IKK-2 S177E S181E Citations (32)

Originally described in: IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.
Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BL, Li J, Young DB, Barbosa M, Mann M, Manning A, Rao A Science. 1997 Oct 31. 278(5339):860-6. PubMed Journal

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Articles Citing IKK-2 S177E S181E

Articles
Regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cells. Chen R, Alvero AB, Silasi DA, Kelly MG, Fest S, Visintin I, Leiser A, Schwartz PE, Rutherford T, Mor G. Oncogene. 2008 Aug 7;27(34):4712-23. doi: 10.1038/onc.2008.112. Epub 2008 Apr 14. PubMed
Sulindac induces apoptotic cell death in susceptible human breast cancer cells through, at least in part, inhibition of IKKbeta. Seo AM, Hong SW, Shin JS, Park IC, Hong NJ, Kim DJ, Lee WK, Lee WJ, Jin DH, Lee MS. Apoptosis. 2009 Jul;14(7):913-22. doi: 10.1007/s10495-009-0367-1. PubMed
Evidence that alpha-lipoic acid inhibits NF-kappaB activation independent of its antioxidant function. Ying Z, Kampfrath T, Sun Q, Parthasarathy S, Rajagopalan S. Inflamm Res. 2011 Mar;60(3):219-25. doi: 10.1007/s00011-010-0256-7. Epub 2010 Oct 7. PubMed
Mechanisms controlling neurite outgrowth in a pheochromocytoma cell line: the role of TRPC channels. Kumar S, Chakraborty S, Barbosa C, Brustovetsky T, Brustovetsky N, Obukhov AG. J Cell Physiol. 2012 Apr;227(4):1408-19. doi: 10.1002/jcp.22855. PubMed
Kinase-independent feedback of the TAK1/TAB1 complex on BCL10 turnover and NF-kappaB activation. Moreno-Garcia ME, Sommer K, Rincon-Arano H, Brault M, Ninomiya-Tsuji J, Matesic LE, Rawlings DJ. Mol Cell Biol. 2013 Mar;33(6):1149-63. doi: 10.1128/MCB.06407-11. Epub 2013 Jan 7. PubMed
Trichothecin induces cell death in NF-kappaB constitutively activated human cancer cells via inhibition of IKKbeta phosphorylation. Su J, Zhao P, Kong L, Li X, Yan J, Zeng Y, Li Y. PLoS One. 2013 Aug 1;8(8):e71333. doi: 10.1371/journal.pone.0071333. Print 2013. PubMed
The hypoxia-inducible transcription factor ZNF395 is controlled by IkB kinase-signaling and activates genes involved in the innate immune response and cancer. Jordanovski D, Herwartz C, Pawlowski A, Taute S, Frommolt P, Steger G. PLoS One. 2013 Sep 23;8(9):e74911. doi: 10.1371/journal.pone.0074911. eCollection 2013. PubMed
Identification of plumericin as a potent new inhibitor of the NF-kappaB pathway with anti-inflammatory activity in vitro and in vivo. Fakhrudin N, Waltenberger B, Cabaravdic M, Atanasov AG, Malainer C, Schachner D, Heiss EH, Liu R, Noha SM, Grzywacz AM, Mihaly-Bison J, Awad EM, Schuster D, Breuss JM, Rollinger JM, Bochkov V, Stuppner H, Dirsch VM. Br J Pharmacol. 2014 Apr;171(7):1676-86. doi: 10.1111/bph.12558. PubMed
Activation of the transcription factor c-Maf in T cells is dependent on the CARMA1-IKKbeta signaling cascade. Blonska M, Joo D, Nurieva RI, Zhao X, Chiao P, Sun SC, Dong C, Lin X. Sci Signal. 2013 Dec 17;6(306):ra110. doi: 10.1126/scisignal.2004273. PubMed
p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-kappaB pathway. Tyagi N, Bhardwaj A, Singh AP, McClellan S, Carter JE, Singh S. Oncotarget. 2014 Sep 30;5(18):8778-89. PubMed
Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M. Miyata M, Lee JY, Susuki-Miyata S, Wang WY, Xu H, Kai H, Kobayashi KS, Flavell RA, Li JD. Nat Commun. 2015 Jan 14;6:6062. doi: 10.1038/ncomms7062. PubMed
Cytosolic PTEN-induced Putative Kinase 1 Is Stabilized by the NF-kappaB Pathway and Promotes Non-selective Mitophagy. Lim GG, Chua DS, Basil AH, Chan HY, Chai C, Arumugam T, Lim KL. J Biol Chem. 2015 Jul 3;290(27):16882-93. doi: 10.1074/jbc.M114.622399. Epub 2015 May 18. PubMed
MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation. Lahiri A, Hedl M, Abraham C. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10461-6. doi: 10.1073/pnas.1501752112. Epub 2015 Aug 3. PubMed
Inhibition of NF-kappaB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocelular apoptosis. M Rodrigues P, B Afonso M, L Simao A, M Borralho P, M P Rodrigues C, E Castro R. Sci Rep. 2015 Dec 1;5:17528. doi: 10.1038/srep17528. PubMed
TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair. Ogura Y, Hindi SM, Sato S, Xiong G, Akira S, Kumar A. Nat Commun. 2015 Dec 9;6:10123. doi: 10.1038/ncomms10123. PubMed
IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation. Hedl M, Yan J, Abraham C. Cell Rep. 2016 Aug 30;16(9):2442-55. doi: 10.1016/j.celrep.2016.07.060. Epub 2016 Aug 18. PubMed
Honokiol suppresses pancreatic tumor growth, metastasis and desmoplasia by interfering with tumor-stromal cross-talk. Averett C, Bhardwaj A, Arora S, Srivastava SK, Khan MA, Ahmad A, Singh S, Carter JE, Khushman M, Singh AP. Carcinogenesis. 2016 Sep 8. pii: bgw096. PubMed
Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1. Jin YR, Stohn JP, Wang Q, Nagano K, Baron R, Bouxsein ML, Rosen CJ, Adarichev VA, Lindner V. Bone. 2017 Apr;97:153-167. doi: 10.1016/j.bone.2017.01.022. Epub 2017 Jan 21. PubMed
The IKK/NF-kappaB signaling pathway requires Morgana to drive breast cancer metastasis. Fusella F, Secli L, Busso E, Krepelova A, Moiso E, Rocca S, Conti L, Annaratone L, Rubinetto C, Mello-Grand M, Singh V, Chiorino G, Silengo L, Altruda F, Turco E, Morotti A, Oliviero S, Castellano I, Cavallo F, Provero P, Tarone G, Brancaccio M. Nat Commun. 2017 Nov 21;8(1):1636. doi: 10.1038/s41467-017-01829-1. PubMed
Deletion of IkappaB-Kinase beta in Smooth Muscle Cells Induces Vascular Calcification Through beta-Catenin-Runt-Related Transcription Factor 2 Signaling. Al-Huseini I, Ashida N, Kimura T. J Am Heart Assoc. 2018 Jan 4;7(1). pii: JAHA.117.007405. doi: 10.1161/JAHA.117.007405. PubMed
Palmitate-induced C/EBP homologous protein activation leads to NF-kappaB-mediated increase in BACE1 activity and amyloid beta genesis. Marwarha G, Schommer J, Lund J, Schommer T, Ghribi O. J Neurochem. 2018 Mar;144(6):761-779. doi: 10.1111/jnc.14292. Epub 2018 Feb 14. PubMed
A DGKzeta-FoxO-ubiquitin proteolytic axis controls fiber size during skeletal muscle remodeling. You JS, Dooley MS, Kim CR, Kim EJ, Xu W, Goodman CA, Hornberger TA. Sci Signal. 2018 May 15;11(530). pii: 11/530/eaao6847. doi: 10.1126/scisignal.aao6847. PubMed
NF-kappaB-Dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis. Rodrigues P, Patel SA, Harewood L, Olan I, Vojtasova E, Syafruddin SE, Zaini MN, Richardson EK, Burge J, Warren AY, Stewart GD, Saeb-Parsy K, Samarajiwa SA, Vanharanta S. Cancer Discov. 2018 Jul;8(7):850-865. doi: 10.1158/2159-8290.CD-17-1211. Epub 2018 Jun 6. PubMed
The cirrhotic liver is depleted of docosahexaenoic acid (DHA), a key modulator of NF-kappaB and TGFbeta pathways in hepatic stellate cells. Enguita M, Razquin N, Pamplona R, Quiroga J, Prieto J, Fortes P. Cell Death Dis. 2019 Jan 8;10(1):14. doi: 10.1038/s41419-018-1243-0. PubMed
Chromatin Remodeling in Response to BRCA2-Crisis. Gruber JJ, Chen J, Geller B, Jager N, Lipchik AM, Wang G, Kurian AW, Ford JM, Snyder MP. Cell Rep. 2019 Aug 20;28(8):2182-2193.e6. doi: 10.1016/j.celrep.2019.07.057. PubMed
Highly Efficient Transfection of Primary Macrophages with In Vitro Transcribed mRNA. Herb M, Farid A, Gluschko A, Kronke M, Schramm M. J Vis Exp. 2019 Nov 9;(153). doi: 10.3791/60143. PubMed
Myeloid Cell Expression of LACC1 Is Required for Bacterial Clearance and Control of Intestinal Inflammation. Kang JW, Yan J, Ranjan K, Zhang X, Turner JR, Abraham C. Gastroenterology. 2020 Jul 18. pii: S0016-5085(20)34953-2. doi: 10.1053/j.gastro.2020.07.024. PubMed
IKKbeta Alleviates Neuron Injury in Alzheimer's Disease via Regulating Autophagy and RIPK1-Mediated Necroptosis. Wang W, Gu X, Cheng Z, Lu X, Xie S, Liu X. Mol Neurobiol. 2022 Apr;59(4):2407-2423. doi: 10.1007/s12035-021-02652-y. Epub 2022 Jan 27. PubMed
Macrophage IL-1beta promotes arteriogenesis by autocrine STAT3- and NF-kappaB-mediated transcription of pro-angiogenic VEGF-A. Mantsounga CS, Lee C, Neverson J, Sharma S, Healy A, Berus JM, Parry C, Ceneri NM, Lopez-Giraldez F, Chun HJ, Lu Q, Sellke F, Choudhary G, Morrison AR. Cell Rep. 2022 Feb 1;38(5):110309. doi: 10.1016/j.celrep.2022.110309. PubMed
Sustained activation of NF-kappaB through constitutively active IKKbeta leads to senescence bypass in murine dermal fibroblasts. Harada M, Su-Harada K, Kimura T, Ono K, Ashida N. Cell Cycle. 2024 Feb;23(3):308-327. doi: 10.1080/15384101.2024.2325802. Epub 2024 Mar 10. PubMed
Three Modes of Viral Adaption by the Heart. Griffiths CD, Shah M, Shao W, Borgman CA, Janes KA. bioRxiv [Preprint]. 2024 Mar 29:2024.03.28.587274. doi: 10.1101/2024.03.28.587274. PubMed
METTL8 links mt-tRNA m(3)C modification to the HIF1alpha/RTK/Akt axis to sustain GBM stemness and tumorigenicity. Lee BWL, Chuah YH, Yoon J, Grinchuk OV, Liang Y, Hirpara JL, Shen Y, Wang LC, Lim YT, Zhao T, Sobota RM, Yeo TT, Wong ALA, Teo K, Nga VDW, Tan BWQ, Suda T, Toh TB, Pervaiz S, Lin Z, Ong DST. Cell Death Dis. 2024 May 14;15(5):338. doi: 10.1038/s41419-024-06718-2. PubMed

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