pCINeo-myc-Itch/2859 Citations (7)

Originally described in: WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation.
Magnifico A, Ettenberg S, Yang C, Mariano J, Tiwari S, Fang S, Lipkowitz S, Weissman AM J Biol Chem. 2003 Oct 31. 278(44):43169-77. PubMed Journal

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Articles Citing pCINeo-myc-Itch/2859

Articles
MKK4/SEK1 is negatively regulated through a feedback loop involving the E3 ubiquitin ligase itch. Ahn YH, Kurie JM. J Biol Chem. 2009 Oct 23;284(43):29399-404. doi: 10.1074/jbc.M109.044958. Epub 2009 Sep 8. PubMed
MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-kappaB activity. Moreno-Garcia ME, Sommer K, Shinohara H, Bandaranayake AD, Kurosaki T, Rawlings DJ. Mol Cell Biol. 2010 Feb;30(4):922-34. doi: 10.1128/MCB.01129-09. Epub 2009 Dec 14. PubMed
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Perez-Mancera PA, Rust AG, van der Weyden L, Kristiansen G, Li A, Sarver AL, Silverstein KA, Grutzmann R, Aust D, Rummele P, Knosel T, Herd C, Stemple DL, Kettleborough R, Brosnan JA, Li A, Morgan R, Knight S, Yu J, Stegeman S, Collier LS, ten Hoeve JJ, de Ridder J, Klein AP, Goggins M, Hruban RH, Chang DK, Biankin AV, Grimmond SM, Wessels LF, Wood SA, Iacobuzio-Donahue CA, Pilarsky C, Largaespada DA, Adams DJ, Tuveson DA. Nature. 2012 Apr 29;486(7402):266-70. doi: 10.1038/nature11114. PubMed
Ubiquitin ligase ITCH recruitment suppresses the aggregation and cellular toxicity of cytoplasmic misfolded proteins. Chhangani D, Upadhyay A, Amanullah A, Joshi V, Mishra A. Sci Rep. 2014 May 28;4:5077. doi: 10.1038/srep05077. PubMed
Itch E3 ubiquitin ligase positively regulates TGF-beta signaling to EMT via Smad7 ubiquitination. Park SH, Jung EH, Kim GY, Kim BC, Lim JH, Woo CH. Mol Cells. 2015 Jan 31;38(1):20-5. doi: 10.14348/molcells.2015.2120. Epub 2014 Dec 16. PubMed
DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT Proteins. Nguyen HT, Kugler JM, Cohen SM. PLoS One. 2017 Jan 6;12(1):e0169587. doi: 10.1371/journal.pone.0169587. eCollection 2017. PubMed
K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling. Yin Q, Han T, Fang B, Zhang G, Zhang C, Roberts ER, Izumi V, Zheng M, Jiang S, Yin X, Kim M, Cai J, Haura EB, Koomen JM, Smalley KSM, Wan L. Nat Commun. 2019 Apr 23;10(1):1870. doi: 10.1038/s41467-019-09844-0. PubMed

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