pTP2620 Citations (2)
Originally described in: Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.Lee JH, Mand MR, Deshpande RA, Kinoshita E, Yang SH, Wyman C, Paull TT J Biol Chem. 2013 May 3;288(18):12840-51. doi: 10.1074/jbc.M113.460378. Epub 2013 Mar 22. PubMed Journal
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TRIM24 is critical for the cellular response to DNA double-strand breaks through regulating the recruitment of MRN complex. Wang Y, Yao Y, Wei Q, Long S, Chen Y, Xie J, Tan R, Jiang W, Zhang Q, Wu D, Xiao S, Wan F, Fu K. Oncogene. 2023 Feb;42(8):586-600. doi: 10.1038/s41388-022-02580-8. Epub 2022 Dec 22. PubMed |
MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis.
Cho MG, Kumar RJ, Lin CC, Boyer JA, Shahir JA, Fagan-Solis K, Simpson DA, Fan C, Foster CE, Goddard AM, Lerner LM, Ellington SW, Wang Q, Wang Y, Ho AY, Liu P, Perou CM, Zhang Q, McGinty RK, Purvis JE, Gupta GP.
Nature. 2024 Jan 10. doi: 10.1038/s41586-023-06889-6.
PubMed
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