IKK-2 WT Citations (14)

Originally described in: IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.
Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BL, Li J, Young DB, Barbosa M, Mann M, Manning A, Rao A Science. 1997 Oct 31. 278(5339):860-6. PubMed Journal

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Articles Citing IKK-2 WT

Articles
Fibroblast growth factor homologous factor 1 interacts with NEMO to regulate NF-kappaB signaling in neurons. Konig HG, Fenner BJ, Byrne JC, Schwamborn RF, Bernas T, Jefferies CA, Prehn JH. J Cell Sci. 2012 Dec 15;125(Pt 24):6058-70. doi: 10.1242/jcs.111880. Epub 2012 Oct 24. PubMed
Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKalpha/IKKbeta. Jin S, Mutvei AP, Chivukula IV, Andersson ER, Ramskold D, Sandberg R, Lee KL, Kronqvist P, Mamaeva V, Ostling P, Mpindi JP, Kallioniemi O, Screpanti I, Poellinger L, Sahlgren C, Lendahl U. Oncogene. 2013 Oct 10;32(41):4892-902. doi: 10.1038/onc.2012.517. Epub 2012 Nov 26. PubMed
Characterization of a novel curcumin analog P1 as potent inhibitor of the NF-kappaB signaling pathway with distinct mechanisms. Peng YM, Zheng JB, Zhou YB, Li J. Acta Pharmacol Sin. 2013 Jul;34(7):939-50. doi: 10.1038/aps.2013.2. Epub 2013 Apr 22. PubMed
The hypoxia-inducible transcription factor ZNF395 is controlled by IkB kinase-signaling and activates genes involved in the innate immune response and cancer. Jordanovski D, Herwartz C, Pawlowski A, Taute S, Frommolt P, Steger G. PLoS One. 2013 Sep 23;8(9):e74911. doi: 10.1371/journal.pone.0074911. eCollection 2013. PubMed
Cytosolic PTEN-induced Putative Kinase 1 Is Stabilized by the NF-kappaB Pathway and Promotes Non-selective Mitophagy. Lim GG, Chua DS, Basil AH, Chan HY, Chai C, Arumugam T, Lim KL. J Biol Chem. 2015 Jul 3;290(27):16882-93. doi: 10.1074/jbc.M114.622399. Epub 2015 May 18. PubMed
PATZ1 induces PP4R2 to form a negative feedback loop on IKK/NF-kappaB signaling in lung cancer. Ho MY, Liang CM, Liang SM. Oncotarget. 2016 Aug 9;7(32):52255-52269. doi: 10.18632/oncotarget.10427. PubMed
IKKbeta promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. Reid MA, Lowman XH, Pan M, Tran TQ, Warmoes MO, Ishak Gabra MB, Yang Y, Locasale JW, Kong M. Genes Dev. 2016 Aug 15;30(16):1837-51. doi: 10.1101/gad.287235.116. Epub 2016 Sep 1. PubMed
NF-kappaB regulates neuronal ankyrin-G via a negative feedback loop. Konig HG, Schwamborn R, Andresen S, Kinsella S, Watters O, Fenner B, Prehn JH. Sci Rep. 2017 Feb 9;7:42006. doi: 10.1038/srep42006. PubMed
The IKK/NF-kappaB signaling pathway requires Morgana to drive breast cancer metastasis. Fusella F, Secli L, Busso E, Krepelova A, Moiso E, Rocca S, Conti L, Annaratone L, Rubinetto C, Mello-Grand M, Singh V, Chiorino G, Silengo L, Altruda F, Turco E, Morotti A, Oliviero S, Castellano I, Cavallo F, Provero P, Tarone G, Brancaccio M. Nat Commun. 2017 Nov 21;8(1):1636. doi: 10.1038/s41467-017-01829-1. PubMed
IKKbeta activates p53 to promote cancer cell adaptation to glutamine deprivation. Ishak Gabra MB, Yang Y, Lowman XH, Reid MA, Tran TQ, Kong M. Oncogenesis. 2018 Nov 26;7(11):93. doi: 10.1038/s41389-018-0104-0. PubMed
Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates. Cockman ME, Lippl K, Tian YM, Pegg HB, Figg WD Jnr, Abboud MI, Heilig R, Fischer R, Myllyharju J, Schofield CJ, Ratcliffe PJ. Elife. 2019 Sep 10;8. pii: 46490. doi: 10.7554/eLife.46490. PubMed
Highly Efficient Transfection of Primary Macrophages with In Vitro Transcribed mRNA. Herb M, Farid A, Gluschko A, Kronke M, Schramm M. J Vis Exp. 2019 Nov 9;(153). doi: 10.3791/60143. PubMed
IKKalpha plays a major role in canonical NF-kappaB signalling in colorectal cells. Prescott JA, Balmanno K, Mitchell JP, Okkenhaug H, Cook SJ. Biochem J. 2022 Feb 11;479(3):305-325. doi: 10.1042/BCJ20210783. PubMed
Sustained activation of NF-kappaB through constitutively active IKKbeta leads to senescence bypass in murine dermal fibroblasts. Harada M, Su-Harada K, Kimura T, Ono K, Ashida N. Cell Cycle. 2024 Feb;23(3):308-327. doi: 10.1080/15384101.2024.2325802. Epub 2024 Mar 10. PubMed

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