Nme2Cas9_AAV Citations (6)

Originally described in: A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In Vivo Genome Editing.
Edraki A, Mir A, Ibraheim R, Gainetdinov I, Yoon Y, Song CQ, Cao Y, Gallant J, Xue W, Rivera-Perez JA, Sontheimer EJ Mol Cell. 2018 Dec 18. pii: S1097-2765(18)31033-5. doi: 10.1016/j.molcel.2018.12.003. PubMed Journal

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Articles Citing Nme2Cas9_AAV

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A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors. Chen Z, Kwan SY, Mir A, Hazeltine M, Shin M, Liang SQ, Chan IL, Kelly K, Ghanta KS, Gaston N, Cao Y, Xie J, Gao G, Xue W, Sontheimer EJ, Watts JK. CRISPR J. 2023 Dec;6(6):570-582. doi: 10.1089/crispr.2023.0048. PubMed
Nme(2) Cas9-mediated therapeutic editing in inhibiting angiogenesis after wet age-related macular degeneration onset. Hu S, Chen Y, Xie D, Xu K, Fu Y, Chi W, Liu H, Huang J. Clin Transl Med. 2023 Aug;13(8):e1383. doi: 10.1002/ctm2.1383. PubMed
Closely related type II-C Cas9 orthologs recognize diverse PAMs. Wei J, Hou L, Liu J, Wang Z, Gao S, Qi T, Gao S, Sun S, Wang Y. Elife. 2022 Aug 12;11. pii: 77825. doi: 10.7554/eLife.77825. PubMed Associated Plasmids Nsp2Cas9_AAV Nsp2-SmuCas9_AAV NarCas9_AAV U6-Nme2_tracr
Adenine Base Editing In Vivo with a Single Adeno-Associated Virus Vector. Zhang H, Bamidele N, Liu P, Ojelabi O, Gao XD, Rodriguez T, Cheng H, Kelly K, Watts JK, Xie J, Gao G, Wolfe SA, Xue W, Sontheimer EJ. GEN Biotechnol. 2022 Jun 1;1(3):285-299. doi: 10.1089/genbio.2022.0015. Epub 2022 Jun 14. PubMed Associated Plasmids pEJS-HZ79 All-in-one AAV-U1a-NmeABE8e-2xBPSV40-U6-Rosa26_V2 pEJS1964 All-in-one AAV-U1a-NmeABE-8e-2xBPSV40-miniU6-Rosa26 pEJS1830 All-in-one AAV-U1a-NmeABE-8e-2xBPSV40-U6-Fah pEJS1831 All-in-one AAV-U1a-NmeABE-8e-2xBPSV40-miniU6-Fah pEJS-HZ54 All-in-one AAV-U1a-NmeABE8e-2xBPSV40-U6-Rosa26
Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo. Ibraheim R, Tai PWL, Mir A, Javeed N, Wang J, Rodriguez TC, Namkung S, Nelson S, Khokhar ES, Mintzer E, Maitland S, Chen Z, Cao Y, Tsagkaraki E, Wolfe SA, Wang D, Pai AA, Xue W, Gao G, Sontheimer EJ. Nat Commun. 2021 Nov 1;12(1):6267. doi: 10.1038/s41467-021-26518-y. PubMed Associated Plasmids pEJS1089: mini-AAV.sgRNA.Nme2Cas9 pEJS1099: Dual-sgRNA.Design 4 pEJS1096 Dual-sgRNA.Design 1
Single AAV-mediated CRISPR-Nme2Cas9 efficiently reduces mutant hTTR expression in a transgenic mouse model of transthyretin amyloidosis. Wen J, Cao T, Wu J, Chen Y, Zhi S, Huang Y, Zhen P, Wu G, Aagaard L, Zhong J, Liang P, Huang J. Mol Ther. 2022 Jan 5;30(1):164-174. doi: 10.1016/j.ymthe.2021.05.010. Epub 2021 May 14. PubMed

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