EGFP-LC3 Citations (171)
Originally described in: Subversion of cellular autophagosomal machinery by RNA viruses.Jackson WT, Giddings TH, Taylor MP, Mulinyawe S, Rabinovitch M, Kopito RR, Kirkegaard K PLoS Biol. 2005 May . 3(5):e156. PubMed Journal
Articles Citing EGFP-LC3
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| TBK1 protects vacuolar integrity during intracellular bacterial infection. Radtke AL, Delbridge LM, Balachandran S, Barber GN, O'Riordan MX. PLoS Pathog. 2007 Mar;3(3):e29. PubMed |
| Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy. Zabirnyk O, Liu W, Khalil S, Sharma A, Phang JM. Carcinogenesis. 2010 Mar;31(3):446-54. doi: 10.1093/carcin/bgp299. Epub 2009 Nov 25. PubMed |
| Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells. Carayol N, Vakana E, Sassano A, Kaur S, Goussetis DJ, Glaser H, Druker BJ, Donato NJ, Altman JK, Barr S, Platanias LC. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12469-74. doi: 10.1073/pnas.1005114107. Epub 2010 Jun 28. PubMed |
| Autophagy is a critical mechanism for the induction of the antileukemic effects of arsenic trioxide. Goussetis DJ, Altman JK, Glaser H, McNeer JL, Tallman MS, Platanias LC. J Biol Chem. 2010 Sep 24;285(39):29989-97. doi: 10.1074/jbc.M109.090530. Epub 2010 Jul 23. PubMed |
| Fragmentation of the Golgi apparatus provides replication membranes for human rhinovirus 1A. Quiner CA, Jackson WT. Virology. 2010 Nov 25;407(2):185-95. doi: 10.1016/j.virol.2010.08.012. Epub 2010 Sep 9. PubMed |
| Alix regulates egress of hepatitis B virus naked capsid particles in an ESCRT-independent manner. Bardens A, Doring T, Stieler J, Prange R. Cell Microbiol. 2011 Apr;13(4):602-19. doi: 10.1111/j.1462-5822.2010.01557.x. Epub 2010 Dec 28. PubMed |
| Mutant A53T alpha-synuclein induces neuronal death by increasing mitochondrial autophagy. Choubey V, Safiulina D, Vaarmann A, Cagalinec M, Wareski P, Kuum M, Zharkovsky A, Kaasik A. J Biol Chem. 2011 Mar 25;286(12):10814-24. doi: 10.1074/jbc.M110.132514. Epub 2011 Jan 20. PubMed |
| Pancreatic cancers require autophagy for tumor growth. Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC. Genes Dev. 2011 Apr 1;25(7):717-29. doi: 10.1101/gad.2016111. Epub 2011 Mar 15. PubMed |
| Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a gamma-secretase-independent manner. Neely KM, Green KN, LaFerla FM. J Neurosci. 2011 Feb 23;31(8):2781-91. doi: 10.1523/JNEUROSCI.5156-10.2010. PubMed |
| Role of autophagy in angiogenesis in aortic endothelial cells. Du J, Teng RJ, Guan T, Eis A, Kaul S, Konduri GG, Shi Y. Am J Physiol Cell Physiol. 2012 Jan 15;302(2):C383-91. doi: 10.1152/ajpcell.00164.2011. Epub 2011 Oct 26. PubMed |
| PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity. Ramonet D, Podhajska A, Stafa K, Sonnay S, Trancikova A, Tsika E, Pletnikova O, Troncoso JC, Glauser L, Moore DJ. Hum Mol Genet. 2012 Apr 15;21(8):1725-43. doi: 10.1093/hmg/ddr606. Epub 2011 Dec 20. PubMed |
| Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma. O'Dell MR, Huang JL, Whitney-Miller CL, Deshpande V, Rothberg P, Grose V, Rossi RM, Zhu AX, Land H, Bardeesy N, Hezel AF. Cancer Res. 2012 Mar 15;72(6):1557-67. doi: 10.1158/0008-5472.CAN-11-3596. Epub 2012 Jan 20. PubMed |
| Mcl-1 determines the imiquimod-induced apoptosis but not imiquimod-induced autophagy in skin cancer cells. Huang SW, Chang CC, Lin CC, Tsai JJ, Chen YJ, Wu CY, Liu KT, Shieh JJ. J Dermatol Sci. 2012 Mar;65(3):170-8. doi: 10.1016/j.jdermsci.2011.11.001. Epub 2011 Nov 16. PubMed |
| Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. Scheibye-Knudsen M, Ramamoorthy M, Sykora P, Maynard S, Lin PC, Minor RK, Wilson DM 3rd, Cooper M, Spencer R, de Cabo R, Croteau DL, Bohr VA. J Exp Med. 2012 Apr 9;209(4):855-69. doi: 10.1084/jem.20111721. Epub 2012 Apr 2. PubMed |
| A knockout of the Tsg101 gene leads to decreased expression of ErbB receptor tyrosine kinases and induction of autophagy prior to cell death. Morris CR, Stanton MJ, Manthey KC, Oh KB, Wagner KU. PLoS One. 2012;7(3):e34308. doi: 10.1371/journal.pone.0034308. Epub 2012 Mar 30. PubMed |
| Identification of novel human damage response proteins targeted through yeast orthology. Svensson JP, Fry RC, Wang E, Somoza LA, Samson LD. PLoS One. 2012;7(5):e37368. doi: 10.1371/journal.pone.0037368. Epub 2012 May 16. PubMed |
| Glutaminolysis activates Rag-mTORC1 signaling. Duran RV, Oppliger W, Robitaille AM, Heiserich L, Skendaj R, Gottlieb E, Hall MN. Mol Cell. 2012 Aug 10;47(3):349-58. doi: 10.1016/j.molcel.2012.05.043. Epub 2012 Jun 29. PubMed |
| Dysregulation of autophagy in murine fibroblasts resistant to HSV-1 infection. Le Sage V, Banfield BW. PLoS One. 2012;7(8):e42636. doi: 10.1371/journal.pone.0042636. Epub 2012 Aug 10. PubMed |
| Impaired autophagy leads to abnormal dendritic cell-epithelial cell interactions. Strisciuglio C, Duijvestein M, Verhaar AP, Vos AC, van den Brink GR, Hommes DW, Wildenberg ME. J Crohns Colitis. 2013 Aug;7(7):534-41. doi: 10.1016/j.crohns.2012.08.009. Epub 2012 Sep 13. PubMed |
| Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome. Tumbarello DA, Waxse BJ, Arden SD, Bright NA, Kendrick-Jones J, Buss F. Nat Cell Biol. 2012 Oct;14(10):1024-35. doi: 10.1038/ncb2589. Epub 2012 Sep 30. PubMed |
| Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells. Zou Z, Yuan Z, Zhang Q, Long Z, Chen J, Tang Z, Zhu Y, Chen S, Xu J, Yan M, Wang J, Liu Q. Autophagy. 2012 Dec;8(12):1798-810. doi: 10.4161/auto.22110. Epub 2012 Oct 1. PubMed |
| The ubiquitin ligase Mul1 induces mitophagy in skeletal muscle in response to muscle-wasting stimuli. Lokireddy S, Wijesoma IW, Teng S, Bonala S, Gluckman PD, McFarlane C, Sharma M, Kambadur R. Cell Metab. 2012 Nov 7;16(5):613-24. doi: 10.1016/j.cmet.2012.10.005. PubMed |
| p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells. Huang SW, Wu CY, Wang YT, Kao JK, Lin CC, Chang CC, Mu SW, Chen YY, Chiu HW, Chang CH, Liang SM, Chen YJ, Huang JL, Shieh JJ. Toxicol Appl Pharmacol. 2013 Feb 15;267(1):113-24. doi: 10.1016/j.taap.2012.12.016. Epub 2012 Dec 27. PubMed |
| Human papillomavirus infection is inhibited by host autophagy in primary human keratinocytes. Griffin LM, Cicchini L, Pyeon D. Virology. 2013 Mar 1;437(1):12-9. doi: 10.1016/j.virol.2012.12.004. Epub 2013 Jan 4. PubMed |
| Heat shock factor 1 (HSF1) controls chemoresistance and autophagy through transcriptional regulation of autophagy-related protein 7 (ATG7). Desai S, Liu Z, Yao J, Patel N, Chen J, Wu Y, Ahn EE, Fodstad O, Tan M. J Biol Chem. 2013 Mar 29;288(13):9165-76. doi: 10.1074/jbc.M112.422071. Epub 2013 Feb 5. PubMed |
| Mesenchymal bone marrow stem cells within polyglycolic acid tube observed in vivo after six weeks enhance facial nerve regeneration. Costa HJ, Ferreira Bento R, Salomone R, Azzi-Nogueira D, Zanatta DB, Paulino Costa M, da Silva CF, Strauss BE, Haddad LA. Brain Res. 2013 May 13;1510:10-21. doi: 10.1016/j.brainres.2013.03.025. Epub 2013 Mar 28. PubMed |
| Streptolysin O and its co-toxin NAD-glycohydrolase protect group A Streptococcus from Xenophagic killing. O'Seaghdha M, Wessels MR. PLoS Pathog. 2013;9(6):e1003394. doi: 10.1371/journal.ppat.1003394. Epub 2013 Jun 6. PubMed |
| Spatiotemporally controlled induction of autophagy-mediated lysosome turnover. Hung YH, Chen LM, Yang JY, Yang WY. Nat Commun. 2013;4:2111. doi: 10.1038/ncomms3111. PubMed |
| Bit-by-bit autophagic removal of parkin-labelled mitochondria. Yang JY, Yang WY. Nat Commun. 2013;4:2428. doi: 10.1038/ncomms3428. PubMed |
| Describing autophagy via analysis of individual organelles by capillary electrophoresis with laser induced fluorescence detection. Satori CP, Arriaga EA. Anal Chem. 2013 Dec 3;85(23):11391-400. doi: 10.1021/ac4023549. Epub 2013 Nov 14. PubMed |
| Autophagy mediates avian influenza H5N1 pseudotyped particle-induced lung inflammation through NF-kappaB and p38 MAPK signaling pathways. Pan H, Zhang Y, Luo Z, Li P, Liu L, Wang C, Wang H, Li H, Ma Y. Am J Physiol Lung Cell Mol Physiol. 2014 Jan;306(2):L183-95. doi: 10.1152/ajplung.00147.2013. Epub 2013 Nov 15. PubMed |
| Resveratrol induced ER expansion and ER caspase-mediated apoptosis in human nasopharyngeal carcinoma cells. Chow SE, Kao CH, Liu YT, Cheng ML, Yang YW, Huang YK, Hsu CC, Wang JS. Apoptosis. 2014 Mar;19(3):527-41. doi: 10.1007/s10495-013-0945-0. PubMed |
| In vitro and in vivo antitumor effects of Peanut agglutinin through induction of apoptotic and autophagic cell death. Mukhopadhyay S, Panda PK, Behera B, Das CK, Hassan MK, Das DN, Sinha N, Bissoyi A, Pramanik K, Maiti TK, Bhutia SK. Food Chem Toxicol. 2014 Feb;64:369-77. doi: 10.1016/j.fct.2013.11.046. Epub 2013 Dec 9. PubMed |
| The Vac14-interaction network is linked to regulators of the endolysosomal and autophagic pathway. Schulze U, Vollenbroker B, Braun DA, Van Le T, Granado D, Kremerskothen J, Franzel B, Klosowski R, Barth J, Fufezan C, Wolters DA, Pavenstadt H, Weide T. Mol Cell Proteomics. 2014 Jun;13(6):1397-411. doi: 10.1074/mcp.M113.034108. Epub 2014 Feb 27. PubMed |
| Role of autophagy in high linear energy transfer radiation-induced cytotoxicity to tumor cells. Jin X, Liu Y, Ye F, Liu X, Furusawa Y, Wu Q, Li F, Zheng X, Dai Z, Li Q. Cancer Sci. 2014 Jul;105(7):770-8. doi: 10.1111/cas.12422. Epub 2014 May 24. PubMed |
| Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik. Chen S, Zhou L, Zhang Y, Leng Y, Pei XY, Lin H, Jones R, Orlowski RZ, Dai Y, Grant S. Mol Cell Biol. 2014 Sep 15;34(18):3435-49. doi: 10.1128/MCB.01383-13. Epub 2014 Jul 7. PubMed |
| Endoplasmic reticulum vacuolation and unfolded protein response leading to paraptosis like cell death in cyclosporine A treated cancer cervix cells is mediated by cyclophilin B inhibition. Ram BM, Ramakrishna G. Biochim Biophys Acta. 2014 Nov;1843(11):2497-512. doi: 10.1016/j.bbamcr.2014.06.020. Epub 2014 Jul 5. PubMed |
| Antitumor effect of soybean lectin mediated through reactive oxygen species-dependent pathway. Panda PK, Mukhopadhyay S, Behera B, Bhol CS, Dey S, Das DN, Sinha N, Bissoyi A, Pramanik K, Maiti TK, Bhutia SK. Life Sci. 2014 Aug 28;111(1-2):27-35. doi: 10.1016/j.lfs.2014.07.004. Epub 2014 Jul 23. PubMed |
| A Bim-targeting strategy overcomes adaptive bortezomib resistance in myeloma through a novel link between autophagy and apoptosis. Chen S, Zhang Y, Zhou L, Leng Y, Lin H, Kmieciak M, Pei XY, Jones R, Orlowski RZ, Dai Y, Grant S. Blood. 2014 Oct 23;124(17):2687-97. doi: 10.1182/blood-2014-03-564534. Epub 2014 Sep 10. PubMed |
| YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Cheng SM, Chang YC, Liu CY, Lee JY, Chan HH, Kuo CW, Lin KY, Tsai SL, Chen SH, Li CF, Leung E, Kanwar JR, Huang CC, Chang JY, Cheung CH. Br J Pharmacol. 2015 Jan;172(1):214-34. doi: 10.1111/bph.12935. Epub 2014 Dec 1. PubMed |
| Molecular mechanisms of fenofibrate-induced metabolic catastrophe and glioblastoma cell death. Wilk A, Wyczechowska D, Zapata A, Dean M, Mullinax J, Marrero L, Parsons C, Peruzzi F, Culicchia F, Ochoa A, Grabacka M, Reiss K. Mol Cell Biol. 2015 Jan;35(1):182-98. doi: 10.1128/MCB.00562-14. Epub 2014 Oct 20. PubMed |
| Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer. Wen Y, Graybill WS, Previs RA, Hu W, Ivan C, Mangala LS, Zand B, Nick AM, Jennings NB, Dalton HJ, Sehgal V, Ram P, Lee JS, Vivas-Mejia PE, Coleman RL, Sood AK. Clin Cancer Res. 2015 Jan 15;21(2):448-59. doi: 10.1158/1078-0432.CCR-14-1578. Epub 2014 Nov 21. PubMed |
| Iron alters cell survival in a mitochondria-dependent pathway in ovarian cancer cells. Bauckman K, Haller E, Taran N, Rockfield S, Ruiz-Rivera A, Nanjundan M. Biochem J. 2015 Mar 1;466(2):401-13. doi: 10.1042/BJ20140878. PubMed |
| Targeting Hedgehog signaling pathway and autophagy overcomes drug resistance of BCR-ABL-positive chronic myeloid leukemia. Zeng X, Zhao H, Li Y, Fan J, Sun Y, Wang S, Wang Z, Song P, Ju D. Autophagy. 2015;11(2):355-72. doi: 10.4161/15548627.2014.994368. PubMed |
| A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications. Guo S, Liang Y, Murphy SF, Huang A, Shen H, Kelly DF, Sobrado P, Sheng Z. Autophagy. 2015;11(3):560-72. doi: 10.1080/15548627.2015.1017181. PubMed |
| Imiquimod-induced AMPK activation causes translation attenuation and apoptosis but not autophagy. Wang ST, Huang SW, Kao JK, Liang SM, Chen YJ, Chen YY, Wu CY, Shieh JJ. J Dermatol Sci. 2015 May;78(2):108-16. doi: 10.1016/j.jdermsci.2015.02.008. Epub 2015 Feb 23. PubMed |
| Impaired autophagy in mouse embryonic fibroblasts null for Kruppel-like Factor 4 promotes DNA damage and increases apoptosis upon serum starvation. Liu C, DeRoo EP, Stecyk C, Wolsey M, Szuchnicki M, Hagos EG. Mol Cancer. 2015 May 6;14:101. doi: 10.1186/s12943-015-0373-6. PubMed |
| Altered lysosomal positioning affects lysosomal functions in a cellular model of Huntington's disease. Erie C, Sacino M, Houle L, Lu ML, Wei J. Eur J Neurosci. 2015 May 22. doi: 10.1111/ejn.12957. PubMed |
| Impacts of autophagy-inducing ingredient of areca nut on tumor cells. Yen CY, Chiang WF, Liu SY, Lin CC, Liao KA, Lin CY, Hsieh WF, Cheng YC, Hsu KC, Lin PY, Chen TC, Lee IL, Lin MH, Liu YC. PLoS One. 2015 May 27;10(5):e0128011. doi: 10.1371/journal.pone.0128011. eCollection 2015. PubMed |
| alpha-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway. Hasanain M, Bhattacharjee A, Pandey P, Ashraf R, Singh N, Sharma S, Vishwakarma AL, Datta D, Mitra K, Sarkar J. Cell Death Dis. 2015 Aug 27;6:e1860. doi: 10.1038/cddis.2015.219. PubMed |
| Autophagy Contributes to the Induction of Anti-TNF Induced Macrophages. Levin AD, Koelink PJ, Bloemendaal FM, Vos AC, D'Haens GR, van den Brink GR, Wildenberg ME. J Crohns Colitis. 2015 Sep 27. pii: jjv174. PubMed |
| EGCG antagonizes Bortezomib cytotoxicity in prostate cancer cells by an autophagic mechanism. Modernelli A, Naponelli V, Giovanna Troglio M, Bonacini M, Ramazzina I, Bettuzzi S, Rizzi F. Sci Rep. 2015 Oct 16;5:15270. doi: 10.1038/srep15270. PubMed |
| CGK733-induced LC3 II formation is positively associated with the expression of cyclin-dependent kinase inhibitor p21Waf1/Cip1 through modulation of the AMPK and PERK/CHOP signaling pathways. Wang Y, Kuramitsu Y, Baron B, Kitagawa T, Tokuda K, Akada J, Nakamura K. Oncotarget. 2015 Nov 24;6(37):39692-701. doi: 10.18632/oncotarget.5625. PubMed |
| TSG101 Silencing Suppresses Hepatocellular Carcinoma Cell Growth by Inducing Cell Cycle Arrest and Autophagic Cell Death. Shao Z, Ji W, Liu A, Qin A, Shen L, Li G, Zhou Y, Hu X, Yu E, Jin G. Med Sci Monit. 2015 Nov 5;21:3371-9. PubMed |
| Ferritinophagy drives uropathogenic Escherichia coli persistence in bladder epithelial cells. Bauckman KA, Mysorekar IU. Autophagy. 2016 May 3;12(5):850-63. doi: 10.1080/15548627.2016.1160176. PubMed |
| Inhibition of BMI1 induces autophagy-mediated necroptosis. Dey A, Mustafi SB, Saha S, Kumar Dhar Dwivedi S, Mukherjee P, Bhattacharya R. Autophagy. 2016 Apr 2;12(4):659-70. doi: 10.1080/15548627.2016.1147670. PubMed |
| Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipids. Swiader A, Nahapetyan H, Faccini J, D'Angelo R, Mucher E, Elbaz M, Boya P, Vindis C. Oncotarget. 2016 May 17;7(20):28821-35. doi: 10.18632/oncotarget.8936. PubMed |
| Abrus agglutinin, a type II ribosome inactivating protein inhibits Akt/PH domain to induce endoplasmic reticulum stress mediated autophagy-dependent cell death. Panda PK, Behera B, Meher BR, Das DN, Mukhopadhyay S, Sinha N, Naik PP, Roy B, Das J, Paul S, Maiti TK, Agarwal R, Bhutia SK. Mol Carcinog. 2016 May 16. doi: 10.1002/mc.22502. PubMed |
| TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells. Ra EA, Lee TA, Won Kim S, Park A, Choi HJ, Jang I, Kang S, Hee Cheon J, Cho JW, Eun Lee J, Lee S, Park B. Nat Commun. 2016 May 24;7:11726. doi: 10.1038/ncomms11726. PubMed |
| Delivery of a survivin promoter-driven antisense survivin-expressing plasmid DNA as a cancer therapeutic: a proof-of-concept study. Lin KY, Cheng SM, Tsai SL, Tsai JY, Lin CH, Cheung CH. Onco Targets Ther. 2016 May 3;9:2601-13. doi: 10.2147/OTT.S101209. eCollection 2016. PubMed |
| Bacopa monnieri-Induced Protective Autophagy Inhibits Benzo[a]pyrene-Mediated Apoptosis. Das DN, Naik PP, Nayak A, Panda PK, Mukhopadhyay S, Sinha N, Bhutia SK. Phytother Res. 2016 Nov;30(11):1794-1801. doi: 10.1002/ptr.5682. Epub 2016 Jul 19. PubMed |
| TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy. Garcia-Aguilar A, Guillen C, Nellist M, Bartolome A, Benito M. Biochim Biophys Acta. 2016 Nov;1863(11):2658-2667. doi: 10.1016/j.bbamcr.2016.08.006. Epub 2016 Aug 16. PubMed |
| Telomerase reverse transcriptase induces basal and amino acid starvation-induced autophagy through mTORC1. Ali M, Devkota S, Roh JI, Lee J, Lee HW. Biochem Biophys Res Commun. 2016 Sep 23;478(3):1198-204. doi: 10.1016/j.bbrc.2016.08.094. Epub 2016 Aug 18. PubMed |
| PRNP/prion protein regulates the secretion of exosomes modulating CAV1/caveolin-1-suppressed autophagy. Dias MV, Teixeira BL, Rodrigues BR, Sinigaglia-Coimbra R, Porto-Carreiro I, Roffe M, Hajj GN, Martins VR. Autophagy. 2016 Nov;12(11):2113-2128. Epub 2016 Sep 14. PubMed |
| Antiviral activities of selected antimalarials against dengue virus type 2 and Zika virus. Balasubramanian A, Teramoto T, Kulkarni AA, Bhattacharjee AK, Padmanabhan R. Antiviral Res. 2017 Jan;137:141-150. doi: 10.1016/j.antiviral.2016.11.015. Epub 2016 Nov 23. PubMed |
| Subcellular localization of FOXO3a as a potential biomarker of response to combined treatment with inhibitors of PI3K and autophagy in PIK3CA-mutant cancer cells. Kim HJ, Lee SY, Kim CY, Kim YH, Ju W, Kim SC. Oncotarget. 2017 Jan 24;8(4):6608-6622. doi: 10.18632/oncotarget.14245. PubMed |
| mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation. Villar VH, Nguyen TL, Delcroix V, Teres S, Bouchecareilh M, Salin B, Bodineau C, Vacher P, Priault M, Soubeyran P, Duran RV. Nat Commun. 2017 Jan 23;8:14124. doi: 10.1038/ncomms14124. PubMed |
| CQ synergistically sensitizes human colorectal cancer cells to SN-38/CPT-11 through lysosomal and mitochondrial apoptotic pathway via p53-ROS cross-talk. Chen P, Luo X, Nie P, Wu B, Xu W, Shi X, Chang H, Li B, Yu X, Zou Z. Free Radic Biol Med. 2017 Mar;104:280-297. doi: 10.1016/j.freeradbiomed.2017.01.033. Epub 2017 Jan 25. PubMed |
| Glucagon-Like Peptide 1 Protects Pancreatic beta-Cells From Death by Increasing Autophagic Flux and Restoring Lysosomal Function. Zummo FP, Cullen KS, Honkanen-Scott M, Shaw JAM, Lovat PE, Arden C. Diabetes. 2017 May;66(5):1272-1285. doi: 10.2337/db16-1009. Epub 2017 Feb 23. PubMed |
| Cytoprotective effect of kaempferol against palmitic acid-induced pancreatic beta-cell death through modulation of autophagy via AMPK/mTOR signaling pathway. Varshney R, Gupta S, Roy P. Mol Cell Endocrinol. 2017 Jun 15;448:1-20. doi: 10.1016/j.mce.2017.02.033. Epub 2017 Feb 24. PubMed |
| Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells. Tavera-Mendoza LE, Westerling T, Libby E, Marusyk A, Cato L, Cassani R, Cameron LA, Ficarro SB, Marto JA, Klawitter J, Brown M. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2186-E2194. doi: 10.1073/pnas.1615015114. Epub 2017 Feb 27. PubMed |
| Ischemia Induces Quiescence and Autophagy Dependence in Hepatocellular Carcinoma. Gade TPF, Tucker E, Nakazawa MS, Hunt SJ, Wong W, Krock B, Weber CN, Nadolski GJ, Clark TWI, Soulen MC, Furth EE, Winkler JD, Amaravadi RK, Simon MC. Radiology. 2017 Jun;283(3):702-710. doi: 10.1148/radiol.2017160728. Epub 2017 Mar 2. PubMed |
| High-Throughput Quantification of GFP-LC3(+) Dots by Automated Fluorescence Microscopy. Bravo-San Pedro JM, Pietrocola F, Sica V, Izzo V, Sauvat A, Kepp O, Maiuri MC, Kroemer G, Galluzzi L. Methods Enzymol. 2017;587:71-86. doi: 10.1016/bs.mie.2016.10.022. Epub 2016 Dec 29. PubMed |
| Activation of autophagy by elevated reactive oxygen species rather than released silver ions promotes cytotoxicity of polyvinylpyrrolidone-coated silver nanoparticles in hematopoietic cells. Zhu L, Guo D, Sun L, Huang Z, Zhang X, Ma W, Wu J, Xiao L, Zhao Y, Gu N. Nanoscale. 2017 May 4;9(17):5489-5498. doi: 10.1039/c6nr08188f. PubMed |
| Imiquimod-induced autophagy is regulated by ER stress-mediated PKR activation in cancer cells. Chang SH, Huang SW, Wang ST, Chung KC, Hsieh CW, Kao JK, Chen YJ, Wu CY, Shieh JJ. J Dermatol Sci. 2017 Aug;87(2):138-148. doi: 10.1016/j.jdermsci.2017.04.011. Epub 2017 May 2. PubMed |
| Protocols for assessing mitophagy in neuronal cell lines and primary neurons. Dagda RK, Rice M. Neuromethods. 2017;123:249-277. doi: 10.1007/978-1-4939-6890-9_13. Epub 2017 Mar 18. PubMed |
| Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice. Cao B, Parnell LA, Diamond MS, Mysorekar IU. J Exp Med. 2017 Aug 7;214(8):2303-2313. doi: 10.1084/jem.20170957. Epub 2017 Jul 10. PubMed |
| Phosphatidylinositol 4-phosphate 5-kinase alpha contributes to Toll-like receptor 2-mediated immune responses in microglial cells stimulated with lipoteichoic acid. Nguyen TTN, Seo E, Choi J, Le OTT, Kim JY, Jou I, Lee SY. Cell Signal. 2017 Oct;38:159-170. doi: 10.1016/j.cellsig.2017.07.009. Epub 2017 Jul 13. PubMed |
| Elimination of dysfunctional mitochondria through mitophagy suppresses benzo[a]pyrene-induced apoptosis. Das DN, Naik PP, Mukhopadhyay S, Panda PK, Sinha N, Meher BR, Bhutia SK. Free Radic Biol Med. 2017 Nov;112:452-463. doi: 10.1016/j.freeradbiomed.2017.08.020. Epub 2017 Aug 24. PubMed |
| VPS34 stimulation of p62 phosphorylation for cancer progression. Jiang X, Bao Y, Liu H, Kou X, Zhang Z, Sun F, Qian Z, Lin Z, Li X, Liu X, Jiang L, Yang Y. Oncogene. 2017 Dec 14;36(50):6850-6862. doi: 10.1038/onc.2017.295. Epub 2017 Aug 28. PubMed |
| The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome. Park HJ, Ryu D, Parmar M, Giasson BI, McFarland NR. PLoS One. 2017 Sep 6;12(9):e0184262. doi: 10.1371/journal.pone.0184262. eCollection 2017. PubMed |
| MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling. Bartolome A, Garcia-Aguilar A, Asahara SI, Kido Y, Guillen C, Pajvani UB, Benito M. Mol Cell Biol. 2017 Sep 11. pii: MCB.00441-17. doi: 10.1128/MCB.00441-17. PubMed |
| PI3K-C2alpha knockdown decreases autophagy and maturation of endocytic vesicles. Merrill NM, Schipper JL, Karnes JB, Kauffman AL, Martin KR, MacKeigan JP. PLoS One. 2017 Sep 14;12(9):e0184909. doi: 10.1371/journal.pone.0184909. eCollection 2017. PubMed |
Generation of an OCT4 reporter human induced pluripotent stem cell line using CRISPR/SpCas9.
Balboa D, Weltner J, Novik Y, Eurola S, Wartiovaara K, Otonkoski T.
Stem Cell Res. 2017 Aug;23:105-108. doi: 10.1016/j.scr.2017.07.006. Epub 2017 Jul 11.
PubMed
Associated Plasmids |
| Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition. Kim SH, Kim G, Han DH, Lee M, Kim I, Kim B, Kim KH, Song YM, Yoo JE, Wang HJ, Bae SH, Lee YH, Lee BW, Kang ES, Cha BS, Lee MS. Autophagy. 2017 Oct 3;13(10):1767-1781. doi: 10.1080/15548627.2017.1356977. Epub 2017 Sep 21. PubMed |
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| Functional Interaction of Hypoxia-Inducible Factor 2-Alpha and Autophagy Mediates Drug Resistance in Colon Cancer Cells. Saint-Martin A, Martinez-Rios J, Castaneda-Patlan MC, Sarabia-Sanchez MA, Tejeda-Munoz N, Chinney-Herrera A, Soldevila G, Benelli R, Santoyo-Ramos P, Poggi A, Robles-Flores M. Cancers (Basel). 2019 May 30;11(6). pii: cancers11060755. doi: 10.3390/cancers11060755. PubMed |
| Combination of targeting CD24 and inhibiting autophagy suppresses the proliferation and enhances the apoptosis of colorectal cancer cells. Zhuo J, Wang X. Mol Med Rep. 2019 Jul;20(1):539-548. doi: 10.3892/mmr.2019.10288. Epub 2019 May 23. PubMed |
| B-cell lymphoma-2-associated transcription factor 1 is overexpressed and contributes to sorafenib resistance in hepatocellular carcinoma. Yu S, Wang X, Dou N, Zhou J, Gao Y, Li Y. Hepatol Res. 2019 Nov;49(11):1329-1340. doi: 10.1111/hepr.13395. Epub 2019 Jul 23. PubMed |
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| ESCRT-mediated phagophore sealing during mitophagy. Zhen Y, Spangenberg H, Munson MJ, Brech A, Schink KO, Tan KW, Sorensen V, Wenzel EM, Radulovic M, Engedal N, Simonsen A, Raiborg C, Stenmark H. Autophagy. 2019 Aug 1:1-16. doi: 10.1080/15548627.2019.1639301. PubMed |
| Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes. Schott MB, Weller SG, Schulze RJ, Krueger EW, Drizyte-Miller K, Casey CA, McNiven MA. J Cell Biol. 2019 Oct 7;218(10):3320-3335. doi: 10.1083/jcb.201803153. Epub 2019 Aug 7. PubMed |
| The role of APC-mediated actin assembly in microtubule capture and focal adhesion turnover. Juanes MA, Isnardon D, Badache A, Brasselet S, Mavrakis M, Goode BL. J Cell Biol. 2019 Oct 7;218(10):3415-3435. doi: 10.1083/jcb.201904165. Epub 2019 Aug 30. PubMed |
| Synergistic anti-breast cancer effect of pulsatilla saponin D and camptothecin through interrupting autophagic-lysosomal function and promoting p62-mediated ubiquitinated protein aggregation. Wang K, Tu Y, Wan JB, Chen M, He C. Carcinogenesis. 2019 Aug 27. pii: 5554930. doi: 10.1093/carcin/bgz140. PubMed |
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| A Novel Salicylanilide Derivative Induces Autophagy Cell Death in Castration-Resistant Prostate Cancer via ER Stress-Activated PERK Signaling Pathway. Hsieh CL, Huang HS, Chen KC, Saka T, Chiang CY, Chung LWK, Sung SY. Mol Cancer Ther. 2020 Jan;19(1):101-111. doi: 10.1158/1535-7163.MCT-19-0387. Epub 2019 Sep 17. PubMed |
| Long non-coding RNA TUG1 enhances chemosensitivity in non-small cell lung cancer by impairing microRNA-221-dependent PTEN inhibition. Guo S, Zhang L, Zhang Y, Wu Z, He D, Li X, Wang Z. Aging (Albany NY). 2019 Sep 18;11(18):7553-7569. doi: 10.18632/aging.102271. Epub 2019 Sep 18. PubMed |
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| Trans-10-hydroxy-2-decenoic acid protects against LPS-induced neuroinflammation through FOXO1-mediated activation of autophagy. You M, Miao Z, Tian J, Hu F. Eur J Nutr. 2019 Dec 9. pii: 10.1007/s00394-019-02128-9. doi: 10.1007/s00394-019-02128-9. PubMed |
| Terminalia bellirica extract induces anticancer activity through modulation of apoptosis and autophagy in oral squamous cell carcinoma. Patra S, Panda PK, Naik PP, Panigrahi DP, Praharaj PP, Bhol CS, Mahapatra KK, Padhi P, Jena M, Patil S, Patra SK, Bhutia SK. Food Chem Toxicol. 2020 Feb;136:111073. doi: 10.1016/j.fct.2019.111073. Epub 2019 Dec 23. PubMed |
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| HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner. Castro-Gonzalez S, Shi Y, Colomer-Lluch M, Song Y, Mowery K, Almodovar S, Bansal A, Kirchhoff F, Sparrer K, Liang C, Serra-Moreno R. Autophagy. 2021 Feb;17(2):553-577. doi: 10.1080/15548627.2020.1725401. Epub 2020 Feb 25. PubMed |
| Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5. Feng X, Zhang H, Meng L, Song H, Zhou Q, Qu C, Zhao P, Li Q, Zou C, Liu X, Zhang Z. Autophagy. 2021 Mar;17(3):723-742. doi: 10.1080/15548627.2020.1731266. Epub 2020 Mar 18. PubMed |
| Xyloneside A: A New Glycosylated Incisterol Derivative from Xylaria sp. FB. Lee SR, Kreuzenbeck NB, Jang M, Oh T, Ko SK, Ahn JS, Beemelmanns C, Kim KH. Chembiochem. 2020 Aug 17;21(16):2253-2258. doi: 10.1002/cbic.202000065. Epub 2020 May 5. PubMed |
| Neferine, an alkaloid from lotus seed embryo targets HeLa and SiHa cervical cancer cells via pro-oxidant anticancer mechanism. Dasari S, Bakthavachalam V, Chinnapaka S, Venkatesan R, Samy ALPA, Munirathinam G. Phytother Res. 2020 Sep;34(9):2366-2384. doi: 10.1002/ptr.6687. Epub 2020 May 4. PubMed |
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| Cyanidin-3-O-glucoside attenuates high glucose-induced podocyte dysfunction by inhibiting apoptosis and promoting autophagy via activation of SIRT1/AMPK pathway. Wang S, Huang Y, Luo G, Yang X, Huang W. Can J Physiol Pharmacol. 2020 Oct 13:1-10. doi: 10.1139/cjpp-2020-0341. PubMed |
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| Secretory clusterin promotes oral cancer cell survival via inhibiting apoptosis by activation of autophagy in AMPK/mTOR/ULK1 dependent pathway. Naik PP, Mukhopadhyay S, Praharaj PP, Bhol CS, Panigrahi DP, Mahapatra KK, Patra S, Saha S, Panda AK, Panda K, Paul S, Aich P, Patra SK, Bhutia SK. Life Sci. 2021 Jan 1;264:118722. doi: 10.1016/j.lfs.2020.118722. Epub 2020 Nov 5. PubMed |
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| Antimicrobial Peptide against Mycobacterium Tuberculosis That Activates Autophagy Is an Effective Treatment for Tuberculosis. Pelaez Coyotl EA, Barrios Palacios J, Mucino G, Moreno-Blas D, Costas M, Montiel Montes T, Diener C, Uribe-Carvajal S, Massieu L, Castro-Obregon S, Espinosa OR, Mata Espinosa D, Barrios-Payan J, Leon Contreras JC, Corzo G, Hernandez-Pando R, Del Rio G. Pharmaceutics. 2020 Nov 9;12(11). pii: pharmaceutics12111071. doi: 10.3390/pharmaceutics12111071. PubMed |
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| The apple dihydrochalcone phloretin suppresses growth and improves chemosensitivity of breast cancer cells via inhibition of cytoprotective autophagy. Chen M, Gowd V, Wang M, Chen F, Cheng KW. Food Funct. 2021 Jan 7;12(1):177-190. doi: 10.1039/d0fo02362k. Epub 2020 Dec 8. PubMed |
| FV-429 induces autophagy blockage and lysosome-dependent cell death of T-cell malignancies via lysosomal dysregulation. Hu P, Wang J, Qing Y, Li H, Sun W, Yu X, Hui H, Guo Q, Xu J. Cell Death Dis. 2021 Jan 13;12(1):80. doi: 10.1038/s41419-021-03394-4. PubMed |
| Differential Sensitivity of Wild-Type and BRAF-Mutated Cells to Combined BRAF and Autophagy Inhibition. Yeom H, Hwang SH, Han BI, Lee M. Biomol Ther (Seoul). 2021 Jul 1;29(4):434-444. doi: 10.4062/biomolther.2020.203. PubMed |
| Initial Identification of UDP-Glucose Dehydrogenase as a Prognostic Marker in Breast Cancer Patients, Which Facilitates Epirubicin Resistance and Regulates Hyaluronan Synthesis in MDA-MB-231 Cells. Vitale DL, Caon I, Parnigoni A, Sevic I, Spinelli FM, Icardi A, Passi A, Vigetti D, Alaniz L. Biomolecules. 2021 Feb 9;11(2). pii: biom11020246. doi: 10.3390/biom11020246. PubMed |
| Autophagy Mediates Leptin-Induced Migration and ERK Activation in Breast Cancer Cells. Garcia-Miranda A, Solano-Alcala KA, Montes-Alvarado JB, Rosas-Cruz A, Reyes-Leyva J, Navarro-Tito N, Maycotte P, Castaneda-Saucedo E. Front Cell Dev Biol. 2021 Mar 8;9:644851. doi: 10.3389/fcell.2021.644851. eCollection 2021. PubMed |
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| Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy: Dynamic analysis on cytotoxic effects of LW-218. Hu P, Li H, Sun W, Wang H, Yu X, Qing Y, Wang Z, Zhu M, Xu J, Guo Q, Hui H. Acta Pharm Sin B. 2021 Oct;11(10):3178-3192. doi: 10.1016/j.apsb.2021.02.004. Epub 2021 Feb 11. PubMed |
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| Paired-like homeodomain 2B contributes to tumour progression and anti-autophagy in human lung cancer. Wang CC, Lin SY, Huang YH, Hsieh CH, Chang HH, Chen HY, Weng CW, Chang GC, Yu SL, Chen JJ. Am J Cancer Res. 2021 Oct 15;11(10):4900-4918. eCollection 2021. PubMed |
| SARS-CoV-2 ORF3a Induces Incomplete Autophagy via the Unfolded Protein Response. Su WQ, Yu XJ, Zhou CM. Viruses. 2021 Dec 9;13(12). pii: v13122467. doi: 10.3390/v13122467. PubMed |
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| Galectin-9 restricts hepatitis B virus replication via p62/SQSTM1-mediated selective autophagy of viral core proteins. Miyakawa K, Nishi M, Ogawa M, Matsunaga S, Sugiyama M, Nishitsuji H, Kimura H, Ohnishi M, Watashi K, Shimotohno K, Wakita T, Ryo A. Nat Commun. 2022 Jan 27;13(1):531. doi: 10.1038/s41467-022-28171-5. PubMed |
| PINK1/TAX1BP1-directed mitophagy attenuates vascular endothelial injury induced by copper oxide nanoparticles. Fan Y, Cheng Z, Mao L, Xu G, Li N, Zhang M, Weng P, Zheng L, Dong X, Hu S, Wang B, Qin X, Jiang X, Chen C, Zhang J, Zou Z. J Nanobiotechnology. 2022 Mar 19;20(1):149. doi: 10.1186/s12951-022-01338-4. PubMed |
| The role of FYCO1-dependent autophagy in lens fiber cell differentiation. Khan SY, Ali M, Kabir F, Na CH, Delannoy M, Ma Y, Qiu C, Costello MJ, Hejtmancik JF, Riazuddin SA. Autophagy. 2022 Sep;18(9):2198-2215. doi: 10.1080/15548627.2022.2025570. Epub 2022 Mar 28. PubMed |
| Triclosan-induced neuroinflammation develops caspase-independent and TNF-alpha signaling pathway associated necroptosis in Neuro-2a cells. Katiyar P, Banerjee S, Nathani S, Roy P. Curr Res Toxicol. 2022 May 6;3:100072. doi: 10.1016/j.crtox.2022.100072. eCollection 2022. PubMed |
| SOCS5 contributes to temozolomide resistance in glioblastoma by regulating Bcl-2-mediated autophagy. Yu J, Han L, Yang F, Zhao M, Zhou H, Hu L. Bioengineered. 2022 Jun;13(6):14125-14137. doi: 10.1080/21655979.2022.2081463. PubMed |
| Inhibition of autophagy by chloroquine prevents resistance to PI3K/AKT inhibitors and potentiates their antitumor effect in combination with paclitaxel in triple negative breast cancer models. Cocco S, Leone A, Roca MS, Lombardi R, Piezzo M, Caputo R, Ciardiello C, Costantini S, Bruzzese F, Sisalli MJ, Budillon A, De Laurentiis M. J Transl Med. 2022 Jun 27;20(1):290. doi: 10.1186/s12967-022-03462-z. PubMed |
| Paradoxical downregulation of LPAR3 exerts tumor-promoting activity through autophagy induction in Ras-transformed cells. Hwang SH, Kim HG, Lee M. BMC Cancer. 2022 Sep 10;22(1):969. doi: 10.1186/s12885-022-10053-0. PubMed |
| PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805. Bai Y, Yu G, Zhou HM, Amarasinghe O, Zhou Y, Zhu P, Li Q, Zhang L, Nguele Meke F, Miao Y, Chapman E, Tao WA, Zhang ZY. Autophagy. 2023 May;19(5):1562-1581. doi: 10.1080/15548627.2022.2140558. Epub 2022 Nov 7. PubMed |
| Exogenous H(2)S Attenuates Hypertension by Regulating Renin Exocytosis under Hyperglycaemic and Hyperlipidaemic Conditions. Liu N, Li M, Liu S, Kang J, Chen L, Huang J, Wang Y, Chen H, Zhang W. Int J Mol Sci. 2023 Jan 14;24(2):1690. doi: 10.3390/ijms24021690. PubMed |
| Deciphering functional roles and interplay between Beclin1 and Beclin2 in autophagosome formation and mitophagy. Quiles JM, Najor RH, Gonzalez E, Jeung M, Liang W, Burbach SM, Zumaya EA, Diao RY, Lampert MA, Gustafsson AB. Sci Signal. 2023 Jan 31;16(770):eabo4457. doi: 10.1126/scisignal.abo4457. Epub 2023 Jan 31. PubMed |
| Porcine reproductive and respiratory syndrome virus infection triggers autophagy via ER stress-induced calcium signaling to facilitate virus replication. Diao F, Jiang C, Sun Y, Gao Y, Bai J, Nauwynck H, Wang X, Yang Y, Jiang P, Liu X. PLoS Pathog. 2023 Mar 27;19(3):e1011295. doi: 10.1371/journal.ppat.1011295. eCollection 2023 Mar. PubMed |
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