell Rep. 2018 Oct 23;25(4):959-973.e6. doi: 10.1016/j.celrep.2018.09.077. PubMed |
| Increased invasive phenotype of CSF-1R expression in glioma cells via the ERK1/2 signaling pathway. Sun L, Liang H, Yu W, Jin X. Cancer Gene Ther. 2018 Oct 26. pii: 10.1038/s41417-018-0053-y. doi: 10.1038/s41417-018-0053-y. PubMed |
| Delivery of shRNA via lentivirus in human pseudoislets provides a model to test dynamic regulation of insulin secretion and gene function in human islets. Harata M, Liu S, Promes JA, Burand AJ, Ankrum JA, Imai Y. Physiol Rep. 2018 Oct;6(20):e13907. doi: 10.14814/phy2.13907. PubMed |
| p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression. Amelio I, Mancini M, Petrova V, Cairns RA, Vikhreva P, Nicolai S, Marini A, Antonov AA, Le Quesne J, Baena Acevedo JD, Dudek K, Sozzi G, Pastorino U, Knight RA, Mak TW, Melino G. Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10869-E10878. doi: 10.1073/pnas.1808314115. Epub 2018 Oct 31. PubMed |
| Exon Junction Complex Shapes the Transcriptome by Repressing Recursive Splicing. Blazquez L, Emmett W, Faraway R, Pineda JMB, Bajew S, Gohr A, Haberman N, Sibley CR, Bradley RK, Irimia M, Ule J. Mol Cell. 2018 Nov 1;72(3):496-509.e9. doi: 10.1016/j.molcel.2018.09.033. PubMed |
| Tumor-on-a-chip platform to investigate progression and drug sensitivity in cell lines and patient-derived organoids. Shirure VS, Bi Y, Curtis MB, Lezia A, Goedegebuure MM, Goedegebuure SP, Aft R, Fields RC, George SC. Lab Chip. 2018 Dec 7;18(23):3687-3702. doi: 10.1039/c8lc00596f. Epub 2018 Nov 5. PubMed |
| Effective Glucose Uptake by Human Astrocytes Requires Its Sequestration in the Endoplasmic Reticulum by Glucose-6-Phosphatase-beta. Muller MS, Fouyssac M, Taylor CW. Curr Biol. 2018 Nov 5;28(21):3481-3486.e4. doi: 10.1016/j.cub.2018.08.060. Epub 2018 Oct 25. PubMed |
| Long noncoding RNA Fer1like family member 4 suppresses hepatocellular carcinoma cell proliferation by regulating PTEN in vitro and in vivo. Sun X, Zheng G, Li C, Liu C. Mol Med Rep. 2019 Jan;19(1):685-692. doi: 10.3892/mmr.2018.9629. Epub 2018 Nov 7. PubMed |
| Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex. Riad A, Zeng C, Weng CC, Winters H, Xu K, Makvandi M, Metz T, Carlin S, Mach RH. Sci Rep. 2018 Nov 15;8(1):16845. doi: 10.1038/s41598-018-35430-3. PubMed |
| MiRNA-218 regulates osteoclast differentiation and inflammation response in periodontitis rats through Mmp9. Guo J, Zeng X, Miao J, Liu C, Wei F, Liu D, Zheng Z, Ting K, Wang C, Liu Y. Cell Microbiol. 2019 Apr;21(4):e12979. doi: 10.1111/cmi.12979. Epub 2019 Jan 15. PubMed |
| Vasoinhibin comprises a three-helix bundle and its antiangiogenic domain is located within the first 79 residues. Robles JP, Zamora M, Velasco-Bolom JL, Tovar M, Garduno-Juarez R, Bertsch T, Martinez de la Escalera G, Triebel J, Clapp C. Sci Rep. 2018 Nov 20;8(1):17111. doi: 10.1038/s41598-018-35383-7. PubMed |
| Promotion of Myoblast Differentiation by Fkbp5 via Cdk4 Isomerization. Ruiz-Estevez M, Staats J, Paatela E, Munson D, Katoku-Kikyo N, Yuan C, Asakura Y, Hostager R, Kobayashi H, Asakura A, Kikyo N. Cell Rep. 2018 Nov 27;25(9):2537-2551.e8. doi: 10.1016/j.celrep.2018.11.006. PubMed |
| PUFA-Plasmalogens Attenuate the LPS-Induced Nitric Oxide Production by Inhibiting the NF-kB, p38 MAPK and JNK Pathways in Microglial Cells. Youssef M, Ibrahim A, Akashi K, Hossain MS. Neuroscience. 2019 Jan 15;397:18-30. doi: 10.1016/j.neuroscience.2018.11.030. Epub 2018 Nov 26. PubMed |
| Honey bee Royalactin unlocks conserved pluripotency pathway in mammals. Wan DC, Morgan SL, Spencley AL, Mariano N, Chang EY, Shankar G, Luo Y, Li TH, Huh D, Huynh SK, Garcia JM, Dovey CM, Lumb J, Liu L, Brown KV, Bermudez A, Luong R, Zeng H, Mascetti VL, Pitteri SJ, Wang J, Tu H, Quarta M, Sebastiano V, Nusse R, Rando TA, Carette JE, Bazan JF, Wang KC. Nat Commun. 2018 Dec 4;9(1):5078. doi: 10.1038/s41467-018-06256-4. PubMed |
| Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 which contributes to Robinow-like syndrome in Bulldogs and related screw tail dog breeds. Mansour TA, Lucot K, Konopelski SE, Dickinson PJ, Sturges BK, Vernau KL, Choi S, Stern JA, Thomasy SM, Doring S, Verstraete FJM, Johnson EG, York D, Rebhun RB, Ho HH, Brown CT, Bannasch DL. PLoS Genet. 2018 Dec 6;14(12):e1007850. doi: 10.1371/journal.pgen.1007850. eCollection 2018 Dec. PubMed |
| Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through Haplotype Editing. Lo Sardo V, Chubukov P, Ferguson W, Kumar A, Teng EL, Duran M, Zhang L, Cost G, Engler AJ, Urnov F, Topol EJ, Torkamani A, Baldwin KK. Cell. 2018 Dec 13;175(7):1796-1810.e20. doi: 10.1016/j.cell.2018.11.014. Epub 2018 Dec 6. PubMed |
| Cancer Suicide Gene Therapy with TK.007. Hossain JA, Riecken K, Miletic H, Fehse B. Methods Mol Biol. 2019;1895:11-26. doi: 10.1007/978-1-4939-8922-5_2. PubMed |
| Disruption of protein neddylation with MLN4924 attenuates paclitaxel-induced apoptosis and microtubule polymerization in ovarian cancer cells. Hong X, Li S, Li W, Xie M, Wei Z, Guo H, Wei W, Zhang S. Biochem Biophys Res Commun. 2019 Jan 15;508(3):986-990. doi: 10.1016/j.bbrc.2018.12.048. Epub 2018 Dec 11. PubMed |
| The histone chaperone complex FACT promotes proliferative switch of G0 cancer cells. Bi L, Xie C, Yao M, Thae Hnit SS, Vignarajan S, Wang Y, Wang Q, Xi Z, Xu H, Li Z, de Souza P, Tee A, Wong M, Liu T, Zhao X, Zhou J, Xu L, Dong Q. Int J Cancer. 2018 Dec 13. doi: 10.1002/ijc.32065. PubMed |
| Toll-like receptor chaperone HSP90B1 and the immune response to Mycobacteria. Graustein AD, Misch EA, Musvosvi M, Shey M, Shah JA, Seshadri C, Aguoju A, Bowman K, Mulenga H, Veldsman A, Hanekom WA, Hatherill M, Scriba TJ, Hawn TR. PLoS One. 2018 Dec 14;13(12):e0208940. doi: 10.1371/journal.pone.0208940. eCollection 2018. PubMed |
| An amphipathic helix of vinexin alpha is necessary for a substrate stiffness-dependent conformational change in vinculin. Hino N, Ichikawa T, Kimura Y, Matsuda M, Ueda K, Kioka N. J Cell Sci. 2019 Jan 21;132(2). pii: jcs.217349. doi: 10.1242/jcs.217349. PubMed |
| Genome-wide CRISPR Analysis Identifies Substrate-Specific Conjugation Modules in ER-Associated Degradation. Leto DE, Morgens DW, Zhang L, Walczak CP, Elias JE, Bassik MC, Kopito RR. Mol Cell. 2019 Jan 17;73(2):377-389.e11. doi: 10.1016/j.molcel.2018.11.015. Epub 2018 Dec 20. PubMed |
| Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration. Bieri G, Lucin KM, O'Brien CE, Zhang H, Villeda SA, Wyss-Coray T. Mol Neurodegener. 2018 Dec 29;13(1):68. doi: 10.1186/s13024-018-0302-4. PubMed |
| Common ELF1 deletion in prostate cancer bolsters oncogenic ETS function, inhibits senescence and promotes docetaxel resistance. Budka JA, Ferris MW, Capone MJ, Hollenhorst PC. Genes Cancer. 2018 May;9(5-6):198-214. doi: 10.18632/genesandcancer.182. PubMed |
| CD46 Null Packaging Cell Line Improves Measles Lentiviral Vector Production and Gene Delivery to Hematopoietic Stem and Progenitor Cells. Ozog S, Chen CX, Simpson E, Garijo O, Timberlake ND, Minder P, Verhoeyen E, Torbett BE. Mol Ther Methods Clin Dev. 2018 Nov 24;13:27-39. doi: 10.1016/j.omtm.2018.11.006. eCollection 2019 Jun 14. PubMed |
| UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Jachimowicz RD, Beleggia F, Isensee J, Velpula BB, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T, Schmitt A, Distelmaier F, Ludecke HJ, Albrecht B, Kruger M, Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T, Peifer M, Ziv Y, Reinhardt HC, Wieczorek D, Shiloh Y. Cell. 2019 Jan 24;176(3):505-519.e22. doi: 10.1016/j.cell.2018.11.024. Epub 2019 Jan 3. PubMed |
| An efficient method for the transduction of primary pediatric glioma neurospheres. Meel MH, Metselaar DS, Waranecki P, Kaspers GJL, Hulleman E. MethodsX. 2018 Feb 27;5:173-183. doi: 10.1016/j.mex.2018.02.006. eCollection 2018. PubMed |
| Development of a Novel Anti-CD19 Chimeric Antigen Receptor: A Paradigm for an Affordable CAR T Cell Production at Academic Institutions. Castella M, Boronat A, Martin-Ibanez R, Rodriguez V, Sune G, Caballero M, Marzal B, Perez-Amill L, Martin-Antonio B, Castano J, Bueno C, Balague O, Gonzalez-Navarro EA, Serra-Pages C, Engel P, Vilella R, Benitez-Ribas D, Ortiz-Maldonado V, Cid J, Tabera J, Canals JM, Lozano M, Baumann T, Vilarrodona A, Trias E, Campo E, Menendez P, Urbano-Ispizua A, Yague J, Perez-Galan P, Rives S, Delgado J, Juan M. Mol Ther Methods Clin Dev. 2018 Dec 6;12:134-144. doi: 10.1016/j.omtm.2018.11.010. eCollection 2019 Mar 15. PubMed |
| USP15 Participates in Hepatitis C Virus Propagation through Regulation of Viral RNA Translation and Lipid Droplet Formation. Kusakabe S, Suzuki T, Sugiyama Y, Haga S, Horike K, Tokunaga M, Hirano J, Zhang H, Chen DV, Ishiga H, Komoda Y, Ono C, Fukuhara T, Yamamoto M, Ikawa M, Satoh T, Akira S, Tanaka T, Moriishi K, Fukai M, Taketomi A, Yoshio S, Kanto T, Suzuki T, Okamoto T, Matsuura Y. J Virol. 2019 Mar 5;93(6). pii: JVI.01708-18. doi: 10.1128/JVI.01708-18. Print 2019 Mar 15. PubMed |
| Non-Invasive Longitudinal Bioluminescence Imaging of Human Mesoangioblasts in Bioengineered Esophagi. Crowley C, Butler CR, Camilli C, Hynds RE, Kolluri KK, Janes SM, De Coppi P, Urbani L. Tissue Eng Part C Methods. 2019 Feb;25(2):103-113. doi: 10.1089/ten.TEC.2018.0351. PubMed |
| Activating PTEN Tumor Suppressor Expression with the CRISPR/dCas9 System. Moses C, Nugent F, Waryah CB, Garcia-Bloj B, Harvey AR, Blancafort P. Mol Ther Nucleic Acids. 2019 Mar 1;14:287-300. doi: 10.1016/j.omtn.2018.12.003. Epub 2018 Dec 14. PubMed |
| Longitudinal Visualization of Viable Cancer Cell Intratumoral Distribution in Mouse Models Using Oatp1a1-Enhanced Magnetic Resonance Imaging. Nystrom NN, Hamilton AM, Xia W, Liu S, Scholl TJ, Ronald JA. Invest Radiol. 2019 May;54(5):302-311. doi: 10.1097/RLI.0000000000000542. PubMed |
| Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State. Magtanong L, Ko PJ, To M, Cao JY, Forcina GC, Tarangelo A, Ward CC, Cho K, Patti GJ, Nomura DK, Olzmann JA, Dixon SJ. Cell Chem Biol. 2019 Mar 21;26(3):420-432.e9. doi: 10.1016/j.chembiol.2018.11.016. Epub 2019 Jan 24. PubMed |
| Regenerative potential of mouse embryonic stem cell-derived PDGFRalpha(+) cardiac lineage committed cells in infarcted myocardium. Hong SP, Song S, Lee S, Jo H, Kim HK, Han J, Park JH, Cho SW. World J Stem Cells. 2019 Jan 26;11(1):44-54. doi: 10.4252/wjsc.v11.i1.44. PubMed |
| A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity. Cao JY, Poddar A, Magtanong L, Lumb JH, Mileur TR, Reid MA, Dovey CM, Wang J, Locasale JW, Stone E, Cole SPC, Carette JE, Dixon SJ. Cell Rep. 2019 Feb 5;26(6):1544-1556.e8. doi: 10.1016/j.celrep.2019.01.043. PubMed |
Specific, sensitive and stable reporting of human mesenchymal stromal cell chondrogenesis.
De La Vega RE, Scheu M, Brown LA, Evans C, Ferreira E, Porter RM.
Tissue Eng Part C Methods. 2019 Feb 6. doi: 10.1089/ten.TEC.2018.0295.
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| Andrographolide Enhances TRAIL-Induced Apoptosis via p53-Mediated Death Receptors Up-Regulation and Suppression of the NF-small ka, CyrillicB Pathway in Bladder Cancer Cells. Deng Y, Bi R, Guo H, Yang J, Du Y, Wang C, Wei W. Int J Biol Sci. 2019 Jan 24;15(3):688-700. doi: 10.7150/ijbs.30847. eCollection 2019. PubMed |
Delivering SaCas9 mRNA by lentivirus-like bionanoparticles for transient expression and efficient genome editing.
Lu B, Javidi-Parsijani P, Makani V, Mehraein-Ghomi F, Sarhan WM, Sun D, Yoo KW, Atala ZP, Lyu P, Atala A.
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| A20 Orchestrates Inflammatory Response in the Oral Mucosa through Restraining NF-kappaB Activity. Li Y, Mooney EC, Holden SE, Xia XJ, Cohen DJ, Walsh SW, Ma A, Sahingur SE. J Immunol. 2019 Apr 1;202(7):2044-2056. doi: 10.4049/jimmunol.1801286. Epub 2019 Feb 13. PubMed |
| Egr2 overexpression in Schwann cells increases myelination frequency in vitro. Tammia M, Mi R, Sluch VM, Zhu A, Chung T, Shinn D, Zack DJ, Hoke A, Mao HQ. Heliyon. 2018 Nov 29;4(11):e00982. doi: 10.1016/j.heliyon.2018.e00982. eCollection 2018 Nov. PubMed |
| SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions. Kim TS, Jin YB, Kim YS, Kim S, Kim JK, Lee HM, Suh HW, Choe JH, Kim YJ, Koo BS, Kim HN, Jung M, Lee SH, Kim DK, Chung C, Son JW, Min JJ, Kim JM, Deng CX, Kim HS, Lee SR, Jo EK. Autophagy. 2019 Aug;15(8):1356-1375. doi: 10.1080/15548627.2019.1582743. Epub 2019 Mar 4. PubMed |
| Teneurin C-Terminal Associated Peptide (TCAP)-1 and Latrophilin Interaction in HEK293 Cells: Evidence for Modulation of Intercellular Adhesion. Husic M, Barsyte-Lovejoy D, Lovejoy DA. Front Endocrinol (Lausanne). 2019 Feb 1;10:22. doi: 10.3389/fendo.2019.00022. eCollection 2019. PubMed |
| Metastasis-associated protein 1 (MTA1) is transferred by exosomes and contributes to the regulation of hypoxia and estrogen signaling in breast cancer cells. Hannafon BN, Gin AL, Xu YF, Bruns M, Calloway CL, Ding WQ. Cell Commun Signal. 2019 Feb 19;17(1):13. doi: 10.1186/s12964-019-0325-7. PubMed |
| PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells. Tan DQ, Li Y, Yang C, Li J, Tan SH, Chin DWL, Nakamura-Ishizu A, Yang H, Suda T. Cell Rep. 2019 Feb 26;26(9):2316-2328.e6. doi: 10.1016/j.celrep.2019.02.001. PubMed |
| A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing. Angiolini F, Belloni E, Giordano M, Campioni M, Forneris F, Paronetto MP, Lupia M, Brandas C, Pradella D, Di Matteo A, Giampietro C, Jodice G, Luise C, Bertalot G, Freddi S, Malinverno M, Irimia M, Moulton JD, Summerton J, Chiapparino A, Ghilardi C, Giavazzi R, Nyqvist D, Gabellini D, Dejana E, Cavallaro U, Ghigna C. Elife. 2019 Mar 4;8. pii: 44305. doi: 10.7554/eLife.44305. PubMed |
| Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Yan X, Tang B, Chen B, Shan Y, Yang H, Iorns E, Tsui R, Denis A, Perfito N, Errington TM. Elife. 2019 Mar 12;8. pii: 43511. doi: 10.7554/eLife.43511. PubMed |
| Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration. Wang WY, Davidson CD, Lin D, Baker BM. Nat Commun. 2019 Mar 12;10(1):1186. doi: 10.1038/s41467-019-09121-0. PubMed |
| p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake. Lowman XH, Hanse EA, Yang Y, Ishak Gabra MB, Tran TQ, Li H, Kong M. Cell Rep. 2019 Mar 12;26(11):3051-3060.e4. doi: 10.1016/j.celrep.2019.02.037. PubMed |
| The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2. Skjesol A, Yurchenko M, Bosl K, Gravastrand C, Nilsen KE, Grovdal LM, Agliano F, Patane F, Lentini G, Kim H, Teti G, Kumar Sharma A, Kandasamy RK, Sporsheim B, Starheim KK, Golenbock DT, Stenmark H, McCaffrey M, Espevik T, Husebye H. PLoS Pathog. 2019 Mar 18;15(3):e1007684. doi: 10.1371/journal.ppat.1007684. eCollection 2019 Mar. PubMed |
| Autaptic cultures of human induced neurons as a versatile platform for studying synaptic function and neuronal morphology. Fenske P, Grauel MK, Brockmann MM, Dorrn AL, Trimbuch T, Rosenmund C. Sci Rep. 2019 Mar 20;9(1):4890. doi: 10.1038/s41598-019-41259-1. PubMed |
| Production and Validation of Lentiviral Vectors for CRISPR/Cas9 Delivery. Ryo LB, Thomsen EA, Mikkelsen JG. Methods Mol Biol. 2019;1961:93-109. doi: 10.1007/978-1-4939-9170-9_7. PubMed |
| Tacalcitol increases the sensitivity of colorectal cancer cells to 5-fluorouracil by downregulating the thymidylate synthase. Milczarek M, Rossowska J, Klopotowska D, Stachowicz M, Kutner A, Wietrzyk J. J Steroid Biochem Mol Biol. 2019 Jun;190:139-151. doi: 10.1016/j.jsbmb.2019.03.017. Epub 2019 Mar 25. PubMed |
| The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress. Luhr M, Torgersen ML, Szalai P, Hashim A, Brech A, Staerk J, Engedal N. J Biol Chem. 2019 May 17;294(20):8197-8217. doi: 10.1074/jbc.RA118.002829. Epub 2019 Mar 29. PubMed |
| A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma. Lytle NK, Ferguson LP, Rajbhandari N, Gilroy K, Fox RG, Deshpande A, Schurch CM, Hamilton M, Robertson N, Lin W, Noel P, Wartenberg M, Zlobec I, Eichmann M, Galvan JA, Karamitopoulou E, Gilderman T, Esparza LA, Shima Y, Spahn P, French R, Lewis NE, Fisch KM, Sasik R, Rosenthal SB, Kritzik M, Von Hoff D, Han H, Ideker T, Deshpande AJ, Lowy AM, Adams PD, Reya T. Cell. 2019 Apr 18;177(3):572-586.e22. doi: 10.1016/j.cell.2019.03.010. Epub 2019 Apr 4. PubMed |
| Bok regulates mitochondrial fusion and morphology. Schulman JJ, Szczesniak LM, Bunker EN, Nelson HA, Roe MW, Wagner LE 2nd, Yule DI, Wojcikiewicz RJH. Cell Death Differ. 2019 Dec;26(12):2682-2694. doi: 10.1038/s41418-019-0327-4. Epub 2019 Apr 11. PubMed |
| Development of a Synthetic 3-ketosteroid Delta(1)-dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells. D'Arcy BM, Swingle MR, Schambeau L, Pannell L, Prakash A, Honkanen RE. Sci Rep. 2019 Apr 12;9(1):5969. doi: 10.1038/s41598-019-42046-8. PubMed |
| RIG-I Activation by a Designer Short RNA Ligand Protects Human Immune Cells against Dengue Virus Infection without Causing Cytotoxicity. Ho V, Yong HY, Chevrier M, Narang V, Lum J, Toh YX, Lee B, Chen J, Tan EY, Luo D, Fink K. J Virol. 2019 Jun 28;93(14). pii: JVI.00102-19. doi: 10.1128/JVI.00102-19. Print 2019 Jul 15. PubMed |
| Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease. Vezzoli E, Caron I, Talpo F, Besusso D, Conforti P, Battaglia E, Sogne E, Falqui A, Petricca L, Verani M, Martufi P, Caricasole A, Bresciani A, Cecchetti O, Rivetti di Val Cervo P, Sancini G, Riess O, Nguyen H, Seipold L, Saftig P, Biella G, Cattaneo E, Zuccato C. J Clin Invest. 2019 May 6;130:2390-2403. doi: 10.1172/JCI120616. eCollection 2019 May 6. PubMed |
| A standard procedure for lentiviral-mediated labeling of murine mesenchymal stromal cells in vitro. Lupan AM, Preda MB, Burlacu A. Biotechnol Appl Biochem. 2019 May 14. doi: 10.1002/bab.1765. PubMed |
| The Lentiviral Vector Pseudotyped by Modified Rabies Glycoprotein Does Not Cause Reactive Gliosis and Neurodegeneration in Rat Hippocampus Farzaneh M, Sayyah M, Eshraghi HR, Panahi N, Mirzapourdelavar H, Gholami Pourbadie H. Iran Biomed J. 2019 Sep;23(5):324-9. Epub 2019 May 19. PubMed |
| Detection and Quantification of Label-Free Infectious Adenovirus Using a Switch-On Cell-Based Fluorescent Biosensor. Guerreiro MR, Freitas DF, Alves PM, Coroadinha AS. ACS Sens. 2019 Jun 28;4(6):1654-1661. doi: 10.1021/acssensors.9b00489. Epub 2019 Jun 5. PubMed |
| Assessment of PARP4 as a candidate breast cancer susceptibility gene. Prawira A, Munusamy P, Yuan J, Chan CHT, Koh GL, Shuen TWH, Hu J, Yap YS, Tan MH, Ang P, Lee ASG. Breast Cancer Res Treat. 2019 Aug;177(1):145-153. doi: 10.1007/s10549-019-05286-w. Epub 2019 May 22. PubMed |
| RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression. Marshall AE, Roes MV, Passos DT, DeWeerd MC, Chaikovsky AC, Sage J, Howlett CJ, Dick FA. Mol Cell Biol. 2019 Jul 29;39(16). pii: MCB.00105-19. doi: 10.1128/MCB.00105-19. Print 2019 Aug 15. PubMed |
Identification of new transmembrane proteins concentrated at the nuclear envelope using organellar proteomics of mesenchymal cells.
Cheng LC, Baboo S, Lindsay C, Brusman L, Martinez-Bartolome S, Tapia O, Zhang X, Yates JR 3rd, Gerace L.
Nucleus. 2019 Dec;10(1):126-143. doi: 10.1080/19491034.2019.1618175.
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| Allele-specific silencing as treatment for gene duplication disorders: proof-of-principle in autosomal dominant leukodystrophy. Giorgio E, Lorenzati M, Rivetti di Val Cervo P, Brussino A, Cernigoj M, Della Sala E, Bartoletti Stella A, Ferrero M, Caiazzo M, Capellari S, Cortelli P, Conti L, Cattaneo E, Buffo A, Brusco A. Brain. 2019 May 29. pii: 5506062. doi: 10.1093/brain/awz139. PubMed |
| Embryonic Chimeras with Human Pluripotent Stem Cells. De Los Angeles A, Sakurai M, Wu J. Methods Mol Biol. 2019;2005:125-151. doi: 10.1007/978-1-4939-9524-0_9. PubMed |
WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling.
Sneeggen M, Pedersen NM, Campsteijn C, Haugsten EM, Stenmark H, Schink KO.
Nat Commun. 2019 Jun 28;10(1):2850. doi: 10.1038/s41467-019-10794-w.
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| Adenovirus oncoprotein E4orf6 triggers Cullin5 neddylation to activate the CLR5 E3 ligase for p53 degradation. Guo H, Shen S, Li Y, Bi R, Zhang N, Zheng W, Deng Y, Yang Y, Yu XF, Wang C, Wei W. Biochem Biophys Res Commun. 2019 Sep 3;516(4):1242-1247. doi: 10.1016/j.bbrc.2019.07.028. Epub 2019 Jul 10. PubMed |
| Activation of the autophagy pathway by Torovirus infection is irrelevant for virus replication. Avila-Perez G, Diaz-Beneitez E, Cubas-Gaona LL, Nieves-Molina G, Rodriguez JR, Rodriguez JF, Rodriguez D. PLoS One. 2019 Jul 15;14(7):e0219428. doi: 10.1371/journal.pone.0219428. eCollection 2019. PubMed |
| A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells. Olbrich T, Vega-Sendino M, Murga M, de Carcer G, Malumbres M, Ortega S, Ruiz S, Fernandez-Capetillo O. Cell Rep. 2019 Jul 16;28(3):597-604.e4. doi: 10.1016/j.celrep.2019.06.060. PubMed |
| Regulatory mechanisms for the axonal localization of tau protein in neurons. Iwata M, Watanabe S, Yamane A, Miyasaka T, Misonou H. Mol Biol Cell. 2019 Sep 1;30(19):2441-2457. doi: 10.1091/mbc.E19-03-0183. Epub 2019 Aug 7. PubMed |
| ESCRT-mediated phagophore sealing during mitophagy. Zhen Y, Spangenberg H, Munson MJ, Brech A, Schink KO, Tan KW, Sorensen V, Wenzel EM, Radulovic M, Engedal N, Simonsen A, Raiborg C, Stenmark H. Autophagy. 2019 Aug 1:1-16. doi: 10.1080/15548627.2019.1639301. PubMed |
| A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 2. Kamikubo K, Kato H, Kioka H, Yamazaki S, Tsukamoto O, Nishida Y, Asano Y, Imamura H, Kawahara H, Shintani Y, Takashima S. J Biol Chem. 2019 Oct 4;294(40):14562-14573. doi: 10.1074/jbc.RA119.008544. Epub 2019 Aug 1. PubMed |
| Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1. Ramos I, Smith G, Ruf-Zamojski F, Martinez-Romero C, Fribourg M, Carbajal EA, Hartmann BM, Nair VD, Marjanovic N, Monteagudo PL, DeJesus VA, Mutetwa T, Zamojski M, Tan GS, Jayaprakash C, Zaslavsky E, Albrecht RA, Sealfon SC, Garcia-Sastre A, Fernandez-Sesma A. J Virol. 2019 Sep 30;93(20). pii: JVI.00559-19. doi: 10.1128/JVI.00559-19. Print 2019 Oct 15. PubMed |
| The Hippo pathway modulates resistance to BET proteins inhibitors in lung cancer cells. Gobbi G, Donati B, Do Valle IF, Reggiani F, Torricelli F, Remondini D, Castellani G, Ambrosetti DC, Ciarrocchi A, Sancisi V. Oncogene. 2019 Oct;38(42):6801-6817. doi: 10.1038/s41388-019-0924-1. Epub 2019 Aug 12. PubMed |
| Visualization of Single mRNAs in Live Neurons. Shim JY, Lee BH, Park HY. Methods Mol Biol. 2019;2038:47-61. doi: 10.1007/978-1-4939-9674-2_4. PubMed |
| A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling. Frikstad KM, Molinari E, Thoresen M, Ramsbottom SA, Hughes F, Letteboer SJF, Gilani S, Schink KO, Stokke T, Geimer S, Pedersen LB, Giles RH, Akhmanova A, Roepman R, Sayer JA, Patzke S. Cell Rep. 2019 Aug 13;28(7):1907-1922.e6. doi: 10.1016/j.celrep.2019.07.025. PubMed |
| Identification of an ATP-sensitive potassium channel in mitochondria. Paggio A, Checchetto V, Campo A, Menabo R, Di Marco G, Di Lisa F, Szabo I, Rizzuto R, De Stefani D. Nature. 2019 Aug;572(7771):609-613. doi: 10.1038/s41586-019-1498-3. Epub 2019 Aug 21. PubMed |
| A Tag-Based Affinity Purification Mass Spectrometry Workflow for Systematic Isolation of the Human Mitochondrial Protein Complexes. Wu Z, Malty R, Moutaoufik MT, Zhang Q, Jessulat M, Babu M. Adv Exp Med Biol. 2019;1158:83-100. doi: 10.1007/978-981-13-8367-0_6. PubMed |
| Upregulated MiR-9-5p Protects Against Inflammatory Response in Rats with Deep Vein Thrombosis via Inhibition of NF-kappaB p50. Ou M, Zhang Y, Cui S, Zhao S, Tu J. Inflammation. 2019 Dec;42(6):1925-1938. doi: 10.1007/s10753-019-01031-z. PubMed |
| MicroRNA-138 is a Prognostic Biomarker for Triple-Negative Breast Cancer and Promotes Tumorigenesis via TUSC2 repression. Nama S, Muhuri M, Di Pascale F, Quah S, Aswad L, Fullwood M, Sampath P. Sci Rep. 2019 Sep 3;9(1):12718. doi: 10.1038/s41598-019-49155-4. PubMed |
| B7-H3 as a Novel CAR-T Therapeutic Target for Glioblastoma. Tang X, Zhao S, Zhang Y, Wang Y, Zhang Z, Yang M, Zhu Y, Zhang G, Guo G, Tong A, Zhou L. Mol Ther Oncolytics. 2019 Jul 23;14:279-287. doi: 10.1016/j.omto.2019.07.002. eCollection 2019 Sep 27. PubMed |
| A second open reading frame in human enterovirus determines viral replication in intestinal epithelial cells. Guo H, Li Y, Liu G, Jiang Y, Shen S, Bi R, Huang H, Cheng T, Wang C, Wei W. Nat Commun. 2019 Sep 6;10(1):4066. doi: 10.1038/s41467-019-12040-9. PubMed |
| Improved GaLV-TR Glycoproteins to Pseudotype Lentiviral Vectors: Impact of Viral Protease Activity in the Production of LV Pseudotypes. Tomas HA, Mestre DA, Rodrigues AF, Guerreiro MR, Carrondo MJT, Coroadinha AS. Mol Ther Methods Clin Dev. 2019 Aug 14;15:1-8. doi: 10.1016/j.omtm.2019.08.001. eCollection 2019 Dec 13. PubMed |
| CGGBP1 regulates CTCF occupancy at repeats. Patel D, Patel M, Datta S, Singh U. Epigenetics Chromatin. 2019 Sep 23;12(1):57. doi: 10.1186/s13072-019-0305-6. PubMed |
| Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Gomes AP, Ilter D, Low V, Rosenzweig A, Shen ZJ, Schild T, Rivas MA, Er EE, McNally DR, Mutvei AP, Han J, Ou YH, Cavaliere P, Mullarky E, Nagiec M, Shin S, Yoon SO, Dephoure N, Massague J, Melnick AM, Cantley LC, Tyler JK, Blenis J. Cancer Cell. 2019 Oct 14;36(4):402-417.e13. doi: 10.1016/j.ccell.2019.08.006. Epub 2019 Sep 26. PubMed |
| Epigenetic Suppression of Interferon Lambda Receptor Expression Leads to Enhanced Human Norovirus Replication In Vitro. Arthur SE, Sorgeloos F, Hosmillo M, Goodfellow IG. mBio. 2019 Oct 1;10(5). pii: mBio.02155-19. doi: 10.1128/mBio.02155-19. PubMed |
| Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Patzke C, Brockmann MM, Dai J, Gan KJ, Grauel MK, Fenske P, Liu Y, Acuna C, Rosenmund C, Sudhof TC. Cell. 2019 Oct 3;179(2):498-513.e22. doi: 10.1016/j.cell.2019.09.011. PubMed |
| TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis. Huang HL, Liu YM, Sung TY, Huang TC, Cheng YW, Liou JP, Pan SL. Theranostics. 2019 Sep 18;9(22):6676-6689. doi: 10.7150/thno.34020. eCollection 2019. PubMed |
| Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent. Wolf DM, Segawa M, Kondadi AK, Anand R, Bailey ST, Reichert AS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS. EMBO J. 2019 Nov 15;38(22):e101056. doi: 10.15252/embj.2018101056. Epub 2019 Oct 14. PubMed |
| Ectopic expression of BIRC5-targeting miR-101-3p overcomes bone marrow stroma-mediated drug resistance in multiple myeloma cells. Abdi J, Rastgoo N, Chen Y, Chen GA, Chang H. BMC Cancer. 2019 Oct 21;19(1):975. doi: 10.1186/s12885-019-6151-x. PubMed |
| MYC predetermines the sensitivity of gastrointestinal cancer to antifolate drugs through regulating TYMS transcription. Liu T, Han Y, Yu C, Ji Y, Wang C, Chen X, Wang X, Shen J, Zhang Y, Lang JY. EBioMedicine. 2019 Oct;48:289-300. doi: 10.1016/j.ebiom.2019.10.003. Epub 2019 Oct 21. PubMed |
| A centrosome-localized calcium signal is essential for mammalian cell mitosis. Helassa N, Nugues C, Rajamanoharan D, Burgoyne RD, Haynes LP. FASEB J. 2019 Dec;33(12):14602-14610. doi: 10.1096/fj.201901662R. Epub 2019 Nov 2. PubMed |
| Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis. Rodrigues G, Hoshino A, Kenific CM, Matei IR, Steiner L, Freitas D, Kim HS, Oxley PR, Scandariato I, Casanova-Salas I, Dai J, Badwe CR, Gril B, Tesic Mark M, Dill BD, Molina H, Zhang H, Benito-Martin A, Bojmar L, Ararso Y, Offer K, LaPlant Q, Buehring W, Wang H, Jiang X, Lu TM, Liu Y, Sabari JK, Shin SJ, Narula N, Ginter PS, Rajasekhar VK, Healey JH, Meylan E, Costa-Silva B, Wang SE, Rafii S, Altorki NK, Rudin CM, Jones DR, Steeg PS, Peinado H, Ghajar CM, Bromberg J, de Sousa M, Pisapia D, Lyden D. Nat Cell Biol. 2019 Nov;21(11):1403-1412. doi: 10.1038/s41556-019-0404-4. Epub 2019 Nov 4. PubMed |
| LCP1 triggers mTORC2/AKT activity and is pharmacologically targeted by enzastaurin in hypereosinophilia. Ma G, Gezer D, Herrmann O, Feldberg K, Schemionek M, Jawhar M, Reiter A, Brummendorf TH, Koschmieder S, Chatain N. Mol Carcinog. 2020 Jan;59(1):87-103. doi: 10.1002/mc.23131. Epub 2019 Nov 6. PubMed |
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Accurate and live peroxisome biogenesis evaluation achieved by lentiviral expression of a green fluorescent protein fused to a peroxisome targeting signal 1.
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| The Peroxisome Proliferator-Activated Receptor alpha- Agonist Gemfibrozil Promotes Defense Against Mycobacterium abscessus Infections. Kim YS, Kim JK, Hanh BTB, Kim SY, Kim HJ, Kim YJ, Jeon SM, Park CR, Oh GT, Park JW, Kim JM, Jang J, Jo EK. Cells. 2020 Mar 6;9(3). pii: cells9030648. doi: 10.3390/cells9030648. PubMed |
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| Structure-Based Design and Discovery of a Long-Acting Cocaine Hydrolase Mutant with Improved Binding Affinity to Neonatal Fc Receptor for Treatment of Cocaine Abuse. Zheng F, Chen X, Kim K, Zhang T, Huang H, Zhou S, Zhang J, Jin Z, Zhan CG. AAPS J. 2020 Mar 18;22(3):62. doi: 10.1208/s12248-020-00442-3. PubMed |
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| A20 Restricts Inflammatory Response and Desensitizes Gingival Keratinocytes to Apoptosis. Li Y, Mooney EC, Xia XJ, Gupta N, Sahingur SE. Front Immunol. 2020 Mar 10;11:365. doi: 10.3389/fimmu.2020.00365. eCollection 2020. PubMed |
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| Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease. Alvarez-Quilon A, Wojtaszek JL, Mathieu MC, Patel T, Appel CD, Hustedt N, Rossi SE, Wallace BD, Setiaputra D, Adam S, Ohashi Y, Melo H, Cho T, Gervais C, Munoz IM, Grazzini E, Young JTF, Rouse J, Zinda M, Williams RS, Durocher D. Mol Cell. 2020 Jun 18;78(6):1152-1165.e8. doi: 10.1016/j.molcel.2020.05.021. Epub 2020 Jun 8. PubMed |
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| A Novel Function of Sphingosine Kinase 2 in the Metabolism of Sphinga-4,14-Diene Lipids. Couttas TA, Rustam YH, Song H, Qi Y, Teo JD, Chen J, Reid GE, Don AS. Metabolites. 2020 Jun 8;10(6). pii: metabo10060236. doi: 10.3390/metabo10060236. PubMed |
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| Epstein-Barr Virus LMP1 Promotes Syntenin-1- and Hrs-Induced Extracellular Vesicle Formation for Its Own Secretion To Increase Cell Proliferation and Migration. Nkosi D, Sun L, Duke LC, Patel N, Surapaneni SK, Singh M, Meckes DG Jr. mBio. 2020 Jun 16;11(3). pii: mBio.00589-20. doi: 10.1128/mBio.00589-20. PubMed |
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| Overexpression of ER Protein Processing and Apoptosis Regulator Genes in Human Embryonic Kidney 293 Cells Improves Gene Therapy Vectors Production. Formas-Oliveira AS, Basilio JS, Rodrigues AF, Coroadinha AS. Biotechnol J. 2020 Jul 8:e1900562. doi: 10.1002/biot.201900562. PubMed |
| Integrated Transcriptome and Network Analysis Reveals Spatiotemporal Dynamics of Calvarial Suturogenesis. Holmes G, Gonzalez-Reiche AS, Lu N, Zhou X, Rivera J, Kriti D, Sebra R, Williams AA, Donovan MJ, Potter SS, Pinto D, Zhang B, van Bakel H, Jabs EW. Cell Rep. 2020 Jul 7;32(1):107871. doi: 10.1016/j.celrep.2020.107871. PubMed |
| Transcriptional repression of PTEN in neural cells using CRISPR/dCas9 epigenetic editing. Moses C, Hodgetts SI, Nugent F, Ben-Ary G, Park KK, Blancafort P, Harvey AR. Sci Rep. 2020 Jul 9;10(1):11393. doi: 10.1038/s41598-020-68257-y. PubMed |
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| PI3K-targeting strategy using alpelisib to enhance the antitumor effect of paclitaxel in human gastric cancer. Kim KJ, Kim JW, Sung JH, Suh KJ, Lee JY, Kim SH, Lee JO, Kim JW, Kim YJ, Kim JH, Bang SM, Lee JS, Kim HK, Lee KW. Sci Rep. 2020 Jul 23;10(1):12308. doi: 10.1038/s41598-020-68998-w. PubMed |
| Design and Evaluation of AgoshRNAs with 3'-Terminal HDV Ribozymes to Enhance the Silencing Activity. Berkhout B, Herrera-Carrillo E. Methods Mol Biol. 2021;2167:225-252. doi: 10.1007/978-1-0716-0716-9_13. PubMed |
| Lentiviral gene therapy vectors encoding VIP suppressed diabetes-related inflammation and augmented pancreatic beta-cell proliferation. Erendor F, Sahin EO, Sanlioglu AD, Balci MK, Griffith TS, Sanlioglu S. Gene Ther. 2021 Apr;28(3-4):130-141. doi: 10.1038/s41434-020-0183-3. Epub 2020 Jul 30. PubMed |
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| Discovery of a Novel Chemical Scaffold Against Mutant Isocitrate Dehydrogenase 1 (IDH1). Kang CH, Choi SU, Son YH, Lee HK, Jeong HG, Yun CS, Ahn S, Park CH. Anticancer Res. 2020 Sep;40(9):4929-4935. doi: 10.21873/anticanres.14496. PubMed |
A molecular sensor to quantify the localization of proteins, DNA and nanoparticles in cells.
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| In Vivo Reporter Assays Uncover Changes in Enhancer Activity Caused by Type 2 Diabetes-Associated Single Nucleotide Polymorphisms. Eufrasio A, Perrod C, Ferreira FJ, Duque M, Galhardo M, Bessa J. Diabetes. 2020 Dec;69(12):2794-2805. doi: 10.2337/db19-1049. Epub 2020 Sep 10. PubMed |
| Molecular characterization of HLA class II binding to the LAG-3 T cell co-inhibitory receptor. MacLachlan BJ, Mason GH, Greenshields-Watson A, Triebel F, Gallimore A, Cole DK, Godkin A. Eur J Immunol. 2021 Feb;51(2):331-341. doi: 10.1002/eji.202048753. Epub 2020 Oct 9. PubMed |
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| Integration of Multiple Platforms for the Analysis of Multifluorescent Marking Technology Applied to Pediatric GBM and DIPG. Pericoli G, Petrini S, Giorda E, Ferretti R, Ajmone-Cat MA, Court W, Conti LA, De Simone R, Bencivenga P, Palma A, Di Giannatale A, Jones C, Carai A, Mastronuzzi A, de Billy E, Locatelli F, Vinci M. Int J Mol Sci. 2020 Sep 15;21(18). pii: ijms21186763. doi: 10.3390/ijms21186763. PubMed |
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| Co-culture Systems of Drug-Treated Acute Myeloid Leukemia Cells and T Cells for In Vitro and In Vivo Study. Li Y, Su R, Chen J. STAR Protoc. 2020 Sep 18;1(2). doi: 10.1016/j.xpro.2020.100097. Epub 2020 Aug 28. PubMed |
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| Orthotopic Bone Formation by Streamlined Engineering and Devitalization of Human Hypertrophic Cartilage. Pigeot S, Bourgine PE, Claude J, Scotti C, Papadimitropoulos A, Todorov A, Epple C, Peretti GM, Martin I. Int J Mol Sci. 2020 Sep 30;21(19). pii: ijms21197233. doi: 10.3390/ijms21197233. PubMed |
| Protein Disulphide Isomerase A1 Is Involved in the Regulation of Breast Cancer Cell Adhesion and Transmigration via Lung Microvascular Endothelial Cells. Stojak M, Milczarek M, Kurpinska A, Suraj-Prazmowska J, Kaczara P, Wojnar-Lason K, Banach J, Stachowicz-Suhs M, Rossowska J, Kalvins I, Wietrzyk J, Chlopicki S. Cancers (Basel). 2020 Oct 2;12(10). pii: cancers12102850. doi: 10.3390/cancers12102850. PubMed |
| Role of the SIRT1/p53 regulatory axis in oxidative stressmediated granulosa cell apoptosis. Park SA, Joo NR, Park JH, Oh SM. Mol Med Rep. 2021 Jan;23(1). pii: 20. doi: 10.3892/mmr.2020.11658. Epub 2020 Nov 12. PubMed |
| SLX4IP Promotes Telomere Maintenance in Androgen Receptor-Independent Castration-Resistant Prostate Cancer through ALT-like Telomeric PML Localization. Mangosh TL, Awadallah WN, Grabowska MM, Taylor DJ. Mol Cancer Res. 2021 Feb;19(2):301-316. doi: 10.1158/1541-7786.MCR-20-0314. Epub 2020 Nov 13. PubMed |
| EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy. Bao Y, Oguz G, Lee WC, Lee PL, Ghosh K, Li J, Wang P, Lobie PE, Ehmsen S, Ditzel HJ, Wong A, Tan EY, Lee SC, Yu Q. Nat Commun. 2020 Nov 18;11(1):5878. doi: 10.1038/s41467-020-19704-x. PubMed |
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| Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status. Murphy KJ, Reed DA, Vennin C, Conway JRW, Nobis M, Yin JX, Chambers CR, Pereira BA, Lee V, Filipe EC, Trpceski M, Ritchie S, Lucas MC, Warren SC, Skhinas JN, Magenau A, Metcalf XL, Stoehr J, Major G, Parkin A, Bidanel R, Lyons RJ, Zaratzian A, Tayao M, Da Silva A, Abdulkhalek L, Gill AJ, Johns AL, Biankin AV, Samra J, Grimmond SM, Chou A, Goetz JG, Samuel MS, Lyons JG, Burgess A, Caldon CE, Horvath LG, Daly RJ, Gadegaard N, Wang Y, Sansom OJ, Morton JP, Cox TR, Pajic M, Herrmann D, Timpson P. Sci Adv. 2021 Oct;7(40):eabh0363. doi: 10.1126/sciadv.abh0363. Epub 2021 Sep 29. PubMed |
Unraveling the functional role of DNA demethylation at specific promoters by targeted steric blockage of DNA methyltransferase with CRISPR/dCas9.
Sapozhnikov DM, Szyf M.
Nat Commun. 2021 Sep 29;12(1):5711. doi: 10.1038/s41467-021-25991-9.
PubMed
Associated Plasmids |
| A highly potent antibody effective against SARS-CoV-2 variants of concern. Fenwick C, Turelli P, Perez L, Pellaton C, Esteves-Leuenberger L, Farina A, Campos J, Lana E, Fiscalini F, Raclot C, Pojer F, Lau K, Demurtas D, Descatoire M, Joo VS, Foglierini M, Noto A, Abdelnabi R, Foo CS, Vangeel L, Neyts J, Du W, Bosch BJ, Veldman G, Leyssen P, Thiel V, LeGrand R, Levy Y, Trono D, Pantaleo G. Cell Rep. 2021 Oct 12;37(2):109814. doi: 10.1016/j.celrep.2021.109814. Epub 2021 Sep 21. PubMed |
| IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay. Akaki K, Ogata K, Yamauchi Y, Iwai N, Tse KM, Hia F, Mochizuki A, Ishihama Y, Mino T, Takeuchi O. Elife. 2021 Oct 12;10. pii: 71966. doi: 10.7554/eLife.71966. PubMed |
| Benzyl-para-di-[5-methyl-4-(n-octylamino) pyrimidin-2(1H)one] as an interferon beta (IFN-beta) modulator. Trifonov L, Yurchenko M, Skjesol A, Cohen G, Espevik T, Korshin EE, Grovdal LM, Husebye H, Gruzman A. Mol Divers. 2021 Oct 19. pii: 10.1007/s11030-021-10324-1. doi: 10.1007/s11030-021-10324-1. PubMed |
| Resistance of SARS-CoV-2 variants to neutralization by convalescent plasma from early COVID-19 outbreak in Singapore. Wang B, Goh YS, Prince T, Ngoh EZX, Salleh SNM, Hor PX, Loh CY, Fong SW, Hartley C, Tan SY, Young BE, Leo YS, Lye DC, Maurer-Stroh S, Ng LFP, Hiscox JA, Renia L, Wang CI. NPJ Vaccines. 2021 Oct 25;6(1):125. doi: 10.1038/s41541-021-00389-2. PubMed |
| GAS1 is required for NOTCH-dependent facilitation of SHH signaling in the ventral forebrain neuroepithelium. Marczenke M, Sunaga-Franze DY, Popp O, Althaus IW, Sauer S, Mertins P, Christ A, Allen BL, Willnow TE. Development. 2021 Nov 1;148(21). pii: 272617. doi: 10.1242/dev.200080. Epub 2021 Nov 11. PubMed |
| TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change. Payapilly A, Guilbert R, Descamps T, White G, Magee P, Zhou C, Kerr A, Simpson KL, Blackhall F, Dive C, Malliri A. Cell Rep. 2021 Nov 9;37(6):109979. doi: 10.1016/j.celrep.2021.109979. PubMed |
| The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes. Schink KO, Tan KW, Spangenberg H, Martorana D, Sneeggen M, Stevenin V, Enninga J, Campsteijn C, Raiborg C, Stenmark H. Nat Commun. 2021 Nov 12;12(1):6577. doi: 10.1038/s41467-021-26775-x. PubMed |
| Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer. Schenk MW, Humphrey S, Hossain ASMM, Revill M, Pearsall S, Lallo A, Brown S, Bratt S, Galvin M, Descamps T, Zhou C, Pearce SP, Priest L, Greenhalgh M, Chaturvedi A, Kerr A, Blackhall F, Dive C, Frese KK. Nat Commun. 2021 Nov 17;12(1):6652. doi: 10.1038/s41467-021-26823-6. PubMed |
| Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2. Rosarda JD, Baron KR, Nutsch K, Kline GM, Stanton C, Kelly JW, Bollong MJ, Wiseman RL. ACS Chem Biol. 2021 Dec 17;16(12):2852-2863. doi: 10.1021/acschembio.1c00810. Epub 2021 Nov 19. PubMed |
| DNA aptamers masking angiotensin converting enzyme 2 as an innovative way to treat SARS-CoV-2 pandemic. Villa A, Brunialti E, Dellavedova J, Meda C, Rebecchi M, Conti M, Donnici L, De Francesco R, Reggiani A, Lionetti V, Ciana P. Pharmacol Res. 2022 Jan;175:105982. doi: 10.1016/j.phrs.2021.105982. Epub 2021 Nov 16. PubMed |
| Production of human CAR-NK cells with lentiviral vectors and functional assessment in vitro. Portillo AL, Hogg R, Ashkar AA. STAR Protoc. 2021 Nov 17;2(4):100956. doi: 10.1016/j.xpro.2021.100956. eCollection 2021 Dec 17. PubMed |
| The Different Molecular Code in Generation of Dopaminergic Neurons from Astrocytes and Mesenchymal Stem Cells. Wang N, Ji X, Wu Y, Zhou S, Peng H, Wang J, Yu S, Zhang J. Int J Mol Sci. 2021 Nov 9;22(22). pii: ijms222212141. doi: 10.3390/ijms222212141. PubMed |
| The Fusion of CLEC12A and MIR223HG Arises from a trans-Splicing Event in Normal and Transformed Human Cells. Dhungel BP, Monteuuis G, Giardina C, Tabar MS, Feng Y, Metierre C, Ho S, Nagarajah R, Fontaine ARM, Shah JS, Gokal D, Bailey CG, Schmitz U, Rasko JEJ. Int J Mol Sci. 2021 Nov 10;22(22). pii: ijms222212178. doi: 10.3390/ijms222212178. PubMed |
| c-Met-Specific Chimeric Antigen Receptor T Cells Demonstrate Anti-Tumor Effect in c-Met Positive Gastric Cancer. Kang CH, Kim Y, Lee DY, Choi SU, Lee HK, Park CH. Cancers (Basel). 2021 Nov 16;13(22). pii: cancers13225738. doi: 10.3390/cancers13225738. PubMed |
| ELOVL2 promotes cancer progression by inhibiting cell apoptosis in renal cell carcinoma. Tanaka K, Kandori S, Sakka S, Nitta S, Tanuma K, Shiga M, Nagumo Y, Negoro H, Kojima T, Mathis BJ, Shimazui T, Watanabe M, Sato TA, Miyamoto T, Matsuzaka T, Shimano H, Nishiyama H. Oncol Rep. 2022 Feb;47(2). pii: 23. doi: 10.3892/or.2021.8234. Epub 2021 Nov 29. PubMed |
| Lentivirus-mediated Conditional Gene Expression. Rommereim L, Akhade AS, Germain RN, Fraser IDC, Subramanian N. Bio Protoc. 2021 Nov 5;11(21):e4205. doi: 10.21769/BioProtoc.4205. eCollection 2021 Nov 5. PubMed |
| Intersection of regulatory pathways controlling hemostasis and hemochorial placentation. Muto M, Chakraborty D, Varberg KM, Moreno-Irusta A, Iqbal K, Scott RL, McNally RP, Choudhury RH, Aplin JD, Okae H, Arima T, Matsumoto S, Ema M, Mast AE, Grundberg E, Soares MJ. Proc Natl Acad Sci U S A. 2021 Dec 14;118(50). pii: 2111267118. doi: 10.1073/pnas.2111267118. PubMed |
| Sphingosine 1-Phosphate Receptor 4 Promotes Nonalcoholic Steatohepatitis by Activating NLRP3 Inflammasome. Hong CH, Ko MS, Kim JH, Cho H, Lee CH, Yoon JE, Yun JY, Baek IJ, Jang JE, Lee SE, Cho YK, Baek JY, Oh SJ, Lee BY, Lim JS, Lee J, Hartig SM, Conde de la Rosa L, Garcia-Ruiz C, Lee KU, Fernandez-Checa JC, Choi JW, Kim S, Koh EH. Cell Mol Gastroenterol Hepatol. 2022;13(3):925-947. doi: 10.1016/j.jcmgh.2021.12.002. Epub 2021 Dec 8. PubMed |
| Rational design and construction of multi-copy biomanufacturing islands in mammalian cells. Altamura R, Doshi J, Benenson Y. Nucleic Acids Res. 2022 Jan 11;50(1):561-578. doi: 10.1093/nar/gkab1214. PubMed |
| Generation and Hematopoietic Differentiation of Mesenchymal Stromal/Stem Cell-Derived Induced Pluripotent Stem Cell Lines for Disease Modeling of Hematopoietic and Immunological Diseases. Guney-Esken G, Aerts-Kaya F. Methods Mol Biol. 2021 Dec 15. doi: 10.1007/7651_2021_452. PubMed |
Individual human cortical progenitors can produce excitatory and inhibitory neurons.
Delgado RN, Allen DE, Keefe MG, Mancia Leon WR, Ziffra RS, Crouch EE, Alvarez-Buylla A, Nowakowski TJ.
Nature. 2021 Dec 15. pii: 10.1038/s41586-021-04230-7. doi: 10.1038/s41586-021-04230-7.
PubMed
Associated Plasmids |
| Development, Production, and Characterization of Hepatitis B Subviral Envelope Particles as a Third-Generation Vaccine. Battagliotti JM, Fontana D, Etcheverrigaray M, Kratje R, Prieto C. Methods Mol Biol. 2022;2410:273-287. doi: 10.1007/978-1-0716-1884-4_13. PubMed |
| An In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression. Scheidmann MC, Castro-Giner F, Strittmatter K, Krol I, Paasinen-Sohns A, Scherrer R, Donato C, Gkountela S, Szczerba BM, Diamantopoulou Z, Muenst S, Vlajnic T, Kunz L, Vetter M, Rochlitz C, Taylor V, Giachino C, Schroeder T, Platt RJ, Aceto N. Cancer Res. 2022 Feb 15;82(4):681-694. doi: 10.1158/0008-5472.CAN-21-3908. PubMed |
| Confocal Imaging of Single-Cell Signaling in Orthotopic Models of Ovarian Cancer. Matvey DO, Ng TSC, Miller MA. Methods Mol Biol. 2022;2424:295-315. doi: 10.1007/978-1-0716-1956-8_19. PubMed |
| Contribution of protein-protein interactions to the endothelial-barrier-stabilizing function of KRIT1. Swamy H, Glading AJ. J Cell Sci. 2022 Jan 15;135(2). pii: 274104. doi: 10.1242/jcs.258816. Epub 2022 Jan 25. PubMed |
| A novel role for gag as a cis-acting element regulating RNA structure, dimerization and packaging in HIV-1 lentiviral vectors. Vamva E, Griffiths A, Vink CA, Lever AML, Kenyon JC. Nucleic Acids Res. 2022 Jan 11;50(1):430-448. doi: 10.1093/nar/gkab1206. PubMed |
| Targeted core-shell nanoparticles for precise CTCF gene insert in treatment of metastatic breast cancer. Duan J, Bao C, Xie Y, Guo H, Liu Y, Li J, Liu R, Li P, Bai J, Yan Y, Mu L, Li X, Wang G, Lu W. Bioact Mater. 2021 Oct 7;11:1-14. doi: 10.1016/j.bioactmat.2021.10.007. eCollection 2022 May. PubMed |
| Platelet Endothelial Cell Adhesion Molecule 1 (CD31) Is Essential for Clostridium perfringens Beta-Toxin Mediated Cytotoxicity in Human Endothelial and Monocytic Cells. Tarek B, Bruggisser J, Cattalani F, Posthaus H. Toxins (Basel). 2021 Dec 13;13(12). pii: toxins13120893. doi: 10.3390/toxins13120893. PubMed |
| Patient-Derived Xenografts of High-Grade Serous Ovarian Cancer Subtype as a Powerful Tool in Pre-Clinical Research. Cybula M, Wang L, Wang L, Drumond-Bock AL, Moxley KM, Benbrook DM, Gunderson-Jackson C, Ruiz-Echevarria MJ, Bhattacharya R, Mukherjee P, Bieniasz M. Cancers (Basel). 2021 Dec 15;13(24). pii: cancers13246288. doi: 10.3390/cancers13246288. PubMed |
| Entrectinib-A SARS-CoV-2 Inhibitor in Human Lung Tissue (HLT) Cells. Peralta-Garcia A, Torrens-Fontanals M, Stepniewski TM, Grau-Exposito J, Perea D, Ayinampudi V, Waldhoer M, Zimmermann M, Buzon MJ, Genesca M, Selent J. Int J Mol Sci. 2021 Dec 18;22(24). pii: ijms222413592. doi: 10.3390/ijms222413592. PubMed |
| Etched 3D-Printed Polycaprolactone Constructs Functionalized with Reduced Graphene Oxide for Enhanced Attachment of Dental Pulp-Derived Stem Cells. Bow AJ, Masi TJ, Dhar MS. Pharmaceutics. 2021 Dec 13;13(12). pii: pharmaceutics13122146. doi: 10.3390/pharmaceutics13122146. PubMed |
| Intestinal organoid co-culture protocol to study cell competition in vitro. van Neerven SM, Ramadan R, van Driel MS, Huels DJ, Vermeulen L. STAR Protoc. 2021 Dec 16;3(1):101050. doi: 10.1016/j.xpro.2021.101050. eCollection 2022 Mar 18. PubMed |
| Epigenetic regulation of ferroptosis via ETS1/miR-23a-3p/ACSL4 axis mediates sorafenib resistance in human hepatocellular carcinoma. Lu Y, Chan YT, Tan HY, Zhang C, Guo W, Xu Y, Sharma R, Chen ZS, Zheng YC, Wang N, Feng Y. J Exp Clin Cancer Res. 2022 Jan 3;41(1):3. doi: 10.1186/s13046-021-02208-x. PubMed |
| Engineered small extracellular vesicles displaying ACE2 variants on the surface protect against SARS-CoV-2 infection. Kim HK, Cho J, Kim E, Kim J, Yang JS, Kim KC, Lee JY, Shin Y, Palomera LF, Park J, Baek SH, Bae HG, Cho Y, Han J, Sul JH, Lee J, Park JH, Cho YW, Lee W, Jo DG. J Extracell Vesicles. 2022 Jan;11(1):e12179. doi: 10.1002/jev2.12179. PubMed |
| Decreased memory B cell frequencies in COVID-19 delta variant vaccine breakthrough infection. Tay MZ, Rouers A, Fong SW, Goh YS, Chan YH, Chang ZW, Xu W, Tan CW, Chia WN, Torres-Ruesta A, Amrun SN, Huang Y, Hor PX, Loh CY, Yeo NK, Wang B, Ngoh EZX, Salleh SNM, Chavatte JM, Lim AJ, Maurer-Stroh S, Wang LF, Lin RVTP, Wang CI, Tan SY, Young BE, Leo YS, Lye DC, Renia L, Ng LF. EMBO Mol Med. 2022 Mar 7;14(3):e15227. doi: 10.15252/emmm.202115227. Epub 2022 Jan 21. PubMed |
A Two-tiered functional screen identifies herpesviral transcriptional modifiers and their essential domains.
Morgens DW, Nandakumar D, Didychuk AL, Yang KJ, Glaunsinger BA.
PLoS Pathog. 2022 Jan 18;18(1):e1010236. doi: 10.1371/journal.ppat.1010236. eCollection 2022 Jan.
PubMed
Associated Plasmids |
| The Immune-Specific E3 Ubiquitin Ligase MARCH1 Is Upregulated during Human Cytomegalovirus Infection to Regulate Iron Levels. Martin M, Sandhu P, Kumar R, Buchkovich NJ. J Virol. 2022 Mar 23;96(6):e0180621. doi: 10.1128/jvi.01806-21. Epub 2022 Jan 19. PubMed |
| Presynaptic mechanisms underlying GABA(B)-receptor-mediated inhibition of spontaneous neurotransmitter release. Alten B, Guzikowski NJ, Zurawski Z, Hamm HE, Kavalali ET. Cell Rep. 2022 Jan 18;38(3):110255. doi: 10.1016/j.celrep.2021.110255. PubMed |
| Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4. Yamaguchi S, Zhang D, Katayama A, Kurooka N, Sugawara R, Albuayjan HHH, Nakatsuka A, Eguchi J, Wada J. Front Endocrinol (Lausanne). 2022 Jan 3;12:750261. doi: 10.3389/fendo.2021.750261. eCollection 2021. PubMed |
| CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer. Lan B, Zeng S, Zhang S, Ren X, Xing Y, Kutschick I, Pfeffer S, Frey B, Britzen-Laurent N, Grutzmann R, Cordes N, Pilarsky C. Cancers (Basel). 2022 Jan 10;14(2). pii: cancers14020326. doi: 10.3390/cancers14020326. PubMed |
| Isolation and characterization of the immune cell fraction from murine brain tumor microenvironment. Mastandrea I, Sher D, Magod P, Friedmann-Morvinski D. STAR Protoc. 2022 Jan 20;3(1):101106. doi: 10.1016/j.xpro.2021.101106. eCollection 2022 Mar 18. PubMed |
| Protein Allostery and Ligand Design: Computational Design Meets Experiments to Discover Novel Chemical Probes. Triveri A, Sanchez-Martin C, Torielli L, Serapian SA, Marchetti F, D'Acerno G, Pirota V, Castelli M, Moroni E, Ferraro M, Quadrelli P, Rasola A, Colombo G. J Mol Biol. 2022 Sep 15;434(17):167468. doi: 10.1016/j.jmb.2022.167468. Epub 2022 Jan 29. PubMed |
| Histone acetylome-wide associations in immune cells from individuals with active Mycobacterium tuberculosis infection. Del Rosario RCH, Poschmann J, Lim C, Cheng CY, Kumar P, Riou C, Ong ST, Gerges S, Hajan HS, Kumar D, Marzuki M, Lu X, Lee A, Wijaya GC, Rayan NA, Zhuang Z, Du Bruyn E, Chee CBE, Lee B, Lum J, Zolezzi F, Poidinger M, Rotzschke O, Khor CC, Wilkinson RJ, Wang YT, Chandy GK, De Libero G, Singhal A, Prabhakar S. Nat Microbiol. 2022 Feb;7(2):312-326. doi: 10.1038/s41564-021-01049-w. Epub 2022 Jan 31. PubMed |
| Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition. Facchinello N, Astone M, Audano M, Oberkersch RE, Spizzotin M, Calura E, Marques M, Crisan M, Mitro N, Santoro MM. Nat Metab. 2022 Jan;4(1):123-140. doi: 10.1038/s42255-021-00514-4. Epub 2022 Jan 27. PubMed |
| A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection. Zhou P, Yuan M, Song G, Beutler N, Shaabani N, Huang D, He WT, Zhu X, Callaghan S, Yong P, Anzanello F, Peng L, Ricketts J, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Teijaro JR, Rogers TF, Wilson IA, Burton DR, Andrabi R. Sci Transl Med. 2022 Mar 23;14(637):eabi9215. doi: 10.1126/scitranslmed.abi9215. Epub 2022 Mar 23. PubMed |
| Pathway-specific effects of ADSL deficiency on neurodevelopment. Dutto I, Gerhards J, Herrera A, Souckova O, Skopova V, Smak JA, Junza A, Yanes O, Boeckx C, Burkhalter MD, Zikanova M, Pons S, Philipp M, Luders J, Stracker TH. Elife. 2022 Feb 8;11. pii: 70518. doi: 10.7554/eLife.70518. PubMed |
| METTL16 exerts an m(6)A-independent function to facilitate translation and tumorigenesis. Su R, Dong L, Li Y, Gao M, He PC, Liu W, Wei J, Zhao Z, Gao L, Han L, Deng X, Li C, Prince E, Tan B, Qing Y, Qin X, Shen C, Xue M, Zhou K, Chen Z, Xue J, Li W, Qin H, Wu X, Sun M, Nam Y, Chen CW, Huang W, Horne D, Rosen ST, He C, Chen J. Nat Cell Biol. 2022 Feb;24(2):205-216. doi: 10.1038/s41556-021-00835-2. Epub 2022 Feb 10. PubMed |
| A Human-derived Dual MRI/PET Reporter Gene System with High Translational Potential for Cell Tracking. Shalaby N, Kelly J, Martinez F, Fox M, Qi Q, Thiessen J, Hicks J, Scholl TJ, Ronald JA. Mol Imaging Biol. 2022 Apr;24(2):341-351. doi: 10.1007/s11307-021-01697-8. Epub 2022 Feb 10. PubMed |
| Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea. Li XJ, Morgan C, Goff LA, Doetzlhofer A. Sci Adv. 2022 Feb 11;8(6):eabj7651. doi: 10.1126/sciadv.abj7651. Epub 2022 Feb 11. PubMed |
| Longitudinal Monitoring of Intra-Tumoural Heterogeneity Using Optical Barcoding of Patient-Derived Colorectal Tumour Models. Shembrey C, Smith J, Grandin M, Williams N, Cho HJ, Molck C, Behrenbruch C, Thomson BN, Heriot AG, Merino D, Hollande F. Cancers (Basel). 2022 Jan 24;14(3). pii: cancers14030581. doi: 10.3390/cancers14030581. PubMed |
| Combinatorial Approach of Binary Colloidal Crystals and CRISPR Activation to Improve Induced Pluripotent Stem Cell Differentiation into Neurons. Urrutia-Cabrera D, Hsiang-Chi Liou R, Lin J, Shi Y, Liu K, Hung SSC, Hewitt AW, Wang PY, Ching-Bong Wong R. ACS Appl Mater Interfaces. 2022 Feb 23;14(7):8669-8679. doi: 10.1021/acsami.1c17975. Epub 2022 Feb 15. PubMed |
| Ferritin-Nanocaged ATP Traverses the Blood-Testis Barrier and Enhances Sperm Motility in an Asthenozoospermia Model. Pang J, Feng X, Liang Q, Zheng X, Duan Y, Zhang X, Zhang J, Chen Y, Fan K, Gao L, Li J. ACS Nano. 2022 Mar 22;16(3):4175-4185. doi: 10.1021/acsnano.1c10029. Epub 2022 Feb 15. PubMed |
| Development of human alveolar epithelial cell models to study distal lung biology and disease. Tran E, Shi T, Li X, Chowdhury AY, Jiang D, Liu Y, Wang H, Yan C, Wallace WD, Lu R, Ryan AL, Marconett CN, Zhou B, Borok Z, Offringa IA. iScience. 2022 Jan 15;25(2):103780. doi: 10.1016/j.isci.2022.103780. eCollection 2022 Feb 18. PubMed |
| Targeted isolation of panels of diverse human protective broadly neutralizing antibodies against SARS-like viruses. He WT, Musharrafieh R, Song G, Dueker K, Tse LV, Martinez DR, Schafer A, Callaghan S, Yong P, Beutler N, Torres JL, Volk RM, Zhou P, Yuan M, Liu H, Anzanello F, Capozzola T, Parren M, Garcia E, Rawlings SA, Smith DM, Wilson IA, Safonova Y, Ward AB, Rogers TF, Baric RS, Gralinski LE, Burton DR, Andrabi R. bioRxiv. 2022 Feb 8:2021.09.08.459480. doi: 10.1101/2021.09.08.459480. Preprint. PubMed |
| PMS2 variant results in loss of ATPase activity without compromising mismatch repair. D'Arcy BM, Arrington J, Weisman J, McClellan SB, Vandana, Yang Z, Deivanayagam C, Blount J, Prakash A. Mol Genet Genomic Med. 2022 Feb 21:e1908. doi: 10.1002/mgg3.1908. PubMed |
| Plasmalogens, the Vinyl Ether-Linked Glycerophospholipids, Enhance Learning and Memory by Regulating Brain-Derived Neurotrophic Factor. Hossain MS, Mawatari S, Fujino T. Front Cell Dev Biol. 2022 Feb 9;10:828282. doi: 10.3389/fcell.2022.828282. eCollection 2022. PubMed |
| DELETE_Ferroptosis regulation by the NGLY1/NFE2L1 pathway. Forcina GC, Pope L, Murray M, Dong W, Abu-Remaileh M, Bertozzi CR, Dixon SJ. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2118646119. doi: 10.1073/pnas.2118646119. Epub 2022 Mar 10. PubMed |
| The response of three-dimensional pancreatic alpha and beta cell co-cultures to oxidative stress. Sthijns MMJPE, Rademakers T, Oosterveer J, Geuens T, van Blitterswijk CA, LaPointe VLS. PLoS One. 2022 Mar 15;17(3):e0257578. doi: 10.1371/journal.pone.0257578. eCollection 2022. PubMed |
Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease.
Zhou P, Song G, Liu H, Yuan M, He WT, Beutler N, Zhu X, Tse LV, Martinez DR, Schafer A, Anzanello F, Yong P, Peng L, Dueker K, Musharrafieh R, Callaghan S, Capozzola T, Limbo O, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Jardine JG, Safonova Y, Briney B, Rogers TF, Wilson IA, Baric RS, Gralinski LE, Burton DR, Andrabi R.
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PubMed
Associated Plasmids |
| PRMT5 regulates ATF4 transcript splicing and oxidative stress response. Szewczyk MM, Luciani GM, Vu V, Murison A, Dilworth D, Barghout SH, Lupien M, Arrowsmith CH, Minden MD, Barsyte-Lovejoy D. Redox Biol. 2022 May;51:102282. doi: 10.1016/j.redox.2022.102282. Epub 2022 Mar 11. PubMed |
| Down-regulation of the transcriptional repressor ZNF802 (JAZF1) reactivates fetal hemoglobin in beta(0)-thalassemia/HbE. Wongborisuth C, Chumchuen S, Sripichai O, Anurathaphan U, Sathirapongsasuti N, Songdej D, Tangprasittipap A, Hongeng S. Sci Rep. 2022 Mar 23;12(1):4952. doi: 10.1038/s41598-022-08920-8. PubMed |
| Identification of SARS-CoV-2 Spike Palmitoylation Inhibitors That Results in Release of Attenuated Virus with Reduced Infectivity. Ramadan AA, Mayilsamy K, McGill AR, Ghosh A, Giulianotti MA, Donow HM, Mohapatra SS, Mohapatra S, Chandran B, Deschenes RJ, Roy A. Viruses. 2022 Mar 4;14(3). pii: v14030531. doi: 10.3390/v14030531. PubMed |
| Efficient silencing of hepatitis B virus S gene through CRISPR-mediated base editing. Zhou H, Wang X, Steer CJ, Song G, Niu J. Hepatol Commun. 2022 Jul;6(7):1652-1663. doi: 10.1002/hep4.1933. Epub 2022 Mar 26. PubMed |
| Crystal structure and cellular functions of uPAR dimer. Yu S, Sui Y, Wang J, Li Y, Li H, Cao Y, Chen L, Jiang L, Yuan C, Huang M. Nat Commun. 2022 Mar 29;13(1):1665. doi: 10.1038/s41467-022-29344-y. PubMed |
| Synapse topology and downmodulation events determine the functional outcome of anti-CD19 T cell-redirecting strategies. Ramirez-Fernandez A, Aguilar-Sopena O, Diez-Alonso L, Segura-Tudela A, Dominguez-Alonso C, Roda-Navarro P, Alvarez-Vallina L, Blanco B. Oncoimmunology. 2022 Mar 23;11(1):2054106. doi: 10.1080/2162402X.2022.2054106. eCollection 2022. PubMed |
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| The MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner. Sanz-Castillo B, Hurtado B, Vara-Ciruelos D, El Bakkali A, Hermida D, Salvador-Barbero B, Martinez-Alonso D, Gonzalez-Martinez J, Santiveri C, Campos-Olivas R, Ximenez-Embun P, Munoz J, Alvarez-Fernandez M, Malumbres M. EMBO J. 2023 Jan 16;42(2):e110833. doi: 10.15252/embj.2022110833. Epub 2022 Nov 10. PubMed |
| Cell-intrinsic differences between human airway epithelial cells from children and adults. Maughan EF, Hynds RE, Pennycuick A, Nigro E, Gowers KHC, Denais C, Gomez-Lopez S, Lazarus KA, Orr JC, Pearce DR, Clarke SE, Lee DDH, Woodall MNJ, Masonou T, Case KM, Teixeira VH, Hartley BE, Hewitt RJ, Al Yaghchi C, Sandhu GS, Birchall MA, O'Callaghan C, Smith CM, De Coppi P, Butler CR, Janes SM. iScience. 2022 Oct 20;25(11):105409. doi: 10.1016/j.isci.2022.105409. eCollection 2022 Nov 18. PubMed |
| A genome-wide CRISPR screen implicates plasma membrane asymmetry in exogenous C6-ceramide toxicity. Morris SNS, Deol KK, Lange M, Olzmann JA. Biol Open. 2022 Dec 15;11(12):bio059695. doi: 10.1242/bio.059695. Epub 2022 Dec 19. PubMed |
| Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation. Muller F, Lim JKM, Bebber CM, Seidel E, Tishina S, Dahlhaus A, Stroh J, Beck J, Yapici FI, Nakayama K, Torres Fernandez L, Bragelmann J, Leprivier G, von Karstedt S. Cell Death Differ. 2023 Feb;30(2):442-456. doi: 10.1038/s41418-022-01096-8. Epub 2022 Nov 29. PubMed |
| Systematic generation and imaging of tandem repeats reveal base-pairing properties that promote RNA aggregation. Isiktas AU, Eshov A, Yang S, Guo JU. Cell Rep Methods. 2022 Nov 9;2(11):100334. doi: 10.1016/j.crmeth.2022.100334. eCollection 2022 Nov 21. PubMed |
| Acute COG complex inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra-Golgi recycling vesicles. Sumya FT, Pokrovskaya ID, D'Souza Z, Lupashin VV. Traffic. 2023 Feb;24(2):52-75. doi: 10.1111/tra.12876. Epub 2022 Dec 15. PubMed |
| Hyperactivation of p53 using CRISPRa kills human papillomavirus-driven cervical cancer cells. Idres YM, Lai AJ, McMillan NAJ, Idris A. Virus Genes. 2023 Apr;59(2):312-316. doi: 10.1007/s11262-022-01960-2. Epub 2022 Dec 6. PubMed |
| Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels. Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H. J Extracell Vesicles. 2022 Dec;11(12):e12279. doi: 10.1002/jev2.12279. PubMed |
| Transcription Factor-Forced Astrocytic Differentiation Impairs Human Glioblastoma Growth In Vitro and In Vivo. Trovato F, Stefani FR, Li J, Zetterdahl OG, Canals I, Ahlenius H, Bengzon J. Mol Cancer Ther. 2023 Feb 1;22(2):274-286. doi: 10.1158/1535-7163.MCT-21-0903. PubMed |
| A fast-growing dengue virus mutant reveals a dual role of STING in response to infection. Ng WC, Kwek SS, Sun B, Yousefi M, Ong EZ, Tan HC, Puschnik AS, Chan KR, Ooi YS, Ooi EE. Open Biol. 2022 Dec;12(12):220227. doi: 10.1098/rsob.220227. Epub 2022 Dec 14. PubMed |
| Tumor necrosis factor is a necroptosis-associated alarmin. Pinci F, Gaidt MM, Jung C, Nagl D, Kuut G, Hornung V. Front Immunol. 2022 Dec 12;13:1074440. doi: 10.3389/fimmu.2022.1074440. eCollection 2022. PubMed |
| Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2. Miluzio A, Cuomo A, Cordiglieri C, Donnici L, Pesce E, Bombaci M, Conti M, Fasciani A, Terracciano L, Manganaro L, Toccafondi M, Scagliola A, Oliveto S, Ricciardi S, Grifantini R, De Francesco R, Abrignani S, Manfrini N, Biffo S. EBioMedicine. 2023 Jan;87:104390. doi: 10.1016/j.ebiom.2022.104390. Epub 2022 Dec 28. PubMed |
| Transcriptional regulation of Satb1 in mouse trophoblast stem cells. Yu W, Chakravarthi VP, Borosha S, Dilower I, Lee EB, Ratri A, Starks RR, Fields PE, Wolfe MW, Faruque MO, Tuteja G, Rumi MAK. Front Cell Dev Biol. 2022 Dec 14;10:918235. doi: 10.3389/fcell.2022.918235. eCollection 2022. PubMed |
| MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axis. Khan P, Siddiqui JA, Kshirsagar PG, Venkata RC, Maurya SK, Mirzapoiazova T, Perumal N, Chaudhary S, Kanchan RK, Fatima M, Khan MA, Rehman AU, Lakshmanan I, Mahapatra S, Talmon GA, Kulkarni P, Ganti AK, Jain M, Salgia R, Batra SK, Nasser MW. Mol Cancer. 2023 Jan 4;22(1):1. doi: 10.1186/s12943-022-01695-6. PubMed |
CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis.
Ratnayeke N, Baris Y, Chung M, Yeeles JTP, Meyer T.
Mol Cell. 2023 Jan 5;83(1):26-42.e13. doi: 10.1016/j.molcel.2022.12.004.
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| Enhanced mitophagy driven by ADAR1-GLI1 editing supports the self-renewal of cancer stem cells in hepatocellular carcinoma. Luo J, Gong L, Yang Y, Zhang Y, Liu Q, Bai L, Fang X, Zhang B, Huang J, Liu M, Liu B, Tang Y, Wong CN, Huang J, Liu S, Li S, Ding T, Man K, Lee VH, Li Y, Ma S, Guan XY. Hepatology. 2023 Jan 24. doi: 10.1097/HEP.0000000000000299. PubMed |
| Inhibiting the Deubiquitinase UCHL1 Reduces SARS-CoV-2 Viral Uptake by ACE2. Bednash JS, Johns F, Farkas D, Elhance A, Adair J, Cress K, Yount JS, Kenney AD, Londino JD, Mallampalli RK. Am J Respir Cell Mol Biol. 2023 May;68(5):566-576. doi: 10.1165/rcmb.2022-0331OC. PubMed |
| A rabies virus-based toolkit for efficient retrograde labeling and monosynaptic tracing. Lin KZ, Li L, Ma WY, Yang X, Han ZP, Luo NS, Wang J, Xu FQ. Neural Regen Res. 2023 Aug;18(8):1827-1833. doi: 10.4103/1673-5374.358618. PubMed |
| Pharmacological tumor PDL1 depletion with chlorambucil treats ovarian cancer and melanoma: improves antitumor immunity and renders anti-PDL1-resistant tumors anti-PDL1-sensitive through NK cell effects. Bai H, Padron AS, Deng Y, Liao YJ, Murray CJ, Ontiveros C, Kari SJ, Kancharla A, Kornepati AVR, Garcia M, Reyes RM, Gupta HB, Conejo-Garcia JR, Curiel T. J Immunother Cancer. 2023 Feb;11(2):e004871. doi: 10.1136/jitc-2022-004871. PubMed |
| Tet-Regulated Expression and Optical Clearing for In Vivo Visualization of Genetically Encoded Chimeric dCas9/Fluorescent Protein Probes. Maloshenok L, Abushinova G, Kazachkina N, Bogdanov A Jr, Zherdeva V. Materials (Basel). 2023 Jan 19;16(3):940. doi: 10.3390/ma16030940. PubMed |
| Reprogramming of IL-12 secretion in the PDCD1 locus improves the anti-tumor activity of NY-ESO-1 TCR-T cells. Kim S, Park CI, Lee S, Choi HR, Kim CH. Front Immunol. 2023 Jan 30;14:1062365. doi: 10.3389/fimmu.2023.1062365. eCollection 2023. PubMed |
| Knockout of AMD-associated gene POLDIP2 reduces mitochondrial superoxide in human retinal pigment epithelial cells. Nguyen T, Urrutia-Cabrera D, Wang L, Lees JG, Wang JH, Hung SSC, Hewitt AW, Edwards TL, McLenachan S, Chen FK, Lim SY, Luu CD, Guymer R, Wong RCB. Aging (Albany NY). 2023 Feb 16;15(6):1713-1733. doi: 10.18632/aging.204522. Epub 2023 Feb 16. PubMed |
| HBZ upregulates myoferlin expression to facilitate HTLV-1 infection. Polakowski N, Sarker MAK, Hoang K, Boateng G, Rushing AW, Kendle W, Pique C, Green PL, Panfil AR, Lemasson I. PLoS Pathog. 2023 Feb 24;19(2):e1011202. doi: 10.1371/journal.ppat.1011202. eCollection 2023 Feb. PubMed |
| Efficient Redirection of NK Cells by Genetic Modification with Chemokine Receptors CCR4 and CCR2B. Feigl FF, Stahringer A, Peindl M, Dandekar G, Koehl U, Fricke S, Schmiedel D. Int J Mol Sci. 2023 Feb 4;24(4):3129. doi: 10.3390/ijms24043129. PubMed |
| Study of Effector CD8+ T Cell Interactions with Cortical Neurons in Response to Inflammation in Mouse Brain Slices and Neuronal Cultures. Lin CH, Scheller A, Liu Y, Krause E, Chang HF. Int J Mol Sci. 2023 Feb 6;24(4):3166. doi: 10.3390/ijms24043166. PubMed |
| Development of a CRISPRi Human Retinal Pigmented Epithelium Model for Functional Study of Age-Related Macular Degeneration Genes. Wang JH, Urrutia-Cabrera D, Lees JG, Mesa Mora S, Nguyen T, Hung SSC, Hewitt AW, Lim SY, Edwards TL, Wong RCB. Int J Mol Sci. 2023 Feb 8;24(4):3417. doi: 10.3390/ijms24043417. PubMed |
| NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis. Ilter D, Drapela S, Schild T, Ward NP, Adhikari E, Low V, Asara J, Oskarsson T, Lau EK, DeNicola GM, McReynolds MR, Gomes AP. Redox Biol. 2023 May;61:102627. doi: 10.1016/j.redox.2023.102627. Epub 2023 Feb 9. PubMed |
| Pterostilbene, an active constituent of blueberries, enhances innate immune activation and restricts enterovirus D68 infection. Yang Q, Li H, Li Z, Yang J, Zhang Z, Zhang L, Guo H, Wei W. Front Immunol. 2023 Feb 9;14:1118933. doi: 10.3389/fimmu.2023.1118933. eCollection 2023. PubMed |
| The MYC-regulated lncRNA LNROP (ENSG00000254887) enables MYC-driven cell proliferation by controlling the expression of OCT2. Garcia-Caballero D, Hart JR, Vogt PK. Cell Death Dis. 2023 Feb 27;14(2):168. doi: 10.1038/s41419-023-05683-6. PubMed |
| Influenza virus reduces ubiquitin E3 ligase MARCH10 expression to decrease ciliary beat frequency. Tsai M, Rayner RE, Chafin L, Farkas D, Adair J, Mishan C, Mallampalli RK, Kim SH, Cormet-Boyaka E, Londino JD. Am J Physiol Lung Cell Mol Physiol. 2023 May 1;324(5):L666-L676. doi: 10.1152/ajplung.00191.2022. Epub 2023 Feb 28. PubMed |
| CLIC and membrane wound repair pathways enable pandemic norovirus entry and infection. Ayyar BV, Ettayebi K, Salmen W, Karandikar UC, Neill FH, Tenge VR, Crawford SE, Bieberich E, Prasad BVV, Atmar RL, Estes MK. Nat Commun. 2023 Feb 28;14(1):1148. doi: 10.1038/s41467-023-36398-z. PubMed |
| CAMKK2 is upregulated in primary human osteoarthritis and its inhibition protects against chondrocyte apoptosis. Dilley JE, Seetharam A, Ding X, Bello MA, Shutter J, Burr DB, Natoli RM, McKinley TO, Sankar U. Osteoarthritis Cartilage. 2023 Jul;31(7):908-918. doi: 10.1016/j.joca.2023.02.072. Epub 2023 Feb 27. PubMed |
| Human 3D nucleus pulposus microtissue model to evaluate the potential of pre-conditioned nasal chondrocytes for the repair of degenerated intervertebral disc. Kasamkattil J, Gryadunova A, Schmid R, Gay-Dujak MHP, Dasen B, Hilpert M, Pelttari K, Martin I, Scharen S, Barbero A, Krupkova O, Mehrkens A. Front Bioeng Biotechnol. 2023 Feb 14;11:1119009. doi: 10.3389/fbioe.2023.1119009. eCollection 2023. PubMed |
| Arf6 Regulates Endocytosis and Angiogenesis by Promoting Filamentous Actin Assembly. Francis CR, Bell ML, Skripnichuk MM, Kushner EJ. bioRxiv. 2023 Feb 22:2023.02.22.529543. doi: 10.1101/2023.02.22.529543. Preprint. PubMed |
| Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma. Hastings JF, Latham SL, Kamili A, Wheatley MS, Han JZR, Wong-Erasmus M, Phimmachanh M, Nobis M, Pantarelli C, Cadell AL, O'Donnell YEI, Leong KH, Lynn S, Geng FS, Cui L, Yan S, Achinger-Kawecka J, Stirzaker C, Norris MD, Haber M, Trahair TN, Speleman F, De Preter K, Cowley MJ, Bogdanovic O, Timpson P, Cox TR, Kolch W, Fletcher JI, Fey D, Croucher DR. Sci Adv. 2023 Mar 3;9(9):eabp8314. doi: 10.1126/sciadv.abp8314. Epub 2023 Mar 3. PubMed |
| Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner. Liao L, He Y, Li SJ, Yu XM, Liu ZC, Liang YY, Yang H, Yang J, Zhang GG, Deng CM, Wei X, Zhu YD, Xu TY, Zheng CC, Cheng C, Li A, Li ZG, Liu JB, Li B. Cell Res. 2023 May;33(5):355-371. doi: 10.1038/s41422-023-00793-4. Epub 2023 Mar 8. PubMed |
| Mitochondrial redox adaptations enable alternative aspartate synthesis in SDH-deficient cells. Hart ML, Quon E, Vigil ABG, Engstrom IA, Newsom OJ, Davidsen K, Hoellerbauer P, Carlisle SM, Sullivan LB. Elife. 2023 Mar 8;12:e78654. doi: 10.7554/eLife.78654. PubMed |
Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease.
Zhou P, Song G, Liu H, Yuan M, He WT, Beutler N, Zhu X, Tse LV, Martinez DR, Schafer A, Anzanello F, Yong P, Peng L, Dueker K, Musharrafieh R, Callaghan S, Capozzola T, Limbo O, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Jardine JG, Safonova Y, Briney B, Rogers TF, Wilson IA, Baric RS, Gralinski LE, Burton DR, Andrabi R.
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| Hox genes are crucial regulators of periosteal stem cell identity. Leclerc K, Remark LH, Ramsukh M, Josephson AM, Palma L, Parente PEL, Sambon M, Lee S, Lopez EM, Morgani SM, Leucht P. Development. 2023 Mar 15;150(6):dev201391. doi: 10.1242/dev.201391. Epub 2023 Mar 24. PubMed |
| ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis. Deng CM, Zhang GG, Liu QW, Xu JJ, Liu ZC, Yang J, Xu TY, Li ZG, Zhang F, Li B. Cancer Res. 2023 Jun 2;83(11):1851-1865. doi: 10.1158/0008-5472.CAN-22-3490. PubMed |
| Restoration of mitochondrial function through activation of hypomodified tRNAs with pathogenic mutations associated with mitochondrial diseases. Tomoda E, Nagao A, Shirai Y, Asano K, Suzuki T, Battersby BJ, Suzuki T. Nucleic Acids Res. 2023 Aug 11;51(14):7563-7579. doi: 10.1093/nar/gkad139. PubMed |
| Development of SpCas9-expressing bovine mammary epithelial cell lines. Trevarton AJ, Mears ER, Moody J, Lopdell TJ, Chometon TQ, Taylor JA, Wang CJ, Littlejohn MD, Snell RG. In Vitro Cell Dev Biol Anim. 2023 Mar;59(3):163-165. doi: 10.1007/s11626-023-00756-4. Epub 2023 Mar 17. PubMed |
| GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program. Lewis M, Terre B, Knobel PA, Cheng T, Lu H, Attolini CS, Smak J, Coyaud E, Garcia-Cao I, Sharma S, Vineethakumari C, Querol J, Gil-Gomez G, Piergiovanni G, Costanzo V, Peiro S, Raught B, Zhao H, Salvatella X, Roy S, Mahjoub MR, Stracker TH. Cell Death Dis. 2023 Mar 17;14(3):201. doi: 10.1038/s41419-023-05720-4. PubMed |
| Regulatory and coding sequences of TRNP1 co-evolve with brain size and cortical folding in mammals. Kliesmete Z, Wange LE, Vieth B, Esgleas M, Radmer J, Hulsmann M, Geuder J, Richter D, Ohnuki M, Gotz M, Hellmann I, Enard W. Elife. 2023 Mar 22;12:e83593. doi: 10.7554/eLife.83593. PubMed |
| Protocol for performing pooled CRISPR-Cas9 loss-of-function screens. Mathiowetz AJ, Roberts MA, Morgens DW, Olzmann JA, Li Z. STAR Protoc. 2023 Mar 30;4(2):102201. doi: 10.1016/j.xpro.2023.102201. PubMed |
| Combined therapy with methotrexate nanoconjugate and dendritic cells with downregulated IL-10R expression modulates the tumor microenvironment and enhances the systemic anti-tumor immune response in MC38 murine colon carcinoma. Szczygiel A, Wegierek-Ciura K, Wroblewska A, Mierzejewska J, Rossowska J, Szermer-Olearnik B, Switalska M, Anger-Gora N, Goszczynski TM, Pajtasz-Piasecka E. Front Immunol. 2023 Mar 23;14:1155377. doi: 10.3389/fimmu.2023.1155377. eCollection 2023. PubMed |
| Reticulocalbin 3 Is a Novel Mediator of Glioblastoma Progression. He Y, Alejo S, Johnson JD, Jayamohan S, Sareddy GR. Cancers (Basel). 2023 Mar 28;15(7):2008. doi: 10.3390/cancers15072008. PubMed |
| The circadian protein BMAL1 supports endothelial cell cycle during angiogenesis. Astone M, Oberkersch RE, Tosi G, Biscontin A, Santoro MM. Cardiovasc Res. 2023 Aug 19;119(10):1952-1968. doi: 10.1093/cvr/cvad057. PubMed |
| Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2. Cui H, Diedrich JK, Wu DC, Lim JJ, Nottingham RM, Moresco JJ, Yates JR 3rd, Blencowe BJ, Lambowitz AM, Schimmel P. Nat Cell Biol. 2023 Apr;25(4):592-603. doi: 10.1038/s41556-023-01118-8. Epub 2023 Apr 14. PubMed |
The viral packaging motor potentiates Kaposi's sarcoma-associated herpesvirus gene expression late in infection.
McCollum CO, Didychuk AL, Liu D, Murray-Nerger LA, Cristea IM, Glaunsinger BA.
PLoS Pathog. 2023 Apr 17;19(4):e1011163. doi: 10.1371/journal.ppat.1011163. eCollection 2023 Apr.
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| Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma. Sgro A, Cursons J, Waryah C, Woodward EA, Foroutan M, Lyu R, Yeoh GCT, Leedman PJ, Blancafort P. Clin Epigenetics. 2023 Apr 29;15(1):73. doi: 10.1186/s13148-023-01482-0. PubMed |
| Protocol to screen for Sorafenib resistance regulators using pooled lentiviral shRNA library and a Sorafenib-resistant hepatocellular carcinoma cell model. Gao R, Tang F, Christofori G. STAR Protoc. 2023 Apr 30;4(2):102273. doi: 10.1016/j.xpro.2023.102273. PubMed |
| Epigenetic priming improves salvage chemotherapy in diffuse large B-cell lymphoma via endogenous retrovirus-induced cGAS-STING activation. Liu J, Min S, Kim D, Park J, Park E, Koh Y, Shin DY, Kim TK, Byun JM, Yoon SS, Hong J. Clin Epigenetics. 2023 May 3;15(1):75. doi: 10.1186/s13148-023-01493-x. PubMed |
| Pteropine orthoreoviruses use cell surface heparan sulphate as an attachment receptor. Tan CW, Gamage AM, Yap WC, Wei Tang LJ, Sun Y, Yang XL, Pyke A, Chua KB, Wang LF. Emerg Microbes Infect. 2023 Dec;12(1):2208683. doi: 10.1080/22221751.2023.2208683. PubMed |
| HER2 chimeric antigen receptor T cell immunotherapy is an effective treatment for diffuse intrinsic pontine glioma. Wang SS, Davenport AJ, Iliopoulos M, Hughes-Parry HE, Watson KA, Arcucci V, Mulazzani M, Eisenstat DD, Hansford JR, Cross RS, Jenkins MR. Neurooncol Adv. 2023 May 4;5(1):vdad024. doi: 10.1093/noajnl/vdad024. eCollection 2023 Jan-Dec. PubMed |
| Ex vivo factor VIII-modified proliferating human hepatocytes therapy for haemophilia A. Zhang K, Wu N, Cen J, Li J, Wang Z, Xia Q, Hui L. Cell Prolif. 2023 May;56(5):e13467. doi: 10.1111/cpr.13467. Epub 2023 May 17. PubMed |
Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry.
Joensuu M, Syed P, Saber SH, Lanoue V, Wallis TP, Rae J, Blum A, Gormal RS, Small C, Sanders S, Jiang A, Mahrhold S, Krez N, Cousin MA, Cooper-White R, Cooper-White JJ, Collins BM, Parton RG, Balistreri G, Rummel A, Meunier FA.
EMBO J. 2023 Jul 3;42(13):e112095. doi: 10.15252/embj.2022112095. Epub 2023 May 25.
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| FH Variant Pathogenicity Promotes Purine Salvage Pathway Dependence in Kidney Cancer. Wilde BR, Chakraborty N, Matulionis N, Hernandez S, Ueno D, Gee ME, Esplin ED, Ouyang K, Nykamp K, Shuch B, Christofk HR. Cancer Discov. 2023 Sep 6;13(9):2072-2089. doi: 10.1158/2159-8290.CD-22-0874. PubMed |
| A spike-targeting bispecific T cell engager strategy provides dual layer protection against SARS-CoV-2 infection in vivo. Li F, Xu W, Zhang X, Wang W, Su S, Han P, Wang H, Xu Y, Li M, Fan L, Zhang H, Dai Q, Lin H, Qi X, Liang J, Wang X, Jiang S, Xie Y, Lu L, Yang X. Commun Biol. 2023 Jun 1;6(1):592. doi: 10.1038/s42003-023-04955-3. PubMed |
| Anti-apoptotic protein BCL-XL as a therapeutic vulnerability in gastric cancer. Wei Y, Zhang L, Wang C, Li Z, Luo M, Xie G, Yang X, Li M, Ren S, Zhao D, Gao R, Gong JN. Animal Model Exp Med. 2023 Jun;6(3):245-254. doi: 10.1002/ame2.12330. Epub 2023 Jun 4. PubMed |
| Microbiota produced indole metabolites disrupt host cell mitochondrial energy production and inhibit Cryptosporidium parvum growth. Funkhouser-Jones LJ, Xu R, Wilke G, Fu Y, Shriefer LA, Makimaa H, Rodgers R, Kennedy EA, VanDussen KL, Stappenbeck TS, Baldridge MT, Sibley LD. bioRxiv. 2023 May 25:2023.05.25.542157. doi: 10.1101/2023.05.25.542157. Preprint. PubMed |
| Integration site-dependent HIV-1 promoter activity shapes host chromatin conformation. Collora JA, Ho YC. Genome Res. 2023 Jun;33(6):891-906. doi: 10.1101/gr.277698.123. Epub 2023 Jun 9. PubMed |
| Variants in SART3 cause a spliceosomopathy characterised by failure of testis development and neuronal defects. Ayers KL, Eggers S, Rollo BN, Smith KR, Davidson NM, Siddall NA, Zhao L, Bowles J, Weiss K, Zanni G, Burglen L, Ben-Shachar S, Rosensaft J, Raas-Rothschild A, Jorgensen A, Schittenhelm RB, Huang C, Robevska G, van den Bergen J, Casagranda F, Cyza J, Pachernegg S, Wright DK, Bahlo M, Oshlack A, O'Brien TJ, Kwan P, Koopman P, Hime GR, Girard N, Hoffmann C, Shilon Y, Zung A, Bertini E, Milh M, Ben Rhouma B, Belguith N, Bashamboo A, McElreavey K, Banne E, Weintrob N, BenZeev B, Sinclair AH. Nat Commun. 2023 Jun 9;14(1):3403. doi: 10.1038/s41467-023-39040-0. PubMed |
| Genetic Ablation of LAT1 Inhibits Growth of Liver Cancer Cells and Downregulates mTORC1 Signaling. Kim SY, Ong Q, Liao Y, Ding Z, Tan AQL, Lim LTR, Tan HM, Lim SL, Lee QY, Han W. Int J Mol Sci. 2023 May 24;24(11):9171. doi: 10.3390/ijms24119171. PubMed |
| SLIT2/ROBO1 signaling suppresses mTORC1 for organelle control and bacterial killing. Bhosle VK, Tan JM, Li T, Hua R, Kwon H, Li Z, Patel S, Tessier-Lavigne M, Robinson LA, Kim PK, Brumell JH. Life Sci Alliance. 2023 Jun 13;6(8):e202301964. doi: 10.26508/lsa.202301964. Print 2023 Aug. PubMed |
| Paraoxonase 2 (PON2) plays a limited role in murine lung tumorigenesis. Whitt AG, Neely AM, Sarkar OS, Meng S, Arumugam S, Yaddanapudi K, Li C. Sci Rep. 2023 Jun 19;13(1):9929. doi: 10.1038/s41598-023-37146-5. PubMed |
| Unrestricted Ketogenic Diet Feeding Enhances Epithelial Ovarian Cancer Growth In Vivo. AlHilli MM, Rhoades EE, Chau D, Tewari S, Reich A, Myers A, Lindner DJ, Lathia JD, Zhang R, Willard B, Cresci G, Berger NA, Reizes O. Nutrients. 2023 Jun 13;15(12):2730. doi: 10.3390/nu15122730. PubMed |
| Obesity-dependent increase in RalA activity disrupts mitochondrial dynamics in white adipocytes. Xia W, Veeragandham P, Cao Y, Xu Y, Rhyne T, Qian J, Hung CW, Zhao P, Jones Y, Gao H, Liddle C, Yu R, Downes M, Evans R, Ryden M, Wabitsch M, Reilly S, Huang J, Saltiel A. Res Sq. 2023 Jun 2:rs.3.rs-2923510. doi: 10.21203/rs.3.rs-2923510/v1. Preprint. PubMed |
| CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis. Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Parra Bravo C, Goodness D, Tian R, Grosjean P, Abskharon R, Eisenberg D, Kanaan NM, Gan L, Condello C, Swaney DL, Kampmann M. bioRxiv. 2023 Jun 26:2023.06.16.545386. doi: 10.1101/2023.06.16.545386. Preprint. PubMed |
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| The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk. Clement D, Szabo EK, Krokeide SZ, Wiiger MT, Vincenti M, Palacios D, Chang YT, Grimm C, Patel S, Stenmark H, Brech A, Majhi RK, Malmberg KJ. J Immunol. 2023 Nov 1;211(9):1348-1358. doi: 10.4049/jimmunol.2300406. PubMed |
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| MUC13 drives cancer aggressiveness and metastasis through the YAP1-dependent pathway. Doxtater K, Tripathi MK, Sekhri R, Hafeez BB, Khan S, Zafar N, Behrman SW, Yallapu MM, Jaggi M, Chauhan SC. Life Sci Alliance. 2023 Oct 4;6(12):e202301975. doi: 10.26508/lsa.202301975. Print 2023 Dec. PubMed |
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| Hypoxia-Responsive CAR-T Cells Exhibit Reduced Exhaustion and Enhanced Efficacy in Solid Tumors. Zhu X, Chen J, Li W, Xu Y, Shan J, Hong J, Zhao Y, Xu H, Ma J, Shen J, Qian C. Cancer Res. 2024 Jan 2;84(1):84-100. doi: 10.1158/0008-5472.CAN-23-1038. PubMed |
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| CD44v6 specific CAR-NK cells for targeted immunotherapy of head and neck squamous cell carcinoma. Ciulean IS, Fischer J, Quaiser A, Bach C, Abken H, Tretbar US, Fricke S, Koehl U, Schmiedel D, Grunwald T. Front Immunol. 2023 Nov 10;14:1290488. doi: 10.3389/fimmu.2023.1290488. eCollection 2023. PubMed |
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| Protocol for lentivirus-mediated delivery of genes to study neurogenesis and cognitive function in adult rodents. Xu L, Tang C. STAR Protoc. 2023 Dec 15;4(4):102761. doi: 10.1016/j.xpro.2023.102761. Epub 2023 Dec 2. PubMed |
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| NOTUM-MEDIATED WNT SILENCING DRIVES EXTRAVILLOUS TROPHOBLAST CELL LINEAGE DEVELOPMENT. Shukla V, Moreno-Irusta A, Varberg KM, Kuna M, Iqbal K, Galligos AM, Aplin JD, Choudhury RH, Okae H, Arima T, Soares MJ. bioRxiv [Preprint]. 2024 Feb 14:2024.02.13.579974. doi: 10.1101/2024.02.13.579974. PubMed |
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| An EBV-related CD4 TCR immunotherapy inhibits tumor growth in an HLA-DP5+ nasopharyngeal cancer mouse model. Wang C, Chen J, Li J, Xu Z, Huang L, Zhao Q, Chen L, Liang X, Hu H, Li G, Xiong C, Wu B, You H, Du D, Wang X, Li H, Wang Z, Chen L. J Clin Invest. 2024 Feb 27;134(8):e172092. doi: 10.1172/JCI172092. PubMed |
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| Histone H2A variant H2A.B is enriched in transcriptionally active and replicating HSV-1 lytic chromatin. Flores Cortes E, Saddoris SM, Owens AK, Gibeault R, Depledge DP, Schang LM. J Virol. 2024 Apr 16;98(4):e0201523. doi: 10.1128/jvi.02015-23. Epub 2024 Mar 7. PubMed |
| Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models. Ha HT, Liu S, Nguyen XT, Vo LK, Leong NC, Nguyen DT, Balamurugan S, Lim PY, Wu Y, Seong E, Nguyen TQ, Oh J, Wenk MR, Cazenave-Gassiot A, Yapici Z, Ong WY, Burmeister M, Nguyen LN. JCI Insight. 2024 Mar 7;9(8):e175462. doi: 10.1172/jci.insight.175462. PubMed |
| CRISPR/Cas9 model of prostate cancer identifies Kmt2c deficiency as a metastatic driver by Odam/Cabs1 gene cluster expression. Cai H, Zhang B, Ahrenfeldt J, Joseph JV, Riedel M, Gao Z, Thomsen SK, Christensen DS, Bak RO, Hager H, Vendelbo MH, Gao X, Birkbak N, Thomsen MK. Nat Commun. 2024 Mar 7;15(1):2088. doi: 10.1038/s41467-024-46370-0. PubMed |
| Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Zhang S, Yun D, Yang H, Eckstein M, Elbait GD, Zhou Y, Lu Y, Yang H, Zhang J, Dorflein I, Britzen-Laurent N, Pfeffer S, Stemmler MP, Dahl A, Mukhopadhyay D, Chang D, He H, Zeng S, Lan B, Frey B, Hampel C, Lentsch E, Gollavilli PN, Buttner C, Ekici AB, Biankin A, Schneider-Stock R, Ceppi P, Grutzmann R, Pilarsky C. Cell Death Discov. 2024 Mar 9;10(1):124. doi: 10.1038/s41420-024-01890-y. PubMed |
| Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2. Schmitt L, Lechtenberg I, Driessen D, Flores-Romero H, Skowron MA, Sekeres M, Hoppe J, Krings KS, Llewellyn TR, Peter C, Stork B, Qin N, Bhatia S, Nettersheim D, Fritz G, Garcia-Saez AJ, Muller TJJ, Wesselborg S. Cell Death Discov. 2024 Mar 9;10(1):125. doi: 10.1038/s41420-024-01901-y. PubMed |
| Novel Estrogen Receptor Dimerization BRET-Based Biosensors for Screening Estrogenic Endocrine-Disrupting Chemicals. Choi G, Kang H, Suh JS, Lee H, Han K, Yoo G, Jo H, Shin YM, Kim TJ, Youn B. Biomater Res. 2024 Mar 7;28:0010. doi: 10.34133/bmr.0010. eCollection 2024. PubMed |
| The recruitment of TRiC chaperonin in rotavirus viroplasms correlates with virus replication. Vetter J, Papa G, Tobler K, Rodriguez JM, Kley M, Myers M, Wiesendanger M, Schraner EM, Luque D, Burrone OR, Fraefel C, Eichwald C. mBio. 2024 Apr 10;15(4):e0049924. doi: 10.1128/mbio.00499-24. Epub 2024 Mar 12. PubMed |
| Detecting subtle transcriptomic perturbations induced by lncRNAs knock-down in single-cell CRISPRi screening using a new sparse supervised autoencoder neural network. Truchi M, Lacoux C, Gille C, Fassy J, Magnone V, Lopes Goncalves R, Girard-Riboulleau C, Manosalva-Pena I, Gautier-Isola M, Lebrigand K, Barbry P, Spicuglia S, Vassaux G, Rezzonico R, Barlaud M, Mari B. Front Bioinform. 2024 Mar 4;4:1340339. doi: 10.3389/fbinf.2024.1340339. eCollection 2024. PubMed |
| A gut-derived hormone regulates cholesterol metabolism. Hu X, Chen F, Jia L, Long A, Peng Y, Li X, Huang J, Wei X, Fang X, Gao Z, Zhang M, Liu X, Chen YG, Wang Y, Zhang H, Wang Y. Cell. 2024 Mar 28;187(7):1685-1700.e18. doi: 10.1016/j.cell.2024.02.024. Epub 2024 Mar 18. PubMed |
NFATC2IP is a mediator of SUMO-dependent genome integrity.
Cho T, Hoeg L, Setiaputra D, Durocher D.
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| Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons. Hees JT, Wanderoy S, Lindner J, Helms M, Murali Mahadevan H, Harbauer AB. Nat Metab. 2024 Mar;6(3):514-530. doi: 10.1038/s42255-024-01007-w. Epub 2024 Mar 19. PubMed |
| Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse. Chen M, Mainardi S, Lieftink C, Velds A, de Rink I, Yang C, Kuiken HJ, Morris B, Edwards F, Jochems F, van Tellingen O, Boeije M, Proost N, Jansen RA, Qin S, Jin H, Koen van der Mijn JC, Schepers A, Venkatesan S, Qin W, Beijersbergen RL, Wang L, Bernards R. Cell Rep Med. 2024 Mar 19;5(3):101471. doi: 10.1016/j.xcrm.2024.101471. PubMed |
| Circular RNA as a source of neoantigens for cancer vaccines. Ren Y, Manoharan T, Liu B, Cheng CZM, En Siew B, Cheong WK, Lee KY, Tan IJ, Lieske B, Tan KK, Chia G. J Immunother Cancer. 2024 Mar 19;12(3):e008402. doi: 10.1136/jitc-2023-008402. PubMed |
| Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion. Ye F, Yuan Z, Tang Y, Li J, Liu X, Sun X, Chen S, Ye X, Zeng Z, Zhang XK, Zhou H. Cell Rep. 2024 Apr 23;43(4):114002. doi: 10.1016/j.celrep.2024.114002. Epub 2024 Mar 27. PubMed |
| Mesenchymal glioma stem cells trigger vasectasia-distinct neovascularization process stimulated by extracellular vesicles carrying EGFR. Spinelli C, Adnani L, Meehan B, Montermini L, Huang S, Kim M, Nishimura T, Croul SE, Nakano I, Riazalhosseini Y, Rak J. Nat Commun. 2024 Apr 3;15(1):2865. doi: 10.1038/s41467-024-46597-x. PubMed |
| Human iPSC 4R tauopathy model uncovers modifiers of tau propagation. Parra Bravo C, Giani AM, Madero-Perez J, Zhao Z, Wan Y, Samelson AJ, Wong MY, Evangelisti A, Cordes E, Fan L, Ye P, Zhu D, Pozner T, Mercedes M, Patel T, Yarahmady A, Carling GK, Sterky FH, Lee VMY, Lee EB, DeTure M, Dickson DW, Sharma M, Mok SA, Luo W, Zhao M, Kampmann M, Gong S, Gan L. Cell. 2024 May 9;187(10):2446-2464.e22. doi: 10.1016/j.cell.2024.03.015. Epub 2024 Apr 5. PubMed |
| MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer. Zheng SM, Feng YC, Zhu Q, Li RQ, Yan QQ, Teng L, Yue YM, Han MM, Ye K, Zhang SN, Qi TF, Tang CX, Zhao XH, Zhang YY, Xu L, Xu R, Xing J, Baker M, Liu T, Thorne RF, Jin L, Preiss T, Zhang XD, Cang S, Gao JN. Cancer Res. 2024 May 2;84(9):1460-1474. doi: 10.1158/0008-5472.CAN-23-3046. PubMed |
| FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines. Macri C, Paxman M, Jenika D, Lin XP, Elahi Z, Gleeson PA, Caminschi I, Lahoud MH, Villadangos JA, Mintern JD. NPJ Vaccines. 2024 Apr 9;9(1):76. doi: 10.1038/s41541-024-00854-8. PubMed |
| Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons. Zhou X, Lee YK, Li X, Kim H, Sanchez-Priego C, Han X, Tan H, Zhou S, Fu Y, Purtell K, Wang Q, Holstein GR, Tang B, Peng J, Yang N, Yue Z. Nat Commun. 2024 Apr 10;15(1):3113. doi: 10.1038/s41467-024-47440-z. PubMed |
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